NZ520300A - Morpholino-substituted pyridopyrimidine, quinolone and benzopyranone derivatives that inhibit the enzyme phosphoinositide (PI) 3-kinase - Google Patents
Morpholino-substituted pyridopyrimidine, quinolone and benzopyranone derivatives that inhibit the enzyme phosphoinositide (PI) 3-kinaseInfo
- Publication number
- NZ520300A NZ520300A NZ520300A NZ52030001A NZ520300A NZ 520300 A NZ520300 A NZ 520300A NZ 520300 A NZ520300 A NZ 520300A NZ 52030001 A NZ52030001 A NZ 52030001A NZ 520300 A NZ520300 A NZ 520300A
- Authority
- NZ
- New Zealand
- Prior art keywords
- aryl
- chr3
- tgx
- compound
- substituted
- Prior art date
Links
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- 150000003906 phosphoinositides Chemical class 0.000 title abstract description 18
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- 150000001875 compounds Chemical class 0.000 claims abstract description 109
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 claims abstract description 35
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS604170A (ja) * | 1983-06-21 | 1985-01-10 | Nippon Shinyaku Co Ltd | キノロン誘導体 |
| US5703075A (en) * | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| JPH04502322A (ja) | 1988-12-21 | 1992-04-23 | ジ・アップジョン・カンパニー | 抗アテローム性動脈硬化症性および抗血栓性１―ベンゾピラン―４―オン類および２―アミノ―１，３―ベンゾオキサジン―４―オン類 |
| JPH05509302A (ja) | 1990-06-20 | 1993-12-22 | ジ・アップジョン・カンパニー | 抗アテローム性動脈硬化性および抗血栓性１―ベンゾピラン―４―オン類および２―アミノ―１，３―ベンゾオキサジン―４―オン類 |
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2001
- 2001-01-24 CN CNB018067522A patent/CN1263743C/zh not_active Expired - Fee Related
- 2001-01-24 AT AT01902568T patent/ATE363471T1/de active
- 2001-01-24 DK DK01902568T patent/DK1257537T3/da active
- 2001-01-24 AU AU3042601A patent/AU3042601A/xx active Pending
- 2001-01-24 CN CNA2006100847155A patent/CN1891699A/zh active Pending
- 2001-01-24 PT PT01902568T patent/PT1257537E/pt unknown
- 2001-01-24 EP EP01902568A patent/EP1257537B1/en not_active Expired - Lifetime
- 2001-01-24 EP EP07009194A patent/EP1857443B1/en not_active Expired - Lifetime
- 2001-01-24 WO PCT/IB2001/000079 patent/WO2001053266A1/en not_active Ceased
- 2001-01-24 CA CA2398163A patent/CA2398163C/en not_active Expired - Fee Related
- 2001-01-24 AU AU2001230426A patent/AU2001230426C1/en not_active Ceased
- 2001-01-24 US US10/181,485 patent/US6977255B2/en not_active Expired - Fee Related
- 2001-01-24 DE DE60128655T patent/DE60128655T2/de not_active Expired - Lifetime
- 2001-01-24 JP JP2001553268A patent/JP4820518B2/ja not_active Expired - Fee Related
- 2001-01-24 NZ NZ520300A patent/NZ520300A/en not_active IP Right Cessation
- 2001-01-24 ES ES01902568T patent/ES2286093T3/es not_active Expired - Lifetime
- 2001-01-24 AT AT07009194T patent/ATE551325T1/de active
- 2001-01-24 CN CNA200610084723XA patent/CN1891693A/zh active Pending
-
2004
- 2004-10-12 US US10/961,062 patent/US7405211B2/en not_active Expired - Fee Related
-
2007
- 2007-07-20 CY CY20071100971T patent/CY1108023T1/el unknown
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2008
- 2008-01-24 US US12/019,061 patent/US7572791B2/en not_active Expired - Fee Related
- 2008-05-06 US US12/115,563 patent/US20080312233A1/en not_active Abandoned
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Owner name: ASTRAZENECA AB, SE Free format text: OLD OWNER(S): KINACIA PTY LTD. |
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| RENW | Renewal (renewal fees accepted) | ||
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