JP2003531148A5 - - Google Patents
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- JP2003531148A5 JP2003531148A5 JP2001576852A JP2001576852A JP2003531148A5 JP 2003531148 A5 JP2003531148 A5 JP 2003531148A5 JP 2001576852 A JP2001576852 A JP 2001576852A JP 2001576852 A JP2001576852 A JP 2001576852A JP 2003531148 A5 JP2003531148 A5 JP 2003531148A5
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- Prior art keywords
- compound
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- give
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C[C@](C1)C(C(CC2)[C@](C)(CC3)[C@]2[C@](*)C=O)C3[C@@](C)(CC2)[C@]1CC21OCC*1 Chemical compound C[C@](C1)C(C(CC2)[C@](C)(CC3)[C@]2[C@](*)C=O)C3[C@@](C)(CC2)[C@]1CC21OCC*1 0.000 description 14
- IAKFWMWAVRWBGB-XFFGTECRSA-N C[C@@](CCC1[C@@](C)(CC2)[C@@H](C3)CC22OCCO2)([C@H](CC2)[C@@H](CO)N)C2C1[C@@H]3O Chemical compound C[C@@](CCC1[C@@](C)(CC2)[C@@H](C3)CC22OCCO2)([C@H](CC2)[C@@H](CO)N)C2C1[C@@H]3O IAKFWMWAVRWBGB-XFFGTECRSA-N 0.000 description 1
- KHAASJIVTYLGID-OQQDYATLSA-O C[C@H](CO)[C@@H](CC1)[C@@](C)(CCC2[C@@](C)(CC3)C(C4)=CC3=[OH+])C1C2[C@@H]4O Chemical compound C[C@H](CO)[C@@H](CC1)[C@@](C)(CCC2[C@@](C)(CC3)C(C4)=CC3=[OH+])C1C2[C@@H]4O KHAASJIVTYLGID-OQQDYATLSA-O 0.000 description 1
- VCUOXSHEOYYSER-RPMLJLICSA-N C[C@H](CO)[C@@H](CC1)[C@@](C)(CCC2[C@@](C)(CC3)[C@@H](C4)CC3=O)C1C2[C@@H]4O Chemical compound C[C@H](CO)[C@@H](CC1)[C@@](C)(CCC2[C@@](C)(CC3)[C@@H](C4)CC3=O)C1C2[C@@H]4O VCUOXSHEOYYSER-RPMLJLICSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19664600P | 2000-04-12 | 2000-04-12 | |
| US60/196,646 | 2000-04-12 | ||
| PCT/US2001/012004 WO2001079255A1 (en) | 2000-04-12 | 2001-04-12 | A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003531148A JP2003531148A (ja) | 2003-10-21 |
| JP2003531148A5 true JP2003531148A5 (https=) | 2008-05-29 |
Family
ID=22726246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001576852A Pending JP2003531148A (ja) | 2000-04-12 | 2001-04-12 | 保護されていない７−α−ヒドロキシ基を有する中間体を使用する、７−α−ヒドロキシ３−アミノ置換ステロイドの調製のためのプロセス |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6933383B2 (https=) |
| EP (1) | EP1274718B1 (https=) |
| JP (1) | JP2003531148A (https=) |
| AT (1) | ATE342912T1 (https=) |
| AU (2) | AU2001253427B2 (https=) |
| CA (1) | CA2406847C (https=) |
| CY (1) | CY1105870T1 (https=) |
| DE (1) | DE60123939T2 (https=) |
| DK (1) | DK1274718T3 (https=) |
| ES (1) | ES2273831T3 (https=) |
| PT (1) | PT1274718E (https=) |
| WO (1) | WO2001079255A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7410959B1 (en) * | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
| EP1731526A4 (en) * | 2004-03-31 | 2009-04-01 | Kuraray Co | METHOD OF PREPARING A 5-ALPHA PRIMING DERIVATIVE |
| WO2005095434A1 (ja) * | 2004-03-31 | 2005-10-13 | Kuraray Co., Ltd. | ５α－プレグナン誘導体の製造方法 |
| US20070197490A1 (en) * | 2004-03-31 | 2007-08-23 | Kuraray Co., Ltd. | Method for producing 5alpha-pregnane derivative |
| JP2008504292A (ja) | 2004-06-24 | 2008-02-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | 免疫増強用の化合物 |
| US20070203106A1 (en) * | 2005-03-31 | 2007-08-30 | Kuraray Co., Ltd. | Method for Producing 5Alpha-Pregnane Derivative |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| TW200808739A (en) | 2006-04-06 | 2008-02-16 | Novartis Vaccines & Diagnostic | Quinazolines for PDK1 inhibition |
| JP2010538072A (ja) * | 2007-09-06 | 2010-12-09 | ジェナエラ コーポレイション | 糖尿病を治療する方法 |
| EP2240475B1 (en) | 2007-12-20 | 2013-09-25 | Novartis AG | Thiazole derivatives used as pi 3 kinase inhibitors |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| US20110161139A1 (en) * | 2009-12-31 | 2011-06-30 | Accenture Global Services Gmbh | Capability Accelerator |
| AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
| JP5963777B2 (ja) | 2011-01-31 | 2016-08-03 | ノバルティス アーゲー | 新規ヘテロ環誘導体 |
| CN104039790B (zh) | 2011-10-28 | 2016-04-13 | 诺华股份有限公司 | 嘌呤衍生物及它们在治疗疾病中的应用 |
| KR20150009540A (ko) | 2012-05-16 | 2015-01-26 | 노파르티스 아게 | Pi-3 키나제 억제제에 대한 투여 요법 |
| SI3076969T1 (sl) | 2013-12-06 | 2021-12-31 | Novartis Ag | Režim omderjanja izooblike alfa selektivnega zaviralca fosfatidilino- zitol 3-kinaze |
| US20180280370A1 (en) | 2015-11-02 | 2018-10-04 | Novartis Ag | Dosage regimen for a phosphatidylinositol 3-kinase inhibitor |
| WO2018060833A1 (en) | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
| CN109651475B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种制备16a-羟基泼尼松龙的新方法 |
| CN109575096B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种制备16a-羟基泼尼松龙产品的新方法 |
| CN109734765B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种17a-脱羟醋酸泼尼松龙产品的制备方法 |
| CN109734764B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种17a-脱羟醋酸泼尼松龙的制备方法 |
| CN113621016B (zh) * | 2021-09-06 | 2022-05-17 | 北京泛球生物科技有限公司 | 一种地屈孕酮关键中间体的合成方法 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3016390A (en) | 1960-06-30 | 1962-01-09 | Searle & Co | N-(substituted alkyl) amino-5alpha-androstan-17beta-ols |
| US3370070A (en) | 1965-06-16 | 1968-02-20 | Searle & Co | [n-alkyl-17-(dialkylaminoalkyl)amino] androst-4-en-3-ones |
| GB1565351A (en) | 1975-06-02 | 1980-04-16 | Theramex | Steroid aminoethers |
| US4220598A (en) | 1977-11-14 | 1980-09-02 | Abbott Laboratories | Method and reagents for measuring the level of conjugated bile acids |
| US4550163A (en) | 1979-02-05 | 1985-10-29 | Abbott Laboratories | Ligand analog-irreversible enzyme inhibitor conjugates |
| US4301246A (en) * | 1979-04-12 | 1981-11-17 | Hoffmann-La Roche Inc. | Process for chenodeoxycholic acid production |
| US4230625A (en) * | 1979-04-12 | 1980-10-28 | Hoffmann-La Roche Inc. | Process for chenodeoxycholic acid and intermediates therefore |
| US4372888A (en) | 1980-08-26 | 1983-02-08 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Nondenaturing zwitterionic detergents |
| JPS5842878B2 (ja) | 1981-12-02 | 1983-09-22 | 名糖産業株式会社 | １２−オキソコラン酸トシルヒドラゾン化合物、その製法ならびに利用 |
| DE3366932D1 (en) | 1982-07-29 | 1986-11-20 | Lehner Ag | New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same |
| US5001116A (en) | 1982-12-20 | 1991-03-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| US4994443A (en) | 1982-12-20 | 1991-02-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| IT1221734B (it) | 1983-02-24 | 1990-07-12 | Schiena Michele Giuseppe Di | Ursodesossicolico solfato acido sale sodico |
| US4545938A (en) | 1983-11-02 | 1985-10-08 | Beth Israel Medical Center | Chemical synthesis |
| WO1987002367A2 (en) | 1985-10-18 | 1987-04-23 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| US4771042A (en) | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
| JPS62175497A (ja) | 1986-01-28 | 1987-08-01 | Wakunaga Pharmaceut Co Ltd | 胆汁酸誘導体およびその製造法 |
| US5075464A (en) | 1987-04-22 | 1991-12-24 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropylamino)androstene derivatives |
| SE8702254D0 (sv) | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| US5135919A (en) | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| IT1229569B (it) | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
| IT1229570B (it) | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
| JPH07116215B2 (ja) | 1989-04-19 | 1995-12-13 | エスエス製薬株式会社 | 新規なステロイド化合物 |
| PT93847A (pt) | 1989-04-24 | 1990-11-20 | Harvard College | Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem |
| US4966897A (en) | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US5004737A (en) | 1989-09-22 | 1991-04-02 | Pacific Chemical Co., Ltd. | Quaternary ammonium-substituted sterol derivatives |
| EP0466315A3 (en) | 1990-05-30 | 1992-07-01 | Larrian Gillespie | Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation |
| WO1991019731A1 (en) | 1990-06-11 | 1991-12-26 | The Upjohn Company | Steroids which inhibit angiogenesis |
| NZ240846A (en) | 1990-12-06 | 1994-04-27 | Hoechst Ag | Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions |
| US5192756A (en) | 1992-03-18 | 1993-03-09 | The Children's Hospital Of Pennsylvania | Aminosterol antibiotic |
| WO1993025197A1 (en) | 1992-06-12 | 1993-12-23 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| US5247104A (en) | 1992-11-04 | 1993-09-21 | Wisconsin Alumni Research Foundation | Preparation of 1α, 24-dihydroxyvitamin D analogs |
| JPH06329679A (ja) | 1993-01-20 | 1994-11-29 | Nissan Chem Ind Ltd | 光学活性β−アミノアルコキシボラン錯体 |
| WO1994019366A1 (en) | 1993-02-26 | 1994-09-01 | Magainin Pharmaceuticals Inc. | Chemical synthesis of squalamine |
| DE69412596T2 (de) | 1993-03-10 | 1999-03-04 | Magainin Pharmaceuticals Inc., Plymouth Meeting, Pa. | Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel |
| WO1994024800A1 (en) | 1993-04-12 | 1994-10-27 | Unisys Corporation | Portable adapter for portable pc |
| JPH09509959A (ja) | 1994-03-10 | 1997-10-07 | マガイニン ファーマシューティカルズ インク． | ステロイド誘導体、それらを含む薬剤組成物、及びそれらの薬剤学的用途 |
| US5792635A (en) | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
| ATE259375T1 (de) | 1995-06-07 | 2004-02-15 | Genaera Corp | Aminosterinverbindungen als inhibitoren der natrium/proton-pump, pharmazeutische methoden und präparaten davon |
| US6262283B1 (en) * | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
-
2001
- 2001-04-12 PT PT01926924T patent/PT1274718E/pt unknown
- 2001-04-12 ES ES01926924T patent/ES2273831T3/es not_active Expired - Lifetime
- 2001-04-12 AU AU2001253427A patent/AU2001253427B2/en not_active Ceased
- 2001-04-12 JP JP2001576852A patent/JP2003531148A/ja active Pending
- 2001-04-12 EP EP01926924A patent/EP1274718B1/en not_active Expired - Lifetime
- 2001-04-12 DK DK01926924T patent/DK1274718T3/da active
- 2001-04-12 AU AU5342701A patent/AU5342701A/xx active Pending
- 2001-04-12 AT AT01926924T patent/ATE342912T1/de not_active IP Right Cessation
- 2001-04-12 WO PCT/US2001/012004 patent/WO2001079255A1/en not_active Ceased
- 2001-04-12 DE DE60123939T patent/DE60123939T2/de not_active Expired - Lifetime
- 2001-04-12 CA CA002406847A patent/CA2406847C/en not_active Expired - Lifetime
-
2002
- 2002-10-11 US US10/268,660 patent/US6933383B2/en not_active Expired - Lifetime
-
2005
- 2005-03-21 US US11/083,961 patent/US7728157B2/en not_active Expired - Fee Related
-
2006
- 2006-12-20 CY CY20061101829T patent/CY1105870T1/el unknown
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