JP2004525117A - 置換アミノジカルボン酸誘導体 - Google Patents
置換アミノジカルボン酸誘導体 Download PDFInfo
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- JP2004525117A JP2004525117A JP2002569783A JP2002569783A JP2004525117A JP 2004525117 A JP2004525117 A JP 2004525117A JP 2002569783 A JP2002569783 A JP 2002569783A JP 2002569783 A JP2002569783 A JP 2002569783A JP 2004525117 A JP2004525117 A JP 2004525117A
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- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 229940083618 sodium nitroprusside Drugs 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- MFPWEWYKQYMWRO-UHFFFAOYSA-N tert-butyl carboxy carbonate Chemical compound CC(C)(C)OC(=O)OC(O)=O MFPWEWYKQYMWRO-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- USFPINLPPFWTJW-UHFFFAOYSA-N tetraphenylphosphonium Chemical compound C1=CC=CC=C1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 USFPINLPPFWTJW-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- AWLILQARPMWUHA-UHFFFAOYSA-M thiopental sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC([S-])=NC1=O AWLILQARPMWUHA-UHFFFAOYSA-M 0.000 description 1
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical group SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- PIILXFBHQILWPS-UHFFFAOYSA-N tributyltin Chemical class CCCC[Sn](CCCC)CCCC PIILXFBHQILWPS-UHFFFAOYSA-N 0.000 description 1
- 125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
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- 230000002883 vasorelaxation effect Effects 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10110749A DE10110749A1 (de) | 2001-03-07 | 2001-03-07 | Substituierte Aminodicarbonsäurederivate |
| PCT/EP2002/001941 WO2002070462A1 (de) | 2001-03-07 | 2002-02-25 | Substituierte aminodicarbonsäurederivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525117A true JP2004525117A (ja) | 2004-08-19 |
| JP2004525117A5 JP2004525117A5 (https=) | 2005-12-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569783A Pending JP2004525117A (ja) | 2001-03-07 | 2002-02-25 | 置換アミノジカルボン酸誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040176446A1 (https=) |
| EP (1) | EP1368300A1 (https=) |
| JP (1) | JP2004525117A (https=) |
| CA (1) | CA2439759A1 (https=) |
| DE (1) | DE10110749A1 (https=) |
| WO (1) | WO2002070462A1 (https=) |
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| JP2009512647A (ja) * | 2005-10-21 | 2009-03-26 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ジフルオロフェノール誘導体およびそれらの使用 |
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| WO2015056663A1 (ja) * | 2013-10-15 | 2015-04-23 | トーアエイヨー株式会社 | ４－アミノメチル安息香酸誘導体 |
| JP2015524401A (ja) * | 2012-07-20 | 2015-08-24 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換アミノインダン−およびアミノテトラリンカルボン酸ならびにその使用 |
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| KR20240144177A (ko) | 2021-12-29 | 2024-10-02 | 바이엘 악티엔게젤샤프트 | (5s)-{[2-(4-카르복시페닐)에틸][2-(2-{[3-클로로-4'-(트리플루오로메틸)비페닐-4-일]메톡시}페닐)에틸]아미노}-5,6,7,8-테트라히드로퀴놀린-2-카르복실산및 약학적 활성 화합물로서 사용하기 위한 이의 결정질 형태를 제조하는 방법 |
| EP4456896A1 (en) | 2021-12-29 | 2024-11-06 | Bayer Aktiengesellschaft | Treatment of cardiopulmonary disorders |
| EP4536205A1 (en) | 2022-06-09 | 2025-04-16 | Bayer Aktiengesellschaft | Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women |
| EP4541794A1 (en) | 2022-07-29 | 2025-04-23 | Suzhong Pharmaceutical Group Co., Ltd. | Phenyl-substituted dihydronaphthyridine compounds, and preparation and use thereof |
| WO2025068514A1 (en) | 2023-09-28 | 2025-04-03 | Bayer Aktiengesellschaft | Substituted heterocyclic carboxamindes and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2132535T3 (es) * | 1994-09-20 | 1999-08-16 | Ono Pharmaceutical Co | Derivados de amidinofenol como inhibidores de proteasa. |
| AR006520A1 (es) * | 1996-03-20 | 1999-09-08 | Astra Pharma Prod | Derivados de 2-arilpirazolisoquinolina y cinolinona y procedimiento para su preparacion. |
| DE19649460A1 (de) * | 1996-11-26 | 1998-05-28 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943635A1 (de) * | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10109858A1 (de) * | 2001-03-01 | 2002-09-05 | Bayer Ag | Neuartige halogensubstituierte Aminodicarbonsäurederivate |
| DE10109861A1 (de) * | 2001-03-01 | 2002-09-05 | Bayer Ag | Neuartige seitenkettenhalogenierte Aminodicarbonsäurederivate |
-
2001
- 2001-03-07 DE DE10110749A patent/DE10110749A1/de not_active Withdrawn
-
2002
- 2002-02-25 EP EP02703602A patent/EP1368300A1/de not_active Withdrawn
- 2002-02-25 CA CA002439759A patent/CA2439759A1/en not_active Abandoned
- 2002-02-25 US US10/471,077 patent/US20040176446A1/en not_active Abandoned
- 2002-02-25 JP JP2002569783A patent/JP2004525117A/ja active Pending
- 2002-02-25 WO PCT/EP2002/001941 patent/WO2002070462A1/de not_active Ceased
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009512647A (ja) * | 2005-10-21 | 2009-03-26 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ジフルオロフェノール誘導体およびそれらの使用 |
| JP2010522703A (ja) * | 2007-03-29 | 2010-07-08 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 置換二安息香酸誘導体およびそれらの使用 |
| JP2015524401A (ja) * | 2012-07-20 | 2015-08-24 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換アミノインダン−およびアミノテトラリンカルボン酸ならびにその使用 |
| WO2015056663A1 (ja) * | 2013-10-15 | 2015-04-23 | トーアエイヨー株式会社 | ４－アミノメチル安息香酸誘導体 |
| JPWO2015056663A1 (ja) * | 2013-10-15 | 2017-03-09 | トーアエイヨー株式会社 | ４−アミノメチル安息香酸誘導体 |
| US9714213B2 (en) | 2013-10-15 | 2017-07-25 | Toa Eiyo Ltd. | 4-aminomethylbenzoic acid derivative |
| RU2673245C2 (ru) * | 2013-10-15 | 2018-11-23 | Тоа Эйо Лтд. | Производные 4-аминометилбензойной кислоты |
| JP2018188460A (ja) * | 2013-10-15 | 2018-11-29 | トーアエイヨー株式会社 | ４−アミノメチル安息香酸誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1368300A1 (de) | 2003-12-10 |
| CA2439759A1 (en) | 2002-09-12 |
| DE10110749A1 (de) | 2002-09-12 |
| US20040176446A1 (en) | 2004-09-09 |
| WO2002070462A1 (de) | 2002-09-12 |
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