JP2004307506A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004307506A5 JP2004307506A5 JP2004111761A JP2004111761A JP2004307506A5 JP 2004307506 A5 JP2004307506 A5 JP 2004307506A5 JP 2004111761 A JP2004111761 A JP 2004111761A JP 2004111761 A JP2004111761 A JP 2004111761A JP 2004307506 A5 JP2004307506 A5 JP 2004307506A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- receptor agonist
- composition
- mannitol
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 30
- 150000005846 sugar alcohols Chemical class 0.000 claims 10
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 claims 8
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 claims 8
- 239000000018 receptor agonist Substances 0.000 claims 8
- 229940044601 receptor agonist Drugs 0.000 claims 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 5
- 229930195725 Mannitol Natural products 0.000 claims 5
- 235000010355 mannitol Nutrition 0.000 claims 5
- 239000000594 mannitol Substances 0.000 claims 5
- 239000000314 lubricant Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000005484 gravity Effects 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 206010047470 viral myocarditis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical group CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims 1
- SWZTYAVBMYWFGS-UHFFFAOYSA-N fingolimod hydrochloride Chemical group Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 SWZTYAVBMYWFGS-UHFFFAOYSA-N 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 12
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical group 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000003884 phenylalkyl group Chemical group 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- -1 amino, hydroxyl group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46121503P | 2003-04-08 | 2003-04-08 | |
| US60/461215 | 2003-04-08 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188835A Division JP5543298B2 (ja) | 2003-04-08 | 2010-08-25 | 固形医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004307506A JP2004307506A (ja) | 2004-11-04 |
| JP2004307506A5 true JP2004307506A5 (cg-RX-API-DMAC10.html) | 2010-10-14 |
| JP5495467B2 JP5495467B2 (ja) | 2014-05-21 |
Family
ID=32326722
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004111761A Expired - Lifetime JP5495467B2 (ja) | 2003-04-08 | 2004-04-06 | 固形医薬組成物 |
| JP2010188835A Expired - Lifetime JP5543298B2 (ja) | 2003-04-08 | 2010-08-25 | 固形医薬組成物 |
| JP2013090602A Pending JP2013177404A (ja) | 2003-04-08 | 2013-04-23 | 固形医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188835A Expired - Lifetime JP5543298B2 (ja) | 2003-04-08 | 2010-08-25 | 固形医薬組成物 |
| JP2013090602A Pending JP2013177404A (ja) | 2003-04-08 | 2013-04-23 | 固形医薬組成物 |
Country Status (41)
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080096972A1 (en) * | 2004-07-30 | 2008-04-24 | Thitiwan Buranachokpaisan | Compound formulations of 2-amino-1, 3-propanediol compounds |
| CN1891212B (zh) * | 2005-07-07 | 2010-10-13 | 马启明 | 一种口服制剂及其制备方法 |
| PT2295049E (pt) * | 2005-09-09 | 2015-03-02 | Novartis Ag | Tratamento de doenças auto-imunes |
| MX2008006090A (es) | 2005-11-09 | 2008-10-23 | Proteolix Inc | Compuestos para inhibicion de la enzima. |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| RU2450016C2 (ru) | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| KR101884047B1 (ko) * | 2006-09-26 | 2018-07-31 | 노파르티스 아게 | Ｓ１ｐ 조정제를 포함하는 제약 조성물 |
| AU2011235934A1 (en) * | 2006-09-26 | 2011-11-03 | Novartis Ag | Pharmaceutical compositions comprising an S1P modulator |
| EP1923054A1 (en) * | 2006-09-26 | 2008-05-21 | Novartis AG | Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator |
| EP1923055A1 (en) * | 2006-09-26 | 2008-05-21 | Novartis AG | Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator |
| EP1905434A1 (en) * | 2006-09-26 | 2008-04-02 | Novartis AG | Organic compounds comprising an S1P receptor agonist and their therapeutic use |
| EP1923058A1 (en) * | 2006-09-26 | 2008-05-21 | Novartis AG | Coated pharmaceutical composition comprising an S1P agonist or modulator |
| WO2008124210A1 (en) * | 2007-02-14 | 2008-10-16 | Emory University | Methods and compositions for treating or preventing infection using leukocyte sequestration agents |
| CN104324015B (zh) | 2007-03-29 | 2018-08-28 | 第一三共株式会社 | 药物组合物 |
| KR20160086980A (ko) | 2007-10-04 | 2016-07-20 | 오닉스 세라퓨틱스, 인크. | 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성 |
| PL2465492T3 (pl) | 2007-10-12 | 2015-11-30 | Novartis Ag | Mieszaniny zawierające modulatory receptora 1-fosforanu sfingozyny (S1P) |
| AU2012216630B2 (en) * | 2007-10-12 | 2015-01-22 | Novartis Ag | Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators |
| JP5534645B2 (ja) * | 2008-01-11 | 2014-07-02 | 日医工株式会社 | 無包装状態において安定性に優れた塩酸サルポグレラート含有経口投与製剤 |
| WO2009099174A1 (ja) | 2008-02-07 | 2009-08-13 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| HRP20170246T4 (hr) | 2008-03-17 | 2020-02-07 | Actelion Pharmaceuticals Ltd. | Režim doziranja za selektivni agonist s1p1-receptora |
| MX2010014223A (es) | 2008-06-20 | 2011-01-21 | Novartis Ag | Composiciones pediatricas para el tratamiento de esclerosis multiple. |
| EP2299982B1 (de) * | 2008-06-20 | 2018-04-04 | Merck Patent GmbH | Direkt verpressbare und schnell zerfallende tablettenmatirx |
| RU2498636C2 (ru) * | 2008-09-04 | 2013-11-20 | Карджилл Инкорпорейтед | Таблетирование эритрита |
| MX2011004225A (es) | 2008-10-21 | 2011-06-21 | Onyx Therapeutics Inc | Terapia de combinacion con epoxicetonas peptidicas. |
| AU2009315735B2 (en) | 2008-11-11 | 2013-01-10 | Novartis Ag | Salts of fingolimod |
| US8530522B2 (en) * | 2008-11-11 | 2013-09-10 | Novartis Ag | Organic compounds |
| AU2013100532B4 (en) * | 2008-11-11 | 2013-11-28 | Novartis Ag | Crystalline forms of fingolimod HCL |
| CA2747427C (en) | 2008-12-17 | 2015-10-13 | Daiichi Sankyo Company, Limited | Method for producing diamine derivative |
| JPWO2010082531A1 (ja) | 2009-01-13 | 2012-07-05 | 第一三共株式会社 | 活性化血液凝固因子阻害剤 |
| CN102348688B (zh) | 2009-03-10 | 2014-07-09 | 第一三共株式会社 | 用于制备二胺衍生物的方法 |
| EP2407450B1 (en) | 2009-03-13 | 2015-04-22 | Daiichi Sankyo Company, Limited | Method for producing optically active diamine derivative |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| SG176934A1 (en) * | 2009-06-18 | 2012-01-30 | Daiichi Sankyo Co Ltd | Pharmaceutical composition having improved solubility |
| US9675566B2 (en) | 2009-07-16 | 2017-06-13 | Pathologica Llc | Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing |
| WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
| BR112012022060A2 (pt) | 2010-03-01 | 2018-05-08 | Onyx Therapeutics Inc | composto para a inibição de imunoproteassoma |
| EP2548556B1 (en) | 2010-03-19 | 2016-08-10 | Daiichi Sankyo Company, Limited | Method for improving dissolvability of anticoagulant |
| ES2560955T3 (es) | 2010-03-19 | 2016-02-23 | Daiichi Sankyo Company, Limited | Cristal de derivado de diamina y procedimiento de producción del mismo |
| US20130095177A1 (en) * | 2010-04-22 | 2013-04-18 | Ratiopharm Gmbh | Method of preparing an oral dosage form comprising fingolimod |
| KR101795096B1 (ko) | 2010-07-02 | 2017-12-01 | 다이이찌 산쿄 가부시키가이샤 | 광학 활성 디아민 유도체의 염의 제조 방법 |
| EP2646409A4 (en) | 2010-11-25 | 2015-12-16 | Shilpa Medicare Ltd | FINGOLIMOD POLYMORPHES AND METHOD THEREFOR |
| HRP20191842T1 (hr) | 2011-01-07 | 2019-12-27 | Novartis Ag | Formulacije imunosupresiva |
| US8858991B2 (en) | 2011-01-19 | 2014-10-14 | Pathologica Llc | Delayed release oral pharmaceutical dosage forms comprising MGBG |
| AR085749A1 (es) * | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
| EA028950B1 (ru) | 2011-08-01 | 2018-01-31 | Тева Фармасьютикал Индастриз Лтд. | Способ получения фармацевтических композиций, содержащих финголимод |
| JPWO2013022059A1 (ja) | 2011-08-10 | 2015-03-05 | 第一三共株式会社 | ジアミン誘導体含有医薬組成物 |
| WO2013091704A1 (en) | 2011-12-22 | 2013-06-27 | Synthon Bv | Pharmaceutical composition comprising fingolimod |
| RU2482842C1 (ru) * | 2012-04-26 | 2013-05-27 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения |
| RU2506949C1 (ru) * | 2012-06-13 | 2014-02-20 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний |
| WO2014011695A2 (en) | 2012-07-09 | 2014-01-16 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
| RU2496486C1 (ru) * | 2012-07-11 | 2013-10-27 | Александр Васильевич Иващенко | Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение |
| EP3831372A1 (en) | 2013-01-08 | 2021-06-09 | Pathologica LLC | Mitoguazone for preventing the relapse or the progression of multiple sclerosis |
| WO2014141298A2 (en) * | 2013-03-11 | 2014-09-18 | Astron Research Limited | Stable pharmaceutical composition of fingolimod |
| US9629834B2 (en) * | 2013-04-26 | 2017-04-25 | Kyoto University | Medicinal composition for inhibiting formation and/or enlargement of cerebral aneurysm or shrinking same |
| WO2013190151A1 (en) * | 2013-05-13 | 2013-12-27 | Synthon B.V. | Pharmaceutical composition comprising fingolimod |
| US20160128951A1 (en) * | 2013-07-29 | 2016-05-12 | Aizant Drug Research Solutions Pvt Ltd | Pharmaceutical compositions of fingolimod |
| RU2530626C1 (ru) * | 2013-10-21 | 2014-10-10 | Ооо "Валента-Интеллект" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний |
| WO2016026461A1 (en) * | 2014-08-22 | 2016-02-25 | Sunshine Lake Pharma Co., Ltd. | Solid composition of fingolimod and preparation thereof |
| WO2016042493A1 (en) * | 2014-09-19 | 2016-03-24 | Aizant Drug Research Pvt. Ltd | Pharmaceutical compositions of fingolimod |
| US9925138B2 (en) | 2015-01-20 | 2018-03-27 | Handa Pharmaceuticals, Llc | Stable solid fingolimod dosage forms |
| CN107530301A (zh) * | 2015-01-20 | 2018-01-02 | 汉达医药有限责任公司 | 稳定的固体芬戈莫德剂型 |
| US20180042895A1 (en) | 2015-02-26 | 2018-02-15 | Novartis Ag | Treatment of autoimmune disease in a patient receiving additionally a beta-blocker |
| RU2577230C1 (ru) * | 2015-04-09 | 2016-03-10 | Общество с ограниченной ответственностью "Лонг Шенг Фарма Рус" | Способ получения капсул финголимода гидрохлорида |
| US9690975B2 (en) | 2015-05-28 | 2017-06-27 | Axogen Corporation | Quantitative structural assay of a nerve graft |
| US11434200B2 (en) | 2017-03-09 | 2022-09-06 | Novartis Ag | Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof |
| EP3419607B1 (en) | 2017-03-29 | 2019-11-20 | Deva Holding Anonim Sirketi | Stable formulations of fingolimod |
| GR1009654B (el) | 2018-08-31 | 2019-11-18 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου |
| DE102018217334A1 (de) * | 2018-10-10 | 2020-04-16 | Harbins Ruhr Bioscience, Inc. | Sphingoid-Base und/oder Wirkstoff zur Verwendung bei der Prophylaxe und/oder Therapie einer viralen Infektion und/oder viralen Infektionskrankheit oder der Desinfektion, Nahrungsmittel/Nahrungsergänzungsmittel, Futtermittel/Futterergänzungsmittel und Pflanzenschutzmittel |
| JP7503420B2 (ja) * | 2020-05-18 | 2024-06-20 | 東和薬品株式会社 | フィンゴリモドを含む医薬組成物とその製造方法及び安定化方法 |
| EP4181906A1 (en) | 2020-07-16 | 2023-05-24 | Harbins Ruhr Bioscience, Inc. | Sphingoid compounds for use in prophylaxis and/or therapy of coronaviridae infection |
| JP2024506825A (ja) * | 2021-01-28 | 2024-02-15 | プリオセラ エスエーエス | Ｓ１ｐ受容体調節剤による処置の方法 |
| AU2021424131A1 (en) * | 2021-01-28 | 2023-07-27 | Priothera Limited | Methods of treatment with s1p receptor modulators |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7607683A (nl) * | 1976-07-12 | 1978-01-16 | Akzo Nv | Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan. |
| US4110332A (en) * | 1977-05-05 | 1978-08-29 | Chevron Research Company | 1-Triorganostannyl-3-organothio-4-substituted-1,2,4-delta2 -triazolidin-5-ones |
| US4559153A (en) | 1983-10-25 | 1985-12-17 | Phillips Petroleum Company | Metal working lubricant |
| US5112616A (en) * | 1988-11-30 | 1992-05-12 | Schering Corporation | Fast dissolving buccal tablet |
| JP2841857B2 (ja) * | 1990-11-29 | 1998-12-24 | 田辺製薬株式会社 | 長期間安定な経口用医薬製剤 |
| JP2579602B2 (ja) | 1992-10-21 | 1997-02-05 | 吉富製薬株式会社 | ２−アミノ−１，３−プロパンジオール化合物および免疫抑制剤 |
| WO1996006068A1 (en) | 1994-08-22 | 1996-02-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and medicinal use thereof |
| DE69633613T2 (de) | 1995-12-28 | 2006-02-09 | Mitsubishi Pharma Corp. | 2-amino-2-(2-(4-octylphenyl)ethyl)propan-1,3-diol enthaltendes Arzneimittel zur topischen Anwendung zur Behandlung von Erkrankungen,die durch eine Störung des Immunsystems hervorgerufen werden |
| JPH11209277A (ja) | 1998-01-19 | 1999-08-03 | Yoshitomi Pharmaceut Ind Ltd | 医薬組成物 |
| US6476004B1 (en) * | 1996-07-18 | 2002-11-05 | Mitsubishi Pharma Corporation | Pharmaceutical composition |
| JP2002241272A (ja) | 1996-07-18 | 2002-08-28 | Mitsubishi Pharma Corp | 医薬処方組成物 |
| GB9624038D0 (en) | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| PT990440E (pt) * | 1997-02-27 | 2009-02-05 | Novartis Ag | Composição farmacêutica compreendendo 2-amino-2-[2-(4-octilfenil)etil]propano-1,3-diol, uma lecitina e um sacárido |
| PT1319651E (pt) * | 1997-04-04 | 2005-09-30 | Mitsubishi Pharma Corp | Composto 2-aminopropano-1,3-diol, sua utilizacao farmaceutica e seus intermediarios sinteticos |
| JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
| JP3545595B2 (ja) | 1998-04-01 | 2004-07-21 | 花王株式会社 | スフィンゴ糖脂質の製造法 |
| JP4627356B2 (ja) * | 1999-06-30 | 2011-02-09 | 昭 松森 | ウイルス性心筋炎の予防または治療薬剤 |
| EP1195165A4 (en) * | 1999-07-12 | 2005-08-10 | Ono Pharmaceutical Co | FIBROSIS INHIBITORS CONTAINING THE ACTIVE INGREDIENT OF SPHINGOSINE A PHOSPHATE OR ITS RECEPTOR AGONISTS |
| AU2001269503B2 (en) | 2000-07-13 | 2005-02-17 | Sankyo Company, Limited | Amino alcohol derivatives |
| CA2421893A1 (en) * | 2000-08-31 | 2002-03-07 | Merck And Co., Inc. | Phosphate derivatives as immunoregulatory agents |
| US6953332B1 (en) | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
| MXPA03008755A (es) | 2001-03-26 | 2004-02-18 | Novartis Ag | Derivados de 2-amino-propanol. |
| US7521192B2 (en) | 2001-04-18 | 2009-04-21 | Rigel Pharmaceuticals, Inc. | EDG: modulators of lymphocyte activation and migration |
| JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
| US20040235794A1 (en) | 2001-09-04 | 2004-11-25 | Shinji Nakade | Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller |
| CA2460640C (en) | 2001-09-27 | 2011-03-29 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivatives, salts thereof and immunosuppressive agents using the same |
| AU2002332289B2 (en) | 2001-09-27 | 2007-05-10 | Kyorin Pharmaceutical Co., Ltd. | Diaryl sulfide derivative, addition salt thereof, and immunosuppressant |
| AU2003216054B2 (en) | 2002-01-18 | 2007-01-04 | Merck & Co., Inc. | Selective S1P1/Edg1 receptor agonists |
| ATE441654T1 (de) | 2002-01-18 | 2009-09-15 | Merck & Co Inc | Edg-rezeptoragonisten |
| CA2473740A1 (en) | 2002-01-18 | 2003-07-31 | David Solow-Cordero | Methods of treating conditions associated with an edg receptor |
| WO2003062248A2 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists |
| MX2007000564A (es) * | 2004-07-16 | 2007-03-30 | Kyorin Seiyaku Kk | Metodo para utilizar efectivamente medicamentos referentes a la prevencion de efectos secundarios. |
-
2004
- 2004-04-06 CA CA2521325A patent/CA2521325C/en not_active Expired - Lifetime
- 2004-04-06 HR HRP20100601AA patent/HRP20100601B1/hr not_active IP Right Cessation
- 2004-04-06 EP EP10186307A patent/EP2319502A1/en not_active Withdrawn
- 2004-04-06 NZ NZ542622A patent/NZ542622A/xx not_active IP Right Cessation
- 2004-04-06 KR KR1020107029859A patent/KR20110005320A/ko not_active Ceased
- 2004-04-06 EP EP04725895A patent/EP1613288B1/en not_active Expired - Lifetime
- 2004-04-06 DK DK04725895T patent/DK1613288T3/da active
- 2004-04-06 KR KR1020057019066A patent/KR20050121712A/ko not_active Ceased
- 2004-04-06 AT ATA606/2004A patent/AT501681B1/de not_active IP Right Cessation
- 2004-04-06 ES ES200400852A patent/ES2228282B1/es not_active Expired - Fee Related
- 2004-04-06 HU HUE10184951A patent/HUE028247T2/en unknown
- 2004-04-06 SI SI200432283T patent/SI2316431T1/sl unknown
- 2004-04-06 WO PCT/EP2004/003656 patent/WO2004089341A1/en not_active Ceased
- 2004-04-06 PL PL10184951.1T patent/PL2316431T3/pl unknown
- 2004-04-06 SG SG2008040545A patent/SG175449A1/en unknown
- 2004-04-06 GR GR20040100121A patent/GR1005052B/el unknown
- 2004-04-06 NZ NZ586280A patent/NZ586280A/en not_active IP Right Cessation
- 2004-04-06 PT PT04725895T patent/PT1613288E/pt unknown
- 2004-04-06 DK DK10184951.1T patent/DK2316431T3/en active
- 2004-04-06 DE DE202004021680U patent/DE202004021680U1/de not_active Expired - Lifetime
- 2004-04-06 JP JP2004111761A patent/JP5495467B2/ja not_active Expired - Lifetime
- 2004-04-06 CN CN2010101213007A patent/CN101797241B/zh not_active Expired - Lifetime
- 2004-04-06 MX MXPA05010860A patent/MXPA05010860A/es active IP Right Grant
- 2004-04-06 EP EP14163450.1A patent/EP2769713A1/en not_active Withdrawn
- 2004-04-06 AU AU2004228929A patent/AU2004228929B2/en not_active Expired
- 2004-04-06 ES ES04725895T patent/ES2320767T3/es not_active Expired - Lifetime
- 2004-04-06 EP EP08161161A patent/EP2008650A3/en not_active Withdrawn
- 2004-04-06 PE PE2015000303A patent/PE20150676A1/es not_active Application Discontinuation
- 2004-04-06 DE DE102004016947A patent/DE102004016947A1/de not_active Ceased
- 2004-04-06 GB GB0407819A patent/GB2400318B/en not_active Expired - Lifetime
- 2004-04-06 RU RU2005134173/15A patent/RU2358716C2/ru not_active IP Right Cessation
- 2004-04-06 CA CA2707750A patent/CA2707750A1/en not_active Abandoned
- 2004-04-06 PE PE2013000382A patent/PE20131352A1/es active IP Right Grant
- 2004-04-06 KR KR1020127019448A patent/KR101367574B1/ko not_active Expired - Lifetime
- 2004-04-06 US US10/552,005 patent/US20060275357A1/en not_active Abandoned
- 2004-04-06 AR ARP040101162A patent/AR043987A1/es not_active Application Discontinuation
- 2004-04-06 PE PE2012002027A patent/PE20130200A1/es not_active Application Discontinuation
- 2004-04-06 PE PE2004000355A patent/PE20050396A1/es not_active Application Discontinuation
- 2004-04-06 BR BRPI0409250A patent/BRPI0409250B8/pt active IP Right Grant
- 2004-04-06 DE DE602004017847T patent/DE602004017847D1/de not_active Expired - Lifetime
- 2004-04-06 AT AT04725895T patent/ATE414508T1/de active
- 2004-04-06 DE DE201112100047 patent/DE122011100047I1/de active Pending
- 2004-04-06 EP EP10184951.1A patent/EP2316431B1/en not_active Revoked
- 2004-04-06 HR HR20100600A patent/HRP20100600A2/hr not_active Application Discontinuation
- 2004-04-06 CN CN2004800092370A patent/CN1767819B/zh not_active Expired - Lifetime
- 2004-04-06 SI SI200431037T patent/SI1613288T1/sl unknown
- 2004-04-06 IT IT000682A patent/ITMI20040682A1/it unknown
- 2004-04-06 PL PL04725895T patent/PL1613288T3/pl unknown
- 2004-04-06 HR HR20050886A patent/HRP20050886B1/xx not_active IP Right Cessation
- 2004-04-06 PE PE2008001684A patent/PE20090743A1/es not_active Application Discontinuation
- 2004-04-06 FR FR0450692A patent/FR2854073B1/fr not_active Expired - Lifetime
- 2004-04-06 NZ NZ592339A patent/NZ592339A/xx not_active IP Right Cessation
- 2004-04-06 ES ES10184951.1T patent/ES2556947T3/es not_active Expired - Lifetime
- 2004-04-07 MY MYPI20041275A patent/MY141249A/en unknown
- 2004-04-07 TW TW093109631A patent/TWI332847B/zh active
- 2004-04-07 CL CL200400745A patent/CL2004000745A1/es unknown
- 2004-04-07 BE BE2004/0180A patent/BE1015972A5/fr not_active IP Right Cessation
-
2005
- 2005-09-14 ZA ZA200507394A patent/ZA200507394B/en unknown
- 2005-09-15 IL IL170888A patent/IL170888A/en active IP Right Grant
- 2005-10-07 EC EC2005006090A patent/ECSP056090A/es unknown
- 2005-10-07 TN TNP2005000256A patent/TNSN05256A1/en unknown
- 2005-10-19 MA MA28560A patent/MA27729A1/fr unknown
- 2005-11-01 IS IS8114A patent/IS2682B/is unknown
- 2005-11-07 NO NO20055231A patent/NO329332B1/no active Protection Beyond IP Right Term
-
2008
- 2008-05-08 AT AT0074408A patent/AT504853A2/de not_active Application Discontinuation
- 2008-08-11 US US12/189,323 patent/US8324283B2/en not_active Expired - Fee Related
- 2008-08-13 US US12/191,098 patent/US20090203798A1/en not_active Abandoned
-
2009
- 2009-02-17 RU RU2009105403/15A patent/RU2009105403A/ru not_active Application Discontinuation
- 2009-02-19 CY CY20091100192T patent/CY1110260T1/el unknown
- 2009-03-12 IL IL197578A patent/IL197578A/en active IP Right Grant
-
2010
- 2010-02-18 NO NO20100250A patent/NO334116B1/no unknown
- 2010-02-25 IS IS8885A patent/IS8885A/is unknown
- 2010-08-25 JP JP2010188835A patent/JP5543298B2/ja not_active Expired - Lifetime
- 2010-10-26 AR ARP100103931A patent/AR078782A2/es not_active Application Discontinuation
- 2010-10-26 AR ARP100103930A patent/AR078781A2/es not_active Application Discontinuation
- 2010-11-17 RU RU2010146697/15A patent/RU2475236C2/ru active
- 2010-11-18 RU RU2010147000/15A patent/RU2475237C2/ru active
-
2011
- 2011-01-10 US US12/987,726 patent/US20110105620A1/en not_active Abandoned
- 2011-03-01 CL CL2011000450A patent/CL2011000450A1/es unknown
- 2011-09-06 HU HUS1100016C patent/HUS1100016I1/hu unknown
- 2011-09-08 FR FR11C0036C patent/FR11C0036I2/fr active Active
- 2011-09-08 BE BE2011C030C patent/BE2011C030I2/fr unknown
- 2011-09-08 NO NO2011016C patent/NO2011016I2/no unknown
- 2011-09-08 CY CY2011013C patent/CY2011013I1/el unknown
- 2011-09-08 LU LU91867C patent/LU91867I2/fr unknown
-
2012
- 2012-11-15 RU RU2012148593/15A patent/RU2012148593A/ru not_active Application Discontinuation
- 2012-12-20 US US13/721,278 patent/US20130108675A1/en not_active Abandoned
-
2013
- 2013-04-23 JP JP2013090602A patent/JP2013177404A/ja active Pending
- 2013-09-16 US US14/027,943 patent/US20140011885A1/en not_active Abandoned
- 2013-09-26 NO NO20131287A patent/NO335120B1/no unknown
-
2014
- 2014-05-23 US US14/285,808 patent/US20140255497A1/en not_active Abandoned
-
2015
- 2015-10-12 IL IL242037A patent/IL242037A0/en unknown
- 2015-12-29 CY CY20151101194T patent/CY1117071T1/el unknown
-
2017
- 2017-06-27 US US15/634,579 patent/US20170290787A1/en not_active Abandoned
-
2019
- 2019-02-13 US US16/274,357 patent/US20190175527A1/en not_active Abandoned
-
2020
- 2020-04-03 US US16/839,703 patent/US20200237690A1/en not_active Abandoned
-
2021
- 2021-10-14 US US17/501,173 patent/US20220031609A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004307506A5 (cg-RX-API-DMAC10.html) | ||
| RU2009105403A (ru) | Твердая фармацевтическая композиция для перорального введения (варианты) | |
| JP2007533686A5 (cg-RX-API-DMAC10.html) | ||
| JP2008521827A5 (cg-RX-API-DMAC10.html) | ||
| EP1982708A1 (en) | Therapeutic agent for inflammatory bowel disease comprising 2-amino-1,3-propanaediol derivative as active ingredient, and method for treatment of inflammatory bowel disease | |
| JP2003528918A5 (cg-RX-API-DMAC10.html) | ||
| JP2010077141A5 (cg-RX-API-DMAC10.html) | ||
| JP2004519469A5 (cg-RX-API-DMAC10.html) | ||
| JP2005097323A5 (cg-RX-API-DMAC10.html) | ||
| RU2015147509A (ru) | Новые композиции для предупреждения и/или лечения дегенеративных расстройств центральной нервной системы | |
| US20230364044A1 (en) | Methods of Treating or Preventing Acute Respiratory Distress Syndrome | |
| JP2009500455A5 (cg-RX-API-DMAC10.html) | ||
| JP2014505017A5 (cg-RX-API-DMAC10.html) | ||
| JP2008536946A (ja) | うつ病の処置または予防のための新規の治療的組み合わせ | |
| AU2006300485B2 (en) | Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient and therapeutic method for liver disease | |
| JP2006518731A5 (cg-RX-API-DMAC10.html) | ||
| JP2019517586A5 (cg-RX-API-DMAC10.html) | ||
| AU2010211491A1 (en) | Medical use of 5-benzylaminosalicylic acid derivative or its salt | |
| CA2530381A1 (fr) | Association d'un antagoniste ou agoniste inverse du recepteur h3 de l'histamine avec un anti-psychotique ou un antidepresseur et son utilisation pour preparer un medicament prevenant des effets indesirables de medicaments psychotropes | |
| RU2314809C2 (ru) | Способ лечения депрессии соединениями-агонистами дельта-рецепторов | |
| RU2010154417A (ru) | Комбинация частичного агониста никотиновых рецепторов и ингибитора ацетилхолинетеразы, содержащая ее фармацетическая композиция, и ее применение в лечении когнитивных расстройств | |
| JP2007077148A (ja) | うつ病患者における睡眠障害の処置を目的とした医薬品を得るためのアゴメラチンの使用 | |
| JP2019516726A5 (cg-RX-API-DMAC10.html) | ||
| JP2020502106A (ja) | 双極性障害の予防、軽減又は治療のためのカルバメート化合物の使用 | |
| JP2019516722A5 (cg-RX-API-DMAC10.html) |