JP2004511426A5 - - Google Patents
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- JP2004511426A5 JP2004511426A5 JP2001579774A JP2001579774A JP2004511426A5 JP 2004511426 A5 JP2004511426 A5 JP 2004511426A5 JP 2001579774 A JP2001579774 A JP 2001579774A JP 2001579774 A JP2001579774 A JP 2001579774A JP 2004511426 A5 JP2004511426 A5 JP 2004511426A5
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Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8617514B2 (en) | 1999-02-22 | 2013-12-31 | Georgetown University | Tumor-targeted nanodelivery systems to improve early MRI detection of cancer |
| WO2001074406A2 (en) * | 2000-03-31 | 2001-10-11 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health | Dendrimer composition for magnetic resonance analysis |
| US6551344B2 (en) * | 2000-04-26 | 2003-04-22 | Ev3 Inc. | Septal defect occluder |
| CA2492080A1 (en) * | 2002-06-26 | 2004-01-08 | Medigene Oncology Gmbh | Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system |
| ES2611054T3 (es) * | 2002-06-26 | 2017-05-04 | Syncore Biotechnology Co., Ltd | Método para producir una preparación de liposomas catiónicos que comprende un compuesto lipófilo |
| EP1374864A1 (en) * | 2002-06-26 | 2004-01-02 | Munich Biotech AG | Amphiphilic taxane compositions |
| ES2331791T5 (es) * | 2002-06-26 | 2016-01-21 | Medigene Ag | Método de producción de una preparación catiónica de liposomas que comprende un compuesto lipófilo |
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| JP4599292B2 (ja) * | 2002-10-30 | 2010-12-15 | エジソン ファーマシューティカルズ， インコーポレイテッド | 物理的−化学的特性に基づく治療用化合物の同定 |
| ES2431520T3 (es) * | 2003-01-25 | 2013-11-26 | Seno Medical Instruments, Inc. | Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas |
| FR2855315B1 (fr) * | 2003-05-23 | 2005-08-19 | Centre Nat Rech Scient | Ferrofluides stables en milieu neutre et ferrofluides modifies obtenus par modification de la surface des particules de ces ferrofluides |
| US8986736B2 (en) | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
| WO2004112747A2 (en) | 2003-06-24 | 2004-12-29 | Baxter International Inc. | Specific delivery of drugs to the brain |
| WO2005123907A2 (en) | 2004-06-15 | 2005-12-29 | Baxter International Inc. | Ex-vivo application of solid microparticulate therapeutic agents |
| KR20070052747A (ko) * | 2004-09-10 | 2007-05-22 | 도레이 가부시끼가이샤 | 의약품제제 |
| JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| DK3050963T3 (da) | 2005-03-31 | 2019-12-09 | Chugai Pharmaceutical Co Ltd | Fremgangsmåde til fremstilling af polypeptid ved regulering af arrangement |
| EP1896007B1 (en) | 2005-05-04 | 2014-03-19 | Medigene AG | Method of administering a cationic liposomal preparation comprising paclitexel |
| WO2007047981A2 (en) * | 2005-10-20 | 2007-04-26 | Georgetown University | Tumor-targeted nanodelivery systems to improve early mri detection of cancer |
| WO2007107305A2 (en) | 2006-03-22 | 2007-09-27 | Medigene Ag | Treatment of triple receptor negative breast cancer |
| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| DK2009101T3 (en) | 2006-03-31 | 2018-01-15 | Chugai Pharmaceutical Co Ltd | Antibody modification method for purification of a bispecific antibody |
| MX352315B (es) * | 2006-05-02 | 2017-11-17 | Univ Miami | Formulaciones de co-enzima topica q10 y tratamiento de dolor, fatiga y heridas. |
| WO2007133801A2 (en) * | 2006-05-15 | 2007-11-22 | Dmitri B Kirpotin | Magnetic microparticles comprising organic substances |
| US20090232731A1 (en) * | 2006-05-18 | 2009-09-17 | Martin Funk | Cationic Liposomal Preparations for the Treatment of Rheumatoid Arthritis |
| CN101646449A (zh) * | 2006-10-10 | 2010-02-10 | 斯奎科公司 | 用于治疗和诊断癌症的组合物和方法 |
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| CA2700701C (en) | 2007-09-26 | 2020-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| CL2008002886A1 (es) | 2007-09-26 | 2009-12-04 | Chugai Pharmaceutical Co Ltd | Region constante de un anticuerpo humano; anticuerpo anti-receptor de interleucina-6 (il-6) y composicion farmaceutica que la comprende. |
| WO2009072604A1 (ja) | 2007-12-05 | 2009-06-11 | Chugai Seiyaku Kabushiki Kaisha | 抗nr10抗体、およびその利用 |
| CN101965195A (zh) | 2008-03-05 | 2011-02-02 | 巴克斯特国际公司 | 用于药物投送的组合物和方法 |
| NZ717429A (en) | 2008-04-11 | 2018-07-27 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| US8329161B2 (en) * | 2008-05-01 | 2012-12-11 | National Health Research Institutes | Red blood cell-derived vesicles as a nanoparticle drug delivery system |
| CN102137616B (zh) * | 2008-06-18 | 2014-09-10 | 雷神公司 | 确定焦距的透明内窥镜头 |
| US8486735B2 (en) | 2008-07-30 | 2013-07-16 | Raytheon Company | Method and device for incremental wavelength variation to analyze tissue |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| US9060704B2 (en) * | 2008-11-04 | 2015-06-23 | Sarcos Lc | Method and device for wavelength shifted imaging |
| US20100135912A1 (en) * | 2008-12-02 | 2010-06-03 | Gambhir Sanjiv S | Magnetotactic bacteria mri positive contrast enhancement agent and methods of use |
| EP2826789A1 (en) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| US10952965B2 (en) * | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
| CN102459344A (zh) | 2009-05-15 | 2012-05-16 | 中外制药株式会社 | 抗axl抗体 |
| DE102009031274A1 (de) * | 2009-06-30 | 2011-01-13 | Justus-Liebig-Universität Giessen | Liposomen zur pulmonalen Applikation |
| EP2481752B1 (en) | 2009-09-24 | 2016-11-09 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
| WO2011041720A2 (en) | 2009-10-01 | 2011-04-07 | Jacobsen Stephen C | Method and apparatus for manipulating movement of a micro-catheter |
| WO2011041730A2 (en) * | 2009-10-01 | 2011-04-07 | Jacobsen Stephen C | Light diffusion apparatus |
| US8828028B2 (en) | 2009-11-03 | 2014-09-09 | Raytheon Company | Suture device and method for closing a planar opening |
| CA2780851C (en) * | 2009-11-18 | 2016-12-13 | Nanobacterie | Use of chains of magnetosomes to treat tumors by heat therapy |
| WO2011108714A1 (ja) | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | 抗体定常領域改変体 |
| SG10201503234SA (en) | 2010-05-03 | 2015-06-29 | Teikoku Pharma Usa Inc | Non-Aqueous Taxane Pro-Emulsion Formulations and Methods of Making and Using the Same |
| MX355060B (es) | 2010-11-17 | 2018-04-03 | Chugai Pharmaceutical Co Ltd | Molecula multiespecifica de union a antigeno que tiene funcion alternativa a la funcion del factor viii de coagulacion sanguinea. |
| CN108715614A (zh) | 2010-11-30 | 2018-10-30 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| US10029115B2 (en) * | 2011-04-08 | 2018-07-24 | Sanovas Intellectual Property, Llc | Photodynamic therapy for tumors with localized delivery |
| CN102419370B (zh) * | 2011-08-04 | 2014-08-27 | 武汉理工大学 | 用于检测小鼠组织内Bt杀虫蛋白的免疫磁小体及其制备方法 |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| DK3563933T3 (da) | 2012-08-29 | 2022-05-23 | Inguran Llc | Magnetisk fjernelse eller identificering af beskadigede eller svækkede celler eller cellestrukturer |
| US10379026B2 (en) | 2012-08-29 | 2019-08-13 | Inguran, Llc | Cell processing using magnetic particles |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| MX382731B (es) | 2013-09-27 | 2025-03-13 | Chugai Pharmaceutical Co Ltd | Metodo para producir heteromultimeros de polipeptidos. |
| MX384204B (es) | 2013-12-13 | 2025-03-14 | Mercury Asset Man Co Ltd | Composicion para formacion de imagen del cartilago articular. |
| WO2015139051A2 (en) | 2014-03-14 | 2015-09-17 | Rhode Island Hospital | Nanocarriers and their processing for diagnostics and therapeutics |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| TWI617580B (zh) | 2014-12-19 | 2018-03-11 | 中外製藥股份有限公司 | 抗ｃ５抗體及使用方法 |
| KR102650420B1 (ko) | 2014-12-19 | 2024-03-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| EP4269440A3 (en) | 2015-02-27 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
| MX2018007781A (es) | 2015-12-28 | 2018-09-05 | Chugai Pharmaceutical Co Ltd | Metodo para promover la eficiencia de purificacion del polipeptido que contiene la region de fragmento cristalizable (fc). |
| WO2017159287A1 (ja) | 2016-03-14 | 2017-09-21 | 中外製薬株式会社 | 癌の治療に用いるための細胞傷害誘導治療剤 |
| EP3449940B1 (en) | 2016-04-28 | 2025-11-19 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
| TW202300168A (zh) | 2016-08-05 | 2023-01-01 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
| US11339209B2 (en) | 2016-11-14 | 2022-05-24 | Novartis Ag | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| CA3063916A1 (en) | 2017-05-17 | 2018-11-22 | Berg Llc | Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa |
| BR112020008393A2 (pt) | 2017-11-01 | 2020-11-03 | Chugai Seiyaku Kabushiki Kaisha | variante e isoforma de anticorpos com atividade biológica reduzida |
| CN108751397A (zh) * | 2018-05-31 | 2018-11-06 | 北京北华中清环境工程技术有限公司 | 添加功能化磁性微球利用mbr进行煤制气废水处理的方法 |
| WO2021221167A1 (ja) * | 2020-04-30 | 2021-11-04 | 国立大学法人 長崎大学 | ガン治療薬及びガン治療方法 |
| CN112754996B (zh) * | 2021-03-16 | 2023-03-31 | 江西省科学院生物资源研究所 | 一种鱼精蛋白短肽修饰的紫杉醇脂质体及其制备方法 |
| WO2023064316A1 (en) * | 2021-10-11 | 2023-04-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Composite ink formulations for endoscopic imaging |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635180A (en) * | 1988-02-17 | 1997-06-03 | Neorx Corporation | Alteration of pharmacokinetics of proteins by charge modification |
| US5230883A (en) * | 1989-05-04 | 1993-07-27 | Wisconsin Alumni Research Foundation | Method for localization and treatment of tumors using polylysine complexes |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
| DE4428851C2 (de) * | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
| US5908635A (en) * | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
| GB9416884D0 (en) * | 1994-08-20 | 1994-10-12 | Danbiosyst Uk | Drug delivery compositions |
| EP0783325B2 (en) * | 1994-09-27 | 2004-03-31 | Amersham Health AS | Contrast agent |
| US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
| DE19912502A1 (de) * | 1999-03-19 | 2000-09-21 | Inst Neue Mat Gemein Gmbh | Nanoskalige Teilchen, Komplexe mit Polynukleotiden und deren Verwendung |
| JP4848113B2 (ja) * | 1999-09-09 | 2011-12-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 血管新生血管に対するタキサンの陽イオン性リポソーム送達 |
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