JP2004522735A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004522735A5 JP2004522735A5 JP2002557412A JP2002557412A JP2004522735A5 JP 2004522735 A5 JP2004522735 A5 JP 2004522735A5 JP 2002557412 A JP2002557412 A JP 2002557412A JP 2002557412 A JP2002557412 A JP 2002557412A JP 2004522735 A5 JP2004522735 A5 JP 2004522735A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- antigen
- attachment site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001413 amino acids Chemical group 0.000 claims 71
- 239000000203 mixture Substances 0.000 claims 54
- 239000000427 antigen Substances 0.000 claims 41
- 102000036639 antigens Human genes 0.000 claims 35
- 108091007433 antigens Proteins 0.000 claims 35
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 28
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 28
- 230000000890 antigenic effect Effects 0.000 claims 27
- 239000012634 fragment Substances 0.000 claims 25
- 101710132601 Capsid protein Proteins 0.000 claims 15
- 101710094648 Coat protein Proteins 0.000 claims 15
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 15
- 101710125418 Major capsid protein Proteins 0.000 claims 15
- 101710141454 Nucleoprotein Proteins 0.000 claims 15
- 101710083689 Probable capsid protein Proteins 0.000 claims 15
- 239000007771 core particle Substances 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 10
- 235000018102 proteins Nutrition 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 8
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 7
- 241001515965 unidentified phage Species 0.000 claims 7
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 241001534160 Escherichia virus Qbeta Species 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 5
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
- 102000004083 Lymphotoxin-alpha Human genes 0.000 claims 4
- 108090000542 Lymphotoxin-alpha Proteins 0.000 claims 4
- 210000004899 c-terminal region Anatomy 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 239000002062 molecular scaffold Substances 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 108010064733 Angiotensins Proteins 0.000 claims 3
- 241000709738 Enterobacteria phage fr Species 0.000 claims 3
- 101000830603 Homo sapiens Tumor necrosis factor ligand superfamily member 11 Proteins 0.000 claims 3
- 102000003959 Lymphotoxin-beta Human genes 0.000 claims 3
- 108090000362 Lymphotoxin-beta Proteins 0.000 claims 3
- 102000007156 Resistin Human genes 0.000 claims 3
- 108010047909 Resistin Proteins 0.000 claims 3
- 230000001464 adherent effect Effects 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000003636 chemical group Chemical group 0.000 claims 3
- 102000053529 human TNFSF11 Human genes 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical group CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 101001011645 Homo sapiens Muellerian-inhibiting factor Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000015439 Phospholipases Human genes 0.000 claims 2
- 108010064785 Phospholipases Proteins 0.000 claims 2
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 2
- 230000003302 anti-idiotype Effects 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 102000057097 human MIF Human genes 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 244000045947 parasite Species 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 102000015427 Angiotensins Human genes 0.000 claims 1
- 206010003402 Arthropod sting Diseases 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- 101800004538 Bradykinin Proteins 0.000 claims 1
- 102400000967 Bradykinin Human genes 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100036846 C-C motif chemokine 21 Human genes 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 108010061629 Dermatophagoides pteronyssinus antigen p 1 Proteins 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 108010036395 Endoglin Proteins 0.000 claims 1
- 241000709737 Enterobacteria phage GA Species 0.000 claims 1
- 241001261579 Enterobacteria phage M11 Species 0.000 claims 1
- 241001278075 Enterobacteria phage MX1 Species 0.000 claims 1
- 241001278054 Enterobacteria phage NL95 Species 0.000 claims 1
- 241000709747 Enterobacteria phage R17 Species 0.000 claims 1
- 241000709743 Enterobacteria phage SP Species 0.000 claims 1
- 241000709739 Enterobacteria phage f2 Species 0.000 claims 1
- 241000709744 Enterobacterio phage MS2 Species 0.000 claims 1
- 102100023688 Eotaxin Human genes 0.000 claims 1
- 101710139422 Eotaxin Proteins 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims 1
- 101000950847 Homo sapiens Macrophage migration inhibitory factor Proteins 0.000 claims 1
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 claims 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 102100026011 Interleukin-13 Human genes 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 102100039897 Interleukin-5 Human genes 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 108060004872 MIF Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 241000223810 Plasmodium vivax Species 0.000 claims 1
- 102000011195 Profilin Human genes 0.000 claims 1
- 108050001408 Profilin Proteins 0.000 claims 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 241000709749 Pseudomonas phage PP7 Species 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 102100022831 Somatoliberin Human genes 0.000 claims 1
- 101710142969 Somatoliberin Proteins 0.000 claims 1
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 1
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 claims 1
- 241000223996 Toxoplasma Species 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 229940100602 interleukin-5 Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26237901P | 2001-01-19 | 2001-01-19 | |
| US28854901P | 2001-05-04 | 2001-05-04 | |
| US32699801P | 2001-10-05 | 2001-10-05 | |
| US33104501P | 2001-11-07 | 2001-11-07 | |
| PCT/IB2002/000166 WO2002056905A2 (en) | 2001-01-19 | 2002-01-21 | Molecular antigen array |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008274671A Division JP5175160B2 (ja) | 2001-01-19 | 2008-10-24 | 分子抗原アレイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004522735A JP2004522735A (ja) | 2004-07-29 |
| JP2004522735A5 true JP2004522735A5 (cg-RX-API-DMAC7.html) | 2005-12-22 |
Family
ID=27500737
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557412A Withdrawn JP2004522735A (ja) | 2001-01-19 | 2002-01-21 | 分子抗原アレイ |
| JP2002557414A Expired - Fee Related JP4489349B2 (ja) | 2001-01-19 | 2002-01-21 | 分子抗原アレイ |
| JP2008274671A Expired - Fee Related JP5175160B2 (ja) | 2001-01-19 | 2008-10-24 | 分子抗原アレイ |
| JP2012179555A Withdrawn JP2013028608A (ja) | 2001-01-19 | 2012-08-13 | 分子抗原アレイ |
| JP2015094858A Withdrawn JP2015205881A (ja) | 2001-01-19 | 2015-05-07 | 分子抗原アレイ |
| JP2017083363A Pending JP2017171666A (ja) | 2001-01-19 | 2017-04-20 | 分子抗原アレイ |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557414A Expired - Fee Related JP4489349B2 (ja) | 2001-01-19 | 2002-01-21 | 分子抗原アレイ |
| JP2008274671A Expired - Fee Related JP5175160B2 (ja) | 2001-01-19 | 2008-10-24 | 分子抗原アレイ |
| JP2012179555A Withdrawn JP2013028608A (ja) | 2001-01-19 | 2012-08-13 | 分子抗原アレイ |
| JP2015094858A Withdrawn JP2015205881A (ja) | 2001-01-19 | 2015-05-07 | 分子抗原アレイ |
| JP2017083363A Pending JP2017171666A (ja) | 2001-01-19 | 2017-04-20 | 分子抗原アレイ |
Country Status (13)
| Country | Link |
|---|---|
| US (10) | US7264810B2 (cg-RX-API-DMAC7.html) |
| EP (4) | EP2364727A3 (cg-RX-API-DMAC7.html) |
| JP (6) | JP2004522735A (cg-RX-API-DMAC7.html) |
| CN (2) | CN1301133C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE421332T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002226603B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BR0206566A (cg-RX-API-DMAC7.html) |
| CA (2) | CA2433316C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60230963D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1353691T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2321382T3 (cg-RX-API-DMAC7.html) |
| RU (2) | RU2438701C2 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2002056905A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8022270B2 (en) * | 2000-07-31 | 2011-09-20 | Biolex Therapeutics, Inc. | Expression of biologically active polypeptides in duckweed |
| US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| WO2002087510A2 (en) | 2001-04-30 | 2002-11-07 | Symbiontics, Inc. | Subcellular targeting of therapeutic proteins |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20030091593A1 (en) * | 2001-09-14 | 2003-05-15 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| CA2492826C (en) | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
| BR0213117A (pt) | 2001-10-05 | 2004-09-21 | Cytos Biotechnology Ag | Conjugados peptìdeo angiotensina-veìculo e seus usos |
| US7115266B2 (en) * | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| EP1494722A4 (en) * | 2002-03-25 | 2005-11-30 | THERAPEUTIC METHODS AGAINST INFLAMMATORY CONDITIONS RELATED TO EOTAXIN | |
| RU2324704C2 (ru) | 2002-07-17 | 2008-05-20 | Цитос Байотекнолоджи Аг | Молекулярные массивы антигенов |
| NZ537003A (en) * | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| KR20050027168A (ko) * | 2002-07-19 | 2005-03-17 | 사이토스 바이오테크놀로지 아게 | 그렐린-캐리어 컨쥬게이트 |
| CN101711865A (zh) * | 2002-07-19 | 2010-05-26 | 希托斯生物技术股份公司 | 含有淀粉样β1-6抗原阵列的疫苗组合物 |
| WO2004016283A2 (en) * | 2002-08-14 | 2004-02-26 | Avidis Sa | Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use |
| EP2267021B1 (en) | 2002-09-12 | 2015-02-18 | Oncotherapy Science, Inc. | KDR peptides and vaccines comprising the same |
| CA2496687A1 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| JP2006507818A (ja) * | 2002-11-01 | 2006-03-09 | プロメガ コーポレイション | 細胞溶解のための組成物、使用方法、装置およびキット |
| EP1419786A1 (en) * | 2002-11-13 | 2004-05-19 | Bracco Imaging S.p.A. | Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof |
| EP2308968A1 (en) * | 2002-11-26 | 2011-04-13 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| AU2004224284A1 (en) * | 2003-03-24 | 2004-10-07 | Mercia Pharma, Inc | Methods and compositions for treating and preventing inflammatory conditions |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| EP1605972A2 (en) | 2003-03-26 | 2005-12-21 | Cytos Biotechnology AG | Hiv-peptide-carrier-conjugates |
| JP2009513532A (ja) * | 2003-07-10 | 2009-04-02 | サイトス バイオテクノロジー アーゲー | パッケージ化ウイルス様粒子 |
| EA010056B1 (ru) * | 2003-10-10 | 2008-06-30 | Паудерджект Вэксинс, Инк. | Конструкции нуклеиновых кислот |
| US7923109B2 (en) * | 2004-01-05 | 2011-04-12 | Board Of Regents, The University Of Texas System | Inorganic nanowires |
| RU2006130006A (ru) * | 2004-01-20 | 2008-02-27 | Цитос Биотехнологи Аг (Ch) | Конъюгаты грелин-носитель |
| US20050244400A1 (en) | 2004-02-10 | 2005-11-03 | Zystor Therapeutics, Inc. | Acid alpha-glucosidase and fragments thereof |
| KR101013999B1 (ko) * | 2004-03-19 | 2011-02-14 | 재단법인서울대학교산학협력재단 | 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트 |
| CA2608003A1 (en) * | 2004-06-02 | 2005-12-15 | Cytos Biotechnology Ag | Medical uses of carrier conjugates of non-human tnf-peptides |
| WO2005117983A2 (en) * | 2004-06-02 | 2005-12-15 | Cytos Biotechnology Ag | Carrier conjugates of tnf-peptides |
| BRPI0516953A (pt) * | 2004-09-21 | 2008-09-30 | Cytos Biotechnology Ag | partìculas do tipo vìrus compreendendo uma proteìna de fusão da proteìna de revestimento de ap205 e um polipeptìdeo antigênico |
| KR20070059207A (ko) * | 2004-10-05 | 2007-06-11 | 사이토스 바이오테크놀로지 아게 | Vlp-항원 컨쥬게이트 및 백신으로서 그의 용도 |
| WO2006045796A2 (en) * | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| WO2006045849A1 (en) * | 2004-10-29 | 2006-05-04 | Cytos Biotechnology Ag | T-cadherin antigen arrays and uses thereof |
| AU2011253800B2 (en) * | 2004-11-05 | 2013-08-22 | Novartis Ag | Composition comprising VLP and amyloid-beta peptide |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| AU2005307831A1 (en) | 2004-11-17 | 2006-05-26 | Amgen, Inc. | Fully human monoclonal antibodies to IL-13 |
| CN101141979B (zh) | 2005-03-18 | 2013-05-08 | 赛托斯生物技术公司 | 猫变应原融合蛋白及其用途 |
| WO2006125821A2 (en) | 2005-05-26 | 2006-11-30 | Cytos Biotechnology Ag | Scalable fermentation process |
| EP1746165A1 (en) | 2005-07-21 | 2007-01-24 | Cytos Biotechnology AG | Scalable fermentation process |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| EP1931383A1 (en) | 2005-09-28 | 2008-06-18 | Cytos Biotechnology AG | Interleukin-1 conjugates and uses thereof |
| PL1976877T5 (pl) * | 2005-11-30 | 2017-09-29 | Abbvie Inc | Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania |
| PT1954718E (pt) | 2005-11-30 | 2014-12-16 | Abbvie Inc | Anticorpos anti-globulómeros aβ, suas porções de ligação ao antigénio, correspondentes hibridomas, ácidos nucleicos, vectores, células hospedeiras, métodos de produção dos ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos para uso dos ditos anticorpos |
| US20070184068A1 (en) | 2005-12-14 | 2007-08-09 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| AT503690A1 (de) * | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| EP2530086B1 (en) | 2006-06-12 | 2019-03-20 | Kuros Biosciences AG | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
| CA2655933C (en) * | 2006-06-23 | 2014-09-09 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
| WO2008036146A2 (en) | 2006-07-14 | 2008-03-27 | Sanofi Pasteur Biologics Co. | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
| BRPI0603490B1 (pt) * | 2006-07-21 | 2018-04-24 | Universidade Federal De Minas Gerais | Vacina recombinante contra a leishmaniose visceral canina |
| JP2010504760A (ja) | 2006-09-29 | 2010-02-18 | サノフィ パスツール バイオロジクス カンパニー | 組換え型ライノウイルスベクター |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US20100311767A1 (en) * | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| ES2337113B1 (es) | 2007-04-17 | 2011-01-24 | Centre De Recerca En Sanitat Animal (Cresa) | Empleo de la hemaglutinina del virus de la peste porcina africana como adyuvante. |
| EP2012122A1 (en) * | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| ES2331271B1 (es) | 2007-06-29 | 2010-10-14 | Universidad Del Pais Vasco | Metodo para la internalizacion de bacterias no invasivas en celulas eucariotas. |
| WO2009022155A2 (en) * | 2007-08-15 | 2009-02-19 | Circassia Limited | Peptide with reduced dimer formation |
| TWI436775B (zh) | 2007-08-24 | 2014-05-11 | Oncotherapy Science Inc | 以抗原胜肽合併化療藥劑治療胰臟癌 |
| ES2327375B1 (es) | 2007-11-14 | 2010-08-05 | Universidad Del Pais Vasco | Empleo de microparticulas para su uso como vacunas y la liberacion de moleculas biologicamente activas. |
| WO2009067584A1 (en) * | 2007-11-20 | 2009-05-28 | Duke University | Methods and compositions for modulating drug-polymer architecture, pharmacokinetics and biodistribution |
| CA2723412A1 (en) | 2008-05-07 | 2009-11-12 | Zystor Therapeutics, Inc. | Lysosomal targeting peptides and uses thereof |
| WO2010042743A2 (en) * | 2008-10-08 | 2010-04-15 | Chimeros Inc. | Chimeric multiplexes, compositions, and methods for using same |
| CA3050455A1 (en) | 2008-11-03 | 2010-06-03 | Adc Therapeutics Sa | Antibodies that specifically block the biological activity of a tumor antigen |
| SG10201400388QA (en) | 2008-12-09 | 2014-05-29 | Pfizer Vaccines Llc | IgE CH3 peptide vaccine |
| WO2010122164A1 (en) | 2009-04-23 | 2010-10-28 | Cytos Biotechnology Ag | VIRUS-LIKE PARTICLES OF BACTERIOPHAGE φCB5 |
| EP2424570A1 (en) * | 2009-04-30 | 2012-03-07 | Cytos Biotechnology AG | Influenza hemagglutinin compositions and uses thereof |
| WO2010129578A1 (en) * | 2009-05-06 | 2010-11-11 | Cornell Research Foundation, Inc. | E. coli lpfa antigen for prevention and treatment of infectious diseases |
| TW201109029A (en) | 2009-06-11 | 2011-03-16 | Oncotherapy Science Inc | Vaccine therapy for choroidal neovascularization |
| US8993715B2 (en) * | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
| MX2012001194A (es) * | 2009-07-30 | 2012-03-07 | Pfizer Vaccines Llc | Peptidos tau antigenicos y usos de los mismos. |
| NZ620441A (en) | 2009-09-03 | 2015-08-28 | Pfizer Vaccines Llc | Pcsk9 vaccine |
| US20130115189A1 (en) | 2009-09-10 | 2013-05-09 | Cytos Biotechnology Ag | Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes |
| WO2011033493A1 (en) | 2009-09-21 | 2011-03-24 | Conservatoire National des Arts et Métiers | Carrier conjugates of il-23-peptides and their induced antibodies |
| CN102933601B (zh) | 2010-04-15 | 2016-06-08 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| CA2800774A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
| MX358739B (es) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Proteinas de union a amiloide beta. |
| US20140004142A1 (en) | 2011-03-02 | 2014-01-02 | Pfizer Inc. | Pcsk9 vaccine |
| DK3173427T3 (da) | 2011-03-31 | 2019-08-05 | Adc Therapeutics Sa | Antistoffer mod nyre-associeret antigen 1 og antigen-bindende fragmenter deraf |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| CN104114696B (zh) | 2011-12-21 | 2017-05-03 | 阿普斯有限责任公司 | 使用具有对水解酶抗性的衣壳的vlp的方法 |
| IN2014CN04690A (cg-RX-API-DMAC7.html) | 2012-01-09 | 2015-09-18 | Alethia Biotherapeutics Inc | |
| CA2861021A1 (en) * | 2012-01-12 | 2013-07-18 | Stc.Unm | Immunogenic hpv l2-containing vlps and related compositions and methods |
| ES2428405B1 (es) | 2012-03-29 | 2014-06-02 | Universidad De Valladolid | Vehiculización de moléculas antigénicas en polímeros recombinantes similares a elastina |
| US20160000901A1 (en) * | 2013-03-05 | 2016-01-07 | Shifa Biomedical | Compositions and Methods for the Production of Virus-Like Particles |
| US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| HUE053033T2 (hu) * | 2013-06-19 | 2021-06-28 | Apse Llc | Hidrolázoknak ellenálló kapszidokat alkalmazó készítmények és eljárások |
| US10195257B2 (en) | 2013-07-28 | 2019-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response |
| US9017698B2 (en) * | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| WO2015101666A1 (en) | 2014-01-03 | 2015-07-09 | Fundación Biofísica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
| WO2015123291A1 (en) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Pcsk9 vaccine and methods of using the same |
| US10648014B2 (en) * | 2014-05-05 | 2020-05-12 | Purdue Research Foundation | Degradation resistant peptide based biosensors |
| US11111284B2 (en) * | 2014-08-21 | 2021-09-07 | The General Hospital Corporation | Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing |
| US10385115B2 (en) | 2015-03-26 | 2019-08-20 | Duke University | Fibronectin type III domain-based fusion proteins |
| WO2016168159A1 (en) * | 2015-04-14 | 2016-10-20 | Academia Sinica | Anti-vegfr2 human antibody for anti-angiogenic and targeted cancer therapy |
| EP3331557B1 (en) | 2015-08-04 | 2021-04-07 | Duke University | Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same |
| CA2994353A1 (en) | 2015-09-08 | 2017-03-16 | Universitat Zurich | Treatment of insect bite hypersensitivity |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| CN113181106A (zh) | 2016-01-11 | 2021-07-30 | 沃达瑞公司 | 微针组合物及其使用方法 |
| WO2017179025A1 (en) | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
| FR3051192B1 (fr) * | 2016-05-13 | 2020-12-25 | Univ De Lorraine | Methode de purification de proteines recombinantes par affinite basee sur l'activite lectinique du domaine crd d'une galectine |
| US11467156B2 (en) | 2016-06-01 | 2022-10-11 | Duke University | Nonfouling biosensors |
| WO2018017442A1 (en) | 2016-07-18 | 2018-01-25 | President And Fellows Of Harvard College | Methods and compositions relating to covalently circularized nanodiscs |
| CN109890833A (zh) | 2016-09-14 | 2019-06-14 | 杜克大学 | 用于递送亲水性药物的基于三嵌段多肽的纳米粒子 |
| KR20190064600A (ko) | 2016-09-23 | 2019-06-10 | 듀크 유니버시티 | Lcst 거동을 갖는 비구조화된 비-반복적 폴리펩티드 |
| US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| AU2018220515B2 (en) * | 2017-02-17 | 2022-06-30 | DayLife LLC | Universal antivenom |
| CN110381990A (zh) | 2017-03-07 | 2019-10-25 | 苏黎世大学 | 马的瘙痒症的治疗 |
| WO2018191557A1 (en) * | 2017-04-14 | 2018-10-18 | The Regents Of The University Of California | Human resistin compositions and methods of treating tlr4-mediated disease and infection |
| US11554097B2 (en) | 2017-05-15 | 2023-01-17 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| EP3658168A4 (en) | 2017-06-30 | 2021-07-14 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULUS SENSITIVE BIOPOLYMER NETWORKS |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CN107703294B (zh) * | 2017-10-12 | 2019-06-04 | 华派生物工程集团有限公司 | 一种用于检测鸡血清中cLHRH抗体效价的ELISA方法 |
| WO2019147954A1 (en) | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| US11633471B2 (en) | 2018-03-06 | 2023-04-25 | Unm Rainforest Innovations | Compositions and methods for reducing serum triglycerides |
| KR102529094B1 (ko) | 2018-04-05 | 2023-05-08 | 엘지전자 주식회사 | 냉장고 |
| EP3781689A1 (en) | 2018-04-19 | 2021-02-24 | Checkmate Pharmaceuticals, Inc. | Synthetic rig-i-like receptor agonists |
| US12257308B2 (en) | 2018-04-30 | 2025-03-25 | Duke University | Stimuli-responsive PEG-like polymer-based drug delivery platform |
| CN112203682A (zh) | 2018-05-28 | 2021-01-08 | 埃瓦克斯有限公司 | 荨麻疹的治疗 |
| EP3829622A4 (en) | 2018-08-02 | 2022-05-11 | Duke University | DOUBLE AGONIST FUSION PROTEINS |
| CA3127113A1 (en) | 2019-01-30 | 2020-08-06 | Dongxu Sun | Anti-gal3 antibodies and uses thereof |
| CN119306795A (zh) * | 2019-03-25 | 2025-01-14 | 免疫功坊股份有限公司 | 带有金属结合区的复合多肽及其分子构建体 |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| US12161710B2 (en) | 2019-07-24 | 2024-12-10 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| JP7707161B2 (ja) | 2019-10-23 | 2025-07-14 | チェックメイト ファーマシューティカルズ, インコーポレイテッド | 合成rig-i様受容体アゴニスト |
| WO2021083766A1 (en) | 2019-10-29 | 2021-05-06 | Evax Ag | Treatment of pruritus in horses |
| US20230063876A1 (en) * | 2020-03-02 | 2023-03-02 | Unm Rainforest Innovations | Virus-Like Particle Vaccines for Opioid Drugs |
| US20230174591A1 (en) * | 2020-05-19 | 2023-06-08 | National Research Council Of Canada | Use of Human Resistin as a Trimerization Partner for Expression of Trimeric Proteins |
| CN115867304A (zh) | 2020-05-19 | 2023-03-28 | 欧萨尔普罗席纳有限公司 | 用于治疗阿兹海默症的多抗原决定基疫苗 |
| JP2023528797A (ja) | 2020-05-26 | 2023-07-06 | トゥルーバインディング,インコーポレイテッド | ガレクチン-3を遮断することにより炎症性疾患を処置する方法 |
| WO2021250628A1 (en) | 2020-06-12 | 2021-12-16 | Glaxosmithkline Biologicals Sa | Bacterial immunization using nanoparticle vaccine |
| JP2023541669A (ja) * | 2020-09-17 | 2023-10-03 | オター プロシーナ リミテッド | アルツハイマー病の処置のためのβ-アミロイドワクチン |
| US12121574B2 (en) | 2021-09-28 | 2024-10-22 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| WO2023111826A1 (en) | 2021-12-14 | 2023-06-22 | Glaxosmithkline Biologicals Sa | Bacterial immunization using qbeta hairpin nanoparticle constructs |
| JP2025504364A (ja) * | 2022-01-08 | 2025-02-12 | カロジェン コーポレイション | 慢性b型肝炎感染症を処置または防止するための複数抗原治療ワクチン |
| US20250114444A1 (en) | 2022-01-19 | 2025-04-10 | Universität Bern | Compositions of virus-like particles and microcrystalline tyrosine |
| KR20250054791A (ko) | 2022-08-30 | 2025-04-23 | 사이바 애니멀 헬스 아게 | Cmv의 변형된 바이러스-유사 입자 및 ngf 항원의 수의학적 조성물 |
| EP4581044A1 (en) | 2022-08-31 | 2025-07-09 | Unm Rainforest Innovations | Compositions targeting apoptosis-associated speck-like protein with caspase activation and recruitment domain (asc) and methods of use |
| WO2025172894A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified nanoparticle subunits and use thereof |
| WO2025172892A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified proteins and methods |
| US20250281584A1 (en) | 2024-03-04 | 2025-09-11 | Boehringer Ingelheim Vetmedica Gmbh | Active vaccination for the treatment of ngf-related disorders |
| US20250281586A1 (en) | 2024-03-06 | 2025-09-11 | Elanco Us Inc. | Veterinary compositions of modified virus-like particles of cmv and canine il-1 beta mutein antigens |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US522013A (en) * | 1894-06-26 | Wardrobe-bedstead | ||
| US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| JPS61250560A (ja) * | 1985-04-30 | 1986-11-07 | Toshiba Corp | 免疫分析方法 |
| US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
| KR920002165B1 (ko) | 1986-09-22 | 1992-03-19 | 에모리 유니버어시티 | 개선된 백신 및 제조방법 |
| US5220013A (en) | 1986-11-17 | 1993-06-15 | Scios Nova Inc. | DNA sequence useful for the detection of Alzheimer's disease |
| US5187153A (en) | 1986-11-17 | 1993-02-16 | Scios Nova Inc. | Methods of treatment using Alzheimer's amyloid polypeptide derivatives |
| US5223482A (en) | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
| ES2120401T3 (es) | 1986-11-17 | 1998-11-01 | Scios Inc | Proteina recombinante amiloide relacionados con la enfermedad de alzheimer. |
| US5143726A (en) * | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| GB8903313D0 (en) | 1989-02-14 | 1989-04-05 | Wellcome Found | Conjugates |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| GB8913737D0 (en) | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
| DK0425082T3 (da) | 1989-09-04 | 1995-07-03 | Evans Medical Ltd | Vacciner |
| US6174916B1 (en) * | 1990-04-27 | 2001-01-16 | Milkhaus Laboratory, Ltd. | Methods for treating herpes virus infections |
| JP2980677B2 (ja) | 1990-04-27 | 1999-11-22 | マクマイケル,ジョン | 不正常なアミロイドβタンパク質と関連する中枢神経系疾患状態の治療のための方法および組成物 |
| US5753624A (en) * | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
| US5178882A (en) | 1990-06-22 | 1993-01-12 | The Regents Of The University Of California | Viral decoy vaccine |
| US5334394A (en) * | 1990-06-22 | 1994-08-02 | The Regents Of The University Of California | Human immunodeficiency virus decoy |
| SE9003978D0 (sv) * | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| FR2670800B1 (fr) | 1990-12-19 | 1994-05-20 | Gaches Chimie Sa | Procede de traitement de peaux ou cuirs, agents de tannage et procede de fabrication. |
| AU9052091A (en) | 1990-12-20 | 1992-07-22 | Smithkline Beecham Biologicals (Sa) | Vaccines based on hepatitis b surface antigen |
| GB9114003D0 (en) * | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| ZA934199B (en) | 1992-06-18 | 1994-01-10 | Akzo Nv | Carrier system against gnrh |
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| US6004763A (en) * | 1992-09-11 | 1999-12-21 | Institut Pasteur | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| GB2271826B (en) * | 1992-10-26 | 1996-06-05 | British Gas Plc | Apparatus for bending plastic tube |
| CA2153391C (en) * | 1993-01-11 | 2000-08-15 | Kenneth Rock | Inducing cytotoxic t lymphocyte responses |
| WO1994017813A1 (en) * | 1993-02-08 | 1994-08-18 | Paravax, Inc. | Defective sindbis virus vectors that express toxoplasma gondii p30 antigens |
| US6015686A (en) * | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US5602301A (en) * | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
| US5652223A (en) * | 1994-03-14 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | DNA encoding CAI resistance proteins and uses thereof |
| US6727230B1 (en) * | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| DE69521700T2 (de) | 1994-05-25 | 2001-10-25 | John Mcmichael | Mittel und methoden zur behandlung von plaque-krankheiten |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AT402898B (de) | 1994-08-08 | 1997-09-25 | Int Centre Genetic Eng & Bio | Molekulares präsentiersystem |
| US5589154A (en) * | 1994-11-22 | 1996-12-31 | Rutgers, The State University Of New Jersey | Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease |
| US5935821A (en) | 1995-01-17 | 1999-08-10 | Board Of Trustees Of The University Of Kentucky | Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
| US5817626A (en) * | 1995-03-14 | 1998-10-06 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation |
| US6303567B1 (en) * | 1995-03-14 | 2001-10-16 | Praecis Pharmaceuticals, Inc . | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| US5854215A (en) * | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals Incorporated | Modulators of β-amyloid peptide aggregation |
| CA2214247C (en) * | 1995-03-14 | 2004-02-10 | Praecis Pharmaceuticals Incorporated | Modulators of amyloid aggregation |
| EP0817854A2 (en) | 1995-03-31 | 1998-01-14 | Wolf, Hans, Prof. Dr. | Antigen presentation system based on retrovirus-like particles |
| US5792462A (en) * | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| EP0766146B1 (en) * | 1995-09-28 | 2011-04-06 | Canon Kabushiki Kaisha | Image forming apparatus |
| US5985242A (en) * | 1995-10-27 | 1999-11-16 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| US6277826B1 (en) * | 1996-08-27 | 2001-08-21 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| CA2245497C (en) | 1996-03-01 | 2009-02-24 | Novartis Ag | Peptide immunogens for vaccination against and treatment of allergy |
| WO1998008858A1 (en) | 1996-08-26 | 1998-03-05 | Hybridon, Inc. | Improved reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages |
| US5770380A (en) * | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| US6084668A (en) | 1997-07-10 | 2000-07-04 | American Air Liquide Inc. | In-line cell for absorption spectroscopy |
| AU745951B2 (en) | 1997-08-05 | 2002-04-11 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | New immunoprotective influenza antigen and its use in vaccination |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US6054312A (en) * | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| US6703015B1 (en) * | 1999-09-03 | 2004-03-09 | Ramot At Tel-Aviv University Ltd. | Filamentous bacteriophage displaying an β-amyloid epitope |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| CA2312475C (en) | 1997-12-03 | 2010-08-03 | Brigham And Women's Hospital | Method of suppressing .beta.-amyloid-related changes in alzheimer's disease |
| BR9907855A (pt) | 1998-02-12 | 2001-04-24 | Immune Complex Corp | Conjugado de proteìna de núcleo de hepatite b estrategicamente modificada, partìcula de proteìna, conjugado de partìculas de proteìna, conjugado de proteìna de fusão imunogênica, inóculo, e, processo para induzir anticorpos em um hospedeiro animal |
| ATE304603T1 (de) | 1998-03-27 | 2005-09-15 | Cytos Biotechnology Ag | Induzierendes alphavirengen- expressionssystem |
| US5990085A (en) | 1998-05-04 | 1999-11-23 | Michigan State University | Inhibin-HBc fusion protein |
| TWI227241B (en) | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
| US6927278B1 (en) * | 1998-09-01 | 2005-08-09 | Trustees Of The University Of Pennsylvania | Peptide scaffolds for transfer of molecules into eukaryotic cells |
| ES2258869T3 (es) * | 1998-10-21 | 2006-09-01 | The United States Government As Represented By The Department Of Health And Human Services | Particulas similares a virus para la induccion de autoanticuerpos. |
| US6548651B1 (en) * | 1998-11-11 | 2003-04-15 | Pantheco A/S | Modified peptide nucleic acid (PNA) molecules |
| US6380364B1 (en) * | 1998-11-23 | 2002-04-30 | Loyola University Of Chicago | Chimeric biotin-binding papillomavirus protein |
| RU2245163C2 (ru) * | 1998-11-30 | 2005-01-27 | Сайтос Байотекнолэджи АГ | Композиция (варианты), способ получения не природной упорядоченной и содержащей повторы антигенной матрицы, способ терапевтического лечения и способ иммунизации |
| HU229222B1 (en) * | 1998-12-04 | 2013-09-30 | Biogen Idec Ma Inc Cambridge | Hbv core antigen particles with multiple immunogenic components attached via peptide ligands |
| MXPA01008612A (es) | 1999-02-25 | 2003-06-24 | Smithkline Beecham Biolog | Epitopos o mimotopos derivados de los dominos c-epsilon-3 o c-epsilon-4 de ige, antagonistas de los mismos y sus usos terapeuticos. |
| US6613742B1 (en) | 1999-04-07 | 2003-09-02 | Thomas Jefferson University | Chemokine-derived synthetic peptides |
| US20020052311A1 (en) * | 1999-09-03 | 2002-05-02 | Beka Solomon | Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders |
| ES2344189T3 (es) | 1999-09-03 | 2010-08-20 | RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. | Agentes, composiciones y metodos que los utilizan utiles en el tratamiento o la prevencion de la enfermedad de alzheimer. |
| HUP0300067A3 (en) | 2000-02-21 | 2010-03-29 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| AU783144B2 (en) * | 2000-02-21 | 2005-09-29 | H. Lundbeck A/S | Novel method for down-regulation of amyloid |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| US7018638B2 (en) * | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US7097837B2 (en) * | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
| MY144532A (en) | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| CA2492826C (en) * | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
| CN1558774B (zh) * | 2001-10-05 | 2012-03-14 | 赛托斯生物技术公司 | 血管紧张肽-载体偶联物及其用途 |
| US7115266B2 (en) * | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| ATE419007T1 (de) * | 2001-11-07 | 2009-01-15 | Cytos Biotechnology Ag | Antigenraster welche il-5, il-13 oder eotaxin präsentieren, zur behandlung von allergischen, eosinophilen erkrankungen |
| DK1441764T3 (da) * | 2001-11-07 | 2009-01-26 | Cytos Biotechnology Ag | Antigen-Arrays der omfatter RANKL til behandling af knoglesygdom |
| AU2003226513A1 (en) | 2002-03-20 | 2003-10-08 | Health Protection Agency | Antibody that binds to a dimer of a prion protein for the treatment of TSE infection |
| DE10228059B4 (de) * | 2002-06-19 | 2005-12-29 | Eberhard-Karls-Universität Tübingen | Verwendung von amphiphilen Nucleosid-Phosphonoameisensäure-Derivaten zur Behandlung von viralen Infektionskrankheiten |
| RU2324704C2 (ru) * | 2002-07-17 | 2008-05-20 | Цитос Байотекнолоджи Аг | Молекулярные массивы антигенов |
| NZ537003A (en) * | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| CN101711865A (zh) * | 2002-07-19 | 2010-05-26 | 希托斯生物技术股份公司 | 含有淀粉样β1-6抗原阵列的疫苗组合物 |
| KR20050027168A (ko) * | 2002-07-19 | 2005-03-17 | 사이토스 바이오테크놀로지 아게 | 그렐린-캐리어 컨쥬게이트 |
| US7537767B2 (en) * | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| EP1605972A2 (en) * | 2003-03-26 | 2005-12-21 | Cytos Biotechnology AG | Hiv-peptide-carrier-conjugates |
| US6946769B2 (en) * | 2003-05-08 | 2005-09-20 | Asmo Co., Ltd. | Insulator and manufacturing method thereof, and stator for electric rotating machine |
| EP1660433A2 (en) | 2003-07-24 | 2006-05-31 | The Queen's Medical Center | Preparation and use of alkylating agents |
| BRPI0516953A (pt) * | 2004-09-21 | 2008-09-30 | Cytos Biotechnology Ag | partìculas do tipo vìrus compreendendo uma proteìna de fusão da proteìna de revestimento de ap205 e um polipeptìdeo antigênico |
| KR20070059207A (ko) * | 2004-10-05 | 2007-06-11 | 사이토스 바이오테크놀로지 아게 | Vlp-항원 컨쥬게이트 및 백신으로서 그의 용도 |
| WO2006045796A2 (en) * | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| MX2007006832A (es) * | 2004-12-13 | 2007-08-07 | Cytos Biotechnology Ag | Arreglos de antigeno interleucina 15 y usos de los mismos. |
| CN101141979B (zh) * | 2005-03-18 | 2013-05-08 | 赛托斯生物技术公司 | 猫变应原融合蛋白及其用途 |
| EP1982729A1 (en) * | 2007-04-20 | 2008-10-22 | Cytos Biotechnology AG | Vaccination Regimen for B-Cell Vaccines |
-
2002
- 2002-01-18 US US10/050,902 patent/US7264810B2/en not_active Expired - Lifetime
- 2002-01-18 US US10/050,898 patent/US7320793B2/en not_active Expired - Fee Related
- 2002-01-21 DK DK02716207T patent/DK1353691T3/da active
- 2002-01-21 RU RU2006141850/10A patent/RU2438701C2/ru not_active IP Right Cessation
- 2002-01-21 WO PCT/IB2002/000166 patent/WO2002056905A2/en not_active Ceased
- 2002-01-21 JP JP2002557412A patent/JP2004522735A/ja not_active Withdrawn
- 2002-01-21 BR BR0206566-5A patent/BR0206566A/pt not_active Application Discontinuation
- 2002-01-21 DE DE60230963T patent/DE60230963D1/de not_active Expired - Lifetime
- 2002-01-21 WO PCT/IB2002/000168 patent/WO2002056907A2/en not_active Ceased
- 2002-01-21 EP EP10012605A patent/EP2364727A3/en not_active Withdrawn
- 2002-01-21 CA CA2433316A patent/CA2433316C/en not_active Expired - Lifetime
- 2002-01-21 CN CNB02803869XA patent/CN1301133C/zh not_active Expired - Fee Related
- 2002-01-21 AT AT02716207T patent/ATE421332T1/de not_active IP Right Cessation
- 2002-01-21 CA CA2433862A patent/CA2433862C/en not_active Expired - Fee Related
- 2002-01-21 JP JP2002557414A patent/JP4489349B2/ja not_active Expired - Fee Related
- 2002-01-21 CN CNB028038673A patent/CN1301132C/zh not_active Expired - Fee Related
- 2002-01-21 RU RU2003125363/13A patent/RU2295973C2/ru not_active IP Right Cessation
- 2002-01-21 AU AU2002226603A patent/AU2002226603B2/en not_active Ceased
- 2002-01-21 EP EP02716207A patent/EP1353691B1/en not_active Expired - Lifetime
- 2002-01-21 EP EP09150831A patent/EP2055312A1/en not_active Withdrawn
- 2002-01-21 ES ES02716207T patent/ES2321382T3/es not_active Expired - Lifetime
- 2002-01-21 EP EP02710211.0A patent/EP1370290B1/en not_active Expired - Lifetime
- 2002-01-21 BR BRPI0206565A patent/BRPI0206565A8/pt active Search and Examination
-
2006
- 2006-11-03 US US11/592,127 patent/US20070048287A1/en not_active Abandoned
-
2008
- 2008-01-18 US US12/010,107 patent/US20080274131A1/en not_active Abandoned
- 2008-10-24 JP JP2008274671A patent/JP5175160B2/ja not_active Expired - Fee Related
-
2010
- 2010-12-23 US US12/978,365 patent/US20110305723A1/en not_active Abandoned
-
2011
- 2011-04-28 US US13/096,970 patent/US20120114674A1/en not_active Abandoned
-
2012
- 2012-08-13 JP JP2012179555A patent/JP2013028608A/ja not_active Withdrawn
- 2012-12-07 US US13/708,259 patent/US20130315949A1/en not_active Abandoned
-
2013
- 2013-05-30 US US13/906,139 patent/US20150202281A1/en not_active Abandoned
-
2014
- 2014-11-14 US US14/541,248 patent/US20160008453A1/en not_active Abandoned
-
2015
- 2015-05-07 JP JP2015094858A patent/JP2015205881A/ja not_active Withdrawn
-
2017
- 2017-01-17 US US15/407,920 patent/US20180036399A1/en not_active Abandoned
- 2017-04-20 JP JP2017083363A patent/JP2017171666A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004522735A5 (cg-RX-API-DMAC7.html) | ||
| RU2006141850A (ru) | Композиция и способ для иммунизации, способ продуцирования неприродного, упорядоченного и повторяющегося массива антигенов | |
| RU2005104235A (ru) | Молекулярные массивы антигенов | |
| RU2409667C2 (ru) | Вирусоподобные частицы, включающие гибридный белок белка оболочки бактериофага ар205 и антигенного полипептида | |
| JP2008513035A5 (cg-RX-API-DMAC7.html) | ||
| RU2001118274A (ru) | Композиция (варианты), способ получения не природной упорядоченной и содержащей повторы антигенной матрицы, выделенный рекомбинантный альфавирус, клетка-хозяин, способ терапевтического лечения и способ иммунизации | |
| JP4360906B2 (ja) | ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化 | |
| Mettens et al. | Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS, S vaccine antigen | |
| US7094409B2 (en) | Antigen arrays for treatment of allergic eosinophilic diseases | |
| US20110081642A1 (en) | Selection of B Cells with Specificity of Interest: Method of Preparation and Use | |
| CN1558774B (zh) | 血管紧张肽-载体偶联物及其用途 | |
| EP1443960B1 (en) | Antigen arrays presenting il-5, il-13 or eotaxin for treatment of allergic eosinophilic diseases | |
| RU2007126553A (ru) | Упорядоченные ряды антигенов ил-15 и их применение | |
| KR20070058426A (ko) | 비-인간 tnf-펩티드의 담체 콘쥬게이트의 의학적 용도 | |
| JP2004527213A5 (cg-RX-API-DMAC7.html) | ||
| AU2002363382A1 (en) | Antigen arrays presenting IL-5, IL-3 or eotaxin for treatment of allergic eosinophilic diseases | |
| JP2004504067A (ja) | 改良されたウイルス様粒子 | |
| US20080019991A1 (en) | Carrier Conjugates Of Tnf-Peptides | |
| CN101193654A (zh) | 抗原偶联物及其用途 | |
| RU2417793C2 (ru) | Конъюгаты впч-антиген и их применение в качестве вакцин | |
| KR20050034573A (ko) | 안지오텐신 펩티드-캐리어-컨쥬게이트 및 그의 용도 | |
| CN101077416A (zh) | 抗疟疾的疫苗接种方法 | |
| Gilbert et al. | Protein particle vaccines against malaria | |
| JP2005512987A5 (cg-RX-API-DMAC7.html) | ||
| Tarafdar | A brief go-to on the epidemiology of Malariaand the usage of virus like particles (VLPs) as a novel immunogenic vaccine platform |