JP2001515881A5 - - Google Patents
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- Publication number
- JP2001515881A5 JP2001515881A5 JP2000510706A JP2000510706A JP2001515881A5 JP 2001515881 A5 JP2001515881 A5 JP 2001515881A5 JP 2000510706 A JP2000510706 A JP 2000510706A JP 2000510706 A JP2000510706 A JP 2000510706A JP 2001515881 A5 JP2001515881 A5 JP 2001515881A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- fluoroalkyl
- independently
- another
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 24
- 150000001875 compounds Chemical class 0.000 description 19
- 125000003709 fluoroalkyl group Chemical group 0.000 description 16
- 101150065749 Churc1 gene Chemical group 0.000 description 12
- 102100038239 Protein Churchill Human genes 0.000 description 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 10
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical group O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 description 10
- 239000011647 vitamin D3 Substances 0.000 description 6
- 229940021056 vitamin d3 Drugs 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- 125000006763 (C3-C9) cycloalkyl group Chemical group 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 229940002612 prodrug Drugs 0.000 description 3
- 239000000651 prodrug Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 229940079593 drug Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5813297P | 1997-09-08 | 1997-09-08 | |
| US60/058,132 | 1997-09-08 | ||
| PCT/EP1998/005571 WO1999012894A1 (en) | 1997-09-08 | 1998-09-02 | 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001515881A JP2001515881A (ja) | 2001-09-25 |
| JP2001515881A5 true JP2001515881A5 (https=) | 2006-01-05 |
| JP4219553B2 JP4219553B2 (ja) | 2009-02-04 |
Family
ID=22014900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000510706A Expired - Fee Related JP4219553B2 (ja) | 1997-09-08 | 1998-09-02 | １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6492353B1 (https=) |
| EP (1) | EP1015423B1 (https=) |
| JP (1) | JP4219553B2 (https=) |
| AT (1) | ATE238986T1 (https=) |
| AU (1) | AU1022999A (https=) |
| CA (1) | CA2303248A1 (https=) |
| DE (1) | DE69814109T2 (https=) |
| ES (1) | ES2196614T3 (https=) |
| WO (1) | WO1999012894A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19916419B4 (de) * | 1999-04-08 | 2005-06-16 | Schering Ag | Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose |
| AU2001247619A1 (en) * | 2000-03-27 | 2001-10-08 | Wisconsin Alumni Research Foundation | Vitamin d compounds used to stabilize kidney transplants |
| KR100637564B1 (ko) * | 2001-01-26 | 2006-10-20 | 추가이 세이야쿠 가부시키가이샤 | 대사 조절자로서 유용한 말로닐-코에이 데카르복실라제억제제 |
| WO2002094247A2 (en) * | 2001-05-22 | 2002-11-28 | Bioxell S.P.A. | Use of a vitamin d3 analogue for the treatment of autoimmune diabetes |
| MXPA04002640A (es) * | 2001-09-21 | 2004-06-07 | Hoffmann La Roche | Esteres de analogos de 3-desoxi-vitamina d3. |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| JP2007506765A (ja) * | 2003-09-24 | 2007-03-22 | ビオクセル エッセ ピ ア | １，３−ジアシル化２６，２７−アルキル／ハロアルキルビタミンｄ３化合物及びその使用方法 |
| WO2006036813A2 (en) * | 2004-09-24 | 2006-04-06 | Bioxell S.P.A. | 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof |
| CA2586679A1 (en) | 2004-11-12 | 2006-05-18 | Bioxell Spa | Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer |
| JP4961562B2 (ja) * | 2005-03-04 | 2012-06-27 | 国立大学法人 東京医科歯科大学 | １９−ノルビタミンｄ誘導体 |
| WO2007039322A1 (en) * | 2005-09-19 | 2007-04-12 | Bioxell Spa | Use of vitamin d3 compounds for the treatment of uveitis |
| US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
| US8415390B2 (en) | 2008-05-30 | 2013-04-09 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
| EP2621588A4 (en) * | 2010-09-27 | 2014-09-03 | Microdose Therapeutx Inc | METHODS AND COMPOSITIONS FOR TREATING DISEASE USING INHALATION |
| EP2682386B1 (en) * | 2011-03-02 | 2016-08-17 | Nihon University | Novel vitamin d receptor modulator with partial agonist activity |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087619A (en) * | 1988-01-20 | 1992-02-11 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| KR0144358B1 (ko) * | 1988-04-21 | 1998-07-15 | 피. 라이달 크리스텐슨 | 비타민 d 동족체 |
| US4851401A (en) * | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
| US5401731A (en) * | 1989-06-29 | 1995-03-28 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) | Vitamin D analogues |
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| ATE143007T1 (de) | 1991-07-05 | 1996-10-15 | Duphar Int Res | Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür |
| DE4141746A1 (de) * | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| DE69304279T2 (de) * | 1992-05-20 | 1997-02-20 | Hoffmann La Roche | Fluorierte Analoge Vitamins D3 |
| DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| IL107185A (en) | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| CA2096105A1 (en) * | 1992-10-07 | 1994-04-08 | Enrico Giuseppe Baggiolini (Deceased) | Vitamin d3 fluorinated analogs |
| PT972762E (pt) * | 1993-07-09 | 2004-02-27 | Theramex | Novos analogos estruturais da vitamina d |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| ES2144239T3 (es) * | 1995-06-14 | 2000-06-01 | Schering Ag | Derivados de vitamina d con sustituyentes en c-25, procedimiento para su preparacion, productos intermedios y la utilizacion para la preparacion de medicamentos. |
| NO971934L (no) * | 1996-05-23 | 1997-11-24 | Hoffmann La Roche | Flourinerte vitamin D3 -analoger |
| AU743514B2 (en) * | 1997-05-16 | 2002-01-24 | Women & Infants Hospital | Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof |
-
1998
- 1998-09-02 WO PCT/EP1998/005571 patent/WO1999012894A1/en not_active Ceased
- 1998-09-02 JP JP2000510706A patent/JP4219553B2/ja not_active Expired - Fee Related
- 1998-09-02 AU AU10229/99A patent/AU1022999A/en not_active Abandoned
- 1998-09-02 DE DE69814109T patent/DE69814109T2/de not_active Expired - Lifetime
- 1998-09-02 AT AT98952587T patent/ATE238986T1/de not_active IP Right Cessation
- 1998-09-02 ES ES98952587T patent/ES2196614T3/es not_active Expired - Lifetime
- 1998-09-02 EP EP98952587A patent/EP1015423B1/en not_active Expired - Lifetime
- 1998-09-02 CA CA002303248A patent/CA2303248A1/en not_active Abandoned
- 1998-09-03 US US09/148,018 patent/US6492353B1/en not_active Expired - Fee Related
-
2002
- 2002-07-25 US US10/206,430 patent/US20030083319A1/en not_active Abandoned
-
2004
- 2004-02-18 US US10/781,120 patent/US20040167105A1/en not_active Abandoned
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