BRPI0414171A - benzo[b]tiofenos halossubstituìdos com atividade inibidora de pi3k como agentes terapêuticos - Google Patents
benzo[b]tiofenos halossubstituìdos com atividade inibidora de pi3k como agentes terapêuticosInfo
- Publication number
- BRPI0414171A BRPI0414171A BRPI0414171-7A BRPI0414171A BRPI0414171A BR PI0414171 A BRPI0414171 A BR PI0414171A BR PI0414171 A BRPI0414171 A BR PI0414171A BR PI0414171 A BRPI0414171 A BR PI0414171A
- Authority
- BR
- Brazil
- Prior art keywords
- halosubstituted
- thiophenes
- benzo
- therapeutic agents
- inhibitory activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"BENZO¢B!TIOFENOS HALOSSUBSTITUìDOS COM ATIVIDADE INIBIDORA DE PI3K COMO AGENTES TERAPêUTICOS". A presente invenção refere-se a benzo¢bltiofenos de fórmula (1), em que R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, R¬ 7¬, Y e L têm qualquer dos valores para eles definidos na especificação, e os sais farmaceuticamente aceitáveis dos mesmos, que são úteis como agentes no tratamento de doenças e condições, incluindo doenças inflamatórias, doenças cardiovasculares e cânceres. Também estão proporcionadas composições farmacêuticas que compreendem um ou mais compostos de fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50003803P | 2003-09-04 | 2003-09-04 | |
PCT/IB2004/002730 WO2005023800A1 (en) | 2003-09-04 | 2004-08-23 | Halo substituted benzo`b! thiophenes with pi3k inhibitory activity as therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414171A true BRPI0414171A (pt) | 2006-10-31 |
Family
ID=34272904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414171-7A BRPI0414171A (pt) | 2003-09-04 | 2004-08-23 | benzo[b]tiofenos halossubstituìdos com atividade inibidora de pi3k como agentes terapêuticos |
Country Status (7)
Country | Link |
---|---|
US (1) | US20050096350A1 (pt) |
EP (1) | EP1664037A1 (pt) |
JP (1) | JP2007504209A (pt) |
BR (1) | BRPI0414171A (pt) |
CA (1) | CA2536930A1 (pt) |
MX (1) | MXPA06002513A (pt) |
WO (1) | WO2005023800A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004108713A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | Cycloalkyl and heterocycloalkyl substituted benzothiophenes as therapeutic agents |
US8352407B2 (en) * | 2008-01-21 | 2013-01-08 | Hewlett-Packard Development Company, L.P. | Systems and methods for modeling consequences of events |
US8637557B2 (en) | 2009-10-19 | 2014-01-28 | Taisho Pharmaceutical Co., Ltd | Aminothiazole derivative |
EP3594343B1 (en) | 2015-07-23 | 2021-04-21 | Institut Curie | Use of a combination of dbait molecule and parp inhibitors to treat cancer |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
JP2021515580A (ja) | 2018-03-13 | 2021-06-24 | オンクセオOnxeo | がんの治療における獲得耐性に対抗するdbait分子 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE58555B1 (en) * | 1984-12-10 | 1993-10-06 | Warner Almbert Company | Novel benzothiophenes and benzofurans having antiallergy activity |
EP0253650A3 (en) * | 1986-07-18 | 1989-09-13 | Eli Lilly And Company | Improvements relating to benzothiophene derivatives |
US4910317A (en) * | 1987-07-14 | 1990-03-20 | Warner-Lambert Company | Benzofurans and benzothiophenes having antiallergic activity and method of use thereof |
IE64995B1 (en) * | 1987-07-14 | 1995-09-20 | Warner Lambert Co | Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome |
CA2398163C (en) * | 2000-01-24 | 2011-02-22 | Kinacia Pty Ltd. | Therapeutic morpholino-substituted compounds |
CN1173975C (zh) * | 2000-04-27 | 2004-11-03 | 山之内制药株式会社 | 咪唑并吡啶衍生物 |
-
2004
- 2004-08-23 BR BRPI0414171-7A patent/BRPI0414171A/pt not_active IP Right Cessation
- 2004-08-23 JP JP2006525195A patent/JP2007504209A/ja active Pending
- 2004-08-23 MX MXPA06002513A patent/MXPA06002513A/es unknown
- 2004-08-23 EP EP04769160A patent/EP1664037A1/en not_active Withdrawn
- 2004-08-23 WO PCT/IB2004/002730 patent/WO2005023800A1/en not_active Application Discontinuation
- 2004-08-23 CA CA002536930A patent/CA2536930A1/en not_active Abandoned
- 2004-09-07 US US10/935,356 patent/US20050096350A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20050096350A1 (en) | 2005-05-05 |
JP2007504209A (ja) | 2007-03-01 |
EP1664037A1 (en) | 2006-06-07 |
CA2536930A1 (en) | 2005-03-17 |
WO2005023800A1 (en) | 2005-03-17 |
MXPA06002513A (es) | 2006-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |