ES2273831T3 - Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido. - Google Patents

Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido. Download PDF

Info

Publication number
ES2273831T3
ES2273831T3 ES01926924T ES01926924T ES2273831T3 ES 2273831 T3 ES2273831 T3 ES 2273831T3 ES 01926924 T ES01926924 T ES 01926924T ES 01926924 T ES01926924 T ES 01926924T ES 2273831 T3 ES2273831 T3 ES 2273831T3
Authority
ES
Spain
Prior art keywords
compound
react
7alfa
hydroxi
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01926924T
Other languages
English (en)
Spanish (es)
Inventor
William A. Kinney
Xuehai Zhang
Ronald Michalak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genaera Corp
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Application granted granted Critical
Publication of ES2273831T3 publication Critical patent/ES2273831T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES01926924T 2000-04-12 2001-04-12 Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido. Expired - Lifetime ES2273831T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19664600P 2000-04-12 2000-04-12
US196646P 2000-04-12

Publications (1)

Publication Number Publication Date
ES2273831T3 true ES2273831T3 (es) 2007-05-16

Family

ID=22726246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01926924T Expired - Lifetime ES2273831T3 (es) 2000-04-12 2001-04-12 Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido.

Country Status (12)

Country Link
US (2) US6933383B2 (https=)
EP (1) EP1274718B1 (https=)
JP (1) JP2003531148A (https=)
AT (1) ATE342912T1 (https=)
AU (2) AU5342701A (https=)
CA (1) CA2406847C (https=)
CY (1) CY1105870T1 (https=)
DE (1) DE60123939T2 (https=)
DK (1) DK1274718T3 (https=)
ES (1) ES2273831T3 (https=)
PT (1) PT1274718E (https=)
WO (1) WO2001079255A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410959B1 (en) * 2000-07-13 2008-08-12 Genaera Corporation Therapeutic uses for aminosterol compounds
JPWO2005095434A1 (ja) * 2004-03-31 2008-02-21 株式会社クラレ ５α−プレグナン誘導体の製造方法
WO2005095432A1 (ja) * 2004-03-31 2005-10-13 Kuraray Co., Ltd. ５α－プレグナン誘導体の製造方法
EP1767540A4 (en) * 2004-03-31 2009-04-01 Kuraray Co METHOD OF PREPARING A 5-ALPHA PRIMING DERIVATIVE
WO2006002422A2 (en) 2004-06-24 2006-01-05 Novartis Vaccines And Diagnostics Inc. Compounds for immunopotentiation
US20070203106A1 (en) * 2005-03-31 2007-08-30 Kuraray Co., Ltd. Method for Producing 5Alpha-Pregnane Derivative
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
AR060358A1 (es) 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
WO2009032321A2 (en) * 2007-09-06 2009-03-12 Genaera Corporation A method for treating diabetes
EP2240475B1 (en) 2007-12-20 2013-09-25 Novartis AG Thiazole derivatives used as pi 3 kinase inhibitors
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
US20110161139A1 (en) * 2009-12-31 2011-06-30 Accenture Global Services Gmbh Capability Accelerator
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
MX343706B (es) 2011-01-31 2016-11-18 Novartis Ag Derivados heterocíclicos novedosos.
PT2771342T (pt) 2011-10-28 2016-08-17 Novartis Ag Derivados de purina e o seu uso no tratamento de doença
WO2013173283A1 (en) 2012-05-16 2013-11-21 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
CN105979947A (zh) 2013-12-06 2016-09-28 诺华股份有限公司 α-同工型选择性磷脂酰肌醇3-激酶抑制剂的剂量方案
RU2018119085A (ru) 2015-11-02 2019-12-04 Новартис Аг Схема введения ингибитора фосфатидилинозитол-3-киназы
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
CN109734764B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙的制备方法
CN109575096B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙产品的新方法
CN109651475B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙的新方法
CN109734765B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙产品的制备方法
CN113621016B (zh) * 2021-09-06 2022-05-17 北京泛球生物科技有限公司 一种地屈孕酮关键中间体的合成方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016390A (en) * 1960-06-30 1962-01-09 Searle & Co N-(substituted alkyl) amino-5alpha-androstan-17beta-ols
US3370070A (en) * 1965-06-16 1968-02-20 Searle & Co [n-alkyl-17-(dialkylaminoalkyl)amino] androst-4-en-3-ones
GB1565351A (en) 1975-06-02 1980-04-16 Theramex Steroid aminoethers
US4220598A (en) * 1977-11-14 1980-09-02 Abbott Laboratories Method and reagents for measuring the level of conjugated bile acids
US4550163A (en) * 1979-02-05 1985-10-29 Abbott Laboratories Ligand analog-irreversible enzyme inhibitor conjugates
US4230625A (en) * 1979-04-12 1980-10-28 Hoffmann-La Roche Inc. Process for chenodeoxycholic acid and intermediates therefore
US4301246A (en) * 1979-04-12 1981-11-17 Hoffmann-La Roche Inc. Process for chenodeoxycholic acid production
US4372888A (en) * 1980-08-26 1983-02-08 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Nondenaturing zwitterionic detergents
JPS5842878B2 (ja) * 1981-12-02 1983-09-22 名糖産業株式会社 １２−オキソコラン酸トシルヒドラゾン化合物、その製法ならびに利用
DE3366932D1 (en) * 1982-07-29 1986-11-20 Lehner Ag New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
US5001116A (en) * 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) * 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
IT1221734B (it) * 1983-02-24 1990-07-12 Schiena Michele Giuseppe Di Ursodesossicolico solfato acido sale sodico
US4545938A (en) * 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis
US4917826A (en) 1985-10-18 1990-04-17 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US4771042A (en) * 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
JPS62175497A (ja) * 1986-01-28 1987-08-01 Wakunaga Pharmaceut Co Ltd 胆汁酸誘導体およびその製造法
US5075464A (en) * 1987-04-22 1991-12-24 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropylamino)androstene derivatives
SE8702254D0 (sv) * 1987-05-29 1987-05-29 Kabivitrum Ab Novel heparin derivatives
US5135919A (en) * 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
IT1229569B (it) * 1989-04-17 1991-09-04 Giuliani Spa Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
IT1229570B (it) * 1989-04-17 1991-09-04 Giuliani Spa Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
JPH07116215B2 (ja) * 1989-04-19 1995-12-13 エスエス製薬株式会社 新規なステロイド化合物
PT93847A (pt) 1989-04-24 1990-11-20 Harvard College Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
US4966897A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US5004737A (en) * 1989-09-22 1991-04-02 Pacific Chemical Co., Ltd. Quaternary ammonium-substituted sterol derivatives
EP0466315A3 (en) 1990-05-30 1992-07-01 Larrian Gillespie Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation
DE69132048T2 (de) 1990-06-11 2000-07-13 Alcon Laboratories Inc.(N.D.Ges.D.Staates Delaware), Forth Worth Verwendung von Steroiden zur Inhibierung von Angiogenesis
US5250524A (en) * 1990-12-06 1993-10-05 Hoechst Aktiengesellschaft Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals
US5192756A (en) * 1992-03-18 1993-03-09 The Children's Hospital Of Pennsylvania Aminosterol antibiotic
EP0647133A4 (en) 1992-06-12 1997-10-29 Affymax Tech Nv COMPOSITIONS AND METHODS FOR IMPROVED DRUG DELIVERY.
US5247104A (en) * 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
JPH06329679A (ja) 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
AU6392894A (en) 1993-02-26 1994-09-14 Magainin Pharmaceuticals, Inc. Chemical synthesis of squalamine
WO1994020520A1 (en) 1993-03-10 1994-09-15 Magainin Pharmaceuticals Inc. Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants
WO1994024800A1 (en) 1993-04-12 1994-10-27 Unisys Corporation Portable adapter for portable pc
ES2164110T3 (es) 1994-03-10 2002-02-16 Magainin Pharma Usos farmaceuticos de derivados de esteroides.
US5792635A (en) 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
AU723663C (en) 1995-06-07 2001-11-01 Magainin Pharmaceuticals, Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds
US6262283B1 (en) * 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds

Also Published As

Publication number Publication date
WO2001079255A1 (en) 2001-10-25
EP1274718B1 (en) 2006-10-18
DE60123939D1 (de) 2006-11-30
US6933383B2 (en) 2005-08-23
JP2003531148A (ja) 2003-10-21
CY1105870T1 (el) 2011-02-02
CA2406847C (en) 2009-11-17
DE60123939T2 (de) 2007-05-31
EP1274718A1 (en) 2003-01-15
AU5342701A (en) 2001-10-30
US7728157B2 (en) 2010-06-01
US20050187202A1 (en) 2005-08-25
PT1274718E (pt) 2007-01-31
ATE342912T1 (de) 2006-11-15
US20030171576A1 (en) 2003-09-11
DK1274718T3 (da) 2007-02-12
AU2001253427B2 (en) 2007-02-08
CA2406847A1 (en) 2001-10-25

Similar Documents

Publication Publication Date Title
ES2273831T3 (es) Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido.
JP5097724B2 (ja) アミノステロール、ビタミンｄ類似体および他の化合物の製造に有用な２４−ヒドロキシル化された化合物の立体選択的合成
AU2001253427A1 (en) A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group
ES2346053T3 (es) Sintesis de esterol a traves de esteroides derivados de estrona.
JP5703295B2 (ja) １７−スピロラクトンを得る方法
CN113880904B (zh) 合成地屈孕酮的新方法及化合物
AU775831B2 (en) Process for preparing 17alpha-acetoxy-11beta-(4-N,N-(dimethylamino)phenyl)-21- methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes for preparing such intermediates
FI87791B (fi) Foerfarande foer framstaellning av 17 -(cyklopropyloxi)androst-5-en-3 -ol och naerstaoende foereningar, som aer anvaendbara som c17-20 lyas inhibitorer
GB1564806A (en) Cholesterol derivatives
MX2008016425A (es) Derivados amino de b-homoandrostanos y b-heteroandrostanos.
EP0201042B1 (en) 3alpha,5-cyclo-22,23-dihydroxy-5alpha,steroid compounds
JPS58124800A (ja) Δ↑５‖↑７−ステロイドの製造方法
WO1993002096A1 (en) PROCESS FOR THE PREPARATION OF 17β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONE DERIVATIVES
US3325481A (en) 3-(optionally substituted)amino-estra-1, 3, 5(10), 8(9), 14-pentaen - 17 - ones and derivatives thereof
IL31353A (en) 3,5-seco-a-nor-steroids of the androstane and pregnane series
US4105660A (en) Preparation of 3β-hydroxy-27-norcholest-5,7-dien-25-one
JPS59144800A (ja) アンドロステン−１７−ジチオケタ−ル類
AU2002300302B2 (en) Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
WO1993021204A1 (en) Method for preparing cholesta-5,7-diene-3-beta,25-diol and analogs thereof
Göndös et al. Synthesis and oxidation of pregna‐3, 5‐dien‐20‐ols and‐20‐one and selective reduction of pregna‐3, 5‐dien‐20‐one
JP2953665B2 (ja) ステロイド誘導体の製造方法
Komeno et al. Thiosteroid—XXVIII: Steroidal transannular 2α, 5α-episulphide—2. Synthesis of 17β-hydroxy-3-oxo-5α-androstan-2α, 5-episulphide and its 19-nor derivative
US2895970A (en) Bisnorallo-7-cholenaldehydes
US4160772A (en) Steroidal[16α,17-d]cyclohexene-21-carboxylic acid esters
Bakos et al. Steroids, XLVII: A facile synthesis of 3β-hydroxy-5α-cholest-8 (14)-en-15-one