DK1274718T3 - En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppe - Google Patents
En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppeInfo
- Publication number
- DK1274718T3 DK1274718T3 DK01926924T DK01926924T DK1274718T3 DK 1274718 T3 DK1274718 T3 DK 1274718T3 DK 01926924 T DK01926924 T DK 01926924T DK 01926924 T DK01926924 T DK 01926924T DK 1274718 T3 DK1274718 T3 DK 1274718T3
- Authority
- DK
- Denmark
- Prior art keywords
- 7alpha
- hydroxy
- vee
- unprotected
- amino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229930182558 Sterol Natural products 0.000 title 1
- 235000003702 sterols Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108091006649 SLC9A3 Proteins 0.000 abstract 1
- 102100030375 Sodium/hydrogen exchanger 3 Human genes 0.000 abstract 1
- UIRKNQLZZXALBI-MSVGPLKSSA-N Squalamine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 UIRKNQLZZXALBI-MSVGPLKSSA-N 0.000 abstract 1
- UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004037 angiogenesis inhibitor Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229950001248 squalamine Drugs 0.000 abstract 1
- 150000003431 steroids Chemical group 0.000 abstract 1
- 238000006277 sulfonation reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19664600P | 2000-04-12 | 2000-04-12 | |
| PCT/US2001/012004 WO2001079255A1 (en) | 2000-04-12 | 2001-04-12 | A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1274718T3 true DK1274718T3 (da) | 2007-02-12 |
Family
ID=22726246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01926924T DK1274718T3 (da) | 2000-04-12 | 2001-04-12 | En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppe |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6933383B2 (https=) |
| EP (1) | EP1274718B1 (https=) |
| JP (1) | JP2003531148A (https=) |
| AT (1) | ATE342912T1 (https=) |
| AU (2) | AU5342701A (https=) |
| CA (1) | CA2406847C (https=) |
| CY (1) | CY1105870T1 (https=) |
| DE (1) | DE60123939T2 (https=) |
| DK (1) | DK1274718T3 (https=) |
| ES (1) | ES2273831T3 (https=) |
| PT (1) | PT1274718E (https=) |
| WO (1) | WO2001079255A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7410959B1 (en) * | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
| JPWO2005095434A1 (ja) * | 2004-03-31 | 2008-02-21 | 株式会社クラレ | ５α−プレグナン誘導体の製造方法 |
| WO2005095432A1 (ja) * | 2004-03-31 | 2005-10-13 | Kuraray Co., Ltd. | ５α－プレグナン誘導体の製造方法 |
| EP1767540A4 (en) * | 2004-03-31 | 2009-04-01 | Kuraray Co | METHOD OF PREPARING A 5-ALPHA PRIMING DERIVATIVE |
| WO2006002422A2 (en) | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
| US20070203106A1 (en) * | 2005-03-31 | 2007-08-30 | Kuraray Co., Ltd. | Method for Producing 5Alpha-Pregnane Derivative |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| AR060358A1 (es) | 2006-04-06 | 2008-06-11 | Novartis Vaccines & Diagnostic | Quinazolinas para la inhibicion de pdk 1 |
| WO2009032321A2 (en) * | 2007-09-06 | 2009-03-12 | Genaera Corporation | A method for treating diabetes |
| EP2240475B1 (en) | 2007-12-20 | 2013-09-25 | Novartis AG | Thiazole derivatives used as pi 3 kinase inhibitors |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| US20110161139A1 (en) * | 2009-12-31 | 2011-06-30 | Accenture Global Services Gmbh | Capability Accelerator |
| AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
| MX343706B (es) | 2011-01-31 | 2016-11-18 | Novartis Ag | Derivados heterocíclicos novedosos. |
| PT2771342T (pt) | 2011-10-28 | 2016-08-17 | Novartis Ag | Derivados de purina e o seu uso no tratamento de doença |
| WO2013173283A1 (en) | 2012-05-16 | 2013-11-21 | Novartis Ag | Dosage regimen for a pi-3 kinase inhibitor |
| CN105979947A (zh) | 2013-12-06 | 2016-09-28 | 诺华股份有限公司 | α-同工型选择性磷脂酰肌醇3-激酶抑制剂的剂量方案 |
| RU2018119085A (ru) | 2015-11-02 | 2019-12-04 | Новартис Аг | Схема введения ингибитора фосфатидилинозитол-3-киназы |
| WO2018060833A1 (en) | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
| CN109734764B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种17a-脱羟醋酸泼尼松龙的制备方法 |
| CN109575096B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种制备16a-羟基泼尼松龙产品的新方法 |
| CN109651475B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种制备16a-羟基泼尼松龙的新方法 |
| CN109734765B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种17a-脱羟醋酸泼尼松龙产品的制备方法 |
| CN113621016B (zh) * | 2021-09-06 | 2022-05-17 | 北京泛球生物科技有限公司 | 一种地屈孕酮关键中间体的合成方法 |
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| US3370070A (en) * | 1965-06-16 | 1968-02-20 | Searle & Co | [n-alkyl-17-(dialkylaminoalkyl)amino] androst-4-en-3-ones |
| GB1565351A (en) | 1975-06-02 | 1980-04-16 | Theramex | Steroid aminoethers |
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-
2001
- 2001-04-12 DK DK01926924T patent/DK1274718T3/da active
- 2001-04-12 CA CA002406847A patent/CA2406847C/en not_active Expired - Lifetime
- 2001-04-12 AU AU5342701A patent/AU5342701A/xx active Pending
- 2001-04-12 JP JP2001576852A patent/JP2003531148A/ja active Pending
- 2001-04-12 AT AT01926924T patent/ATE342912T1/de not_active IP Right Cessation
- 2001-04-12 WO PCT/US2001/012004 patent/WO2001079255A1/en not_active Ceased
- 2001-04-12 DE DE60123939T patent/DE60123939T2/de not_active Expired - Lifetime
- 2001-04-12 ES ES01926924T patent/ES2273831T3/es not_active Expired - Lifetime
- 2001-04-12 AU AU2001253427A patent/AU2001253427B2/en not_active Ceased
- 2001-04-12 EP EP01926924A patent/EP1274718B1/en not_active Expired - Lifetime
- 2001-04-12 PT PT01926924T patent/PT1274718E/pt unknown
-
2002
- 2002-10-11 US US10/268,660 patent/US6933383B2/en not_active Expired - Lifetime
-
2005
- 2005-03-21 US US11/083,961 patent/US7728157B2/en not_active Expired - Fee Related
-
2006
- 2006-12-20 CY CY20061101829T patent/CY1105870T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001079255A1 (en) | 2001-10-25 |
| EP1274718B1 (en) | 2006-10-18 |
| DE60123939D1 (de) | 2006-11-30 |
| US6933383B2 (en) | 2005-08-23 |
| JP2003531148A (ja) | 2003-10-21 |
| CY1105870T1 (el) | 2011-02-02 |
| CA2406847C (en) | 2009-11-17 |
| DE60123939T2 (de) | 2007-05-31 |
| EP1274718A1 (en) | 2003-01-15 |
| AU5342701A (en) | 2001-10-30 |
| US7728157B2 (en) | 2010-06-01 |
| US20050187202A1 (en) | 2005-08-25 |
| ES2273831T3 (es) | 2007-05-16 |
| PT1274718E (pt) | 2007-01-31 |
| ATE342912T1 (de) | 2006-11-15 |
| US20030171576A1 (en) | 2003-09-11 |
| AU2001253427B2 (en) | 2007-02-08 |
| CA2406847A1 (en) | 2001-10-25 |
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