|
DE60144277D1
(de)
|
2000-04-25 |
2011-05-05 |
Icos Corp |
Hemmer der menschlichen phosphatidyl-inositol-3-kinase delta
|
|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
GB0119863D0
(en)
|
2001-08-14 |
2001-10-10 |
Cancer Res Campaign Tech |
DNA-PK inhibitors
|
|
GB0119865D0
(en)
*
|
2001-08-14 |
2001-10-10 |
Cancer Res Campaign Tech |
DNA-PK inhibitors
|
|
GB2405870B
(en)
*
|
2001-08-14 |
2005-07-06 |
Cancer Rec Tech Ltd |
DNA-PK inhibitors
|
|
CN1551766A
(zh)
*
|
2001-09-05 |
2004-12-01 |
������������ʽ���� |
淋巴细胞活化抑制剂和自身免疫性疾病治疗剂
|
|
US7049313B2
(en)
|
2002-02-25 |
2006-05-23 |
Kudos Pharmaceuticals Ltd. |
ATM inhibitors
|
|
EP2311818B1
(en)
*
|
2002-02-28 |
2013-01-16 |
Novartis AG |
Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
|
|
AR038703A1
(es)
|
2002-02-28 |
2005-01-26 |
Novartis Ag |
Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3
|
|
EP1537102A4
(en)
*
|
2002-08-16 |
2010-12-08 |
Astrazeneca Ab |
INHIBITORS OF PHOSPHOINOSITIDE-3-KINASE BETA
|
|
CN101260104A
(zh)
*
|
2002-08-16 |
2008-09-10 |
阿斯利康(瑞典)有限公司 |
抑制磷酸肌醇3-激酶β
|
|
PL382706A1
(pl)
|
2002-08-26 |
2007-11-26 |
Takeda Pharmaceutical Company Limited |
Związek modulujący receptor wapnia i jego zastosowanie
|
|
BR0316386A
(pt)
|
2002-12-06 |
2005-09-27 |
Warner Lambert Co |
Benzoxazin-3-onas e seus derivados como inibidores de p13k
|
|
GB0305152D0
(en)
*
|
2003-03-06 |
2003-04-09 |
Novartis Ag |
Organic compounds
|
|
WO2004089925A1
(en)
*
|
2003-04-03 |
2004-10-21 |
Semafore Pharmaceuticals, Inc. |
Pi-3 kinase inhibitor prodrugs
|
|
US7547794B2
(en)
|
2003-04-03 |
2009-06-16 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
|
US20040259926A1
(en)
*
|
2003-06-05 |
2004-12-23 |
Bruendl Michelle M. |
3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents
|
|
MXPA05013210A
(es)
*
|
2003-06-05 |
2006-03-09 |
Warner Lambert Co |
Benzo[b]tiofenos cicloalquilsulfanil-sustituidos como agentes terapeuticos.
|
|
WO2004108709A1
(en)
*
|
2003-06-05 |
2004-12-16 |
Warner-Lambert Company Llc |
Tetrazol benzofurancarboxamides with p13k aktivity as therapeutic agents
|
|
KR20060066722A
(ko)
|
2003-08-13 |
2006-06-16 |
쿠도스 파마슈티칼스 리미티드 |
아미노피론 및 atm억제제로서의 이의 용도
|
|
BRPI0414171A
(pt)
*
|
2003-09-04 |
2006-10-31 |
Warner Lambert Co |
benzo[b]tiofenos halossubstituìdos com atividade inibidora de pi3k como agentes terapêuticos
|
|
ATE365732T1
(de)
*
|
2003-10-31 |
2007-07-15 |
Warner Lambert Co |
Pyrimidine als inhibitoren von phosphoinositid-3- kinasen (pi3k)
|
|
AU2005228845A1
(en)
*
|
2004-01-26 |
2005-10-13 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
|
LT2612862T
(lt)
|
2004-05-13 |
2017-01-25 |
Icos Corporation |
Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai
|
|
CN1300163C
(zh)
*
|
2004-06-23 |
2007-02-14 |
南京大学 |
3-羟基色原酮糖苷及其制法和用途
|
|
RU2408596C2
(ru)
|
2004-09-20 |
2011-01-10 |
Кудос Фармасьютикалс Лимитед |
Ингибиторы днк-пк
|
|
JP2008529995A
(ja)
|
2005-02-09 |
2008-08-07 |
クドス ファーマシューティカルズ リミテッド |
Atm阻害剤
|
|
AR054438A1
(es)
|
2005-04-15 |
2007-06-27 |
Kudos Pharm Ltd |
Inhibidores de adn -pk
|
|
WO2007127366A2
(en)
|
2006-04-25 |
2007-11-08 |
Targegen, Inc. |
Kinase inhibitors and methods of use thereof
|
|
JP5415942B2
(ja)
*
|
2006-06-22 |
2014-02-12 |
プラナ バイオテクノロジー リミティッド |
処置の方法およびその処置に有用な薬剤
|
|
WO2008102932A1
(en)
*
|
2007-02-21 |
2008-08-28 |
Biobud Co., Ltd. |
Compositions for treating hyperproliferative vascular disorders and cancers
|
|
EP2157092A4
(en)
|
2007-04-11 |
2011-04-13 |
Ajinomoto Kk |
Remedy for diabetes
|
|
EP2154965A4
(en)
*
|
2007-05-29 |
2011-08-17 |
Glaxosmithkline Llc |
NAPHTHYRIDINE DERIVATIVES AS P13 KINASE INHIBITORS
|
|
EP2170338A2
(en)
*
|
2007-07-06 |
2010-04-07 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Dna-pkcs modulates energy regulation and brain function
|
|
JP2011510071A
(ja)
*
|
2008-01-25 |
2011-03-31 |
アストラゼネカ アクチボラグ |
鏡像異性的に純粋な(−)2−[1−(7−メチル−2−(モルホリン−4−イル)−4−オキソ−4H−ピリド[1,2−a]ピリミジン−9−イル)エチルアミノ]安息香酸、医学的療法における該物質の使用、および該物質を含む薬学的組成物−026
|
|
EP2262366A4
(en)
*
|
2008-04-18 |
2012-02-22 |
Shenogen Pharma Group Ltd |
COMPOUNDS AND METHODS FOR TREATING STROGEN RECEPTOR-RELATED DISEASES
|
|
CA2738794C
(en)
|
2008-09-29 |
2016-01-05 |
Sirtris Pharmaceuticals, Inc. |
Chromenone analogs as sirtuin modulators
|
|
US8110578B2
(en)
*
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
US9492449B2
(en)
|
2008-11-13 |
2016-11-15 |
Gilead Calistoga Llc |
Therapies for hematologic malignancies
|
|
KR20170060179A
(ko)
|
2008-11-13 |
2017-05-31 |
길리아드 칼리스토가 엘엘씨 |
혈액 종양에 대한 요법
|
|
PL2448940T3
(pl)
|
2009-07-02 |
2014-10-31 |
Sanofi Sa |
Pochodne 6,7,8,9-tetrahydro-pirymido{1,2-a} pirymidyn-4-onu, ich wytwarzanie i zastosowanie farmaceutyczne
|
|
KR101745028B1
(ko)
|
2009-07-02 |
2017-06-08 |
사노피 |
신규 2,3-디히드로-1h-이미다조(1,2-a)피리미딘-5-온 유도체, 그의 제조법 및 그의 제약 용도
|
|
AR077628A1
(es)
|
2009-07-02 |
2011-09-14 |
Sanofi Aventis |
Derivados de 6-(morfolin-4-il)-pirimidin-4(3h)-ona, su preparacion y su utilizacion farmaceutica como inhibidores de la fosforilacion de akt(pkb)
|
|
PE20120640A1
(es)
|
2009-07-02 |
2012-06-09 |
Sanofi Sa |
Nuevos derivados de (6-oxo-1,6-dihidro-pirimidin-2-il)-amida, su preparacion y su utilizacion farmaceutica como inhibidores de fosforilacion de akt (pkb)
|
|
CA2768843A1
(en)
|
2009-07-21 |
2011-01-27 |
Gilead Calistoga Llc |
Treatment of liver disorders with pi3k inhibitors
|
|
US8399460B2
(en)
|
2009-10-27 |
2013-03-19 |
Astrazeneca Ab |
Chromenone derivatives
|
|
IT1403156B1
(it)
|
2010-12-01 |
2013-10-04 |
Università Degli Studi Di Torino |
Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi.
|
|
FR2969613B1
(fr)
*
|
2010-12-23 |
2013-02-08 |
Sanofi Aventis |
Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique
|
|
FR2969612B1
(fr)
*
|
2010-12-23 |
2013-02-08 |
Sanofi Aventis |
Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique
|
|
PT2655375E
(pt)
|
2010-12-23 |
2015-03-02 |
Sanofi Sa |
Derivados de pirimidinona, sua preparação e sua utilização farmacêutica
|
|
ES2612492T3
(es)
|
2010-12-28 |
2017-05-17 |
Sanofi |
Nuevos derivados de piridiminas, su preparación y su utilización farmacéutica como inhibidores de fosforilación de AKT (PKB)
|
|
EP2808322B1
(en)
|
2012-01-26 |
2017-08-23 |
Daiichi Sankyo Company, Limited |
Chromone derivative having osteogenesis promoting effect
|
|
EP3406252B1
(en)
|
2012-02-10 |
2020-05-13 |
PTC Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
US9371336B2
(en)
|
2012-03-01 |
2016-06-21 |
Ptc Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
ES2848273T3
(es)
|
2012-03-05 |
2021-08-06 |
Gilead Calistoga Llc |
Formas polimórficas de (S)-2-(1-(9H-purin-6-ilamino)propilo)-5-fluoro-3-fenilquinazolina-4(3H)-ona
|
|
EP2828247B1
(en)
|
2012-03-23 |
2019-01-16 |
PTC Therapeutics, Inc. |
4h-chromen-4-one derivatives for treating spinal muscular atrophy
|
|
ITMI20120514A1
(it)
*
|
2012-03-29 |
2013-09-30 |
Cnr Consiglio Naz Delle Ric Erche |
Agente terapeutico per il trattamento dei vasi sanguigni
|
|
FR2992314B1
(fr)
|
2012-06-22 |
2015-10-16 |
Sanofi Sa |
Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
|
|
WO2015105657A1
(en)
*
|
2013-12-19 |
2015-07-16 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount of rna transcripts
|
|
JP2017500319A
(ja)
|
2013-12-20 |
2017-01-05 |
ギリアード カリストガ エルエルシー |
(s)−2−(1−(9h−プリン−6−イルアミノ)プロピル)−5−フルオロ−3−フェニルキナゾリン−4(3h)−オンの塩酸塩の多形形態
|
|
EP3083630B1
(en)
|
2013-12-20 |
2019-08-21 |
Gilead Calistoga LLC |
Process methods for phosphatidylinositol 3-kinase inhibitors
|
|
US11021467B2
(en)
|
2014-06-13 |
2021-06-01 |
Gilead Sciences, Inc. |
Phosphatidylinositol 3-kinase inhibitors
|
|
EP3298017B1
(en)
*
|
2015-05-20 |
2019-08-14 |
H. Hoffnabb-La Roche Ag |
Compounds for treating spinal muscular atrophy
|
|
EP3310169B1
(en)
|
2015-05-30 |
2023-05-17 |
PTC Therapeutics, Inc. |
Methods for modulating rna splicing
|
|
CA3119019C
(en)
|
2015-12-10 |
2024-06-11 |
Ptc Therapeutics, Inc. |
Compounds and methods for treating huntington's disease
|
|
US11129824B2
(en)
*
|
2015-12-17 |
2021-09-28 |
Biokine Therapeutics Ltd. |
Small molecules for inhibiting chemokine activity and/or cancer cells growth
|
|
US10646465B2
(en)
|
2015-12-17 |
2020-05-12 |
Biokine Therapeutics Ltd. |
Small molecules against cancer
|
|
US11091483B2
(en)
*
|
2016-08-12 |
2021-08-17 |
Madera Therapeutics, LLC |
Protein kinase regulators
|
|
JP2019535789A
(ja)
|
2016-11-28 |
2019-12-12 |
ピーティーシー セラピューティクス,インコーポレーテッド |
Rnaスプライシングを調節する方法
|
|
WO2018140730A1
(en)
|
2017-01-27 |
2018-08-02 |
Signalrx Pharmaceuticals, Inc. |
Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors
|
|
EP4151627A1
(en)
|
2017-06-05 |
2023-03-22 |
PTC Therapeutics, Inc. |
Compounds for treating huntington's disease
|
|
CN111372611A
(zh)
|
2017-06-14 |
2020-07-03 |
Ptc医疗公司 |
修饰rna剪接的方法
|
|
CN111182898B
(zh)
|
2017-06-28 |
2024-04-16 |
Ptc医疗公司 |
用于治疗亨廷顿氏病的方法
|
|
CN111163838B
(zh)
|
2017-06-28 |
2023-03-28 |
Ptc医疗公司 |
用于治疗亨廷顿氏病的方法
|
|
BR112020019373A2
(pt)
|
2018-03-27 |
2020-12-29 |
Ptc Therapeutics, Inc. |
Compostos para o tratamento da doença de hutington
|
|
KR20210038845A
(ko)
|
2018-06-27 |
2021-04-08 |
피티씨 테라퓨틱스, 인크. |
헌팅턴병 치료를 위한 헤테로아릴 화합물
|
|
IL279688B2
(en)
|
2018-06-27 |
2025-01-01 |
Ptc Therapeutics Inc |
Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
|
|
WO2020005882A1
(en)
|
2018-06-27 |
2020-01-02 |
Ptc Therapeutics, Inc. |
Heteroaryl compounds for treating huntington's disease
|
|
CN109748914B
(zh)
*
|
2018-12-29 |
2021-05-25 |
上海珂臻医药科技有限公司 |
吡啶并嘧啶类化合物及其应用
|
|
CA3139821A1
(en)
|
2019-05-13 |
2020-11-19 |
Ptc Therapeutics, Inc. |
Compounds for treating huntington's disease
|
|
CA3090315C
(en)
|
2019-05-15 |
2023-09-19 |
Biokine Therapeutics Ltd. |
8-phenoxy-quinolinone derivatives for treating cancer, inhibiting chemokine activity and/or inducing cell death
|
|
AR121719A1
(es)
|
2020-04-03 |
2022-06-29 |
Petra Pharma Corp |
Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
|
|
CN111533721B
(zh)
*
|
2020-05-15 |
2022-04-26 |
浙江大学 |
苯并吡喃酮或喹啉酮类化合物及其应用
|
|
WO2021247859A1
(en)
*
|
2020-06-03 |
2021-12-09 |
Yumanity Therapeutics, Inc. |
Pyridopyrimidines and methods of their use
|
|
WO2022082030A2
(en)
|
2020-10-15 |
2022-04-21 |
Gritstone Bio, Inc. |
Antigen-binding proteins and related methods of use
|
|
WO2022155503A1
(en)
|
2021-01-14 |
2022-07-21 |
Gritstone Bio, Inc. |
Multi-specific antibodies and methods of use
|
|
CN117615763A
(zh)
*
|
2021-02-01 |
2024-02-27 |
健道生物医药有限公司 |
磷酸肌醇3激酶β抑制剂及其组合物和制备方法
|
|
CA3217937A1
(en)
|
2021-05-03 |
2022-11-10 |
Erin Danielle ANDERSON |
Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
|
|
MX2023013987A
(es)
|
2021-05-27 |
2024-02-12 |
Petra Pharma Corp |
Inhibidores alostéricos de cromenona de la fosfoinosítido 3-quinasa (pi3k) para el tratamiento contra el cáncer.
|
|
TW202329930A
(zh)
|
2021-09-30 |
2023-08-01 |
美商佩特拉製藥公司 |
用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
|
|
EP4412606A4
(en)
*
|
2021-10-07 |
2025-09-24 |
Relay Therapeutics Inc |
PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
|
|
AU2024406047A1
(en)
*
|
2023-12-19 |
2026-07-16 |
Merck Sharp & Dohme Llc |
Agonists of trem2 activity
|