JP2006504653A5 - - Google Patents
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- Publication number
- JP2006504653A5 JP2006504653A5 JP2004522507A JP2004522507A JP2006504653A5 JP 2006504653 A5 JP2006504653 A5 JP 2006504653A5 JP 2004522507 A JP2004522507 A JP 2004522507A JP 2004522507 A JP2004522507 A JP 2004522507A JP 2006504653 A5 JP2006504653 A5 JP 2006504653A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- ghrelin
- attachment site
- antigen
- antigenic determinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101800001586 Ghrelin Proteins 0.000 claims description 58
- 239000000427 antigen Substances 0.000 claims description 45
- 102000036639 antigens Human genes 0.000 claims description 45
- 108091007433 antigens Proteins 0.000 claims description 45
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical group C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims description 45
- 102400000442 Ghrelin-28 Human genes 0.000 claims description 42
- 230000000890 antigenic effect Effects 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 27
- 239000007771 core particle Substances 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 230000003252 repetitive effect Effects 0.000 claims description 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 229960005486 vaccine Drugs 0.000 claims description 5
- 208000008589 Obesity Diseases 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 235000001014 amino acid Nutrition 0.000 claims 6
- 101500025051 Bos taurus Ghrelin Proteins 0.000 claims 2
- 101710132601 Capsid protein Proteins 0.000 claims 2
- 101710094648 Coat protein Proteins 0.000 claims 2
- 241000283073 Equus caballus Species 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 2
- 101710125418 Major capsid protein Proteins 0.000 claims 2
- 101500025060 Mus musculus Ghrelin Proteins 0.000 claims 2
- 101710141454 Nucleoprotein Proteins 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 101710083689 Probable capsid protein Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 101500025062 Canis lupus familiaris Ghrelin Proteins 0.000 claims 1
- 241000282324 Felis Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- -1 n-octanoyl Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000003491 array Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000019439 energy homeostasis Effects 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39663802P | 2002-07-19 | 2002-07-19 | |
| PCT/EP2003/007849 WO2004009124A2 (en) | 2002-07-19 | 2003-07-18 | Ghrelin-carrier conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006504653A JP2006504653A (ja) | 2006-02-09 |
| JP2006504653A5 true JP2006504653A5 (cg-RX-API-DMAC7.html) | 2010-04-02 |
Family
ID=30770928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522507A Pending JP2006504653A (ja) | 2002-07-19 | 2003-07-18 | グレリン−担体複合体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20040076645A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1523372B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2006504653A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20050027168A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1665565A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE441429T1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0311800A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2489008A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60329106D1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL165003A (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04011247A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ537001A (cg-RX-API-DMAC7.html) |
| PL (1) | PL375522A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2325202C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004009124A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200408894B (cg-RX-API-DMAC7.html) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1278542A2 (en) * | 2000-05-05 | 2003-01-29 | Cytos Biotechnology AG | Molecular antigen arrays and vaccines |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| DE60335186D1 (de) * | 2002-06-20 | 2011-01-13 | Cytos Biotechnology Ag | Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung |
| IN2008CN05409A (cg-RX-API-DMAC7.html) * | 2002-07-18 | 2015-10-02 | Cytos Biotechnology Ag | |
| ATE506964T1 (de) * | 2002-07-19 | 2011-05-15 | Cytos Biotechnology Ag | Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays |
| WO2004027064A2 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| MXPA05009289A (es) | 2003-03-26 | 2005-10-18 | Cytos Biotechnology Ag | Conjugados de particulas tipo virus del analogo del peptido melan-a. |
| WO2005068639A2 (en) * | 2004-01-20 | 2005-07-28 | Cytos Biotechnology Ag | Particle-induced ghrelin immune response |
| GB0411014D0 (en) * | 2004-05-18 | 2004-06-23 | Haptogen Ltd | Methods for the control treatment and management of obesity |
| CN101052411B (zh) | 2004-10-05 | 2011-04-06 | 赛托斯生物技术公司 | Vlp-抗原偶联物及其作为疫苗的用途 |
| BRPI0516775A (pt) | 2004-10-25 | 2008-09-23 | Cytos Biotechnology Ag | ensaios de polipeptìdeo de antìgeno de inibidor gástrico (gip) e seus usos |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| RU2007126553A (ru) * | 2004-12-13 | 2009-01-20 | Цитос Биотехнологи Аг (Ch) | Упорядоченные ряды антигенов ил-15 и их применение |
| US7767212B2 (en) | 2005-03-18 | 2010-08-03 | Cytos Biotechnology Ag | CAT allergen conjugates and uses thereof |
| EP1899367A4 (en) * | 2005-06-10 | 2009-06-24 | Univ Singapore | Mutant allergen(s) |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| CA2623287A1 (en) | 2005-09-28 | 2007-04-12 | Cytos Biotechnology Ag | Interleukin-1 conjugates and uses thereof |
| RU2451523C2 (ru) | 2005-12-14 | 2012-05-27 | Цитос Биотехнологи Аг | Упакованные иммуностимулирующей нуклеиновой кислотой частицы, предназначенные для лечения гиперчувствительности |
| CN101336373B (zh) * | 2006-02-03 | 2017-08-25 | 希尔氏宠物营养品公司 | 通过测量脑肠肽激素水平评估猫科动物肾功能的方法 |
| US20100222861A1 (en) * | 2006-02-09 | 2010-09-02 | Alain Dibie | System for Treating Lesions on a Blood Vessel Bifurcation |
| US8992928B2 (en) * | 2006-02-11 | 2015-03-31 | Victor Raso | Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin |
| JP5437797B2 (ja) | 2006-06-12 | 2014-03-12 | サイトス バイオテクノロジー アーゲー | Ｒｎａバクテリオファージのウイルス様粒子にオリゴヌクレオチドをパッケージ化するための方法 |
| KR101510082B1 (ko) * | 2006-08-01 | 2015-04-10 | 더 스크립스 리서치 인스티튜트 | 비만증을 억제하기 위한 백신 및 방법 |
| JP2010096677A (ja) * | 2008-10-17 | 2010-04-30 | Toray Ind Inc | 抗体／抗原結合能を有する高感度免疫学測定用ナノ粒子 |
| PL222496B1 (pl) * | 2009-04-10 | 2016-08-31 | Inst Biochemii I Biofizyki Pan | Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania oraz kompozycja farmaceutyczna zawierająca wektorową cząsteczkę wirusopodobną |
| US8883721B2 (en) | 2009-05-12 | 2014-11-11 | Mcgill University | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US20110105389A1 (en) | 2009-10-30 | 2011-05-05 | Hoveyda Hamid R | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same |
| WO2011159917A2 (en) * | 2010-06-16 | 2011-12-22 | The Administrators Of The Tulane Educational Fund | Growth hormone secretatogue receptor antagonists and uses thereof |
| WO2013092720A1 (en) | 2011-12-22 | 2013-06-27 | F. Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use |
| KR20220051197A (ko) | 2012-05-17 | 2022-04-26 | 익스텐드 바이오사이언시즈, 인크. | 개선된 약물 전달용 캐리어 |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| DE16703049T1 (de) | 2015-01-15 | 2018-07-12 | University Of Copenhagen | Virusähnliche partikel mit effizienter epitopanzeige |
| EP3368068B1 (en) | 2015-10-30 | 2020-11-18 | University of Copenhagen | Virus like particle with efficient epitope display |
| CN107253984B (zh) * | 2017-05-08 | 2020-09-01 | 河南金大众生物工程有限公司 | 促生长复合多肽及其应用 |
| CN112876535B (zh) * | 2021-02-08 | 2023-06-30 | 浙江华缔药业集团医药开发有限公司 | 生物活性多肽及其应用 |
| WO2023224236A1 (ko) * | 2022-05-18 | 2023-11-23 | 한국과학기술원 | 면역 회피 효능이 강화된 박테리오파지 |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH512848A (de) * | 1970-02-25 | 1971-09-15 | Bbc Brown Boveri & Cie | Spulenwicklung und Verfahren zu deren Herstellung |
| US4918166A (en) * | 1987-04-10 | 1990-04-17 | Oxford Gene Systems Limited | Particulate hybrid HIV antigens |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| DE69133566T2 (de) * | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| US5935821A (en) * | 1995-01-17 | 1999-08-10 | Board Of Trustees Of The University Of Kentucky | Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
| US6627729B1 (en) * | 1997-03-24 | 2003-09-30 | Zymogenetics, Inc. | TML peptides |
| US6291653B1 (en) * | 1997-03-24 | 2001-09-18 | Zymogenetics, Inc. | Antibodies to motilin homologs |
| CN100534529C (zh) * | 1998-11-30 | 2009-09-02 | 希托斯生物技术股份公司 | 抗原的有序分子呈递，制备及使用的方法 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| IL147652A0 (en) * | 1999-07-23 | 2002-08-14 | Kangawa Kenji | Novel peptides |
| US6558695B2 (en) * | 1999-12-16 | 2003-05-06 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
| US6527165B1 (en) * | 2000-03-24 | 2003-03-04 | General Electric Company | Method of making an environmental resistant brazed assembly including a wear resistant surface portion |
| EP1278542A2 (en) * | 2000-05-05 | 2003-01-29 | Cytos Biotechnology AG | Molecular antigen arrays and vaccines |
| CA2411667A1 (en) * | 2000-05-30 | 2001-12-06 | Merck & Co. Inc. | Ghrelin analogs |
| CN1443198A (zh) * | 2000-07-24 | 2003-09-17 | 阿达纳生物科学有限公司 | Ghrelin拮抗剂 |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| AU2002339224B2 (en) * | 2001-09-14 | 2008-10-09 | Kuros Us Llc | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| JP4671389B2 (ja) * | 2001-10-05 | 2011-04-13 | サイトス バイオテクノロジー アーゲー | アンジオテンシンペプチド−担体複合体およびその使用 |
| DK1443960T3 (da) * | 2001-11-07 | 2009-03-23 | Cytos Biotechnology Ag | Antigen-arrays der betegner IL-5, IL-13 eller eotaxin til behandling af allergiske eosinofile sygdomme |
| DE60229659D1 (de) * | 2001-11-07 | 2008-12-11 | Cytos Biotechnology Ag | Antigen-raster enthaltend rankl zur behandlung von knochenerkrankungen |
| WO2003051389A2 (en) * | 2001-12-18 | 2003-06-26 | Theratechnologies Inc. | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
-
2003
- 2003-07-18 RU RU2005104565/13A patent/RU2325202C2/ru not_active IP Right Cessation
- 2003-07-18 DE DE60329106T patent/DE60329106D1/de not_active Expired - Lifetime
- 2003-07-18 CN CN038151022A patent/CN1665565A/zh active Pending
- 2003-07-18 NZ NZ537001A patent/NZ537001A/en not_active IP Right Cessation
- 2003-07-18 EP EP03765046A patent/EP1523372B1/en not_active Expired - Lifetime
- 2003-07-18 AT AT03765046T patent/ATE441429T1/de not_active IP Right Cessation
- 2003-07-18 PL PL03375522A patent/PL375522A1/xx not_active Application Discontinuation
- 2003-07-18 CA CA002489008A patent/CA2489008A1/en not_active Abandoned
- 2003-07-18 WO PCT/EP2003/007849 patent/WO2004009124A2/en not_active Ceased
- 2003-07-18 BR BR0311800-2A patent/BR0311800A/pt not_active IP Right Cessation
- 2003-07-18 US US10/622,124 patent/US20040076645A1/en not_active Abandoned
- 2003-07-18 KR KR1020047018442A patent/KR20050027168A/ko not_active Ceased
- 2003-07-18 MX MXPA04011247A patent/MXPA04011247A/es not_active Application Discontinuation
- 2003-07-18 JP JP2004522507A patent/JP2006504653A/ja active Pending
-
2004
- 2004-11-03 IL IL165003A patent/IL165003A/en not_active IP Right Cessation
- 2004-11-03 ZA ZA200408894A patent/ZA200408894B/en unknown
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