IT1403156B1 - Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi. - Google Patents

Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi.

Info

Publication number
IT1403156B1
IT1403156B1 ITTO2010A000956A ITTO20100956A IT1403156B1 IT 1403156 B1 IT1403156 B1 IT 1403156B1 IT TO2010A000956 A ITTO2010A000956 A IT TO2010A000956A IT TO20100956 A ITTO20100956 A IT TO20100956A IT 1403156 B1 IT1403156 B1 IT 1403156B1
Authority
IT
Italy
Prior art keywords
chinase
phosphatidylinositol
inhibitors
related compositions
compositions
Prior art date
Application number
ITTO2010A000956A
Other languages
English (en)
Inventor
Elisa Ciraolo
Emilio Hirsch
Alberto Massarotti
Giovanni Sorba
Tracey Pirali
Gian Cesare Tron
Ubaldina Galli
Original Assignee
Università Degli Studi Di Torino
Università Degli Studi Del Piemonte Orientale Amedeo Avogadro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Università Degli Studi Di Torino, Università Degli Studi Del Piemonte Orientale Amedeo Avogadro filed Critical Università Degli Studi Di Torino
Priority to ITTO2010A000956A priority Critical patent/IT1403156B1/it
Priority to EP11799850.0A priority patent/EP2646427B1/en
Priority to US13/988,979 priority patent/US8841288B2/en
Priority to CN201180057822.8A priority patent/CN103237797B/zh
Priority to PCT/IB2011/055346 priority patent/WO2012073184A1/en
Publication of ITTO20100956A1 publication Critical patent/ITTO20100956A1/it
Application granted granted Critical
Publication of IT1403156B1 publication Critical patent/IT1403156B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ITTO2010A000956A 2010-12-01 2010-12-01 Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi. IT1403156B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITTO2010A000956A IT1403156B1 (it) 2010-12-01 2010-12-01 Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi.
EP11799850.0A EP2646427B1 (en) 2010-12-01 2011-11-28 Quinolin-4(1h)-one derivatives as inhibitors of phosphatidylinositol 3-kinases
US13/988,979 US8841288B2 (en) 2010-12-01 2011-11-28 Quinolin-4 (1H)-one derivatives as inhibitors of phosphatidylinositol 3-kinases
CN201180057822.8A CN103237797B (zh) 2010-12-01 2011-11-28 作为磷脂酰肌醇3-激酶抑制剂的喹啉-4(1h)-酮衍生物
PCT/IB2011/055346 WO2012073184A1 (en) 2010-12-01 2011-11-28 Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITTO2010A000956A IT1403156B1 (it) 2010-12-01 2010-12-01 Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi.

Publications (2)

Publication Number Publication Date
ITTO20100956A1 ITTO20100956A1 (it) 2012-06-02
IT1403156B1 true IT1403156B1 (it) 2013-10-04

Family

ID=43737348

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO2010A000956A IT1403156B1 (it) 2010-12-01 2010-12-01 Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi.

Country Status (5)

Country Link
US (1) US8841288B2 (it)
EP (1) EP2646427B1 (it)
CN (1) CN103237797B (it)
IT (1) IT1403156B1 (it)
WO (1) WO2012073184A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35675A (es) 2013-07-24 2015-02-27 Novartis Ag Derivados sustituidos de quinazolin-4-ona
WO2015153498A1 (en) * 2014-03-31 2015-10-08 Epitherapeutics, Aps Inhibitors of histone demethylases
CN104496966B (zh) * 2014-12-24 2017-03-08 广西师范大学 用邻苯二胺、苯乙炔和叠氮合成喹喔啉‑三氮唑类化合物的方法
CN106008479B (zh) 2015-03-06 2020-01-10 南京圣和药业股份有限公司 作为磷脂酰肌醇3-激酶δ抑制剂的取代嘧啶类化合物及其应用
CN105936635B (zh) * 2015-03-06 2019-06-21 南京圣和药业股份有限公司 作为磷脂酰肌醇3-激酶δ抑制剂的化合物及其应用
CA3098348A1 (en) 2018-04-29 2019-11-07 Beigene, Ltd. Bcl-2 inhibitors
CN110204489B (zh) * 2019-07-09 2022-08-02 陕西师范大学 使用固体羰基源的喹诺酮类化合物安全合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1257537T3 (da) * 2000-01-24 2007-10-01 Astrazeneca Ab Terapeutiske morpholino-substituerede forbindelser
JP4646626B2 (ja) * 2002-08-16 2011-03-09 アストラゼネカ アクチボラグ ホスホイノシチド３−キナーゼβの阻害

Also Published As

Publication number Publication date
ITTO20100956A1 (it) 2012-06-02
EP2646427A1 (en) 2013-10-09
US20130245005A1 (en) 2013-09-19
CN103237797B (zh) 2016-01-20
US8841288B2 (en) 2014-09-23
WO2012073184A1 (en) 2012-06-07
EP2646427B1 (en) 2016-02-03
CN103237797A (zh) 2013-08-07

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