FR2969612B1 - Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique - Google Patents

Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique

Info

Publication number
FR2969612B1
FR2969612B1 FR1061194A FR1061194A FR2969612B1 FR 2969612 B1 FR2969612 B1 FR 2969612B1 FR 1061194 A FR1061194 A FR 1061194A FR 1061194 A FR1061194 A FR 1061194A FR 2969612 B1 FR2969612 B1 FR 2969612B1
Authority
FR
France
Prior art keywords
imidazo
pyrimidin
dihydro
derivatives
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1061194A
Other languages
English (en)
Other versions
FR2969612A1 (fr
Inventor
Jerome Arigon
Maurice Brollo
Jacques Clement
Ahmad Youssef El
Jean Robert Labrosse
Baptiste Ronan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1061194A priority Critical patent/FR2969612B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to PT11799724T priority patent/PT2655375E/pt
Priority to ES11799724.7T priority patent/ES2531465T3/es
Priority to SI201130400T priority patent/SI2655375T1/sl
Priority to PL11799724T priority patent/PL2655375T3/pl
Priority to US13/996,866 priority patent/US8815853B2/en
Priority to HUE11799724A priority patent/HUE024504T2/en
Priority to DK11799724.7T priority patent/DK2655375T3/en
Priority to PCT/EP2011/073874 priority patent/WO2012085244A1/fr
Priority to EP11799724.7A priority patent/EP2655375B1/fr
Publication of FR2969612A1 publication Critical patent/FR2969612A1/fr
Application granted granted Critical
Publication of FR2969612B1 publication Critical patent/FR2969612B1/fr
Priority to HRP20150235TT priority patent/HRP20150235T1/hr
Priority to CY20151100220T priority patent/CY1116100T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR1061194A 2010-12-23 2010-12-23 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique Expired - Fee Related FR2969612B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR1061194A FR2969612B1 (fr) 2010-12-23 2010-12-23 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique
PCT/EP2011/073874 WO2012085244A1 (fr) 2010-12-23 2011-12-22 Derives de pyrimidinone, leur preparation et leur utilisation pharmaceutique
SI201130400T SI2655375T1 (sl) 2010-12-23 2011-12-22 Derivati pirimidinona, njihova priprava in njihova farmacevtska uporaba
PL11799724T PL2655375T3 (pl) 2010-12-23 2011-12-22 Pochodne pirymidynonu, ich wytwarzanie i ich farmaceutyczne zastosowanie
US13/996,866 US8815853B2 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
HUE11799724A HUE024504T2 (en) 2010-12-23 2011-12-22 Pyrimidine derivatives, a process for their preparation and their use in medicine
PT11799724T PT2655375E (pt) 2010-12-23 2011-12-22 Derivados de pirimidinona, sua preparação e sua utilização farmacêutica
ES11799724.7T ES2531465T3 (es) 2010-12-23 2011-12-22 Derivados de pirimidinona, su preparación y su utilización farmacéutica
EP11799724.7A EP2655375B1 (fr) 2010-12-23 2011-12-22 Derives de pyrimidinone, leur preparation et leur utilisation pharmaceutique
DK11799724.7T DK2655375T3 (en) 2010-12-23 2011-12-22 PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF
HRP20150235TT HRP20150235T1 (hr) 2010-12-23 2015-03-02 Derivati pirimidina, njihovo dobivanje i njihova farmaceutska upotreba
CY20151100220T CY1116100T1 (el) 2010-12-23 2015-03-03 Παραγωγα πυριμιδινονης, η παρασκευη τους και η φαρμακευτικη τους χρηση

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1061194A FR2969612B1 (fr) 2010-12-23 2010-12-23 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique

Publications (2)

Publication Number Publication Date
FR2969612A1 FR2969612A1 (fr) 2012-06-29
FR2969612B1 true FR2969612B1 (fr) 2013-02-08

Family

ID=44201979

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1061194A Expired - Fee Related FR2969612B1 (fr) 2010-12-23 2010-12-23 Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique

Country Status (1)

Country Link
FR (1) FR2969612B1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014053568A1 (fr) * 2012-10-02 2014-04-10 Sanofi Dérivés d'indolyldihydroimidazopyrimidinone, leur préparation et utilisation thérapeutique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1257537E (pt) * 2000-01-24 2007-08-03 Astrazeneca Ab Compostos terapêuticos morfolino-substituídos.
US7598377B2 (en) * 2002-08-16 2009-10-06 Astrazeneca Ab Inhibition of phosphoinositide 3-kinase β
WO2008148074A2 (fr) * 2007-05-24 2008-12-04 Research Foundation Of State University Of New York Inhibiteurs de mtor et methodes de traitement mettant en œuvre ces inhibiteurs
CN101925601A (zh) * 2008-01-25 2010-12-22 阿斯利康(瑞典)有限公司 对映异构体纯(-)2-[1-(7-甲基-2-(吗啉-4-基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-9-基)乙氨基]苯甲酸、其在医学疗法中的用途及包含其的药物组合物-026
AU2010267814B2 (en) * 2009-07-02 2015-07-16 Sanofi Novel 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
FR2969612A1 (fr) 2012-06-29

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