ATE238986T1 - 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga - Google Patents

1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga

Info

Publication number
ATE238986T1
ATE238986T1 AT98952587T AT98952587T ATE238986T1 AT E238986 T1 ATE238986 T1 AT E238986T1 AT 98952587 T AT98952587 T AT 98952587T AT 98952587 T AT98952587 T AT 98952587T AT E238986 T1 ATE238986 T1 AT E238986T1
Authority
AT
Austria
Prior art keywords
dihydroxy
dialkyl
vitamin
analogue
analogs
Prior art date
Application number
AT98952587T
Other languages
English (en)
Inventor
Percy Sarwood Manchand
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE238986T1 publication Critical patent/ATE238986T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98952587T 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga ATE238986T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5813297P 1997-09-08 1997-09-08
PCT/EP1998/005571 WO1999012894A1 (en) 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs

Publications (1)

Publication Number Publication Date
ATE238986T1 true ATE238986T1 (de) 2003-05-15

Family

ID=22014900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98952587T ATE238986T1 (de) 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga

Country Status (9)

Country Link
US (3) US6492353B1 (de)
EP (1) EP1015423B1 (de)
JP (1) JP4219553B2 (de)
AT (1) ATE238986T1 (de)
AU (1) AU1022999A (de)
CA (1) CA2303248A1 (de)
DE (1) DE69814109T2 (de)
ES (1) ES2196614T3 (de)
WO (1) WO1999012894A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19916419B4 (de) * 1999-04-08 2005-06-16 Schering Ag Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose
EP1267886B1 (de) * 2000-03-27 2006-03-08 Wisconsin Alumni Research Foundation Vitamin d-verbindungen zur behandlung von chronischer tranplantatnephropathie bei nieren transplantieren patienten
CN101596191B (zh) * 2001-01-26 2011-06-15 中外制药株式会社 用作代谢调节剂的丙二酰基辅酶a脱羧酶抑制剂
DE60229240D1 (de) * 2001-05-22 2008-11-20 Bioxell Spa Verwendung eines analoges des vitamins d3 zur behandlung des autoimmunen diabetes
PL370352A1 (en) * 2001-09-21 2005-05-16 F.Hoffmann-La Roche Ag 3-desoxy-vitamin d3 analog esters
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
US20080064668A1 (en) * 2003-09-24 2008-03-13 Bioxell S.P.A. 1,3-Diacylated, 26,27-Alkyl/Haloakyl Vitamin D3 Compounds and Methods of Use Thereof
US20080318911A1 (en) * 2004-09-24 2008-12-25 Bioxell S.P.A. 20-Cyclopropyl, 26,27-Alkyl/Haloalkyl Vitamin D3 Compounds and Methods of Use Thereof
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
WO2006093291A1 (ja) * 2005-03-04 2006-09-08 Tokyo Medical And Dental University １９－ノルビタミンｄ誘導体
WO2007039322A1 (en) * 2005-09-19 2007-04-12 Bioxell Spa Use of vitamin d3 compounds for the treatment of uveitis
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
WO2012047674A2 (en) * 2010-09-27 2012-04-12 Microdose Therapeutx, Inc. Methods and compositions for disease treatment using inhalation
JP5950413B2 (ja) * 2011-03-02 2016-07-13 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンｄ受容体モジュレーター

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
KR0144358B1 (ko) * 1988-04-21 1998-07-15 피. 라이달 크리스텐슨 비타민 d 동족체
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
ES2093180T3 (es) 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
EP0580968B1 (de) * 1992-05-20 1996-08-28 F. Hoffmann-La Roche Ag Fluorierte Analoge Vitamins D3
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
RU2153491C2 (ru) * 1993-07-09 2000-07-27 Лаборатуар Терамекс С.А. Аналоги витамина d, соединения, способы их получения и фармацевтическая композиция
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
WO1997000242A1 (de) * 1995-06-14 1997-01-03 Schering Aktiengesellschaft Neue vitamin d-derivate mit substituenten an c-25, verfahren zu ihrer herstellung, zwischenprodukte und die verwendung zur herstellung von arzneimitteln
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
WO1998051678A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF

Also Published As

Publication number Publication date
WO1999012894A1 (en) 1999-03-18
DE69814109T2 (de) 2004-02-26
US20040167105A1 (en) 2004-08-26
EP1015423A1 (de) 2000-07-05
US20030083319A1 (en) 2003-05-01
ES2196614T3 (es) 2003-12-16
EP1015423B1 (de) 2003-05-02
DE69814109D1 (de) 2003-06-05
JP4219553B2 (ja) 2009-02-04
US6492353B1 (en) 2002-12-10
CA2303248A1 (en) 1999-03-18
JP2001515881A (ja) 2001-09-25
AU1022999A (en) 1999-03-29

Similar Documents

Publication Publication Date Title
ATE238986T1 (de) 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga
BG104315A (en) Prostaglandine agonists and their application for the treatment of osteal diseases
LU91145I9 (de)
DK1914237T3 (da) Antivirale fosfonatesterforbindelser
BG102172A (en) New stable medicamentous compositions for the preparation of propellant-free aerosols
MX9500072A (es) Compuestos con propiedades de liberacion de la hormona del crecimiento.
EP0911321A3 (de) Verbindungen zur Behandlung von Osteoporose
NZ314839A (en) 1,25-Dihydroxy-16,23Z-diene-20-epi-16-ene-cholecalciferol (Vitamin D3) analogues
AP9801269A0 (en) Prostaglandin agonists.
HK1028568A1 (en) Alpha-ketoamide multicatalytic protease inhibitors
AP9200410A0 (en) Retroviral protease inhibitors.
PT2009025E (pt) Método de inibição da actividade dos osteoclastos
FR2757857B1 (fr) Diselenures et selenosulfures aromatiques, leur preparation et leurs utilisations, notamment therapeutiques
SE8505488L (sv) Isosilybinfri silibinin
PL350917A1 (en) C16 unsaturated fp-selective prostaglandins analogs
AU623805B2 (en) New use of anti-progestomimetic compounds
DE69715173D1 (en) Bisarylcyclobutenderivate als cyclooxygenasehemmer
DE69816047D1 (en) (methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer
MXPA03008801A (es) Aril oxima-piperazinas utiles como antagonistas de ccr5.
MXPA04001986A (es) Composiciones y metodos para el tratamiento de enfermedades relacionadas a la inmunidad.
MXPA03010737A (es) Aril-8-azabiciclo(3.2.1) octanos para tratamiento de depresion.
YU48200A (sh) Farmaceutski preparati
TW371661B (en) Novel intermediates and their use to prepare N,N'-bridged bisindolylmaleimides
GB9015774D0 (en) Novel treatment
FI982198A (fi) IL-muteiini

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties