ATE342912T1 - Ein verfahren zur herstellung von 7.alpha.- hydroxy 3-aminosubstituierten sterol-verbindungen,ohne schutz der 7.alpha.-hydroxy-gruppe - Google Patents

Ein verfahren zur herstellung von 7.alpha.- hydroxy 3-aminosubstituierten sterol-verbindungen,ohne schutz der 7.alpha.-hydroxy-gruppe

Info

Publication number
ATE342912T1
ATE342912T1 AT01926924T AT01926924T ATE342912T1 AT E342912 T1 ATE342912 T1 AT E342912T1 AT 01926924 T AT01926924 T AT 01926924T AT 01926924 T AT01926924 T AT 01926924T AT E342912 T1 ATE342912 T1 AT E342912T1
Authority
AT
Austria
Prior art keywords
alpha
hydroxy
aminosubstituted
producing
protection
Prior art date
Application number
AT01926924T
Other languages
German (de)
English (en)
Inventor
William A Kinney
Xuehai Zhang
Ronald Michalak
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Application granted granted Critical
Publication of ATE342912T1 publication Critical patent/ATE342912T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT01926924T 2000-04-12 2001-04-12 Ein verfahren zur herstellung von 7.alpha.- hydroxy 3-aminosubstituierten sterol-verbindungen,ohne schutz der 7.alpha.-hydroxy-gruppe ATE342912T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19664600P 2000-04-12 2000-04-12

Publications (1)

Publication Number Publication Date
ATE342912T1 true ATE342912T1 (de) 2006-11-15

Family

ID=22726246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01926924T ATE342912T1 (de) 2000-04-12 2001-04-12 Ein verfahren zur herstellung von 7.alpha.- hydroxy 3-aminosubstituierten sterol-verbindungen,ohne schutz der 7.alpha.-hydroxy-gruppe

Country Status (12)

Country Link
US (2) US6933383B2 (https=)
EP (1) EP1274718B1 (https=)
JP (1) JP2003531148A (https=)
AT (1) ATE342912T1 (https=)
AU (2) AU2001253427B2 (https=)
CA (1) CA2406847C (https=)
CY (1) CY1105870T1 (https=)
DE (1) DE60123939T2 (https=)
DK (1) DK1274718T3 (https=)
ES (1) ES2273831T3 (https=)
PT (1) PT1274718E (https=)
WO (1) WO2001079255A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410959B1 (en) * 2000-07-13 2008-08-12 Genaera Corporation Therapeutic uses for aminosterol compounds
EP1731526A4 (en) * 2004-03-31 2009-04-01 Kuraray Co METHOD OF PREPARING A 5-ALPHA PRIMING DERIVATIVE
WO2005095434A1 (ja) * 2004-03-31 2005-10-13 Kuraray Co., Ltd. ５α－プレグナン誘導体の製造方法
US20070197490A1 (en) * 2004-03-31 2007-08-23 Kuraray Co., Ltd. Method for producing 5alpha-pregnane derivative
JP2008504292A (ja) 2004-06-24 2008-02-14 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 免疫増強用の化合物
US20070203106A1 (en) * 2005-03-31 2007-08-30 Kuraray Co., Ltd. Method for Producing 5Alpha-Pregnane Derivative
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
TW200808739A (en) 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
JP2010538072A (ja) * 2007-09-06 2010-12-09 ジェナエラ コーポレイション 糖尿病を治療する方法
EP2240475B1 (en) 2007-12-20 2013-09-25 Novartis AG Thiazole derivatives used as pi 3 kinase inhibitors
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
US20110161139A1 (en) * 2009-12-31 2011-06-30 Accenture Global Services Gmbh Capability Accelerator
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
JP5963777B2 (ja) 2011-01-31 2016-08-03 ノバルティス アーゲー 新規ヘテロ環誘導体
CN104039790B (zh) 2011-10-28 2016-04-13 诺华股份有限公司 嘌呤衍生物及它们在治疗疾病中的应用
KR20150009540A (ko) 2012-05-16 2015-01-26 노파르티스 아게 Pi-3 키나제 억제제에 대한 투여 요법
SI3076969T1 (sl) 2013-12-06 2021-12-31 Novartis Ag Režim omderjanja izooblike alfa selektivnega zaviralca fosfatidilino- zitol 3-kinaze
US20180280370A1 (en) 2015-11-02 2018-10-04 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
CN109651475B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙的新方法
CN109575096B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙产品的新方法
CN109734765B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙产品的制备方法
CN109734764B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙的制备方法
CN113621016B (zh) * 2021-09-06 2022-05-17 北京泛球生物科技有限公司 一种地屈孕酮关键中间体的合成方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016390A (en) 1960-06-30 1962-01-09 Searle & Co N-(substituted alkyl) amino-5alpha-androstan-17beta-ols
US3370070A (en) 1965-06-16 1968-02-20 Searle & Co [n-alkyl-17-(dialkylaminoalkyl)amino] androst-4-en-3-ones
GB1565351A (en) 1975-06-02 1980-04-16 Theramex Steroid aminoethers
US4220598A (en) 1977-11-14 1980-09-02 Abbott Laboratories Method and reagents for measuring the level of conjugated bile acids
US4550163A (en) 1979-02-05 1985-10-29 Abbott Laboratories Ligand analog-irreversible enzyme inhibitor conjugates
US4301246A (en) * 1979-04-12 1981-11-17 Hoffmann-La Roche Inc. Process for chenodeoxycholic acid production
US4230625A (en) * 1979-04-12 1980-10-28 Hoffmann-La Roche Inc. Process for chenodeoxycholic acid and intermediates therefore
US4372888A (en) 1980-08-26 1983-02-08 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Nondenaturing zwitterionic detergents
JPS5842878B2 (ja) 1981-12-02 1983-09-22 名糖産業株式会社 １２−オキソコラン酸トシルヒドラゾン化合物、その製法ならびに利用
DE3366932D1 (en) 1982-07-29 1986-11-20 Lehner Ag New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
IT1221734B (it) 1983-02-24 1990-07-12 Schiena Michele Giuseppe Di Ursodesossicolico solfato acido sale sodico
US4545938A (en) 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis
WO1987002367A2 (en) 1985-10-18 1987-04-23 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US4771042A (en) 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
JPS62175497A (ja) 1986-01-28 1987-08-01 Wakunaga Pharmaceut Co Ltd 胆汁酸誘導体およびその製造法
US5075464A (en) 1987-04-22 1991-12-24 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropylamino)androstene derivatives
SE8702254D0 (sv) 1987-05-29 1987-05-29 Kabivitrum Ab Novel heparin derivatives
US5135919A (en) 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
IT1229569B (it) 1989-04-17 1991-09-04 Giuliani Spa Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
IT1229570B (it) 1989-04-17 1991-09-04 Giuliani Spa Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
JPH07116215B2 (ja) 1989-04-19 1995-12-13 エスエス製薬株式会社 新規なステロイド化合物
PT93847A (pt) 1989-04-24 1990-11-20 Harvard College Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
US4966897A (en) 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US5004737A (en) 1989-09-22 1991-04-02 Pacific Chemical Co., Ltd. Quaternary ammonium-substituted sterol derivatives
EP0466315A3 (en) 1990-05-30 1992-07-01 Larrian Gillespie Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation
WO1991019731A1 (en) 1990-06-11 1991-12-26 The Upjohn Company Steroids which inhibit angiogenesis
NZ240846A (en) 1990-12-06 1994-04-27 Hoechst Ag Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions
US5192756A (en) 1992-03-18 1993-03-09 The Children's Hospital Of Pennsylvania Aminosterol antibiotic
WO1993025197A1 (en) 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5247104A (en) 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
JPH06329679A (ja) 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
WO1994019366A1 (en) 1993-02-26 1994-09-01 Magainin Pharmaceuticals Inc. Chemical synthesis of squalamine
DE69412596T2 (de) 1993-03-10 1999-03-04 Magainin Pharmaceuticals Inc., Plymouth Meeting, Pa. Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel
WO1994024800A1 (en) 1993-04-12 1994-10-27 Unisys Corporation Portable adapter for portable pc
JPH09509959A (ja) 1994-03-10 1997-10-07 マガイニン ファーマシューティカルズ インク． ステロイド誘導体、それらを含む薬剤組成物、及びそれらの薬剤学的用途
US5792635A (en) 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
ATE259375T1 (de) 1995-06-07 2004-02-15 Genaera Corp Aminosterinverbindungen als inhibitoren der natrium/proton-pump, pharmazeutische methoden und präparaten davon
US6262283B1 (en) * 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds

Also Published As

Publication number Publication date
AU5342701A (en) 2001-10-30
US6933383B2 (en) 2005-08-23
US7728157B2 (en) 2010-06-01
JP2003531148A (ja) 2003-10-21
EP1274718A1 (en) 2003-01-15
WO2001079255A1 (en) 2001-10-25
CY1105870T1 (el) 2011-02-02
ES2273831T3 (es) 2007-05-16
US20030171576A1 (en) 2003-09-11
DK1274718T3 (da) 2007-02-12
CA2406847C (en) 2009-11-17
CA2406847A1 (en) 2001-10-25
EP1274718B1 (en) 2006-10-18
DE60123939T2 (de) 2007-05-31
US20050187202A1 (en) 2005-08-25
DE60123939D1 (de) 2006-11-30
PT1274718E (pt) 2007-01-31
AU2001253427B2 (en) 2007-02-08

Similar Documents

Publication Publication Date Title
ATE342912T1 (de) Ein verfahren zur herstellung von 7.alpha.- hydroxy 3-aminosubstituierten sterol-verbindungen,ohne schutz der 7.alpha.-hydroxy-gruppe
DE69838146D1 (de) Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben
DE69927547D1 (de) Verfahren zur Herstellung von mikro-elektromechanischen Anordnungen hoher Isolation
BR9714510A (pt) Processo e preparo de esteróides de 9,11-époxi e intermediários úteis dos mesmos
EP1230419A4 (en) COMPOSITION AND METHOD FOR CVD DEPOSITION OF Zr/Hf SILICATE FILMS
BR9509665A (pt) Composto composições e métodos
NO972909L (no) Substituerte azetidin-2-oner for behandling av atherosklerose
ATE250077T1 (de) Steroid sulfataseinhibitoren, verfahren zu ihrer herstellung und verwendung
NO961693L (no) Delta16-umettede C17-heterocykliske steroider som er anvendbare som steroid C17-20-lyaseinhibitorer
DK1051177T3 (da) Steroide 3-O-Sulfamatderivater som inhibitorer af östronsulfatase
DE59606057D1 (de) Verfahren zur herstellung von dihydroxypyrimidin-derivaten
DE69510869D1 (de) Verfahren zur Sicherung der Vertraulichkeit einer Audioverbindung und lokales Telekommunikationsnetz zur Durchführung dieses Verfahrens
NO20023276L (no) Fremgangsmåter fremstilling av betulinsyre
DE69823970D1 (de) Verfahren zur Herstellung einer Rückwand für eine Plasmaanzeige
DE69817000D1 (de) Verfahren zur schnellen isolierung von rns
DE60019780D1 (de) Verfahren zur herstellung von czochralski-silizium ohne agglomierte eigenzwischengitteratom-defekte
YU22903A (sh) 17alfa-fluoroalkil steroidi, postupak njihove proizvodnje i farmaceutski sastavi koji sadrže ova jedinjenja
ES2150151T3 (es) Derivados de 21-(2-oxo-tetrahidrofuran)-tio-pregnano, un procedimiento para su produccion y composiciones farmaceuticas que los contienen.
DE60034236D1 (de) System und Verfahren zur Synchronisation von Netzelementen
DE59811148D1 (de) Verfahren zur Herstellung von Methylendi(phenylamin)
DE60003807D1 (de) Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung
AR015137A1 (es) Un proceso para la preparacion de un compuesto derivado de difenil eter
ATE406376T1 (de) Verfahren zur herstellung von finasterid form i
DK0559706T3 (da) 2 beta,19-methylenamino-broforbundne steroider som aromataseinhibitorer.
NO20020260L (no) 11<beta>-aryl-17,17-spirotiolansubstituerte steroider

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1274718

Country of ref document: EP

REN Ceased due to non-payment of the annual fee