JP2003520195A5 - - Google Patents
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- JP2003520195A5 JP2003520195A5 JP2000617919A JP2000617919A JP2003520195A5 JP 2003520195 A5 JP2003520195 A5 JP 2003520195A5 JP 2000617919 A JP2000617919 A JP 2000617919A JP 2000617919 A JP2000617919 A JP 2000617919A JP 2003520195 A5 JP2003520195 A5 JP 2003520195A5
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- JP
- Japan
- Prior art keywords
- cooh
- alkyl
- substituted
- oxide
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- -1 heteroaryl compound Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 description 7
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 description 1
- 101800004564 Transforming growth factor alpha Proteins 0.000 description 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31228499A | 1999-05-14 | 1999-05-14 | |
| US09/312,284 | 1999-05-14 | ||
| US37402899A | 1999-08-13 | 1999-08-13 | |
| US09/374,028 | 1999-08-13 | ||
| PCT/US2000/011756 WO2000069459A1 (en) | 1999-05-14 | 2000-05-01 | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008244928A Division JP2009120583A (ja) | 1999-05-14 | 2008-09-24 | 上皮成長因子受容体アンタゴニストによる難治性ヒト腫瘍の処理 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003520195A JP2003520195A (ja) | 2003-07-02 |
| JP2003520195A5 true JP2003520195A5 (https=) | 2008-11-13 |
Family
ID=26978320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617919A Pending JP2003520195A (ja) | 1999-05-14 | 2000-05-01 | 上皮成長因子受容体アンタゴニストによる難治性ヒト腫瘍の処理 |
| JP2008244928A Pending JP2009120583A (ja) | 1999-05-14 | 2008-09-24 | 上皮成長因子受容体アンタゴニストによる難治性ヒト腫瘍の処理 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008244928A Pending JP2009120583A (ja) | 1999-05-14 | 2008-09-24 | 上皮成長因子受容体アンタゴニストによる難治性ヒト腫瘍の処理 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20020012663A1 (https=) |
| EP (2) | EP1218032A4 (https=) |
| JP (2) | JP2003520195A (https=) |
| KR (1) | KR20020000223A (https=) |
| CN (1) | CN1200734C (https=) |
| AU (1) | AU782994C (https=) |
| BG (1) | BG106110A (https=) |
| BR (1) | BR0010524A (https=) |
| CA (1) | CA2373815A1 (https=) |
| CZ (1) | CZ20014083A3 (https=) |
| EE (1) | EE200100603A (https=) |
| HK (1) | HK1047236A1 (https=) |
| HU (1) | HUP0201480A3 (https=) |
| IL (1) | IL146480A0 (https=) |
| MX (1) | MXPA01011632A (https=) |
| NO (1) | NO20015546L (https=) |
| PL (1) | PL365999A1 (https=) |
| RU (1) | RU2294761C2 (https=) |
| SK (1) | SK16522001A3 (https=) |
| WO (1) | WO2000069459A1 (https=) |
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| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| HK1047236A1 (zh) * | 1999-05-14 | 2003-02-14 | Imclone Llc | 用表皮生长因子受体拮抗剂治疗难治的人肿瘤 |
| US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
| AU9500201A (en) * | 2000-08-09 | 2002-02-18 | Imclone Systems Inc | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
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| US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
| US7498029B2 (en) | 2001-05-01 | 2009-03-03 | The General Hospital Corporation | Photoimmunotherapies for cancer using combination therapies |
| JP2004528368A (ja) * | 2001-05-08 | 2004-09-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 抗ｅｇｆｒ抗体と抗ホルモン剤を用いた組合せ療法 |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| EP1392359B2 (en) | 2001-05-11 | 2013-03-13 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| KR100719624B1 (ko) * | 2001-05-18 | 2007-05-21 | 석정철 | 시각장애인을 위한 접착형 점자유도블록 및점자유도블록의 접착방법 |
| US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| DK1399484T3 (da) * | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
| MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
| AU2003219029B2 (en) * | 2002-03-08 | 2008-09-11 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V | Use of EGFR transactivation inhibitors in human cancer |
| ES2263984T3 (es) * | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
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| US20060167026A1 (en) * | 2003-01-06 | 2006-07-27 | Hiroyuki Nawa | Antipsychotic molecular-targeting epithelial growth factor receptor |
| EP1599484A2 (en) * | 2003-02-21 | 2005-11-30 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic camptothecin derivatives |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| CN1972712A (zh) | 2003-06-09 | 2007-05-30 | 塞缪尔·瓦克萨尔 | 用胞外拮抗物和胞内拮抗物抑制受体酪氨酸激酶的方法 |
| EP1493445A1 (en) * | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
| EA010485B1 (ru) | 2003-07-23 | 2008-10-30 | Байер Фамэсьютиклс Копэрейшн | Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты) |
| WO2005027970A1 (ja) * | 2003-09-24 | 2005-03-31 | Kyowa Hakko Kogyo Co., Ltd. | 癌治療用医薬 |
| KR100872204B1 (ko) * | 2003-10-15 | 2008-12-09 | 오에스아이 파마슈티컬스, 인코포레이티드 | 이미다조피라진 티로신 키나제 억제제 |
| EP2332990A1 (en) * | 2004-03-19 | 2011-06-15 | Imclone LLC | Human anti-epidermal growth factor receptor antibody |
| TWI378934B (en) * | 2004-04-02 | 2012-12-11 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
| RU2413731C2 (ru) | 2004-04-09 | 2011-03-10 | Чугаи Сейяку Кабусики Кайся | Новые растворимые в воде пролекарства |
| WO2005117877A1 (en) * | 2004-06-03 | 2005-12-15 | F.Hoffmann-La Roche Ag | Treatment with irinotecan (cpt-11) and an egfr-inhibitor |
| KR100881043B1 (ko) * | 2004-06-03 | 2009-01-30 | 에프. 호프만-라 로슈 아게 | 옥살리플라틴 및 ｅｇｆｒ억제제로의 치료 |
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| US20060084691A1 (en) * | 2004-10-18 | 2006-04-20 | Bilal Piperdi | Combined treatment with bortezomib and an epidermal growth factor receptor kinase inhibitor |
| US20070099856A1 (en) * | 2005-05-13 | 2007-05-03 | Gumerlock Paul H | Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen |
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| CA2626330A1 (en) * | 2005-10-19 | 2007-04-26 | Chugai Seiyaku Kabushiki Kaisha | Preventive or therapeutic agents for pancreatic cancer, ovarian cancer, or liver cancer comprising a novel water-solube prodrug |
| WO2007049361A1 (ja) * | 2005-10-27 | 2007-05-03 | Stelic Corp. | 肝線維化抑制剤 |
| CA2632866A1 (en) * | 2005-12-01 | 2007-06-07 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
| US8575164B2 (en) * | 2005-12-19 | 2013-11-05 | OSI Pharmaceuticals, LLC | Combination cancer therapy |
| US20080045589A1 (en) * | 2006-05-26 | 2008-02-21 | Susan Kelley | Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer |
| KR100723641B1 (ko) * | 2006-06-07 | 2007-06-04 | 실버레이 주식회사 | 다중 조리가 가능한 솥 |
| US20070286864A1 (en) * | 2006-06-09 | 2007-12-13 | Buck Elizabeth A | Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors |
| WO2008046107A2 (en) * | 2006-10-13 | 2008-04-17 | The Regents Of The University Of California | Novel inhibitors of the egfr kinase targeting the asymmetric activating dimer interface |
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| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| WO2009067548A1 (en) * | 2007-11-19 | 2009-05-28 | The Regents Of The University Of California | Novel assay for inhibitors of egfr |
| JP2011510018A (ja) * | 2008-01-18 | 2011-03-31 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 癌治療のためのイミダゾピラジノール誘導体 |
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| EP2283020B8 (en) * | 2008-05-19 | 2012-12-12 | OSI Pharmaceuticals, LLC | Substituted imidazopyr-and imidazotri-azines |
| EP2408479A1 (en) | 2009-03-18 | 2012-01-25 | OSI Pharmaceuticals, LLC | Combination cancer therapy comprising administration of an egfr inhibitor and an igf-1r inhibitor |
| CN104447995A (zh) * | 2009-03-20 | 2015-03-25 | 霍夫曼-拉罗奇有限公司 | 双特异性抗-her抗体 |
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| EP2427192A1 (en) * | 2009-05-07 | 2012-03-14 | OSI Pharmaceuticals, LLC | Use of osi-906 for treating adrenocortical carcinoma |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
| PL2902030T3 (pl) | 2010-05-14 | 2017-07-31 | Dana-Farber Cancer Institute, Inc. | Związki tienotriazolodiazepinowe do leczenia nowotworu |
| RU2457546C1 (ru) * | 2011-03-09 | 2012-07-27 | Учреждение Российской академии медицинских наук Научный центр реконструктивной и восстановительной хирургии Сибирского отделения РАМН (НЦРВХ СО РАМН) | Способ моделирования аденокарциномы толстой кишки человека |
| WO2012129145A1 (en) | 2011-03-18 | 2012-09-27 | OSI Pharmaceuticals, LLC | Nscle combination therapy |
| KR102023496B1 (ko) | 2011-04-21 | 2019-09-20 | 시애틀 지네틱스, 인크. | 신규 결합제-약물 콘주게이트 (adc) 및 그의 용도 |
| SG2014011316A (en) | 2011-08-31 | 2014-06-27 | Genentech Inc | Diagnostic markers |
| JP2014531213A (ja) | 2011-09-30 | 2014-11-27 | ジェネンテック， インコーポレイテッド | 上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるｅｇｆｒキナーゼ阻害薬に対する応答 |
| CA2929652A1 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| US11649291B2 (en) | 2016-05-24 | 2023-05-16 | Insmed Incorporated | Antibodies and methods of making same |
| TWI910093B (zh) * | 2017-07-18 | 2026-01-01 | 日商協和麒麟股份有限公司 | 抗人類ｃｃｒ１單株抗體與其製造方法及其用途、產生抗人類ｃｃｒ１單株抗體之細胞、編碼抗人類ｃｃｒ１單株抗體之核酸及包含該核酸之轉形細胞、人類ｃｃｒ１之檢測或測定用試劑、人類ｃｃｒ１相關疾病之診斷及治療藥、以及抗人類ｃｃｒ１單株抗體之衍生物 |
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-
2000
- 2000-05-01 HK HK02108768.1A patent/HK1047236A1/zh unknown
- 2000-05-01 AU AU46871/00A patent/AU782994C/en not_active Ceased
- 2000-05-01 WO PCT/US2000/011756 patent/WO2000069459A1/en not_active Ceased
- 2000-05-01 MX MXPA01011632A patent/MXPA01011632A/es not_active Application Discontinuation
- 2000-05-01 CN CNB008103216A patent/CN1200734C/zh not_active Expired - Fee Related
- 2000-05-01 EP EP00928671A patent/EP1218032A4/en not_active Withdrawn
- 2000-05-01 IL IL14648000A patent/IL146480A0/xx unknown
- 2000-05-01 RU RU2001130771/14A patent/RU2294761C2/ru active
- 2000-05-01 KR KR1020017014494A patent/KR20020000223A/ko not_active Ceased
- 2000-05-01 BR BR0010524-4A patent/BR0010524A/pt not_active IP Right Cessation
- 2000-05-01 PL PL00365999A patent/PL365999A1/xx not_active IP Right Cessation
- 2000-05-01 CA CA002373815A patent/CA2373815A1/en not_active Abandoned
- 2000-05-01 SK SK1652-2001A patent/SK16522001A3/sk unknown
- 2000-05-01 EP EP08015392A patent/EP2042194A3/en not_active Withdrawn
- 2000-05-01 EE EEP200100603A patent/EE200100603A/xx unknown
- 2000-05-01 HU HU0201480A patent/HUP0201480A3/hu unknown
- 2000-05-01 JP JP2000617919A patent/JP2003520195A/ja active Pending
- 2000-05-01 CZ CZ20014083A patent/CZ20014083A3/cs unknown
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2001
- 2001-04-24 US US09/840,146 patent/US20020012663A1/en not_active Abandoned
- 2001-11-13 NO NO20015546A patent/NO20015546L/no not_active Application Discontinuation
- 2001-11-14 BG BG106110A patent/BG106110A/bg unknown
- 2001-11-30 US US09/996,954 patent/US20030157104A1/en not_active Abandoned
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2004
- 2004-12-20 US US11/018,950 patent/US20050112120A1/en not_active Abandoned
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2008
- 2008-09-24 JP JP2008244928A patent/JP2009120583A/ja active Pending
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