CA2483775C - Process for synthesizing pharmaceutically active disulfide salts - Google Patents

Process for synthesizing pharmaceutically active disulfide salts Download PDF

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Publication number
CA2483775C
CA2483775C CA2483775A CA2483775A CA2483775C CA 2483775 C CA2483775 C CA 2483775C CA 2483775 A CA2483775 A CA 2483775A CA 2483775 A CA2483775 A CA 2483775A CA 2483775 C CA2483775 C CA 2483775C
Authority
CA
Canada
Prior art keywords
dimesna
formula
lower alkyl
synthesizing
pharmaceutically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2483775A
Other languages
English (en)
French (fr)
Other versions
CA2483775A1 (en
Inventor
Harry Kochat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioNumerik Pharmaceuticals Inc
Original Assignee
BioNumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNumerik Pharmaceuticals Inc filed Critical BioNumerik Pharmaceuticals Inc
Publication of CA2483775A1 publication Critical patent/CA2483775A1/en
Application granted granted Critical
Publication of CA2483775C publication Critical patent/CA2483775C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/22—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2483775A 2002-04-30 2003-04-29 Process for synthesizing pharmaceutically active disulfide salts Expired - Fee Related CA2483775C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/135,756 US6504049B1 (en) 2002-04-30 2002-04-30 Process for synthesizing pharmaceutically active disulfide salts
US10/135,756 2002-04-30
PCT/US2003/013178 WO2003093226A1 (en) 2002-04-30 2003-04-29 Process for synthesizing pharmaceutically active disulfide salts

Publications (2)

Publication Number Publication Date
CA2483775A1 CA2483775A1 (en) 2003-11-13
CA2483775C true CA2483775C (en) 2011-02-08

Family

ID=22469512

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2483775A Expired - Fee Related CA2483775C (en) 2002-04-30 2003-04-29 Process for synthesizing pharmaceutically active disulfide salts

Country Status (10)

Country Link
US (1) US6504049B1 (https=)
EP (1) EP1499587B1 (https=)
JP (1) JP4478561B2 (https=)
AU (1) AU2003231169B2 (https=)
CA (1) CA2483775C (https=)
DK (1) DK1499587T3 (https=)
ES (1) ES2523653T3 (https=)
MX (1) MXPA04010859A (https=)
PT (1) PT1499587E (https=)
WO (1) WO2003093226A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811987A1 (fr) * 2000-07-18 2002-01-25 Expansia Sa Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium
US8710095B2 (en) 2002-04-30 2014-04-29 Bionumerik Pharmaceuticals, Inc. Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity
US7317124B2 (en) 2003-11-13 2008-01-08 Sanofi-Aventis Deutschland Gmbh Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
CA2548497C (en) * 2003-12-17 2009-06-09 Bionumerik Pharmaceuticals, Inc. Process for synthesizing disulfides
US7282602B2 (en) * 2004-09-21 2007-10-16 Bionumerik Pharmaceuticals, Inc. Medicinal disulfide salts
EP2004175A4 (en) * 2006-03-16 2010-12-15 Bionumerik Pharmaceuticals Inc COMPOUNDS AND FORMULATIONS FOR INCREASING THE EFFECT OF CANCER AND METHOD FOR THEIR USE
JP5109081B2 (ja) * 2006-04-26 2012-12-26 東洋紡株式会社 アルケンスルホン酸塩を用いたチオカルボアルキルアルカンスルホン酸塩、メルカプトアルカンスルホン酸塩およびジチオビス（アルカンスルホン酸）塩の製造方法
CA2706378C (en) * 2007-11-20 2017-09-12 Lankenau Institute For Medical Research Disulfide chemotherapeutic agents and methods of use thereof
CN102014891B (zh) 2008-03-14 2013-12-18 比奥纽默里克药物公司 增加癌症患者存活时间的化合物的组合物和使用方法
CA2717181C (en) 2008-03-14 2013-10-15 Bionumerik Pharmaceuticals, Inc. Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
WO2010132771A1 (en) 2009-05-15 2010-11-18 Lankenau Institute For Medical Research Methods and kits for measuring toxicity and oxidative stress in live cells
CN108914171B (zh) * 2018-07-19 2020-05-19 广东工业大学 一种加速铜沉积添加剂及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2396879A (en) * 1945-04-12 1946-03-19 Eastman Kodak Co Sulphur-containing esters
CS252564B1 (cs) * 1985-06-17 1987-09-17 Jiri Jary Způsob výroby 2-merkaptoethansulfonové kyseliny
CN1082047C (zh) 1996-10-01 2002-04-03 比奥纽默里克药物公司 生产巯基链烷磺酸盐和磷酸盐及其衍生物的方法
FR2811987A1 (fr) * 2000-07-18 2002-01-25 Expansia Sa Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium

Also Published As

Publication number Publication date
EP1499587B1 (en) 2014-11-05
AU2003231169A1 (en) 2003-11-17
ES2523653T3 (es) 2014-11-28
CA2483775A1 (en) 2003-11-13
JP4478561B2 (ja) 2010-06-09
JP2005523935A (ja) 2005-08-11
PT1499587E (pt) 2014-11-21
MXPA04010859A (es) 2005-02-14
DK1499587T3 (en) 2015-01-26
WO2003093226A1 (en) 2003-11-13
AU2003231169B2 (en) 2008-09-04
US6504049B1 (en) 2003-01-07
EP1499587A4 (en) 2006-05-24
EP1499587A1 (en) 2005-01-26

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Effective date: 20220301

MKLA Lapsed

Effective date: 20200831