DE69814109D1 - 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga - Google Patents

1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga

Info

Publication number
DE69814109D1
DE69814109D1 DE69814109T DE69814109T DE69814109D1 DE 69814109 D1 DE69814109 D1 DE 69814109D1 DE 69814109 T DE69814109 T DE 69814109T DE 69814109 T DE69814109 T DE 69814109T DE 69814109 D1 DE69814109 D1 DE 69814109D1
Authority
DE
Germany
Prior art keywords
dihydroxy
dialkyl
vitamin
analog
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814109T
Other languages
English (en)
Other versions
DE69814109T2 (de
Inventor
Sarwood Manchand
Radoje Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69814109D1 publication Critical patent/DE69814109D1/de
Application granted granted Critical
Publication of DE69814109T2 publication Critical patent/DE69814109T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69814109T 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga Expired - Lifetime DE69814109T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5813297P 1997-09-08 1997-09-08
US58132P 1997-09-08
PCT/EP1998/005571 WO1999012894A1 (en) 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs

Publications (2)

Publication Number Publication Date
DE69814109D1 true DE69814109D1 (de) 2003-06-05
DE69814109T2 DE69814109T2 (de) 2004-02-26

Family

ID=22014900

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814109T Expired - Lifetime DE69814109T2 (de) 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga

Country Status (9)

Country Link
US (3) US6492353B1 (de)
EP (1) EP1015423B1 (de)
JP (1) JP4219553B2 (de)
AT (1) ATE238986T1 (de)
AU (1) AU1022999A (de)
CA (1) CA2303248A1 (de)
DE (1) DE69814109T2 (de)
ES (1) ES2196614T3 (de)
WO (1) WO1999012894A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19916419B4 (de) * 1999-04-08 2005-06-16 Schering Ag Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose
DE60117762T2 (de) * 2000-03-27 2006-10-12 Wisconsin Alumni Research Foundation, Madison Vitamin d-verbindung zur behandlung von chronischer tranplantatnephropatie bei nieren transplantierten patienten
US7524969B2 (en) * 2001-01-26 2009-04-28 Chugai Seiyaku Kabushiki Kaisha Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
AU2002314056A1 (en) * 2001-05-22 2002-12-03 Bioxell S.P.A. Use of a vitamin d3 analogue for the treatment of autoimmune diabetes
MXPA04002640A (es) * 2001-09-21 2004-06-07 Hoffmann La Roche Esteres de analogos de 3-desoxi-vitamina d3.
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
EP1663249A4 (de) * 2003-09-24 2006-12-20 Bioxell Spa 1,3-diacylierte,26,27-alkyl/haloalkyl vitamin d sb 3 /sb verbindungen und anwendungsverfahren dafür
WO2006036813A2 (en) * 2004-09-24 2006-04-06 Bioxell S.P.A. 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof
EP1812011A1 (de) 2004-11-12 2007-08-01 Bioxell S.p.a. Kombinierte verwendung von vitamin-d-derivaten und antiproliferativen mitteln zur behandlung von blasenkrebs
JP4961562B2 (ja) * 2005-03-04 2012-06-27 国立大学法人 東京医科歯科大学 １９−ノルビタミンｄ誘導体
WO2007039322A1 (en) * 2005-09-19 2007-04-12 Bioxell Spa Use of vitamin d3 compounds for the treatment of uveitis
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US20120077786A1 (en) * 2010-09-27 2012-03-29 Byron David A Methods and compositions for disease treatment using inhalation
WO2012118154A1 (ja) * 2011-03-02 2012-09-07 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンd受容体モジュレーター

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
EP0412110B1 (de) * 1988-04-21 1993-07-07 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Vitamin d analoge
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
ES2093180T3 (es) 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.
DE4141746A1 (de) 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
EP0580968B1 (de) * 1992-05-20 1996-08-28 F. Hoffmann-La Roche Ag Fluorierte Analoge Vitamins D3
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
NZ271332A (en) * 1993-07-09 2001-03-30 Theramex Vitamin D analogues and pharmaceutical use
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
EP0832063B1 (de) * 1995-06-14 2000-02-23 Schering Aktiengesellschaft Vitamin d-derivate mit substituenten an c-25, verfahren zu ihrer herstellung, zwischenprodukte und die verwendung zur herstellung von arzneimitteln
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
WO1998051678A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF

Also Published As

Publication number Publication date
CA2303248A1 (en) 1999-03-18
AU1022999A (en) 1999-03-29
US6492353B1 (en) 2002-12-10
WO1999012894A1 (en) 1999-03-18
ES2196614T3 (es) 2003-12-16
US20030083319A1 (en) 2003-05-01
JP2001515881A (ja) 2001-09-25
ATE238986T1 (de) 2003-05-15
DE69814109T2 (de) 2004-02-26
EP1015423B1 (de) 2003-05-02
US20040167105A1 (en) 2004-08-26
EP1015423A1 (de) 2000-07-05
JP4219553B2 (ja) 2009-02-04

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