JP2005523935A5 - - Google Patents
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- Publication number
- JP2005523935A5 JP2005523935A5 JP2004501366A JP2004501366A JP2005523935A5 JP 2005523935 A5 JP2005523935 A5 JP 2005523935A5 JP 2004501366 A JP2004501366 A JP 2004501366A JP 2004501366 A JP2004501366 A JP 2004501366A JP 2005523935 A5 JP2005523935 A5 JP 2005523935A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- starting material
- iii
- represented
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 10
- 239000007858 starting material Substances 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims description 3
- -1 disulfide compound Chemical class 0.000 claims description 3
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 3
- 239000002585 base Substances 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229910001882 dioxygen Inorganic materials 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- KOUKXHPPRFNWPP-UHFFFAOYSA-N pyrazine-2,5-dicarboxylic acid;hydrate Chemical compound O.OC(=O)C1=CN=C(C(O)=O)C=N1 KOUKXHPPRFNWPP-UHFFFAOYSA-N 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/135,756 US6504049B1 (en) | 2002-04-30 | 2002-04-30 | Process for synthesizing pharmaceutically active disulfide salts |
| PCT/US2003/013178 WO2003093226A1 (en) | 2002-04-30 | 2003-04-29 | Process for synthesizing pharmaceutically active disulfide salts |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005523935A JP2005523935A (ja) | 2005-08-11 |
| JP2005523935A5 true JP2005523935A5 (https=) | 2006-06-22 |
| JP4478561B2 JP4478561B2 (ja) | 2010-06-09 |
Family
ID=22469512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501366A Expired - Lifetime JP4478561B2 (ja) | 2002-04-30 | 2003-04-29 | 薬学的に活性なジスルフィド塩の合成方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6504049B1 (https=) |
| EP (1) | EP1499587B1 (https=) |
| JP (1) | JP4478561B2 (https=) |
| AU (1) | AU2003231169B2 (https=) |
| CA (1) | CA2483775C (https=) |
| DK (1) | DK1499587T3 (https=) |
| ES (1) | ES2523653T3 (https=) |
| MX (1) | MXPA04010859A (https=) |
| PT (1) | PT1499587E (https=) |
| WO (1) | WO2003093226A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2811987A1 (fr) * | 2000-07-18 | 2002-01-25 | Expansia Sa | Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium |
| US8710095B2 (en) | 2002-04-30 | 2014-04-29 | Bionumerik Pharmaceuticals, Inc. | Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity |
| US7317124B2 (en) | 2003-11-13 | 2008-01-08 | Sanofi-Aventis Deutschland Gmbh | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates |
| CA2548497C (en) * | 2003-12-17 | 2009-06-09 | Bionumerik Pharmaceuticals, Inc. | Process for synthesizing disulfides |
| US7282602B2 (en) * | 2004-09-21 | 2007-10-16 | Bionumerik Pharmaceuticals, Inc. | Medicinal disulfide salts |
| EP2004175A4 (en) * | 2006-03-16 | 2010-12-15 | Bionumerik Pharmaceuticals Inc | COMPOUNDS AND FORMULATIONS FOR INCREASING THE EFFECT OF CANCER AND METHOD FOR THEIR USE |
| JP5109081B2 (ja) * | 2006-04-26 | 2012-12-26 | 東洋紡株式会社 | アルケンスルホン酸塩を用いたチオカルボアルキルアルカンスルホン酸塩、メルカプトアルカンスルホン酸塩およびジチオビス（アルカンスルホン酸）塩の製造方法 |
| CA2706378C (en) * | 2007-11-20 | 2017-09-12 | Lankenau Institute For Medical Research | Disulfide chemotherapeutic agents and methods of use thereof |
| CN102014891B (zh) | 2008-03-14 | 2013-12-18 | 比奥纽默里克药物公司 | 增加癌症患者存活时间的化合物的组合物和使用方法 |
| CA2717181C (en) | 2008-03-14 | 2013-10-15 | Bionumerik Pharmaceuticals, Inc. | Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions |
| WO2010132771A1 (en) | 2009-05-15 | 2010-11-18 | Lankenau Institute For Medical Research | Methods and kits for measuring toxicity and oxidative stress in live cells |
| CN108914171B (zh) * | 2018-07-19 | 2020-05-19 | 广东工业大学 | 一种加速铜沉积添加剂及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396879A (en) * | 1945-04-12 | 1946-03-19 | Eastman Kodak Co | Sulphur-containing esters |
| CS252564B1 (cs) * | 1985-06-17 | 1987-09-17 | Jiri Jary | Způsob výroby 2-merkaptoethansulfonové kyseliny |
| CN1082047C (zh) | 1996-10-01 | 2002-04-03 | 比奥纽默里克药物公司 | 生产巯基链烷磺酸盐和磷酸盐及其衍生物的方法 |
| FR2811987A1 (fr) * | 2000-07-18 | 2002-01-25 | Expansia Sa | Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium |
-
2002
- 2002-04-30 US US10/135,756 patent/US6504049B1/en not_active Expired - Lifetime
-
2003
- 2003-04-29 DK DK03724301.1T patent/DK1499587T3/en active
- 2003-04-29 ES ES03724301.1T patent/ES2523653T3/es not_active Expired - Lifetime
- 2003-04-29 EP EP03724301.1A patent/EP1499587B1/en not_active Expired - Lifetime
- 2003-04-29 JP JP2004501366A patent/JP4478561B2/ja not_active Expired - Lifetime
- 2003-04-29 WO PCT/US2003/013178 patent/WO2003093226A1/en not_active Ceased
- 2003-04-29 PT PT37243011T patent/PT1499587E/pt unknown
- 2003-04-29 AU AU2003231169A patent/AU2003231169B2/en not_active Ceased
- 2003-04-29 MX MXPA04010859A patent/MXPA04010859A/es active IP Right Grant
- 2003-04-29 CA CA2483775A patent/CA2483775C/en not_active Expired - Fee Related
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