JP2004518656A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004518656A5 JP2004518656A5 JP2002551012A JP2002551012A JP2004518656A5 JP 2004518656 A5 JP2004518656 A5 JP 2004518656A5 JP 2002551012 A JP2002551012 A JP 2002551012A JP 2002551012 A JP2002551012 A JP 2002551012A JP 2004518656 A5 JP2004518656 A5 JP 2004518656A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- estrogen
- complex
- present
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 45
- 229940011871 estrogen Drugs 0.000 claims 28
- 239000000262 estrogen Substances 0.000 claims 28
- 229920000858 Cyclodextrin Polymers 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 12
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 11
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 11
- 229960002568 ethinylestradiol Drugs 0.000 claims 11
- 239000000546 pharmaceutical excipient Substances 0.000 claims 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 10
- 238000002360 preparation method Methods 0.000 claims 10
- 239000008187 granular material Substances 0.000 claims 8
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims 7
- 229960004845 drospirenone Drugs 0.000 claims 7
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims 7
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims 3
- JKKFKPJIXZFSSB-UHFFFAOYSA-N 1,3,5(10)-estratrien-17-one 3-sulfate Natural products OS(=O)(=O)OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 JKKFKPJIXZFSSB-UHFFFAOYSA-N 0.000 claims 3
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 claims 3
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 claims 3
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims 3
- 239000001116 FEMA 4028 Substances 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- 229920002774 Maltodextrin Polymers 0.000 claims 3
- 239000005913 Maltodextrin Substances 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 3
- YXYXCSOJKUAPJI-ZBRFXRBCSA-N [(8r,9s,13s,14s,17s)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] sulfamate Chemical compound NS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 YXYXCSOJKUAPJI-ZBRFXRBCSA-N 0.000 claims 3
- 229960004853 betadex Drugs 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 235000010980 cellulose Nutrition 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229950002007 estradiol benzoate Drugs 0.000 claims 3
- 229960004766 estradiol valerate Drugs 0.000 claims 3
- 229960003399 estrone Drugs 0.000 claims 3
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 claims 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 229940035034 maltodextrin Drugs 0.000 claims 3
- 239000000583 progesterone congener Substances 0.000 claims 3
- 239000008107 starch Substances 0.000 claims 3
- 235000019698 starch Nutrition 0.000 claims 3
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 2
- 229930182833 estradiol Natural products 0.000 claims 2
- 229960005309 estradiol Drugs 0.000 claims 2
- 238000005469 granulation Methods 0.000 claims 2
- 230000003179 granulation Effects 0.000 claims 2
- 238000002657 hormone replacement therapy Methods 0.000 claims 2
- 229960004400 levonorgestrel Drugs 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims 1
- 229960003309 dienogest Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims 1
- -1 guestden Chemical compound 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229940053934 norethindrone Drugs 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 230000016087 ovulation Effects 0.000 claims 1
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25648400P | 2000-12-20 | 2000-12-20 | |
| EP00610135A EP1216713A1 (en) | 2000-12-20 | 2000-12-20 | Compositions of estrogen-cyclodextrin complexes |
| US60/256,484 | 2000-12-20 | ||
| EP00610135.6 | 2000-12-20 | ||
| PCT/IB2001/002605 WO2002049675A1 (en) | 2000-12-20 | 2001-12-20 | Compositions of estrogen-cyclodextrin complexes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009025258A Division JP5015976B2 (ja) | 2000-12-20 | 2009-02-05 | エストロゲン−シクロデキストリン複合体の組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004518656A JP2004518656A (ja) | 2004-06-24 |
| JP2004518656A5 true JP2004518656A5 (enExample) | 2005-05-26 |
| JP4782364B2 JP4782364B2 (ja) | 2011-09-28 |
Family
ID=26073713
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002551012A Expired - Lifetime JP4782364B2 (ja) | 2000-12-20 | 2001-12-20 | エストロゲン−シクロデキストリン複合体の組成物 |
| JP2009025258A Expired - Lifetime JP5015976B2 (ja) | 2000-12-20 | 2009-02-05 | エストロゲン−シクロデキストリン複合体の組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009025258A Expired - Lifetime JP5015976B2 (ja) | 2000-12-20 | 2009-02-05 | エストロゲン−シクロデキストリン複合体の組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US6958326B2 (enExample) |
| EP (3) | EP1216713A1 (enExample) |
| JP (2) | JP4782364B2 (enExample) |
| KR (3) | KR20030070905A (enExample) |
| CN (1) | CN1268396C (enExample) |
| AT (1) | ATE311204T1 (enExample) |
| AU (3) | AU2002219418B2 (enExample) |
| BG (1) | BG66050B1 (enExample) |
| BR (1) | BRPI0116417B8 (enExample) |
| CA (2) | CA2756207C (enExample) |
| CY (2) | CY1106071T1 (enExample) |
| CZ (2) | CZ305671B6 (enExample) |
| DE (1) | DE60115499T2 (enExample) |
| DK (2) | DK1632237T3 (enExample) |
| EA (2) | EA011275B1 (enExample) |
| EE (1) | EE05282B1 (enExample) |
| ES (2) | ES2249387T3 (enExample) |
| HR (2) | HRP20070198B1 (enExample) |
| HU (2) | HU230299B1 (enExample) |
| IL (3) | IL156437A0 (enExample) |
| LT (1) | LT1632237T (enExample) |
| ME (1) | MEP38108A (enExample) |
| MX (1) | MXPA03005636A (enExample) |
| NO (1) | NO332726B1 (enExample) |
| NZ (1) | NZ526847A (enExample) |
| RS (2) | RS50362B (enExample) |
| SI (2) | SI1353700T1 (enExample) |
| SK (1) | SK287500B6 (enExample) |
| WO (1) | WO2002049675A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| US6992075B2 (en) * | 2003-04-04 | 2006-01-31 | Barr Laboratories, Inc. | C(14) estrogenic compounds |
| WO2005023217A2 (en) * | 2003-09-03 | 2005-03-17 | Mallinckrodt Inc. | Granular sustained release preparation and production thereof |
| RU2375053C2 (ru) * | 2004-05-18 | 2009-12-10 | Кемийски Инштитут | Новая водорастворимая форма коэнзима q10 в форме комплекса включения с бета-циклодекстрином, способ ее получения и ее применение |
| US8022053B2 (en) * | 2004-11-02 | 2011-09-20 | Bayer Schering Pharma Aktiengesellschaft | Oral solid dosage forms containing a low dose of estradiol |
| UY29527A1 (es) | 2005-05-13 | 2006-12-29 | Schering Ag | Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato. |
| US20070287684A1 (en) * | 2006-05-22 | 2007-12-13 | Irshad Chaudry | Methods and compositions for treating trauma-hemorrhage using estrogen and derivatives thereof |
| CN101489563A (zh) * | 2006-07-06 | 2009-07-22 | 拜耳先灵医药股份有限公司 | 用于避孕和预防先天性畸形风险的药物制剂 |
| US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
| ES2327665T3 (es) * | 2006-08-10 | 2009-11-02 | JENAPHARM GMBH & CO. KG | Forma medicamentosa peroral con dienogest y etinilestradiol para la contracepcion. |
| HUP0700826A3 (en) * | 2007-12-20 | 2010-03-29 | Richter Gedeon Nyrt | Coated tablet containing drospirenone and process for producing the same |
| CA2725578A1 (en) * | 2008-04-24 | 2009-10-29 | Evestra, Inc. | Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen |
| US8735374B2 (en) * | 2009-07-31 | 2014-05-27 | Intelgenx Corp. | Oral mucoadhesive dosage form |
| UY32836A (es) | 2009-08-12 | 2011-03-31 | Bayer Schering Pharma Ag | Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato |
| US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| JP5852639B2 (ja) | 2010-04-15 | 2016-02-03 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ｈｒｔのための低用量固体経口投与形態 |
| JP5820465B2 (ja) | 2010-04-15 | 2015-11-24 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ｈｒｔのための極低用量固体経口投与形態 |
| WO2012120365A1 (en) | 2011-03-07 | 2012-09-13 | Aurobindo Pharma Limited | Stable pharmaceutical composition comprising ethinyl estradiol |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| US8586527B2 (en) | 2011-10-20 | 2013-11-19 | Jaipal Singh | Cerivastatin to treat pulmonary disorders |
| CN102512688A (zh) * | 2011-12-29 | 2012-06-27 | 上海新华联制药有限公司 | 尼尔雌醇-β-环糊精包合物及制剂和制备方法 |
| NZ773177A (en) | 2012-01-23 | 2022-09-30 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| RU2494757C1 (ru) * | 2012-04-12 | 2013-10-10 | Леонид Леонидович Клопотенко | Фармацевтическая композиция, содержащая фермент дезоксирибонуклеазу, альфа-фетопротеин и глицирризиновую кислоту или ее соли: глицирризинат аммония, или дикалия, или тринатрия |
| WO2013172969A1 (en) | 2012-05-15 | 2013-11-21 | The Uab Research Foundation | Methods and compositions for treating trauma-hemorrhage using estrogen and derivatives thereof |
| IL275725B (en) | 2012-08-21 | 2022-08-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| PL3106148T3 (pl) | 2015-06-18 | 2018-08-31 | Mithra Pharmaceuticals S A | Jednostka dawkowania ulegająca rozpadowi w jamie ustnej zawierająca składnik estetrolowy |
| MA45276A (fr) | 2015-06-18 | 2018-04-25 | Sage Therapeutics Inc | Solutions de stéroïdes neuroactifs et leurs méthodes d'utilisation |
| US10894014B2 (en) | 2015-06-18 | 2021-01-19 | Estetra Sprl | Orodispersible tablet containing Estetrol |
| EP3310333B1 (en) | 2015-06-18 | 2020-04-29 | Estetra SPRL | Orodispersible dosage unit containing an estetrol component |
| MD3310346T2 (ro) | 2015-06-18 | 2021-06-30 | Estetra Sprl | Comprimată orodispersabilă ce conține estetrol |
| RU2640081C1 (ru) * | 2016-07-11 | 2017-12-26 | Общество с ограниченной ответственностью "ЛАЙФ САЙНСЕС ОХФК" | Фармацевтическая композиция и лекарственное средство на основе клатратного комплекса N-карбамоилметил-4-фенил-2-пирролидон или 4-фенилпирацетам с циклодекстрином, способы его получения (варианты) |
| KR102712911B1 (ko) | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| EP3666260A1 (en) * | 2018-12-13 | 2020-06-17 | Laboratorios Leon Farma SA | Ethinyl estradiol-beta-cyclodextrin complex and process for preparing thereof |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| CN114225050B (zh) * | 2022-01-29 | 2022-12-13 | 国家卫生健康委科学技术研究所 | 炔雌醇环糊精复合物的制备及应用 |
| CN116617157B (zh) * | 2023-05-25 | 2025-02-18 | 国家卫生健康委科学技术研究所 | 一种制备pH响应性炔雌醇复合水凝胶的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4154820A (en) * | 1976-02-23 | 1979-05-15 | Akzona Incorporated | Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers |
| DE2652761C2 (de) | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| JPS5527558A (en) * | 1978-08-18 | 1980-02-27 | Tokico Ltd | Gas spring |
| HU190356B (en) | 1981-10-27 | 1986-08-28 | Richter Gedeon Vegyeszeti Termekek Gyara Rt,Hu | Process for preparing steroid-gamma-cyclodextrin inclusion complexes with high water-solubility |
| US4383992A (en) | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4596795A (en) * | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| US4727077A (en) | 1985-02-20 | 1988-02-23 | Ishihara Sangyo Kaisha Ltd. | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them |
| US4877774A (en) | 1987-09-09 | 1989-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Administration of steroid hormones |
| NL8801670A (nl) * | 1988-07-01 | 1990-02-01 | Walter Adrianus Josephus Johan | Farmaceutisch preparaat. |
| US5229370A (en) | 1988-08-15 | 1993-07-20 | Ammeraal Robert N | Water soluble branched beta cyclodextrin steroid complex |
| DE3916112A1 (de) | 1989-05-16 | 1990-11-22 | Schering Ag | Dihydrospirorenon als antiandrogen |
| US4978532A (en) | 1989-08-11 | 1990-12-18 | Pharmedic Co. | Dosage form for administration of dehydroepiandrosterone |
| JP3207212B2 (ja) | 1991-03-01 | 2001-09-10 | 久光製薬株式会社 | 吸収促進剤およびこれを含有する外用剤 |
| US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| DE4426709A1 (de) | 1994-07-20 | 1996-01-25 | Schering Ag | Steroidale Sexualhormone enthaltende feste Arzneiformen |
| JP4334616B2 (ja) * | 1994-09-22 | 2009-09-30 | ナームローゼ・フエンノートチヤツプ・オルガノン | 湿式粒状化による投与単位体を製造する方法 |
| JP2920611B2 (ja) | 1995-12-11 | 1999-07-19 | 株式会社シーエーシー | 皮膚炎の治療外用剤 |
| IL127797A (en) * | 1996-07-26 | 2004-08-31 | Wyeth Corp | A one-step method of contraception and a kit containing a combination of progestin and estrogen |
| RO120603B1 (ro) * | 1996-08-22 | 2006-05-30 | Research Triangle Pharmaceuticals Ltd. | Compoziţie conţinând microparticule de substanţe insolubile în apă şi procedeu de preparare |
| DE19652196A1 (de) * | 1996-12-16 | 1998-06-18 | Jenapharm Gmbh | Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen |
| DE19654609A1 (de) * | 1996-12-20 | 1998-06-25 | Schering Ag | Therapeutische Gestagene zur Behandlung von Premenstrual Dysphoric Disorder |
| DE19848303A1 (de) * | 1998-10-14 | 2000-04-20 | Schering Ag | Kombination aus Gestagenen und Zuckern |
| EP1036510B1 (en) * | 1999-03-18 | 2004-01-07 | Bristol-Myers Squibb Company | Vitamin formulation for cardiovascular health |
| JP2000336032A (ja) * | 1999-05-26 | 2000-12-05 | Kissei Pharmaceut Co Ltd | ピペラジンアセトアミド誘導体を含有する徐放性経口医薬品組成物 |
| DE122009000007I2 (de) * | 1999-08-31 | 2011-07-21 | Bayer Schering Pharma | Pharmazeutische kombination von ethinylestradiol und drospirenone als empfangnisverhutendes mittel. |
| SI1611892T1 (sl) * | 2000-01-18 | 2010-01-29 | Bayer Schering Pharma Ag | Farmacevtski sestavki, ki obsegajo drospirenon |
-
2000
- 2000-12-20 EP EP00610135A patent/EP1216713A1/en not_active Withdrawn
-
2001
- 2001-12-20 EP EP05077665.7A patent/EP1632237B1/en not_active Expired - Lifetime
- 2001-12-20 ES ES01271231T patent/ES2249387T3/es not_active Expired - Lifetime
- 2001-12-20 WO PCT/IB2001/002605 patent/WO2002049675A1/en not_active Ceased
- 2001-12-20 CA CA2756207A patent/CA2756207C/en not_active Expired - Lifetime
- 2001-12-20 RS YUP-512/03A patent/RS50362B/sr unknown
- 2001-12-20 EE EEP200300298A patent/EE05282B1/xx unknown
- 2001-12-20 SI SI200130453T patent/SI1353700T1/sl unknown
- 2001-12-20 HR HRP20070198AA patent/HRP20070198B1/hr not_active IP Right Cessation
- 2001-12-20 EA EA200600884A patent/EA011275B1/ru not_active IP Right Cessation
- 2001-12-20 CZ CZ2003-1985A patent/CZ305671B6/cs not_active IP Right Cessation
- 2001-12-20 NZ NZ526847A patent/NZ526847A/en not_active IP Right Cessation
- 2001-12-20 KR KR10-2003-7008216A patent/KR20030070905A/ko not_active Ceased
- 2001-12-20 KR KR1020087028897A patent/KR20080108161A/ko not_active Ceased
- 2001-12-20 SK SK914-2003A patent/SK287500B6/sk not_active IP Right Cessation
- 2001-12-20 AU AU2002219418A patent/AU2002219418B2/en not_active Expired
- 2001-12-20 DK DK05077665.7T patent/DK1632237T3/en active
- 2001-12-20 HU HU0302499A patent/HU230299B1/hu unknown
- 2001-12-20 DK DK01271231T patent/DK1353700T3/da active
- 2001-12-20 CZ CZ2015-831A patent/CZ307876B6/cs not_active IP Right Cessation
- 2001-12-20 BR BR0116417-1 patent/BRPI0116417B8/pt not_active IP Right Cessation
- 2001-12-20 CA CA2432151A patent/CA2432151C/en not_active Expired - Lifetime
- 2001-12-20 JP JP2002551012A patent/JP4782364B2/ja not_active Expired - Lifetime
- 2001-12-20 DE DE60115499T patent/DE60115499T2/de not_active Expired - Lifetime
- 2001-12-20 ME MEP-381/08A patent/MEP38108A/xx unknown
- 2001-12-20 CN CNB018210880A patent/CN1268396C/zh not_active Expired - Lifetime
- 2001-12-20 ES ES05077665.7T patent/ES2639537T3/es not_active Expired - Lifetime
- 2001-12-20 HU HU1500492A patent/HU230745B1/hu unknown
- 2001-12-20 EA EA200300669A patent/EA007411B1/ru not_active IP Right Cessation
- 2001-12-20 LT LTEP05077665.7T patent/LT1632237T/lt unknown
- 2001-12-20 SI SI200131065T patent/SI1632237T1/sl unknown
- 2001-12-20 RS RS20090299A patent/RS57801B1/sr unknown
- 2001-12-20 AT AT01271231T patent/ATE311204T1/de active
- 2001-12-20 AU AU1941802A patent/AU1941802A/xx active Pending
- 2001-12-20 KR KR1020097023221A patent/KR101275372B1/ko not_active Expired - Lifetime
- 2001-12-20 EP EP01271231A patent/EP1353700B1/en not_active Expired - Lifetime
- 2001-12-20 IL IL15643701A patent/IL156437A0/xx active IP Right Grant
- 2001-12-20 HR HR20030592A patent/HRP20030592B1/xx not_active IP Right Cessation
- 2001-12-20 US US10/022,845 patent/US6958326B2/en not_active Expired - Lifetime
- 2001-12-20 MX MXPA03005636A patent/MXPA03005636A/es active IP Right Grant
-
2003
- 2003-06-12 IL IL156437A patent/IL156437A/en unknown
- 2003-06-19 NO NO20032805A patent/NO332726B1/no not_active IP Right Cessation
- 2003-07-18 BG BG108002A patent/BG66050B1/bg unknown
-
2005
- 2005-04-11 US US11/102,681 patent/US7163931B2/en not_active Expired - Lifetime
-
2006
- 2006-02-28 CY CY20061100281T patent/CY1106071T1/el unknown
- 2006-10-04 AU AU2006225232A patent/AU2006225232B8/en not_active Expired
- 2006-12-04 US US11/607,919 patent/US7569557B2/en not_active Expired - Lifetime
-
2007
- 2007-12-19 IL IL188250A patent/IL188250A/en active IP Right Grant
-
2009
- 2009-02-05 JP JP2009025258A patent/JP5015976B2/ja not_active Expired - Lifetime
-
2017
- 2017-09-20 CY CY20171100996T patent/CY1119806T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004518656A5 (enExample) | ||
| TWI508730B (zh) | 含四氫葉酸之醫藥組合物 | |
| JP5820465B2 (ja) | Ｈｒｔのための極低用量固体経口投与形態 | |
| JP3833292B2 (ja) | 糖衣からのステロイドの制御放出 | |
| KR102539030B1 (ko) | 드로스피레논을 포함하는 약학적 조성물 및 피임용 키트 | |
| CA2432151A1 (en) | Compositions of estrogen-cyclodextrin complexes | |
| MD3310346T2 (ro) | Comprimată orodispersabilă ce conține estetrol | |
| MD3310345T2 (ro) | Comprimată orodispersabilă ce conține estetrol | |
| JP2010248270A (ja) | 避妊用の組成 | |
| KR20100117603A (ko) | 안정화 효과를 갖는 약물 전달 시스템 | |
| JPH01501934A (ja) | メチルプレドニソロン／カルボキシメチルスターチナトリウム錠剤組成物 | |
| MXPA06012567A (es) | Tratamiento de la hemorragia de disrupcion en regimenes anticonceptivos extendidos. | |
| JP2005516904A (ja) | 緊急避妊のための薬学的組成物およびその用量処方 | |
| AU7530594A (en) | A novel pharmaceutical for oral administration comprising progresterone and a polyethyelene glycol together with an excipient | |
| RS50972B (sr) | Farmaceutski sastav koji sadrži gestagene i/ili estrogene i 5-metil-(6s)-tetrahidrofolate | |
| EP1898953A1 (en) | Quadraphasic continuous graduated estrogen contraceptive | |
| NO327588B3 (no) | Farmasoytisk sammensetning og preparat omfattende etinylostradiol og drospirenon for anvendelse som antikonsepsjonsmiddel | |
| CN105106149B (zh) | 左炔诺孕酮片及其制法 | |
| CN100540008C (zh) | 延迟固体口服避孕药或终止妊娠药溶解的剂型及其应用 | |
| JP3911125B2 (ja) | 性ホルモン及びシクロデキストリンを含有する経鼻スプレーのための溶液を製造するための方法 | |
| CN107982230A (zh) | 一种醋酸乌利司他分散片及其制备方法 | |
| JP5852639B2 (ja) | Ｈｒｔのための低用量固体経口投与形態 | |
| JP2002541076A (ja) | 望ましくない子宮出血の処置に有用な鼻腔用医薬組成物を得るための性ホルモンの使用 | |
| CN110694075A (zh) | 一种醋酸乌利司他-环糊精包合物的制备方法 | |
| Thorneycroft | Drospirenone: A novel progestin in an OC formulation |