JPH09165336A5 - - Google Patents
Info
- Publication number
- JPH09165336A5 JPH09165336A5 JP1996281918A JP28191896A JPH09165336A5 JP H09165336 A5 JPH09165336 A5 JP H09165336A5 JP 1996281918 A JP1996281918 A JP 1996281918A JP 28191896 A JP28191896 A JP 28191896A JP H09165336 A5 JPH09165336 A5 JP H09165336A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- cancer
- cyclopropyl
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19539638:3 | 1995-10-25 | ||
| DE19539638A DE19539638A1 (de) | 1995-10-25 | 1995-10-25 | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH09165336A JPH09165336A (ja) | 1997-06-24 |
| JPH09165336A5 true JPH09165336A5 (https=) | 2004-10-21 |
| JP3996658B2 JP3996658B2 (ja) | 2007-10-24 |
Family
ID=7775689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28191896A Expired - Fee Related JP3996658B2 (ja) | 1995-10-25 | 1996-10-24 | 癌疾患治療におけるイソオキサゾールおよびクロトンアミド誘導体の使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5886033A (https=) |
| EP (1) | EP0769296B1 (https=) |
| JP (1) | JP3996658B2 (https=) |
| AT (1) | ATE202704T1 (https=) |
| CA (1) | CA2188228C (https=) |
| DE (2) | DE19539638A1 (https=) |
| DK (1) | DK0769296T3 (https=) |
| ES (1) | ES2160197T3 (https=) |
| GR (1) | GR3036754T3 (https=) |
| PT (1) | PT769296E (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
| CA2302438A1 (en) * | 1997-05-19 | 1998-11-26 | Sugen, Inc. | Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders |
| ATE196764T1 (de) * | 1997-08-08 | 2000-10-15 | Aventis Pharma Gmbh | Kristallform von 5-methylisoxazol-4-carbonsäure- (4-trifluormethyl)-anilid |
| EP0933633A1 (en) | 1997-12-11 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Process for obtaining L-dihydroorotic acid and use thereof |
| DE19857009A1 (de) * | 1998-12-10 | 2000-06-15 | Aventis Pharma Gmbh | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
| US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| US7247736B2 (en) * | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
| US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| ATE548359T1 (de) | 2004-06-17 | 2012-03-15 | Infinity Discovery Inc | Verbindungen und verfahren zur inhibierung der wechselwirkung von bcl-proteinen mit bindungspartnern |
| US7842815B2 (en) | 2004-06-17 | 2010-11-30 | Infinity Pharmaceuticals, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
| DE102006014165A1 (de) * | 2006-03-24 | 2007-09-27 | Schebo Biotech Ag | Neue Isooxazol-Derivate und deren Verwendungen |
| TWI389895B (zh) | 2006-08-21 | 2013-03-21 | Infinity Discovery Inc | 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法 |
| WO2017037022A1 (en) * | 2015-09-01 | 2017-03-09 | Bayer Pharma Aktiengesellschaft | Compounds and methods useful for treating or preventing hematological cancers |
| CN111423374B (zh) * | 2020-05-18 | 2023-03-21 | 合肥工业大学 | 一种二氢吡唑磺酰胺类化合物及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| DE59010701D1 (de) * | 1990-05-18 | 1997-05-22 | Hoechst Ag | Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung |
| IL99811A (en) * | 1990-10-30 | 1996-03-31 | Roussel Uclaf | 3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them |
| EP0538783B1 (de) * | 1991-10-23 | 1995-09-27 | Hoechst Aktiengesellschaft | N-phenyl-2-cyano-3-hydroxycrotonsäureamidderivate und deren Verwendung als Arzneimittel mit immunmodulatorischer Eigenschaft |
| GB9200275D0 (en) * | 1992-01-08 | 1992-02-26 | Roussel Lab Ltd | Chemical compounds |
| GB9320299D0 (en) * | 1993-10-01 | 1993-11-17 | Roussel Lab Ltd | Isoxazole derivatives |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
-
1995
- 1995-10-25 DE DE19539638A patent/DE19539638A1/de not_active Withdrawn
-
1996
- 1996-10-14 EP EP96116408A patent/EP0769296B1/de not_active Expired - Lifetime
- 1996-10-14 DK DK96116408T patent/DK0769296T3/da active
- 1996-10-14 PT PT96116408T patent/PT769296E/pt unknown
- 1996-10-14 DE DE59607208T patent/DE59607208D1/de not_active Expired - Lifetime
- 1996-10-14 AT AT96116408T patent/ATE202704T1/de active
- 1996-10-14 ES ES96116408T patent/ES2160197T3/es not_active Expired - Lifetime
- 1996-10-16 US US08/733,050 patent/US5886033A/en not_active Expired - Lifetime
- 1996-10-18 CA CA002188228A patent/CA2188228C/en not_active Expired - Fee Related
- 1996-10-24 JP JP28191896A patent/JP3996658B2/ja not_active Expired - Fee Related
-
1998
- 1998-11-13 US US09/191,375 patent/US6020372A/en not_active Expired - Lifetime
-
2001
- 2001-09-28 GR GR20010401611T patent/GR3036754T3/el unknown
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