JP2004504840A5 - - Google Patents
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- Publication number
- JP2004504840A5 JP2004504840A5 JP2002516291A JP2002516291A JP2004504840A5 JP 2004504840 A5 JP2004504840 A5 JP 2004504840A5 JP 2002516291 A JP2002516291 A JP 2002516291A JP 2002516291 A JP2002516291 A JP 2002516291A JP 2004504840 A5 JP2004504840 A5 JP 2004504840A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- exon
- translation
- dna
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 description 31
- 239000012634 fragment Substances 0.000 description 30
- 238000000034 method Methods 0.000 description 28
- 108020004414 DNA Proteins 0.000 description 24
- 102000004169 proteins and genes Human genes 0.000 description 15
- 108020001580 protein domains Proteins 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 12
- 230000008685 targeting Effects 0.000 description 10
- 230000035897 transcription Effects 0.000 description 9
- 238000013518 transcription Methods 0.000 description 9
- 108091028043 Nucleic acid sequence Proteins 0.000 description 8
- 108020005067 RNA Splice Sites Proteins 0.000 description 8
- 108700024394 Exon Proteins 0.000 description 7
- 108020004705 Codon Proteins 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 4
- 230000006801 homologous recombination Effects 0.000 description 4
- 238000002744 homologous recombination Methods 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 102000035195 Peptidases Human genes 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 108091036066 Three prime untranslated region Proteins 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000014621 translational initiation Effects 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 102400001047 Endostatin Human genes 0.000 description 1
- 108010079505 Endostatins Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101000852559 Homo sapiens Thioredoxin Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102000007999 Nuclear Proteins Human genes 0.000 description 1
- 108010089610 Nuclear Proteins Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 102000014128 RANK Ligand Human genes 0.000 description 1
- 108010025832 RANK Ligand Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 102100036407 Thioredoxin Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001772 anti-angiogenic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0018876.3A GB0018876D0 (en) | 2000-08-01 | 2000-08-01 | Method of producing polypeptides |
| GB0018876.3 | 2000-08-01 | ||
| PCT/GB2001/003455 WO2002010372A1 (en) | 2000-08-01 | 2001-08-01 | Method of producing functional protein domains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004504840A JP2004504840A (ja) | 2004-02-19 |
| JP2004504840A5 true JP2004504840A5 (enExample) | 2012-08-09 |
| JP5068916B2 JP5068916B2 (ja) | 2012-11-07 |
Family
ID=9896767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002516291A Expired - Fee Related JP5068916B2 (ja) | 2000-08-01 | 2001-08-01 | 機能タンパク質ドメインの産生方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8048645B2 (enExample) |
| EP (1) | EP1305411B1 (enExample) |
| JP (1) | JP5068916B2 (enExample) |
| CN (1) | CN1468304B (enExample) |
| AR (1) | AR031717A1 (enExample) |
| AT (1) | ATE398174T1 (enExample) |
| AU (1) | AU7573901A (enExample) |
| BR (1) | BR0112979A (enExample) |
| CA (1) | CA2415768C (enExample) |
| CY (1) | CY1110431T1 (enExample) |
| DE (1) | DE60134410D1 (enExample) |
| DK (1) | DK1305411T3 (enExample) |
| ES (1) | ES2305091T3 (enExample) |
| GB (1) | GB0018876D0 (enExample) |
| IL (1) | IL154212A0 (enExample) |
| NO (1) | NO330897B1 (enExample) |
| PT (1) | PT1305411E (enExample) |
| SI (1) | SI1305411T1 (enExample) |
| WO (1) | WO2002010372A1 (enExample) |
| ZA (1) | ZA200300827B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1572994T3 (da) * | 2002-12-20 | 2007-05-29 | Chromagenics Bv | Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer |
| AU2004245175C1 (en) * | 2003-06-10 | 2010-03-18 | Biogen Ma Inc. | Improved secretion of neublastin |
| US8053191B2 (en) | 2006-08-31 | 2011-11-08 | Westend Asset Clearinghouse Company, Llc | Iterative nucleic acid assembly using activation of vector-encoded traits |
| WO2011053957A2 (en) * | 2009-11-02 | 2011-05-05 | Gen9, Inc. | Compositions and methods for the regulation of multiple genes of interest in a cell |
| CA2817697C (en) | 2010-11-12 | 2021-11-16 | Gen9, Inc. | Methods and devices for nucleic acids synthesis |
| WO2012064975A1 (en) | 2010-11-12 | 2012-05-18 | Gen9, Inc. | Protein arrays and methods of using and making the same |
| JP2014526899A (ja) | 2011-08-26 | 2014-10-09 | ジェン９・インコーポレイテッド | 核酸の高忠実度アセンブリのための組成物および方法 |
| US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
| CA2871505C (en) | 2012-04-24 | 2021-10-12 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
| WO2014004393A1 (en) | 2012-06-25 | 2014-01-03 | Gen9, Inc. | Methods for nucleic acid assembly and high throughput sequencing |
| KR102160389B1 (ko) | 2013-08-05 | 2020-09-28 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| CA2975855C (en) | 2015-02-04 | 2025-09-23 | Twist Bioscience Corporation | SYNTHETIC GENE COMPOSITIONS AND ASSEMBLY METHODS |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| EP3384077A4 (en) | 2015-12-01 | 2019-05-08 | Twist Bioscience Corporation | FUNCTIONALIZED SURFACES AND MANUFACTURE THEREOF |
| WO2018038772A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| EP4664304A3 (en) | 2016-09-21 | 2026-01-21 | Atlas Data Storage, Inc. | Nucleic acid based data storage |
| GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| IL312616B2 (en) | 2018-01-04 | 2025-08-01 | Twist Bioscience Corp | Dna-based digital information storage |
| EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | POLYNUCLEOTIDES, REAGENTS AND METHODS FOR NUCLEIC ACID HYBRIDIZATION |
| EP3902816A4 (en) | 2018-12-26 | 2022-09-14 | Twist Bioscience Corporation | HIGH-PRECISION DE NOVO POLYNUCLEOTIDE SYNTHESIS |
| KR20210144698A (ko) | 2019-02-26 | 2021-11-30 | 트위스트 바이오사이언스 코포레이션 | 항체 최적화를 위한 변이 핵산 라이브러리 |
| CA3131689A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
| EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
| CN115023440B (zh) | 2019-09-23 | 2025-09-12 | 特韦斯特生物科学公司 | 结合CD3ε的抗体 |
| AU2020400030B2 (en) | 2019-12-09 | 2026-05-21 | Twist Bioscience Corporation | Variant nucleic acid libraries for adenosine receptors |
| KR20230078719A (ko) | 2020-09-28 | 2023-06-02 | 베스타론 코포레이션 | 해충 방제용 뮤-디구에톡신-Dc1a 변이형 폴리펩타이드 |
| US20240374761A1 (en) | 2021-05-05 | 2024-11-14 | Radius Pharmaceuticals, Inc. | Animal model having homologous recombination of mouse pth1 receptor |
| WO2023122805A1 (en) | 2021-12-20 | 2023-06-29 | Vestaron Corporation | Sorbitol driven selection pressure method |
| WO2024026406A2 (en) | 2022-07-29 | 2024-02-01 | Vestaron Corporation | Next Generation ACTX Peptides |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2646438B1 (fr) * | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| SG88714A1 (en) | 1989-11-06 | 2002-05-21 | Cell Genesys Inc | Production of proteins using homologous recombination |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| DE779362T1 (de) * | 1989-12-22 | 2001-04-05 | Applied Research Systems Ars Holding N.V., Curacao | DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen |
| WO1993004169A1 (en) * | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US6063630A (en) * | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| CN1256986C (zh) * | 1993-12-02 | 2006-05-24 | 转移染色体治疗公司 | 蛋白质的生产和蛋白质的输送 |
| US5545817A (en) * | 1994-03-11 | 1996-08-13 | Calgene, Inc. | Enhanced expression in a plant plastid |
| WO1997023244A1 (en) | 1995-12-22 | 1997-07-03 | Smithkline Beecham Corporation | Use of antisene oligodeoxynucleotides to produce truncated proteins |
| DE69841723D1 (de) * | 1997-09-26 | 2010-07-29 | Abt Holding Co | Expression von endogenen genen durch homologe rekombination eines vektorkonstruktes mit zellulärer dna |
| US7063960B2 (en) * | 1997-12-12 | 2006-06-20 | The Rockefeller University | Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof |
| CA2323834C (en) | 1998-03-27 | 2009-01-27 | Lexicon Genetics Incorporated | Vectors for gene mutagenesis and gene discovery |
| US6436707B1 (en) * | 1998-03-27 | 2002-08-20 | Lexicon Genetics Incorporated | Vectors for gene mutagenesis and gene discovery |
| JP3688118B2 (ja) * | 1998-05-22 | 2005-08-24 | 独立行政法人科学技術振興機構 | 遺伝子トラップ用ベクターと、このベクターを用いた遺伝子トラップ方法 |
-
2000
- 2000-08-01 GB GBGB0018876.3A patent/GB0018876D0/en not_active Ceased
-
2001
- 2001-07-31 AR ARP010103647A patent/AR031717A1/es active IP Right Grant
- 2001-08-01 BR BR0112979-1A patent/BR0112979A/pt not_active Application Discontinuation
- 2001-08-01 PT PT01953251T patent/PT1305411E/pt unknown
- 2001-08-01 DE DE60134410T patent/DE60134410D1/de not_active Expired - Lifetime
- 2001-08-01 US US10/343,684 patent/US8048645B2/en not_active Expired - Fee Related
- 2001-08-01 WO PCT/GB2001/003455 patent/WO2002010372A1/en not_active Ceased
- 2001-08-01 CN CN01816657.1A patent/CN1468304B/zh not_active Expired - Fee Related
- 2001-08-01 IL IL15421201A patent/IL154212A0/xx unknown
- 2001-08-01 JP JP2002516291A patent/JP5068916B2/ja not_active Expired - Fee Related
- 2001-08-01 ES ES01953251T patent/ES2305091T3/es not_active Expired - Lifetime
- 2001-08-01 SI SI200130842T patent/SI1305411T1/sl unknown
- 2001-08-01 DK DK01953251T patent/DK1305411T3/da active
- 2001-08-01 AT AT01953251T patent/ATE398174T1/de active
- 2001-08-01 AU AU7573901A patent/AU7573901A/xx not_active Withdrawn
- 2001-08-01 EP EP01953251A patent/EP1305411B1/en not_active Expired - Lifetime
- 2001-08-01 CA CA2415768A patent/CA2415768C/en not_active Expired - Fee Related
-
2003
- 2003-01-28 NO NO20030443A patent/NO330897B1/no not_active IP Right Cessation
- 2003-01-30 ZA ZA200300827A patent/ZA200300827B/xx unknown
-
2008
- 2008-07-11 CY CY20081100728T patent/CY1110431T1/el unknown
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