GB1023205A - -triazino(5,6-6) indoles - Google Patents

-triazino(5,6-6) indoles

Info

Publication number
GB1023205A
GB1023205A GB36551/63A GB3655163A GB1023205A GB 1023205 A GB1023205 A GB 1023205A GB 36551/63 A GB36551/63 A GB 36551/63A GB 3655163 A GB3655163 A GB 3655163A GB 1023205 A GB1023205 A GB 1023205A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
cyclizing
optionally substituted
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36551/63A
Inventor
Jan Mieczyslaw Zygmunt Gladych
John Harold Hunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Priority to GB36551/63A priority Critical patent/GB1023205A/en
Priority to GB3519064D priority patent/GB1023720A/en
Priority to BE653091D priority patent/BE653091A/xx
Priority to DE19641445453 priority patent/DE1445453C/en
Priority to DE19641645936 priority patent/DE1645936A1/en
Priority to DE19641645935 priority patent/DE1645935A1/en
Priority to NL646410715A priority patent/NL139235B/en
Priority to DE19641445454 priority patent/DE1445454A1/en
Priority to BE653089D priority patent/BE653089A/xx
Priority to US396721A priority patent/US3312699A/en
Priority to DE19641645934 priority patent/DE1645934A1/en
Priority to FR988258A priority patent/FR1455036A/en
Priority to FR988257A priority patent/FR3963M/fr
Priority to NL6410823A priority patent/NL6410823A/xx
Priority to FR988451A priority patent/FR3964M/fr
Priority to FR1588752D priority patent/FR1588752A/fr
Publication of GB1023205A publication Critical patent/GB1023205A/en
Priority to US745129A priority patent/US3466282A/en
Priority to US74588*[A priority patent/US3493569A/en
Priority to US745126A priority patent/US3467657A/en
Priority to US745086A priority patent/US3493571A/en
Priority to US745089A priority patent/US3510482A/en
Priority to US745124A priority patent/US3466281A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Abstract

The invention comprises imidazo, pyrimido and triazolo-as-triazino-(5,6-b)-indoles of the formula <FORM:1023205/C2/1> wherein R is H or an alkyl or aralkyl group, X is a radical of the formula <FORM:1023205/C2/2> wherein R1 is H, OH, alkyl or phenyl, optionally substituted by one or more halogen atoms and/or one or more alkyl groups and their acid addition and quaternary ammonium salts and the preparation thereof (wherein X is -CR1= N-) by condensing isatin with a 3,4-diamino-1,2,4-triazole of the formula <FORM:1023205/C2/3> or by cyclizing a compound of the formula <FORM:1023205/C2/4> with urea or a carboxylic acid R2COOH, where R2 is H, alkyl or phenyl optionally substituted by one or more halogen atoms and/or one or more alkyl radicals; or (where X is -CH2-CH2CH2-or -CH2.CH2-) by cyclizing a compound of the formula <FORM:1023205/C2/5> with a cyclizing agent, e.g. POCl3. Pharmaceutical compositions having antiviral or antibacterial properties comprise the products of the invention together with a pharmaceutical carrier therefor. The compositions may be formulated as tablets, capsules, suppositories and solutions for injection.
GB36551/63A 1963-09-17 1963-09-17 -triazino(5,6-6) indoles Expired GB1023205A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GB36551/63A GB1023205A (en) 1963-09-17 1963-09-17 -triazino(5,6-6) indoles
GB3519064D GB1023720A (en) 1963-09-17 1963-09-17 as-triazino (5,6-b)indoles
BE653091D BE653091A (en) 1963-09-17 1964-09-15
DE19641445453 DE1445453C (en) 1963-09-17 1964-09-15 s-Triazolo square bracket to 4, 3, -2,3 square bracket to -as-triazino square bracket to 5,6-square bracket to indole, process for their preparation and medicinal products
DE19641645936 DE1645936A1 (en) 1963-09-17 1964-09-15 Process for the preparation of basic substituted as-triazino (5,6-b) indoles
DE19641645935 DE1645935A1 (en) 1963-09-17 1964-09-15 Process for the preparation of as-triazino (5,6-b) indoles
NL646410715A NL139235B (en) 1963-09-17 1964-09-15 PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH AN ANTIVIRUS ACTION AND SUITABLE THERAPEUTICALLY EFFECTIVE HETEROCYCLICAL COMPOUNDS.
DE19641445454 DE1445454A1 (en) 1963-09-17 1964-09-15 3-Mercapto-as-triazino (5,6-b) indoles and process for their preparation
BE653089D BE653089A (en) 1963-09-17 1964-09-15
US396721A US3312699A (en) 1963-09-17 1964-09-15 Asymmetric triazino indoles
DE19641645934 DE1645934A1 (en) 1963-09-17 1964-09-15 Imidazo- or pyrimidino-as-triazino (5,6-b) indoles and processes for their preparation
FR988258A FR1455036A (en) 1963-09-17 1964-09-16 Process for the preparation of new heterocyclic compounds
FR988257A FR3963M (en) 1963-09-17 1964-09-16
NL6410823A NL6410823A (en) 1963-09-17 1964-09-17
FR988451A FR3964M (en) 1963-09-17 1964-09-17
FR1588752D FR1588752A (en) 1963-09-17 1964-09-17
US745129A US3466282A (en) 1963-09-17 1968-07-16 As-triazino(5,6-b)indoles
US74588*[A US3493569A (en) 1963-09-17 1968-07-16 3-aminoalkylthio-as-triazino(5,6-b)-indoles
US745126A US3467657A (en) 1963-09-17 1968-07-16 As-triazino(5,6-b)indoles
US745086A US3493571A (en) 1963-09-17 1968-07-16 As-triazino(5,6-b)indoles
US745089A US3510482A (en) 1963-09-17 1968-07-16 As-triazino(5,6-b)-3-amino indoles
US745124A US3466281A (en) 1963-09-17 1968-07-16 As-triazino(5,6-b)indoles

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB36551/63A GB1023205A (en) 1963-09-17 1963-09-17 -triazino(5,6-6) indoles
GB716864 1964-02-20
GB716964 1964-02-20

Publications (1)

Publication Number Publication Date
GB1023205A true GB1023205A (en) 1966-03-23

Family

ID=27254975

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36551/63A Expired GB1023205A (en) 1963-09-17 1963-09-17 -triazino(5,6-6) indoles

Country Status (5)

Country Link
BE (2) BE653091A (en)
DE (1) DE1445454A1 (en)
FR (4) FR3963M (en)
GB (1) GB1023205A (en)
NL (2) NL139235B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452013A (en) * 1964-08-27 1969-06-24 Allen & Hanburys Ltd As-triazino(5,6-b)indoles

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493569A (en) * 1963-09-17 1970-02-03 Allen & Hanburys Ltd 3-aminoalkylthio-as-triazino(5,6-b)-indoles
US3453276A (en) * 1966-10-06 1969-07-01 Smithkline Corp Triazinoindole compounds
US3480628A (en) * 1967-12-22 1969-11-25 Smithkline Corp 3-chlorotriazinoindoles
US7037909B2 (en) 2003-07-02 2006-05-02 Sugen, Inc. Tetracyclic compounds as c-Met inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452013A (en) * 1964-08-27 1969-06-24 Allen & Hanburys Ltd As-triazino(5,6-b)indoles

Also Published As

Publication number Publication date
FR3964M (en) 1966-02-28
DE1445453A1 (en) 1968-12-19
FR1455036A (en) 1966-04-01
NL6410715A (en) 1965-03-18
FR3963M (en) 1966-02-28
BE653089A (en) 1964-12-31
DE1445454A1 (en) 1968-12-19
BE653091A (en) 1964-12-31
NL6410823A (en) 1965-03-18
NL139235B (en) 1973-07-16
FR1588752A (en) 1970-03-16

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