CA2483775C - Process for synthesizing pharmaceutically active disulfide salts - Google Patents

Process for synthesizing pharmaceutically active disulfide salts Download PDF

Info

Publication number
CA2483775C
CA2483775C CA2483775A CA2483775A CA2483775C CA 2483775 C CA2483775 C CA 2483775C CA 2483775 A CA2483775 A CA 2483775A CA 2483775 A CA2483775 A CA 2483775A CA 2483775 C CA2483775 C CA 2483775C
Authority
CA
Canada
Prior art keywords
dimesna
formula
lower alkyl
synthesizing
pharmaceutically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2483775A
Other languages
English (en)
French (fr)
Other versions
CA2483775A1 (en
Inventor
Harry Kochat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioNumerik Pharmaceuticals Inc
Original Assignee
BioNumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNumerik Pharmaceuticals Inc filed Critical BioNumerik Pharmaceuticals Inc
Publication of CA2483775A1 publication Critical patent/CA2483775A1/en
Application granted granted Critical
Publication of CA2483775C publication Critical patent/CA2483775C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/22—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2483775A 2002-04-30 2003-04-29 Process for synthesizing pharmaceutically active disulfide salts Expired - Fee Related CA2483775C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/135,756 2002-04-30
US10/135,756 US6504049B1 (en) 2002-04-30 2002-04-30 Process for synthesizing pharmaceutically active disulfide salts
PCT/US2003/013178 WO2003093226A1 (en) 2002-04-30 2003-04-29 Process for synthesizing pharmaceutically active disulfide salts

Publications (2)

Publication Number Publication Date
CA2483775A1 CA2483775A1 (en) 2003-11-13
CA2483775C true CA2483775C (en) 2011-02-08

Family

ID=22469512

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2483775A Expired - Fee Related CA2483775C (en) 2002-04-30 2003-04-29 Process for synthesizing pharmaceutically active disulfide salts

Country Status (10)

Country Link
US (1) US6504049B1 (https=)
EP (1) EP1499587B1 (https=)
JP (1) JP4478561B2 (https=)
AU (1) AU2003231169B2 (https=)
CA (1) CA2483775C (https=)
DK (1) DK1499587T3 (https=)
ES (1) ES2523653T3 (https=)
MX (1) MXPA04010859A (https=)
PT (1) PT1499587E (https=)
WO (1) WO2003093226A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811987A1 (fr) * 2000-07-18 2002-01-25 Expansia Sa Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium
US8710095B2 (en) 2002-04-30 2014-04-29 Bionumerik Pharmaceuticals, Inc. Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity
US7317124B2 (en) 2003-11-13 2008-01-08 Sanofi-Aventis Deutschland Gmbh Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
CN100450999C (zh) * 2003-12-17 2009-01-14 比奥纽默里克药物公司 合成二硫化物的方法
US7282602B2 (en) * 2004-09-21 2007-10-16 Bionumerik Pharmaceuticals, Inc. Medicinal disulfide salts
WO2007109184A2 (en) * 2006-03-16 2007-09-27 Bionumerik Pharmaceuticals, Inc. Anti-cancer activity augmentation compounds and formulations and methods of use thereof
JP5109081B2 (ja) * 2006-04-26 2012-12-26 東洋紡株式会社 アルケンスルホン酸塩を用いたチオカルボアルキルアルカンスルホン酸塩、メルカプトアルカンスルホン酸塩およびジチオビス（アルカンスルホン酸）塩の製造方法
CA2706378C (en) * 2007-11-20 2017-09-12 Lankenau Institute For Medical Research Disulfide chemotherapeutic agents and methods of use thereof
AU2008352597B2 (en) 2008-03-14 2012-03-08 Bionumerik Pharmaceuticals, Inc. Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
JP5667886B2 (ja) 2008-03-14 2015-02-12 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド 癌患者の生存時間を増大させるための組成物及び化合物の使用方法
US8697391B2 (en) 2009-05-15 2014-04-15 Lankenau Institute For Medical Research Method of determining cell number or viability using hydroxyethyldisulfide
CN108914171B (zh) * 2018-07-19 2020-05-19 广东工业大学 一种加速铜沉积添加剂及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2396879A (en) * 1945-04-12 1946-03-19 Eastman Kodak Co Sulphur-containing esters
CS252564B1 (cs) * 1985-06-17 1987-09-17 Jiri Jary Způsob výroby 2-merkaptoethansulfonové kyseliny
ES2163197T3 (es) * 1996-10-01 2002-01-16 Bionumerik Pharmaceuticals Inc Procedimiento para producir ditiobis-alcanosulfonatos y fosfonatos.
FR2811987A1 (fr) 2000-07-18 2002-01-25 Expansia Sa Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium

Also Published As

Publication number Publication date
EP1499587A4 (en) 2006-05-24
US6504049B1 (en) 2003-01-07
CA2483775A1 (en) 2003-11-13
JP4478561B2 (ja) 2010-06-09
PT1499587E (pt) 2014-11-21
MXPA04010859A (es) 2005-02-14
EP1499587A1 (en) 2005-01-26
DK1499587T3 (en) 2015-01-26
ES2523653T3 (es) 2014-11-28
JP2005523935A (ja) 2005-08-11
AU2003231169B2 (en) 2008-09-04
EP1499587B1 (en) 2014-11-05
AU2003231169A1 (en) 2003-11-17
WO2003093226A1 (en) 2003-11-13

Similar Documents

Publication Publication Date Title
CA2483775C (en) Process for synthesizing pharmaceutically active disulfide salts
US5808140A (en) Process for making mesna, dimesna and derivatives thereof
Phadnis et al. Internally stabilized selenocysteine derivatives: syntheses, 77Se NMR and biomimetic studies
EP1109779B8 (en) Novel mercaptans and disulfides
Lydon et al. Synthesis and characterization of coordinated disulfides. Single-crystal structural analysis of [(en) 2Co (S (SC (CH3) 2COOH) C (CH3) 2COO)](ClO4) 2. cntdot. H2O
CA2548497C (en) Process for synthesizing disulfides
US6936733B2 (en) Method for preparing disodium 2,2'-dithiobis(ethanesulphonate)
EP0301474B1 (en) New cysteine derivatives having expectorant activity
EP1678129B1 (en) Improved process for preparing benzhydrylthioacetamide
CA2580802C (en) Medicinal disulfide salts
FR2678623A1 (fr) Nouveaux complexes du platine (ii) antitumoraux et procede pour leur preparation.
JPH0386890A (ja) 有機ゲルマニウム化合物及びその製造方法
JPS60258159A (ja) システイン誘導体の製造法

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20220301

MKLA Lapsed

Effective date: 20200831