JP2002528140A5 - - Google Patents
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- Publication number
- JP2002528140A5 JP2002528140A5 JP2000579790A JP2000579790A JP2002528140A5 JP 2002528140 A5 JP2002528140 A5 JP 2002528140A5 JP 2000579790 A JP2000579790 A JP 2000579790A JP 2000579790 A JP2000579790 A JP 2000579790A JP 2002528140 A5 JP2002528140 A5 JP 2002528140A5
- Authority
- JP
- Japan
- Prior art keywords
- cbh
- hcv
- envelope protein
- viral
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 24
- 239000000203 mixture Substances 0.000 description 15
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 12
- 230000003612 virological effect Effects 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 150000003384 small molecules Chemical class 0.000 description 5
- 210000002845 virion Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 101710091045 Envelope protein Proteins 0.000 description 3
- 108700008783 Hepatitis C virus E1 Proteins 0.000 description 3
- 101710188315 Protein X Proteins 0.000 description 3
- 102100021696 Syncytin-1 Human genes 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- -1 Amino Chemical group 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003302 anti-idiotype Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 210000004779 membrane envelope Anatomy 0.000 description 2
- 108010032595 Antibody Binding Sites Proteins 0.000 description 1
- 102100027221 CD81 antigen Human genes 0.000 description 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 1
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18705798A | 1998-11-05 | 1998-11-05 | |
| US09/187,057 | 1998-11-05 | ||
| PCT/US1999/025711 WO2000026418A1 (en) | 1998-11-05 | 1999-10-29 | Human pan-hcv human monoclonal antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002528140A JP2002528140A (ja) | 2002-09-03 |
| JP2002528140A5 true JP2002528140A5 (enExample) | 2006-12-14 |
Family
ID=22687437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579790A Pending JP2002528140A (ja) | 1998-11-05 | 1999-10-29 | ヒトｐａｎ−ｈｃｖヒトモノクローナル抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6692908B1 (enExample) |
| EP (1) | EP1127170A4 (enExample) |
| JP (1) | JP2002528140A (enExample) |
| AU (1) | AU1462300A (enExample) |
| WO (1) | WO2000026418A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6951646B1 (en) | 1998-07-21 | 2005-10-04 | Genmab A/S | Anti hepatitis C virus antibody and uses thereof |
| US20060188511A1 (en) * | 1998-11-05 | 2006-08-24 | Foung Steven K | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
| EP1127170A4 (en) | 1998-11-05 | 2005-04-27 | Univ Leland Stanford Junior | HUMAN MONOCLONAL ANTIBODIES OF THE HEPATITIS C VIRUS (HCV) PAN |
| US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| AU5322800A (en) * | 1999-06-04 | 2000-12-28 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Cloned genone of infectious hepatitis c virus of genotype 2a and uses thereof |
| US7084266B1 (en) | 1999-06-04 | 2006-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof |
| US20030171276A1 (en) * | 1999-12-28 | 2003-09-11 | Naoki Tohdoh | Preventives and remedies for chronic hepatitis |
| AU2001232267A1 (en) * | 2000-02-14 | 2001-08-20 | Japan As Represented By Director General Of Agency Of National Institute Of Infectious Deseases | Remedies for hepatitis c |
| IL137522A (en) * | 2000-07-26 | 2007-06-17 | Drk Blutspendediendst Baden Wu | HCV human monoclonal antibody E2 glycoprotein antibody |
| JP2004524829A (ja) * | 2000-12-01 | 2004-08-19 | アメリカ合衆国 | Ｃ型肝炎ウイルスのｅ２糖タンパク質に特異的なモノクローナル抗体、ならびにｃ型肝炎の診断、治療、および予防におけるそれらの使用 |
| DE60231475D1 (de) | 2001-01-12 | 2009-04-23 | Molecules Of Man Ab | Materialien und methoden zur behandlung von hepatitis c |
| WO2002082089A2 (en) * | 2001-04-03 | 2002-10-17 | Immune Network Ltd. | Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases |
| JP2004525643A (ja) | 2001-04-12 | 2004-08-26 | バイオコア シーオー． エルティーディー． | Ｃ型肝炎ウィルス（ｈｃｖ）の遺伝子型分析のためのオリゴヌクレオチドチップ組成物及びその検査方法 |
| JP4781628B2 (ja) * | 2001-12-05 | 2011-09-28 | センス プロテオミック リミテッド | 対立遺伝子改変体のためのタンパク質アレイおよびその使用 |
| ATE452137T1 (de) * | 2002-05-24 | 2010-01-15 | Restoragen Inc | Verfahren und konstrukte zur expression von clostripain mit hoher ausbeute |
| AU2003243316A1 (en) | 2002-05-24 | 2003-12-12 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
| DK1704234T3 (da) | 2003-11-21 | 2012-05-07 | Nps Pharma Inc | Fremstilling af glucagon-lignende peptid 2 og analoger |
| WO2006028634A2 (en) * | 2004-09-01 | 2006-03-16 | Vijay Ramakrishnan | Site specific pegylation of broadly-neutralizing antibodies against hepatitis c virus and their use in the treatment of chronic hcv infections |
| US7592315B2 (en) | 2004-11-02 | 2009-09-22 | Schering Corporation | Peptide viral entry inhibitors |
| US20090136515A1 (en) * | 2005-06-02 | 2009-05-28 | Akira Matsumori | Methods of diagnosing, preventing and treating infection with Hepatitis C virus |
| WO2007041432A2 (en) * | 2005-09-30 | 2007-04-12 | Novartis Vaccines And Diagnostics, Inc. | Cross-neutralization of hcv with recombinant proteins |
| WO2008022401A1 (en) * | 2006-08-25 | 2008-02-28 | The Macfarlane Burnet Institute For Medical Research And Public Health Limited | Recombinant hcv e2 glycoprotein |
| JP5642972B2 (ja) | 2007-02-21 | 2014-12-17 | ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ | Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用 |
| EP2336173A4 (en) * | 2008-09-30 | 2012-07-25 | Toray Industries | FOR BINDING THE CROP PROTEIN 2 OF THE HEPATITIS C-VIRUS CAPACITIVE ANTIBODY AND METHOD FOR IDENTIFYING THE GENOTYPIC OF THE HEPATITIS C VIRUS USING THEREOF |
| JP2012504602A (ja) | 2008-10-05 | 2012-02-23 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | Ｃ型肝炎抗体およびその使用 |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| HRP20230487T1 (hr) | 2009-02-13 | 2023-07-21 | Immunomedics, Inc. | Imunokonjugati s unutarstaničnom vezom koja se može rascijepiti |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
| BR112012029881A2 (pt) * | 2010-05-25 | 2019-09-24 | Inserm (Institut National De La Santé De La Recherche Médicale) | combinação de anticorpos anti-envelope e anticorpos anti-receptor para o tratamento e a presenção de infecção por hcv |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| AU2013302696B9 (en) | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| PL2900277T3 (pl) | 2012-12-13 | 2022-05-16 | Immunomedics, Inc. | Dawkowanie immunokoniugatów przeciwciał i sn-38 dla poprawy skuteczności i zmniejszenia toksyczności |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ，インコーポレイテッド | Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療 |
| US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
| WO2015200260A1 (en) | 2014-06-24 | 2015-12-30 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| AU2015328370B2 (en) | 2014-10-07 | 2021-08-05 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| PT3313443T (pt) | 2015-06-25 | 2023-08-30 | Immunomedics Inc | Combinação de anticorpos anti-hla-dr ou anti-trop-2 com inibidores de microtúbulos, inibidores de parp, inibidores de bruton quinase ou inibidores de fosfoinositídeo 3-quinase melhora significativamente o resultado terapêutico no cancro |
| PL3316885T3 (pl) | 2015-07-01 | 2021-12-06 | Immunomedics, Inc. | Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a |
| CA3178687A1 (en) * | 2020-04-12 | 2021-10-21 | Aethlon Medical, Inc. | Devices and methods for treating a coronavirus infection and symptoms thereof |
| US20250073349A1 (en) | 2021-05-10 | 2025-03-06 | Kawasaki Institute Of Industrial Promotion | Antibody having reduced binding affinity for antigen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514539A (en) | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| JPH07299655A (ja) | 1994-04-30 | 1995-11-14 | Aisin Seiki Co Ltd | 内スプライン歯面仕上機 |
| US6747136B2 (en) * | 1996-04-19 | 2004-06-08 | Karolinska Innovations Ab | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| US6538114B1 (en) * | 1996-04-19 | 2003-03-25 | Karolina Innovations Ab | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| DE69836758T2 (de) | 1997-11-06 | 2007-10-11 | Innogenetics N.V. | Apo b, annexin v und tubulin: medizinische und diagnostische verwendung und verwendung zur purifikation von hcv |
| EP1127170A4 (en) | 1998-11-05 | 2005-04-27 | Univ Leland Stanford Junior | HUMAN MONOCLONAL ANTIBODIES OF THE HEPATITIS C VIRUS (HCV) PAN |
-
1999
- 1999-10-29 EP EP99971468A patent/EP1127170A4/en not_active Ceased
- 1999-10-29 US US09/430,489 patent/US6692908B1/en not_active Expired - Fee Related
- 1999-10-29 AU AU14623/00A patent/AU1462300A/en not_active Abandoned
- 1999-10-29 JP JP2000579790A patent/JP2002528140A/ja active Pending
- 1999-10-29 WO PCT/US1999/025711 patent/WO2000026418A1/en not_active Ceased
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