ES2164110T3 - Usos farmaceuticos de derivados de esteroides. - Google Patents
Usos farmaceuticos de derivados de esteroides.Info
- Publication number
- ES2164110T3 ES2164110T3 ES94931274T ES94931274T ES2164110T3 ES 2164110 T3 ES2164110 T3 ES 2164110T3 ES 94931274 T ES94931274 T ES 94931274T ES 94931274 T ES94931274 T ES 94931274T ES 2164110 T3 ES2164110 T3 ES 2164110T3
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- iii
- compounds
- side chain
- steroid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LOS COMPUESTOS QUE TIENEN UNA AMPLIA VARIEDAD DE ACTIVIDAD ANTIMICROBIANA GENERALMENTE TIENEN UNA ESTRUCTURA QUE INCLUYE UN NUCLEO DE ESTEROIDES CON UNA CADENA LATERAL (X) CATIONICA, PREFERIBLEMENTE DE POLIAMINAS, Y UNA CADENA LATERAL ANIONICA (Y). LA INVENCION ESTA TAMBIEN DIRIGIDA A COMPUESTOS DE FORMULA (III), PREFERIBLEMENTE DONDE EL NUCLEO DEL ANILLO DE ESTEROIDES ES SATURADO; EL SUSTITUYENTE DEL ANILLO DE ESTEROIDES Z{SUB,5} ES {AL}-H; UN Z{SUB,7} ES {BE}-H Y EL OTRO ES {AL}-H O {AL}-OH; AMBOS SUSTITUYENTES Z{SUB,12} SON HIDROGENO; X'' ES UNA CADENA LATERAL DE POLIAMINAS DE LA FORMULA -NH-(CH{SUB,2}){SUB,P}-NH(CH{SUB,2}){SUB,Q}-N(R{SUP,II})(R{SUP,III}) DONDE P Y Q SON CADA UNO INDEPENDIENTEMENTE 3 O 4, Y R{SUP,II} Y R{SUP,III} SON CADA UNO INDEPENDIENTEMENTE HIDROGENO O METILO; R'' ES METILO; Y Y'' ES (C{SUB,1}-C{SUB,10}-ALQUILO SUSTITUIDO CON UN GRUPO COMO CO{SUB,2}H O -SO{SUB,3}H. TALES COMPUESTOS, ASI COMO LA ESCUALAMINA MISMA, TIENEN ACTIVIDAD ANTIANGIOGENICA Y ACTIVIDAD INHIBIDORA DE NA{SUP,+}/K{SUP,+}-ATPASA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1994/002397 WO1994020520A1 (en) | 1993-03-10 | 1994-03-10 | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2164110T3 true ES2164110T3 (es) | 2002-02-16 |
Family
ID=22242322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94931274T Expired - Lifetime ES2164110T3 (es) | 1994-03-10 | 1994-09-13 | Usos farmaceuticos de derivados de esteroides. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0749437B1 (es) |
JP (1) | JPH09509959A (es) |
AT (1) | ATE210144T1 (es) |
CA (1) | CA2185123C (es) |
DE (1) | DE69429364T2 (es) |
DK (1) | DK0749437T3 (es) |
ES (1) | ES2164110T3 (es) |
PT (1) | PT749437E (es) |
WO (1) | WO1995024415A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856535A (en) * | 1994-08-18 | 1999-01-05 | Magainin Pharmaceuticals, Inc. | Aminosterol ester compounds |
US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
US6596712B2 (en) | 1996-04-26 | 2003-07-22 | Genaera Corporation | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
JP2000510460A (ja) * | 1996-04-26 | 2000-08-15 | マゲイニン・ファーマシューティカルズ・インコーポレーテッド | スクアラミンを他の抗癌剤と併用する上皮性悪性腫瘍の治療 |
US7410959B1 (en) | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
AU5194998A (en) * | 1996-11-01 | 1998-05-29 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and uses therefor |
US6262283B1 (en) | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
ATE269086T1 (de) * | 1998-03-06 | 2004-07-15 | Univ Brigham Young | Antibiotische steroidderivate |
US6767904B2 (en) | 1998-03-06 | 2004-07-27 | Bringham Young University | Steroid derived antibiotics |
US6350738B1 (en) | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
CA2406847C (en) | 2000-04-12 | 2009-11-17 | Genaera Corporation | Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols |
EP2303026B1 (en) | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
JP5147814B2 (ja) * | 2009-11-12 | 2013-02-20 | ブリガム・ヤング・ユニバーシティ | ステロイド由来抗生物質 |
US8871021B2 (en) | 2011-03-08 | 2014-10-28 | Staker & Parson Companies | Concrete mixtures including carbon encapsulating admixture |
US8975310B2 (en) | 2011-07-20 | 2015-03-10 | Brigham Young University | Hydrophobic ceragenin compounds and devices incorporating same |
US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
CA2852989C (en) | 2011-09-13 | 2021-06-29 | Brigham Young University | Compositions for treating bone diseases and broken bones |
MX369385B (es) | 2011-09-13 | 2019-11-07 | Univ Brigham Young | Productos para cicatrizar heridas tisulares. |
US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
JP6051230B2 (ja) | 2011-12-21 | 2016-12-27 | ブリガム ヤング ユニバーシティ | 口腔ケア組成物 |
US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
EP3225113B1 (en) | 2012-05-02 | 2020-09-02 | Brigham Young University | Methods for making ceragenin particulate materials |
WO2014062960A1 (en) | 2012-10-17 | 2014-04-24 | Brigham Young University | Treatment and prevention of mastitis |
CA2897150C (en) | 2013-01-07 | 2021-07-13 | Brigham Young University | Methods for reducing cellular proliferation and treating certain diseases |
RU2669800C2 (ru) | 2013-03-15 | 2018-10-16 | Брихэм Янг Юниверсити | Способы лечения воспаления, аутоиммунных расстройств и боли |
US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
CA2844321C (en) | 2014-02-27 | 2021-03-16 | Brigham Young University | Cationic steroidal antimicrobial compounds |
US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
US9931350B2 (en) | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
WO2016172543A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
US9434759B1 (en) | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
CN108445236B (zh) * | 2018-02-07 | 2021-04-20 | 深圳市新产业生物医学工程股份有限公司 | 甾体类衍生物和其保存液以及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3370070A (en) * | 1965-06-16 | 1968-02-20 | Searle & Co | [n-alkyl-17-(dialkylaminoalkyl)amino] androst-4-en-3-ones |
GB1565351A (en) * | 1975-06-02 | 1980-04-16 | Theramex | Steroid aminoethers |
US5004737A (en) * | 1989-09-22 | 1991-04-02 | Pacific Chemical Co., Ltd. | Quaternary ammonium-substituted sterol derivatives |
US5192756A (en) * | 1992-03-18 | 1993-03-09 | The Children's Hospital Of Pennsylvania | Aminosterol antibiotic |
-
1994
- 1994-09-13 WO PCT/US1994/010265 patent/WO1995024415A1/en active IP Right Grant
- 1994-09-13 JP JP7523429A patent/JPH09509959A/ja not_active Ceased
- 1994-09-13 AT AT94931274T patent/ATE210144T1/de not_active IP Right Cessation
- 1994-09-13 ES ES94931274T patent/ES2164110T3/es not_active Expired - Lifetime
- 1994-09-13 DK DK94931274T patent/DK0749437T3/da active
- 1994-09-13 EP EP94931274A patent/EP0749437B1/en not_active Expired - Lifetime
- 1994-09-13 CA CA2185123A patent/CA2185123C/en not_active Expired - Lifetime
- 1994-09-13 DE DE69429364T patent/DE69429364T2/de not_active Expired - Lifetime
- 1994-09-13 PT PT94931274T patent/PT749437E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
AU700344B2 (en) | 1998-12-24 |
DE69429364T2 (de) | 2002-08-08 |
CA2185123C (en) | 2010-11-16 |
EP0749437A1 (en) | 1996-12-27 |
WO1995024415A1 (en) | 1995-09-14 |
PT749437E (pt) | 2002-03-28 |
AU8010194A (en) | 1995-09-25 |
CA2185123A1 (en) | 1995-09-14 |
JPH09509959A (ja) | 1997-10-07 |
ATE210144T1 (de) | 2001-12-15 |
DE69429364D1 (de) | 2002-01-17 |
EP0749437B1 (en) | 2001-12-05 |
DK0749437T3 (da) | 2002-03-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2164110T3 (es) | Usos farmaceuticos de derivados de esteroides. | |
ES2123133T3 (es) | Derivados esteroidianos, composiciones farmaceuticas que contienen estos derivados esteroidianos y utilizacion de estos ultimos como antibioticos o desinfectantes. | |
CA2157117A1 (en) | Spirocyclic Piperidine Derivatives | |
CA2134964A1 (en) | Bridged Aza-Bicyclic Derivatives as Substance P Antagonists | |
DE69609912T2 (de) | Harnstoff- und Amid-Derivate mit ACAT-Inhibitorwirkung, ihre Herstellung und ihre therapeutische und prophylaktische Verwendung | |
FI102965B1 (fi) | Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö | |
ATE117681T1 (de) | Chinolinderivate, ihre herstellung und verwendung. | |
DE69609325D1 (de) | Derivate des radicicols | |
TR199801782T2 (xx) | Kinoksalindionlar | |
MX9300222A (es) | Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion. | |
CA2114727A1 (en) | Quinoline Derivatives as Immunostimulants | |
DE69311165D1 (de) | Kondensierte heterocyclische Ketonderivate, ihre Herstellung und ihre Verwendung | |
ES2099206T3 (es) | Derivados de benceno que favorecen la produccion del factor de crecimiento de los nervios humanos. | |
NO855241L (no) | Fremgangsmaate til fremstilling av karbapenemforbindelser. | |
ES2055235T3 (es) | Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation. | |
MX170732B (es) | Composicion de derivados de succinimida y su uso | |
DE69001111T2 (de) | Antikrebs-zusammensetzung. | |
DE69629341D1 (de) | Pyrrolocarbazolderivate | |
ES2056194T3 (es) | Compuestos tetraciclicos antidepresivos. | |
DK0420224T3 (da) | Anthihepatopatisk middel | |
DE69533298D1 (de) | Dioxabicyclo 3.3.0 octan-Derivate, z.B. Sesamin etc., zur Vorbeugung und Erleichterung von Allergiesymptomen | |
DE69601451T2 (de) | UCK14-Verbindungen | |
EP0230474A4 (en) | BIS-DIOXOPIPERAZINE COMBATS AND MEDICINAL PRODUCTS THEREOF. | |
DE3781044T2 (de) | Prophylaktische und heilende zusammensetzung enthaltende eine 8-chlorbenzothiazepin-verbindung und dessen verwendung. | |
CA2171972A1 (en) | Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 749437 Country of ref document: ES |