JP2004502684A5 - - Google Patents

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Publication number
JP2004502684A5
JP2004502684A5 JP2002507800A JP2002507800A JP2004502684A5 JP 2004502684 A5 JP2004502684 A5 JP 2004502684A5 JP 2002507800 A JP2002507800 A JP 2002507800A JP 2002507800 A JP2002507800 A JP 2002507800A JP 2004502684 A5 JP2004502684 A5 JP 2004502684A5
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JP
Japan
Prior art keywords
ortho
mammal
substituents
administering
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002507800A
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English (en)
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JP4851051B2 (ja
JP2004502684A (ja
Filing date
Publication date
Priority claimed from FI20001593A external-priority patent/FI20001593A/fi
Application filed filed Critical
Publication of JP2004502684A publication Critical patent/JP2004502684A/ja
Publication of JP2004502684A5 publication Critical patent/JP2004502684A5/ja
Application granted granted Critical
Publication of JP4851051B2 publication Critical patent/JP4851051B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Claims (1)

  1. ＣＯＭＴ酵素の阻害剤が有用であることが示されている疾病または症状の治療方法であって、かかる治療を必要とする哺乳動物に、有効量の一般式Ｉ′
    Figure 2004502684
    （式中、フェニル部分における２つのＯＨ置換基は互いにオルト位であり、Ｒ１はヒドロキシ基の１つとオルト位である；
    そしてＸ、Ｒ１〜Ｒ６は請求項１３で定義されたものと同一である）
    で表わされる化合物を投与することからなる方法。
JP2002507800A 2000-07-03 2001-06-28 Ｃｏｍｔ阻害活性を有するクマリン誘導体 Expired - Fee Related JP4851051B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20001593A FI20001593A (fi) 2000-07-03 2000-07-03 Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
FI20001593 2000-07-03
PCT/FI2001/000613 WO2002002548A1 (en) 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity

Publications (3)

Publication Number Publication Date
JP2004502684A JP2004502684A (ja) 2004-01-29
JP2004502684A5 true JP2004502684A5 (ja) 2005-02-03
JP4851051B2 JP4851051B2 (ja) 2012-01-11

Family

ID=8558717

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002507800A Expired - Fee Related JP4851051B2 (ja) 2000-07-03 2001-06-28 Ｃｏｍｔ阻害活性を有するクマリン誘導体

Country Status (27)

Country Link
US (1) US6951870B2 (ja)
EP (1) EP1301503B1 (ja)
JP (1) JP4851051B2 (ja)
KR (1) KR20030040225A (ja)
CN (1) CN1199963C (ja)
AT (1) ATE260268T1 (ja)
AU (2) AU2001272597B9 (ja)
BG (1) BG107513A (ja)
BR (1) BR0111969A (ja)
CA (1) CA2414787C (ja)
DE (1) DE60102161T2 (ja)
DK (1) DK1301503T3 (ja)
EE (1) EE200300008A (ja)
ES (1) ES2215919T3 (ja)
FI (1) FI20001593A (ja)
HU (1) HUP0301706A3 (ja)
IL (2) IL153352A0 (ja)
MX (1) MXPA02012657A (ja)
NO (1) NO328699B1 (ja)
NZ (1) NZ523121A (ja)
PL (1) PL359068A1 (ja)
PT (1) PT1301503E (ja)
RU (1) RU2282627C2 (ja)
SK (1) SK18452002A3 (ja)
TR (1) TR200400802T4 (ja)
WO (1) WO2002002548A1 (ja)
ZA (1) ZA200210161B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7007292B2 (ja) 2015-12-18 2022-02-10 ケスター、ヒューバート 薬剤としての使用のため、特にパーキンソン病の治療のための新規二環式化合物

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2002951833A0 (en) 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
AU2003265737B2 (en) * 2002-10-02 2008-10-16 Novogen Research Pty Ltd Combination chemotherapy compositions and methods
CN1506359A (zh) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
ATE532777T1 (de) 2004-09-21 2011-11-15 Marshall Edwards Inc Substituierte chromanderivate, medikamente und anwendungen in der therapie
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
WO2007022946A1 (de) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
JP6013349B2 (ja) 2010-11-01 2016-10-25 メイ ファーマ, インク.Mei Pharma, Inc. 癌の処置のためのイソフラボノイド化合物および方法
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚ｏ－甲基轉移酶活性抑制化合物
ES2877712T3 (es) 2015-02-02 2021-11-17 Mei Pharma Inc Terapias combinadas para su uso en el tratamiento del cáncer de mama
CN107868069A (zh) * 2017-10-31 2018-04-03 山东新华制药股份有限公司 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5035393A (ja) * 1973-08-01 1975-04-04
US3973608A (en) 1973-08-01 1976-08-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Microbial production of certain isoflavones
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en) 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
HUT63843A (en) 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
JP3166094B2 (ja) * 1993-09-08 2001-05-14 森永乳業株式会社 クマリン誘導体及びそれらの用途
JPH0892157A (ja) 1994-05-02 1996-04-09 F Hoffmann La Roche Ag プルプロガリン誘導体
GB9626472D0 (en) 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7007292B2 (ja) 2015-12-18 2022-02-10 ケスター、ヒューバート 薬剤としての使用のため、特にパーキンソン病の治療のための新規二環式化合物

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