JP2005528124A5 - - Google Patents
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- Publication number
- JP2005528124A5 JP2005528124A5 JP2004510698A JP2004510698A JP2005528124A5 JP 2005528124 A5 JP2005528124 A5 JP 2005528124A5 JP 2004510698 A JP2004510698 A JP 2004510698A JP 2004510698 A JP2004510698 A JP 2004510698A JP 2005528124 A5 JP2005528124 A5 JP 2005528124A5
- Authority
- JP
- Japan
- Prior art keywords
- anv
- seq
- genetically modified
- protein
- dna molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000672 Annexin A5 Proteins 0.000 claims 6
- 102000004121 Annexin A5 Human genes 0.000 claims 6
- 102000053602 DNA Human genes 0.000 claims 4
- 239000002506 anticoagulant protein Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108700019335 ANV-6L15 Proteins 0.000 claims 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 2
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 2
- 239000003146 anticoagulant agent Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000001732 thrombotic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38693202P | 2002-06-06 | 2002-06-06 | |
| PCT/US2003/017442 WO2003103577A2 (en) | 2002-06-06 | 2003-06-04 | Novel recombinant anticoagulant proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005528124A JP2005528124A (ja) | 2005-09-22 |
| JP2005528124A5 true JP2005528124A5 (enExample) | 2006-07-20 |
| JP4444821B2 JP4444821B2 (ja) | 2010-03-31 |
Family
ID=29736237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510698A Expired - Fee Related JP4444821B2 (ja) | 2002-06-06 | 2003-06-04 | 遺伝子組み換えによる新しい抗凝血性蛋白質 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7378393B2 (enExample) |
| EP (1) | EP1509541B1 (enExample) |
| JP (1) | JP4444821B2 (enExample) |
| CN (1) | CN1659180B (enExample) |
| AT (1) | ATE534658T1 (enExample) |
| AU (1) | AU2003237351B2 (enExample) |
| CA (1) | CA2486362A1 (enExample) |
| WO (1) | WO2003103577A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635676B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
| US7635680B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
| US7671013B2 (en) * | 2003-04-03 | 2010-03-02 | Canadian Blood Services, Inc. | Coagulation proteins, coagulation-anticoagulation protein complexes, derivatives thereof and their uses |
| JP5134362B2 (ja) * | 2004-03-11 | 2013-01-30 | アラビタ・ファーマシューティカルズ・インコーポレーテッド | 修飾アネキシンタンパク質および血栓症を防止するための方法 |
| US7511016B2 (en) | 2004-07-07 | 2009-03-31 | Mosamedix B.V. | Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof |
| JP2011506590A (ja) | 2007-12-18 | 2011-03-03 | アセラ・バイオテクノロジーズ・アーベー | 血管疾患を治療するための化合物および方法 |
| ES2630013T3 (es) * | 2008-02-22 | 2017-08-17 | Annexin Pharmaceuticals Ab | Compuestos y procedimientos para la prevención o tratamiento de reestenosis |
| EP2349321B1 (en) | 2008-10-17 | 2020-04-22 | London Health Sciences Centre Research Inc. | Annexin and its use to treat inflammatory disorders |
| US9238080B2 (en) | 2010-05-21 | 2016-01-19 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
| EP3355907B1 (en) | 2015-10-02 | 2021-01-20 | Silver Creek Pharmaceuticals, Inc. | Bi-specific therapeutic proteins for tissue repair |
| BR102017005783A2 (pt) | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
| TW202146042A (zh) * | 2020-03-06 | 2021-12-16 | 瑞典商阿斯特捷利康公司 | 用於治療動脈和靜脈血栓形成的協同且靶向的組成物 |
| CN113956339B (zh) * | 2021-10-28 | 2023-02-24 | 中国药科大学 | 宽体金线蛭抗凝血因子XIa多肽及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007676A1 (fr) | 1987-03-27 | 1988-10-06 | Terumo Kabushiki Kaisha | Capteur enzymatique |
| CA2276091A1 (en) | 1996-12-27 | 1998-07-09 | Mochida Pharmaceutical Co., Ltd. | Cell membrane-directed drugs |
-
2003
- 2003-06-04 WO PCT/US2003/017442 patent/WO2003103577A2/en not_active Ceased
- 2003-06-04 AU AU2003237351A patent/AU2003237351B2/en not_active Ceased
- 2003-06-04 US US10/516,908 patent/US7378393B2/en not_active Expired - Lifetime
- 2003-06-04 AT AT03736814T patent/ATE534658T1/de active
- 2003-06-04 CN CN03812999XA patent/CN1659180B/zh not_active Expired - Fee Related
- 2003-06-04 CA CA002486362A patent/CA2486362A1/en not_active Abandoned
- 2003-06-04 EP EP03736814A patent/EP1509541B1/en not_active Expired - Lifetime
- 2003-06-04 JP JP2004510698A patent/JP4444821B2/ja not_active Expired - Fee Related
-
2008
- 2008-04-11 US US12/101,343 patent/US20090029444A1/en not_active Abandoned
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