MX9703775A - Analogos de vitamina d3 fluorados. - Google Patents
Analogos de vitamina d3 fluorados.Info
- Publication number
- MX9703775A MX9703775A MX9703775A MX9703775A MX9703775A MX 9703775 A MX9703775 A MX 9703775A MX 9703775 A MX9703775 A MX 9703775A MX 9703775 A MX9703775 A MX 9703775A MX 9703775 A MX9703775 A MX 9703775A
- Authority
- MX
- Mexico
- Prior art keywords
- analogs
- fluorinated vitamin
- fluorinated
- vitamin
- osteoporosis
- Prior art date
Links
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 title abstract 2
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Nuevos derivado fluorados de la vitamina D3 de formula I, en donde X es (H,H)o =CH2, R1 y R2, son independientemente entre sí, hidrogeno, alquilo o fluoroalquilo de 1 a 4 átomos de carbono o R1 y R2 juntamente con el carbono 20 forman un cicloalquilo o ciclofluoroalquilo de 3 a 6 átomos de carbono, o R1 y R2 juntos forman =CH2; R3 y R4 son independientemente entre sí, un alquilo o fluoroalquilo de 1 a 4 átomos de carbono, o R3 y R4 juntamente con el carbono 25 forman un cicloalquilo o ciclofluoroalquilo de 3 a 9 átomos de carbono; A es un enlace simple o un doble enlace; y B es un doble enlace o enlace triple; excepto: (i) cuando X es =CH2, R3 y R4 son cada uno CF3, A es un doble enlace y uno de R1 y R2 es hidrogeno, entonces el otro R1 o R2 no puede ser CH2; (ii) cuando X es =CH2, R3 y R4 son cada uno un alquilo de 1 a 2 átomos de carbono, A es un doble enlace y R2 es hidrogeno, entonces R1 no puede ser CH3; (iii) cuando X es =CH2, R3 y R4 son cada uno un alquilo de 1 a 4 átomos de carbono, A es un doble enlace y R1 es hidrogeno, entonces R2 no puede ser CH3; (iv) cuando X es =CH2, uno de R3 o R4 es un CF3, A es un doble enlace, R1 es CH3 y R2 es hidrogeno, entonces el otro de R3 o R4 no puede ser CH3; y (v) cuando x es (H,H), R3 y R4 son cada uno CF3, A es un doble enlace, B es un enlace triple y R2 es hidrogeno, entonces R1 no puede ser CH3, y los compuestos de la formula anterior I, en donde: X es (H,H) o =CH2; R1 y R2, son independientemente entre sí, hidrogeno, alquilo o fluoroalquilo de 1 a 4 átomos de carbono o R1 y R2 juntamente con el carbono 20 forman un cicloalquilo o ciclofluoroalquilo de 3 a 6 átomos de carbono, o R1 y R2 juntos forman =CH2; R3 y R4 son independientemente entre sí, un alquilo o fluoroalquilo de 1 a 4 átomos de carbono, o R3 y R4 juntamente con el carbono 25 forman un cicloalquilo o ciclofluoroalquio de 3 a 9 átomos de carbono; A es un enlace simple o un doble enlace; y B es un doble enlace o un enlace triple; excepto que cuando R3 y R4 son cada uno CF3, A es un doble enlace, B es un enlace triple y R2 es hidrogeno, entonces R1 no puede ser CH3, son de utilidad en el tratamiento de la osteoporosis.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1821996P | 1996-05-23 | 1996-05-23 | |
| US60/018.219 | 1996-05-23 | ||
| US3990197P | 1997-03-19 | 1997-03-19 | |
| US60/039,901 | 1997-03-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9703775A true MX9703775A (es) | 1998-06-30 |
| MXPA97003775A MXPA97003775A (es) | 1998-10-30 |
Family
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |