JP2003514549A5 - - Google Patents

Info

Publication number

JP2003514549A5

JP2003514549A5 JP2001538968A JP2001538968A JP2003514549A5 JP 2003514549 A5 JP2003514549 A5 JP 2003514549A5 JP 2001538968 A JP2001538968 A JP 2001538968A JP 2001538968 A JP2001538968 A JP 2001538968A JP 2003514549 A5 JP2003514549 A5 JP 2003514549A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

expression vector

nucleic acid

amino acid

Prior art date

2000-11-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• 229920001184 polypeptide Polymers 0.000 description 34
• 102000004196 processed proteins & peptides Human genes 0.000 description 34
• 108090000765 processed proteins & peptides Proteins 0.000 description 34
• 238000000034 method Methods 0.000 description 29
• 239000013604 expression vector Substances 0.000 description 17
• 125000003275 alpha amino acid group Chemical group 0.000 description 13
• 102000039446 nucleic acids Human genes 0.000 description 13
• 108020004707 nucleic acids Proteins 0.000 description 13
• 150000007523 nucleic acids Chemical class 0.000 description 13
• 230000000694 effects Effects 0.000 description 12
• 150000001875 compounds Chemical class 0.000 description 11
• 239000002773 nucleotide Substances 0.000 description 10
• 125000003729 nucleotide group Chemical group 0.000 description 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 8
• 101800002739 Melanin-concentrating hormone Proteins 0.000 description 6
• 102400001132 Melanin-concentrating hormone Human genes 0.000 description 6
• 150000001413 amino acids Chemical class 0.000 description 6
• 239000003446 ligand Substances 0.000 description 5
• 238000012216 screening Methods 0.000 description 5
• 239000012634 fragment Substances 0.000 description 4
• 102000029828 Melanin-concentrating hormone receptor Human genes 0.000 description 3
• 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 description 3
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 2
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 2
• 101500028288 Homo sapiens Melanin-concentrating hormone Proteins 0.000 description 2
• 230000000295 complement effect Effects 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 101100244725 Caenorhabditis elegans pef-1 gene Proteins 0.000 description 1
• BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 108091006027 G proteins Proteins 0.000 description 1
• 102000030782 GTP binding Human genes 0.000 description 1
• 108091000058 GTP-Binding Proteins 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 229910001424 calcium ion Inorganic materials 0.000 description 1
• 108700010039 chimeric receptor Proteins 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1