PT1499587E - Processo para síntese de sais de dissulfureto farmaceuticamente activos - Google Patents

Processo para síntese de sais de dissulfureto farmaceuticamente activos Download PDF

Info

Publication number
PT1499587E
PT1499587E PT37243011T PT03724301T PT1499587E PT 1499587 E PT1499587 E PT 1499587E PT 37243011 T PT37243011 T PT 37243011T PT 03724301 T PT03724301 T PT 03724301T PT 1499587 E PT1499587 E PT 1499587E
Authority
PT
Portugal
Prior art keywords
pharmaceutically active
active disulfide
disulfide salts
synthesizing
synthesizing pharmaceutically
Prior art date
Application number
PT37243011T
Other languages
English (en)
Inventor
Harry Kochat
Original Assignee
Bionumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionumerik Pharmaceuticals Inc filed Critical Bionumerik Pharmaceuticals Inc
Publication of PT1499587E publication Critical patent/PT1499587E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/22—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT37243011T 2002-04-30 2003-04-29 Processo para síntese de sais de dissulfureto farmaceuticamente activos PT1499587E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/135,756 US6504049B1 (en) 2002-04-30 2002-04-30 Process for synthesizing pharmaceutically active disulfide salts

Publications (1)

Publication Number Publication Date
PT1499587E true PT1499587E (pt) 2014-11-21

Family

ID=22469512

Family Applications (1)

Application Number Title Priority Date Filing Date
PT37243011T PT1499587E (pt) 2002-04-30 2003-04-29 Processo para síntese de sais de dissulfureto farmaceuticamente activos

Country Status (10)

Country Link
US (1) US6504049B1 (pt)
EP (1) EP1499587B1 (pt)
JP (1) JP4478561B2 (pt)
AU (1) AU2003231169B2 (pt)
CA (1) CA2483775C (pt)
DK (1) DK1499587T3 (pt)
ES (1) ES2523653T3 (pt)
MX (1) MXPA04010859A (pt)
PT (1) PT1499587E (pt)
WO (1) WO2003093226A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811987A1 (fr) * 2000-07-18 2002-01-25 Expansia Sa Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium
US8710095B2 (en) 2002-04-30 2014-04-29 Bionumerik Pharmaceuticals, Inc. Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity
US7317124B2 (en) 2003-11-13 2008-01-08 Sanofi-Aventis Deutschland Gmbh Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
WO2005058005A2 (en) * 2003-12-17 2005-06-30 Bionumerik Pharmaceuticals, Inc. Process for synthesizing disulfides
US7282602B2 (en) * 2004-09-21 2007-10-16 Bionumerik Pharmaceuticals, Inc. Medicinal disulfide salts
CA2647297A1 (en) * 2006-03-16 2007-09-27 Bionumerik Pharmaceuticals, Inc. Anti-cancer activity augmentation compounds and formulations and methods of use thereof
JP5109081B2 (ja) * 2006-04-26 2012-12-26 東洋紡株式会社 アルケンスルホン酸塩を用いたチオカルボアルキルアルカンスルホン酸塩、メルカプトアルカンスルホン酸塩およびジチオビス（アルカンスルホン酸）塩の製造方法
CA2706378C (en) * 2007-11-20 2017-09-12 Lankenau Institute For Medical Research Disulfide chemotherapeutic agents and methods of use thereof
CA2718233A1 (en) 2008-03-14 2009-09-17 Bionumerik Pharmaceuticals, Inc. Compositions and methods of use of compounds to increase cancer patient survival time
DK2249825T3 (en) 2008-03-14 2016-01-11 Bionumerik Pharmaceuticals Inc Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
EP2430178B1 (en) 2009-05-15 2014-07-09 Lankenau Institute for Medical Research Methods and kits for measuring toxicity and oxidative stress in live cells
CN108914171B (zh) * 2018-07-19 2020-05-19 广东工业大学 一种加速铜沉积添加剂及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2396879A (en) * 1945-04-12 1946-03-19 Eastman Kodak Co Sulphur-containing esters
CS252564B1 (cs) * 1985-06-17 1987-09-17 Jiri Jary Způsob výroby 2-merkaptoethansulfonové kyseliny
EP0934261B1 (en) * 1996-10-01 2001-10-31 Bionumerik Pharmaceuticals, Inc. Process for producing dithiobis-alkanesulfonates and phosphonates
FR2811987A1 (fr) 2000-07-18 2002-01-25 Expansia Sa Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium

Also Published As

Publication number Publication date
JP4478561B2 (ja) 2010-06-09
AU2003231169A1 (en) 2003-11-17
ES2523653T3 (es) 2014-11-28
CA2483775C (en) 2011-02-08
AU2003231169B2 (en) 2008-09-04
US6504049B1 (en) 2003-01-07
DK1499587T3 (en) 2015-01-26
CA2483775A1 (en) 2003-11-13
EP1499587A1 (en) 2005-01-26
WO2003093226A1 (en) 2003-11-13
JP2005523935A (ja) 2005-08-11
EP1499587B1 (en) 2014-11-05
MXPA04010859A (es) 2005-02-14
EP1499587A4 (en) 2006-05-24

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