JP2002528140A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002528140A5 JP2002528140A5 JP2000579790A JP2000579790A JP2002528140A5 JP 2002528140 A5 JP2002528140 A5 JP 2002528140A5 JP 2000579790 A JP2000579790 A JP 2000579790A JP 2000579790 A JP2000579790 A JP 2000579790A JP 2002528140 A5 JP2002528140 A5 JP 2002528140A5
- Authority
- JP
- Japan
- Prior art keywords
- cbh
- hcv
- envelope protein
- viral
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 24
- 239000000203 mixture Substances 0.000 description 15
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 12
- 230000003612 virological effect Effects 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 150000003384 small molecules Chemical class 0.000 description 5
- 210000002845 virion Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 101710091045 Envelope protein Proteins 0.000 description 3
- 108700008783 Hepatitis C virus E1 Proteins 0.000 description 3
- 101710188315 Protein X Proteins 0.000 description 3
- 102100021696 Syncytin-1 Human genes 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- -1 Amino Chemical group 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003302 anti-idiotype Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 210000004779 membrane envelope Anatomy 0.000 description 2
- 108010032595 Antibody Binding Sites Proteins 0.000 description 1
- 102100027221 CD81 antigen Human genes 0.000 description 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 1
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18705798A | 1998-11-05 | 1998-11-05 | |
| US09/187,057 | 1998-11-05 | ||
| PCT/US1999/025711 WO2000026418A1 (en) | 1998-11-05 | 1999-10-29 | Human pan-hcv human monoclonal antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002528140A JP2002528140A (ja) | 2002-09-03 |
| JP2002528140A5 true JP2002528140A5 (enExample) | 2006-12-14 |
Family
ID=22687437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579790A Pending JP2002528140A (ja) | 1998-11-05 | 1999-10-29 | ヒトｐａｎ−ｈｃｖヒトモノクローナル抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6692908B1 (enExample) |
| EP (1) | EP1127170A4 (enExample) |
| JP (1) | JP2002528140A (enExample) |
| AU (1) | AU1462300A (enExample) |
| WO (1) | WO2000026418A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5285899A (en) * | 1998-07-21 | 2000-02-14 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
| EP1127170A4 (en) | 1998-11-05 | 2005-04-27 | Univ Leland Stanford Junior | HUMAN MONOCLONAL ANTIBODIES OF THE HEPATITIS C VIRUS (HCV) PAN |
| US7091324B2 (en) * | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| US20060188511A1 (en) * | 1998-11-05 | 2006-08-24 | Foung Steven K | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
| DE60034884T2 (de) * | 1999-06-04 | 2008-01-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Klonierte genome von infektiösen hepatitis c viren genotyp 2a und deren verwendungen |
| US7084266B1 (en) | 1999-06-04 | 2006-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof |
| EP1245236A4 (en) * | 1999-12-28 | 2004-09-22 | Sumitomo Pharma | PROPHYLACTICS AND THERAPEUTICS FOR TREATING CHRONIC HEPATITIS |
| CN100391469C (zh) | 2000-02-14 | 2008-06-04 | 三菱制药株式会社 | 丙型肝炎治疗药 |
| IL137522A (en) * | 2000-07-26 | 2007-06-17 | Drk Blutspendediendst Baden Wu | HCV human monoclonal antibody E2 glycoprotein antibody |
| JP2004524829A (ja) * | 2000-12-01 | 2004-08-19 | アメリカ合衆国 | Ｃ型肝炎ウイルスのｅ２糖タンパク質に特異的なモノクローナル抗体、ならびにｃ型肝炎の診断、治療、および予防におけるそれらの使用 |
| DE60231475D1 (de) | 2001-01-12 | 2009-04-23 | Molecules Of Man Ab | Materialien und methoden zur behandlung von hepatitis c |
| WO2002082089A2 (en) * | 2001-04-03 | 2002-10-17 | Immune Network Ltd. | Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases |
| US7179600B2 (en) | 2001-04-12 | 2007-02-20 | Biocore Co., Ltd. | Oligonucleotide chip composition and a method for analyzing a hepatitis C virus genotype using the composition |
| ES2289169T3 (es) * | 2001-12-05 | 2008-02-01 | Sense Proteomic Limited | Redes de proteinas para variantes alelicas y sus usos. |
| EP1572720A4 (en) | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | PROCESS FOR THE ENZYMATIC PRODUCTION OF GLP-2 (1-34) AND GLP-2 (1-33) PEPTIDES |
| WO2003100020A2 (en) | 2002-05-24 | 2003-12-04 | Restoragen, Inc. | Methods and constructs for high yield expression of clostripain |
| CA2546319A1 (en) | 2003-11-21 | 2005-07-28 | Nps Allelix Corp. | Production of glucagon like peptide 2 and analogs |
| WO2006028634A2 (en) * | 2004-09-01 | 2006-03-16 | Vijay Ramakrishnan | Site specific pegylation of broadly-neutralizing antibodies against hepatitis c virus and their use in the treatment of chronic hcv infections |
| US7592315B2 (en) | 2004-11-02 | 2009-09-22 | Schering Corporation | Peptide viral entry inhibitors |
| JP4958773B2 (ja) * | 2005-06-02 | 2012-06-20 | 松森 昭 | Ｃ型肝炎ウイルス感染の診断、予防および治療方法 |
| WO2007041432A2 (en) * | 2005-09-30 | 2007-04-12 | Novartis Vaccines And Diagnostics, Inc. | Cross-neutralization of hcv with recombinant proteins |
| KR101500017B1 (ko) * | 2006-08-25 | 2015-03-09 | 더 맥파레인 버넷 인스티튜트 포 메디칼 리서치 앤드 퍼블릭 헬스 리미티드 | 재조합 ｈｃｖ ｅ2 당단백질 |
| CA2678888C (en) | 2007-02-21 | 2015-04-14 | University Of Massachusetts | Human antibodies against hepatitis c virus (hcv) and uses thereof |
| DK2862876T3 (en) * | 2008-09-30 | 2016-05-23 | Toray Industries | Antibody binding to envelope protein 2 of hepatitis C virus and method for identifying the genotype of hepatitis C virus using the same |
| AU2008362482A1 (en) | 2008-10-05 | 2010-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Hepatitis C antibodies and uses thereof |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| US20160095939A1 (en) | 2014-10-07 | 2016-04-07 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| PL3939617T3 (pl) | 2009-02-13 | 2025-03-17 | Immunomedics, Inc. | Związki pośrednie do wytwarzania koniugatów z wiązaniem rozszczepialnym wewnątrzkomórkowo |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
| BR112012029881A2 (pt) * | 2010-05-25 | 2019-09-24 | Inserm (Institut National De La Santé De La Recherche Médicale) | combinação de anticorpos anti-envelope e anticorpos anti-receptor para o tratamento e a presenção de infecção por hcv |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| WO2014028560A2 (en) | 2012-08-14 | 2014-02-20 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| BR112015013444B1 (pt) | 2012-12-13 | 2022-11-01 | Immunomedics, Inc | Uso de um imunoconjugado |
| EP3107577B1 (en) | 2014-02-21 | 2024-03-20 | IBC Pharmaceuticals, Inc. | Disease therapy by inducing immune response to trop-2 expressing cells |
| EP3110445A4 (en) | 2014-02-25 | 2017-09-27 | Immunomedics, Inc. | Humanized rfb4 anti-cd22 antibody |
| EP3160504B1 (en) | 2014-06-24 | 2020-09-16 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| EP3286224A4 (en) | 2015-04-22 | 2018-11-14 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| CN107735104B (zh) | 2015-06-25 | 2022-05-03 | 免疫医疗公司 | 组合抗hla-dr抗体或抗trop-2抗体与微管抑制剂、parp抑制剂、布鲁顿激酶抑制剂或磷酸肌醇3-激酶抑制剂使癌症治疗结果显著改善 |
| EP3316885B1 (en) | 2015-07-01 | 2021-06-23 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| AU2021256402A1 (en) * | 2020-04-12 | 2022-11-17 | Aethlon Medical, Inc. | Devices and methods for treating a coronavirus infection and symptoms thereof |
| WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514539A (en) | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| JPH07299655A (ja) | 1994-04-30 | 1995-11-14 | Aisin Seiki Co Ltd | 内スプライン歯面仕上機 |
| US6538114B1 (en) * | 1996-04-19 | 2003-03-25 | Karolina Innovations Ab | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| US6747136B2 (en) | 1996-04-19 | 2004-06-08 | Karolinska Innovations Ab | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| ATE349225T1 (de) | 1997-11-06 | 2007-01-15 | Innogenetics Nv | Apo b, annexin v und tubulin: medizinische und diagnostische verwendung und verwendung zur purifikation von hcv |
| EP1127170A4 (en) | 1998-11-05 | 2005-04-27 | Univ Leland Stanford Junior | HUMAN MONOCLONAL ANTIBODIES OF THE HEPATITIS C VIRUS (HCV) PAN |
-
1999
- 1999-10-29 EP EP99971468A patent/EP1127170A4/en not_active Ceased
- 1999-10-29 JP JP2000579790A patent/JP2002528140A/ja active Pending
- 1999-10-29 AU AU14623/00A patent/AU1462300A/en not_active Abandoned
- 1999-10-29 WO PCT/US1999/025711 patent/WO2000026418A1/en not_active Ceased
- 1999-10-29 US US09/430,489 patent/US6692908B1/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002528140A5 (enExample) | ||
| Paton et al. | Epitope mapping of the gp53 envelope protein of bovine viral diarrhea virus | |
| CN102220286B (zh) | 杂交瘤细胞株2c9、其产生的抗黄曲霉毒素m1单克隆抗体及其应用 | |
| JP3408793B2 (ja) | ウイルスの検出又は測定方法 | |
| US8546075B2 (en) | Method of detecting hepatitis C virus | |
| JPH06510192A (ja) | 推定上のｈｃｖ ｅ２／ｎｓ１蛋白に対するモノクローナル抗体およびその使用方法 | |
| DK175364B1 (da) | Antigent syntetisk peptid, antigen polymer samt receptormolekyle | |
| KR100730529B1 (ko) | Ｈｃｖ 코어 항원의 검출 또는 정량 방법 및 이에사용하기 위한 검출 또는 정량용 시약 | |
| CN111999497B (zh) | 检测狂犬病毒糖蛋白抗原的酶联免疫试剂盒及其应用 | |
| Margolis et al. | Identification of virus components in circulating immune complexes isolated during hepatitis A virus infection | |
| EP1328811A2 (en) | Hcv mosaic antigen composition | |
| TW201925781A (zh) | Ｂ型肝炎病毒ｓ抗原之測定方法及測定套組 | |
| WO2013043125A1 (en) | Enterovirus 71 specific antibodies and uses thereof | |
| JP4554472B2 (ja) | パルボウイルス抗原検出用キット | |
| KR101876535B1 (ko) | 소바이러스성 설사병 바이러스의 탐지용 항체, 이를 이용한 항원 검출 방법, 및 이를 포함하는 탐지키트 | |
| CN104277110A (zh) | 一种针对人Tudor-SN蛋白T73位点的应激磷酸化抗体制备方法 | |
| CN104277109A (zh) | 一种针对人Tudor-SN蛋白T103位点的应激磷酸化抗体制备方法 | |
| DK174060B1 (da) | Antigent syntetisk polypeptid, vandopløselig eller vanddispergerbar polymer indeholdende polypeptidet, receptormolekyle, der kan immunoreagere dermed, diagnostisk analysesystem til bestemmelse af HBxAg, samt fremgangsmåder til bestemmelse..... | |
| JP3292727B2 (ja) | Ｃ型肝炎ウイルスに対するモノクローナル抗体およびその使用法 | |
| CA2072092A1 (en) | Non-a non-b sequences | |
| JP2837669B2 (ja) | Ｔ−細胞リンパ趨行性ウイルス蛋白及びその分析 | |
| EP1342727A1 (en) | Antibody against norwalk virus and method of detecting virus by using the antibody | |
| JP2003532420A5 (enExample) | ||
| CN105319372B (zh) | 莱克多巴胺检测试纸卡及试剂盒 | |
| JP2006071631A (ja) | フラビウイルス科ペスチウイルス属ウイルスの検出法およびそのイムノクロマトグラフィーにおける使用 |