BRPI0412130A - compostos tetracìclicos como inibidores de c-met - Google Patents

compostos tetracìclicos como inibidores de c-met

Info

Publication number
BRPI0412130A
BRPI0412130A BRPI0412130-9A BRPI0412130A BRPI0412130A BR PI0412130 A BRPI0412130 A BR PI0412130A BR PI0412130 A BRPI0412130 A BR PI0412130A BR PI0412130 A BRPI0412130 A BR PI0412130A
Authority
BR
Brazil
Prior art keywords
compounds
met
met inhibitors
tetracyclic compounds
tetracyclic
Prior art date
Application number
BRPI0412130-9A
Other languages
English (en)
Inventor
Tomas Vojkovsky
Marcel Koenig
Fang-Jie Zhang
Jingrong Cui
Original Assignee
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Publication of BRPI0412130A publication Critical patent/BRPI0412130A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSTOS TETRACìCLICOS COMO INIBIDORES DE C-MET". A presente invenção refere-se a compostos de fórmulas (I) e (II), em que R~ 1~-R~ 10~ e G são definidos neste documento e os sais farmaceuticamente aceitáveis dos mesmos. Estes compostos modulam a atividade de c-Met e portanto espera-se que sejam úteis na prevenção e tratamento de distúrbios relacionados com c-Met, como seja o câncer.
BRPI0412130-9A 2003-07-02 2004-06-30 compostos tetracìclicos como inibidores de c-met BRPI0412130A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48422203P 2003-07-02 2003-07-02
US10/878,632 US7037909B2 (en) 2003-07-02 2004-06-29 Tetracyclic compounds as c-Met inhibitors
PCT/US2004/020929 WO2005004808A2 (en) 2003-07-02 2004-06-30 TETRACYCLIC COMPOUNDS AS c-MET INHIBITORS

Publications (1)

Publication Number Publication Date
BRPI0412130A true BRPI0412130A (pt) 2006-08-15

Family

ID=34068190

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412130-9A BRPI0412130A (pt) 2003-07-02 2004-06-30 compostos tetracìclicos como inibidores de c-met

Country Status (6)

Country Link
US (1) US7037909B2 (pt)
JP (1) JP2007521299A (pt)
BR (1) BRPI0412130A (pt)
CA (1) CA2529323A1 (pt)
MX (1) MXPA06000166A (pt)
WO (1) WO2005004808A2 (pt)

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US8652786B2 (en) * 2005-04-05 2014-02-18 The General Hospital Corporation Method for predicting responsiveness to drugs
CN101198590B (zh) 2005-08-24 2012-05-09 卫材R&D管理有限公司 吡啶衍生物及嘧啶衍生物（3）
ME02736B (me) * 2005-12-21 2017-10-20 Janssen Pharmaceutica Nv Triazolopiridazini kao modulatori tirozin kinaze
JP2009529047A (ja) 2006-03-07 2009-08-13 アレイ バイオファーマ、インコーポレイテッド ヘテロ二環系ピラゾール化合物およびその使用
WO2008021781A1 (en) 2006-08-07 2008-02-21 Incyte Corporation Triazolotriazines as kinase inhibitors
CA2661333C (en) 2006-08-23 2014-08-05 Eisai R&D Management Co., Ltd. Salt of phenoxypyridine derivative or crystal thereof and process for producing the same
US7790885B2 (en) 2006-08-31 2010-09-07 Eisai R&D Management Co., Ltd. Process for preparing phenoxypyridine derivatives
CL2007003049A1 (es) 2006-10-23 2008-05-16 Cephalon Inc Pharmacopeia Drug Compuestos derivados de 2,4-diaminopirimidina; composicion farmaceutica, utiles para tratar trastornos proliferativos.
HUE026659T2 (en) 2006-11-22 2016-07-28 Incyte Holdings Corp Imidazotriazines and imidazopyrimidines as kinase inhibitors
JP2009132660A (ja) 2007-11-30 2009-06-18 Eisai R & D Management Co Ltd 食道癌治療用組成物
EP2265614A1 (en) 2008-02-28 2010-12-29 Novartis AG Imidazo [1,2-b]pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease
US20110092452A1 (en) * 2008-03-05 2011-04-21 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating pancreatic cancer
SI2300455T1 (sl) 2008-05-21 2017-12-29 Incyte Holdings Corporation Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo
TW201035088A (en) 2009-02-27 2010-10-01 Supergen Inc Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
SI2513115T1 (sl) 2009-12-18 2014-02-28 Basilea Pharmaceutica Ag Triciklični antibiotiki
AU2011269788B2 (en) 2010-02-03 2015-12-10 Incyte Holdings Corporation Imidazo[1,2-b][1,2,4]triazines as c-Met inhibitors
CN102532141A (zh) 2010-12-08 2012-07-04 中国科学院上海药物研究所 [1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途
ES2596369T3 (es) 2011-06-17 2017-01-09 Basilea Pharmaceutica Ag Antibióticos N-heterotricíclicos
US20140348819A1 (en) 2011-06-24 2014-11-27 Dana-Farber Cancer Institute, Inc. Methods of Treating Cancer
CN102503959B (zh) * 2011-10-25 2015-04-08 南方医科大学 一种稠三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
CN104250257B (zh) * 2013-06-25 2017-06-16 上海翰森生物医药科技有限公司 3,4‑二氢‑1H‑苯并[c][1,2]噁硼酸类化合物或其可药用盐及其制备方法和用途
MX2016012285A (es) 2014-03-24 2017-01-23 Genentech Inc Tratamiento de cáncer con antagonista de c-met y correlación de estos con la expresión de hgf.
CN105272995B (zh) 2015-09-24 2017-10-27 上海海聚生物科技有限公司 喹啉类衍生物、其药物组合物、制备方法及应用
CN106278988A (zh) * 2016-08-12 2017-01-04 合肥久诺医药科技有限公司 一种溴芬酸钠杂质标准品的合成方法

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CH606334A5 (pt) * 1974-06-21 1978-10-31 Ciba Geigy Ag
US4159375A (en) * 1978-08-24 1979-06-26 American Cyanamid Company 6- AND 7-Aryl-1,2,4-triazolo[4,3-b]-1,2,4-triazines
US4405619A (en) * 1981-09-02 1983-09-20 Diamond Shamrock Corporation Antiinflammatory substituted-1,2,4-triazolo[4,3-b]-1,2,4-triazines
EP0717143A1 (de) 1994-12-16 1996-06-19 Lignozym GmbH Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung
EP0845026A1 (de) 1996-06-19 1998-06-03 CALL, Hans-Peter Dr. Mehrkomponentensystem zur verwendung mit waschaktiven substanzen
DE19726241A1 (de) 1997-06-20 1998-12-24 Call Krimhild Erweitertes enzymatisches Multikomponentensystem zur Behandlung von Abwässern, zur Herstellung von Holzverbundstoffen, zum Deinken von Altpapier, Colour stripping von Altpapier, zum Einsatz als Oxidationssystem bei der organischen Synthese und zum Einsatz bei der Kohleverflüssigung

Also Published As

Publication number Publication date
MXPA06000166A (es) 2006-04-27
US7037909B2 (en) 2006-05-02
US20050014755A1 (en) 2005-01-20
WO2005004808A2 (en) 2005-01-20
CA2529323A1 (en) 2005-01-20
WO2005004808A3 (en) 2005-03-17
JP2007521299A (ja) 2007-08-02

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]