ATE534658T1 - Neue rekombinante antikoagulationsproteine - Google Patents
Neue rekombinante antikoagulationsproteineInfo
- Publication number
- ATE534658T1 ATE534658T1 AT03736814T AT03736814T ATE534658T1 AT E534658 T1 ATE534658 T1 AT E534658T1 AT 03736814 T AT03736814 T AT 03736814T AT 03736814 T AT03736814 T AT 03736814T AT E534658 T1 ATE534658 T1 AT E534658T1
- Authority
- AT
- Austria
- Prior art keywords
- anv
- kpi
- methods
- fusions
- recombinant
- Prior art date
Links
- 230000010100 anticoagulation Effects 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004121 Annexin A5 Human genes 0.000 abstract 5
- 108090000672 Annexin A5 Proteins 0.000 abstract 5
- 230000004927 fusion Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 229940127217 antithrombotic drug Drugs 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 208000018910 keratinopathic ichthyosis Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 238000002161 passivation Methods 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229960001153 serine Drugs 0.000 abstract 1
- 230000002885 thrombogenetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38693202P | 2002-06-06 | 2002-06-06 | |
| PCT/US2003/017442 WO2003103577A2 (en) | 2002-06-06 | 2003-06-04 | Novel recombinant anticoagulant proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE534658T1 true ATE534658T1 (de) | 2011-12-15 |
Family
ID=29736237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03736814T ATE534658T1 (de) | 2002-06-06 | 2003-06-04 | Neue rekombinante antikoagulationsproteine |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7378393B2 (enExample) |
| EP (1) | EP1509541B1 (enExample) |
| JP (1) | JP4444821B2 (enExample) |
| CN (1) | CN1659180B (enExample) |
| AT (1) | ATE534658T1 (enExample) |
| AU (1) | AU2003237351B2 (enExample) |
| CA (1) | CA2486362A1 (enExample) |
| WO (1) | WO2003103577A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635676B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
| US7635680B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
| US7671013B2 (en) * | 2003-04-03 | 2010-03-02 | Canadian Blood Services, Inc. | Coagulation proteins, coagulation-anticoagulation protein complexes, derivatives thereof and their uses |
| JP5134362B2 (ja) * | 2004-03-11 | 2013-01-30 | アラビタ・ファーマシューティカルズ・インコーポレーテッド | 修飾アネキシンタンパク質および血栓症を防止するための方法 |
| US7511016B2 (en) | 2004-07-07 | 2009-03-31 | Mosamedix B.V. | Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof |
| JP2011506590A (ja) | 2007-12-18 | 2011-03-03 | アセラ・バイオテクノロジーズ・アーベー | 血管疾患を治療するための化合物および方法 |
| ES2630013T3 (es) * | 2008-02-22 | 2017-08-17 | Annexin Pharmaceuticals Ab | Compuestos y procedimientos para la prevención o tratamiento de reestenosis |
| EP2349321B1 (en) | 2008-10-17 | 2020-04-22 | London Health Sciences Centre Research Inc. | Annexin and its use to treat inflammatory disorders |
| US9238080B2 (en) | 2010-05-21 | 2016-01-19 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
| EP3355907B1 (en) | 2015-10-02 | 2021-01-20 | Silver Creek Pharmaceuticals, Inc. | Bi-specific therapeutic proteins for tissue repair |
| BR102017005783A2 (pt) | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
| TW202146042A (zh) * | 2020-03-06 | 2021-12-16 | 瑞典商阿斯特捷利康公司 | 用於治療動脈和靜脈血栓形成的協同且靶向的組成物 |
| CN113956339B (zh) * | 2021-10-28 | 2023-02-24 | 中国药科大学 | 宽体金线蛭抗凝血因子XIa多肽及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007676A1 (fr) | 1987-03-27 | 1988-10-06 | Terumo Kabushiki Kaisha | Capteur enzymatique |
| CA2276091A1 (en) | 1996-12-27 | 1998-07-09 | Mochida Pharmaceutical Co., Ltd. | Cell membrane-directed drugs |
-
2003
- 2003-06-04 WO PCT/US2003/017442 patent/WO2003103577A2/en not_active Ceased
- 2003-06-04 AU AU2003237351A patent/AU2003237351B2/en not_active Ceased
- 2003-06-04 US US10/516,908 patent/US7378393B2/en not_active Expired - Lifetime
- 2003-06-04 AT AT03736814T patent/ATE534658T1/de active
- 2003-06-04 CN CN03812999XA patent/CN1659180B/zh not_active Expired - Fee Related
- 2003-06-04 CA CA002486362A patent/CA2486362A1/en not_active Abandoned
- 2003-06-04 EP EP03736814A patent/EP1509541B1/en not_active Expired - Lifetime
- 2003-06-04 JP JP2004510698A patent/JP4444821B2/ja not_active Expired - Fee Related
-
2008
- 2008-04-11 US US12/101,343 patent/US20090029444A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1659180A (zh) | 2005-08-24 |
| EP1509541A2 (en) | 2005-03-02 |
| WO2003103577A3 (en) | 2004-03-04 |
| JP4444821B2 (ja) | 2010-03-31 |
| CN1659180B (zh) | 2010-06-02 |
| AU2003237351A2 (en) | 2003-12-22 |
| JP2005528124A (ja) | 2005-09-22 |
| WO2003103577A2 (en) | 2003-12-18 |
| CA2486362A1 (en) | 2003-12-18 |
| AU2003237351B2 (en) | 2009-12-03 |
| EP1509541A4 (en) | 2006-06-07 |
| US7378393B2 (en) | 2008-05-27 |
| US20090029444A1 (en) | 2009-01-29 |
| AU2003237351A1 (en) | 2003-12-22 |
| US20050164926A1 (en) | 2005-07-28 |
| EP1509541B1 (en) | 2011-11-23 |
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