JP2008509682A5 - - Google Patents
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- Publication number
- JP2008509682A5 JP2008509682A5 JP2007526148A JP2007526148A JP2008509682A5 JP 2008509682 A5 JP2008509682 A5 JP 2008509682A5 JP 2007526148 A JP2007526148 A JP 2007526148A JP 2007526148 A JP2007526148 A JP 2007526148A JP 2008509682 A5 JP2008509682 A5 JP 2008509682A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- expression vector
- yebf
- polypeptide
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 239000013604 expression vector Substances 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 108020001507 fusion proteins Proteins 0.000 claims 15
- 102000037865 fusion proteins Human genes 0.000 claims 15
- 108020004511 Recombinant DNA Proteins 0.000 claims 9
- 230000001580 bacterial effect Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 241000588724 Escherichia coli Species 0.000 claims 7
- 230000007026 protein scission Effects 0.000 claims 5
- 102000053602 DNA Human genes 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 210000001322 periplasm Anatomy 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 230000032258 transport Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52212504P | 2004-08-18 | 2004-08-18 | |
| PCT/CA2005/001249 WO2006017929A1 (en) | 2004-08-18 | 2005-08-12 | Protein production method utilizing yebf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008509682A JP2008509682A (ja) | 2008-04-03 |
| JP2008509682A5 true JP2008509682A5 (enExample) | 2008-09-18 |
Family
ID=35907194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526148A Pending JP2008509682A (ja) | 2004-08-18 | 2005-08-12 | Ｙｅｂｆを利用するタンパク質の製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060246539A1 (enExample) |
| EP (1) | EP1791961B1 (enExample) |
| JP (1) | JP2008509682A (enExample) |
| AT (1) | ATE512230T1 (enExample) |
| AU (1) | AU2005274628A1 (enExample) |
| CA (1) | CA2576083A1 (enExample) |
| WO (1) | WO2006017929A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10611805B2 (en) | 2011-05-11 | 2020-04-07 | Children's Medical Center Corporation | Modified biotin-binding protein, fusion proteins thereof and applications |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006050332A1 (de) | 2006-10-25 | 2008-04-30 | Wacker Chemie Ag | DNS-Konstrukt und Verfahren zur fermentativen Herstellung von Fusionsproteinen |
| EP4272750A3 (en) | 2013-02-07 | 2024-01-24 | Children's Medical Center, Corp. | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| SG11201703528YA (en) * | 2014-11-03 | 2017-05-30 | Univ Nanyang Tech | A recombinant expression system that senses pathogenic microorganisms |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US12351805B2 (en) | 2015-11-19 | 2025-07-08 | Northeastern University | Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria |
| WO2017087827A1 (en) * | 2015-11-19 | 2017-05-26 | President And Fellows Of Harvard College | Method of making recombinant silk andsilk-amyloid hybrid proteins using bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| EP3600400A4 (en) | 2017-03-28 | 2021-01-13 | The Children's Medical Center Corporation | MULTIPLE ANTIGEN (MAPS) BASED STAPHYLOCOCCUS AUREUS VACCINE, IMMUNOGENIC COMPOSITION AND USES THEREOF |
| SG11201912601RA (en) | 2017-06-23 | 2020-01-30 | Nosocomial Vaccine Corp | Immunogenic compositions |
| CN112969474A (zh) | 2018-09-12 | 2021-06-15 | 艾芬尼维克斯公司 | 多价肺炎球菌疫苗 |
| CN113164580B (zh) | 2018-09-12 | 2025-06-10 | 儿童医疗中心公司 | 肺炎球菌融合蛋白疫苗 |
| WO2020165874A1 (en) * | 2019-02-15 | 2020-08-20 | Oncosimis Biotech Private Limited | A bacterial expression vector for enhanced protein secretion |
| EP3927733A4 (en) * | 2019-02-24 | 2022-07-06 | Oncosimis Biotech Private Limited | PROCESS FOR THE CONTINUOUS PRODUCTION OF RECOMBINANT GLP-1 PEPTIDE BY BACTERIA |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
| MX2024002779A (es) | 2021-09-09 | 2024-06-11 | Affinivax Inc | Vacunas neumocócicas multivalentes. |
| CN116555308A (zh) * | 2023-04-14 | 2023-08-08 | 华南农业大学 | 一种促进目标蛋白在大肠杆菌细胞外分泌表达的表达载体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335357C (en) * | 1987-10-30 | 1995-04-25 | Timothy M. Rose | Expression systems for preparation of polypeptides in prokaryotic cells |
| US5646016A (en) * | 1991-02-06 | 1997-07-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules |
| US6033877A (en) * | 1995-11-02 | 2000-03-07 | Research Foundation Of State University Of New York | Peptide expression and delivery system |
| US6022952A (en) * | 1998-04-01 | 2000-02-08 | University Of Alberta | Compositions and methods for protein secretion |
| US6733997B1 (en) * | 1998-10-30 | 2004-05-11 | National University Of Singapore | Isolated nucleic acids encoding a secretory signal for expression and secretion of heterologous recombinant proteins |
| FI109361B (fi) | 1999-05-04 | 2002-07-15 | Korpela Timo | Mikrobinen proteiinin ilmentämisjärjestelmä |
| CA2414775A1 (en) * | 2000-05-03 | 2001-11-08 | Expressive Constructs, Inc. | A method and device for improving protein stability and solubility |
| EP1343870A4 (en) * | 2000-11-09 | 2005-07-13 | Univ Queensland | BACTERIAL EXPRESSION SYSTEMS |
| US20040142429A1 (en) * | 2001-01-25 | 2004-07-22 | Grant Chris W.M. | Method for the expression, purification, and structure recovery and handling of hydrophobic proteins, polypeptides or peptides |
| AU2002257243A1 (en) * | 2001-05-04 | 2002-11-18 | Cornell Research Foundation, Inc. | Rapidly cleavable sumo fusion protein expression system for difficult to express proteins |
| KR100447530B1 (ko) * | 2001-08-14 | 2004-09-08 | 한국과학기술원 | ＯｍｐＦ를 이용하여 목적 단백질을 대장균 세포외로분비생산하는 방법 |
| US6790051B1 (en) * | 2003-12-20 | 2004-09-14 | Lear Corporation | Connector for printed circuit board |
-
2005
- 2005-08-12 JP JP2007526148A patent/JP2008509682A/ja active Pending
- 2005-08-12 WO PCT/CA2005/001249 patent/WO2006017929A1/en not_active Ceased
- 2005-08-12 AU AU2005274628A patent/AU2005274628A1/en not_active Abandoned
- 2005-08-12 CA CA002576083A patent/CA2576083A1/en not_active Abandoned
- 2005-08-12 AT AT05774845T patent/ATE512230T1/de not_active IP Right Cessation
- 2005-08-12 EP EP05774845A patent/EP1791961B1/en not_active Expired - Lifetime
- 2005-08-15 US US11/203,168 patent/US20060246539A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10611805B2 (en) | 2011-05-11 | 2020-04-07 | Children's Medical Center Corporation | Modified biotin-binding protein, fusion proteins thereof and applications |
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