JP2003530433A5 - - Google Patents
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- Publication number
- JP2003530433A5 JP2003530433A5 JP2001576013A JP2001576013A JP2003530433A5 JP 2003530433 A5 JP2003530433 A5 JP 2003530433A5 JP 2001576013 A JP2001576013 A JP 2001576013A JP 2001576013 A JP2001576013 A JP 2001576013A JP 2003530433 A5 JP2003530433 A5 JP 2003530433A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- sulfamyl
- amino
- acetoxy
- phosphonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Hydrogen Chemical class 0.000 description 76
- 125000003545 alkoxy group Chemical group 0.000 description 42
- 229910052736 halogen Inorganic materials 0.000 description 25
- 150000002367 halogens Chemical class 0.000 description 25
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 25
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 24
- 229910052739 hydrogen Inorganic materials 0.000 description 23
- 239000001257 hydrogen Substances 0.000 description 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 22
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 20
- 125000000217 alkyl group Chemical group 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 16
- 150000002431 hydrogen Chemical class 0.000 description 16
- 150000003839 salts Chemical class 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- SBSLPPMPINEXNI-YDWXAUTNSA-N 1,2,3,4,5-pentafluoro-6-[(e)-3-(4-fluorophenyl)-1-[(e)-3-(4-fluorophenyl)-1-(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]sulfonylprop-2-enyl]benzene Chemical compound C1=CC(F)=CC=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C=CC(F)=CC=1)C=1C(=C(F)C(F)=C(F)C=1F)F)C1=C(F)C(F)=C(F)C(F)=C1F SBSLPPMPINEXNI-YDWXAUTNSA-N 0.000 description 1
- JYQVQRVNPTWWPZ-WGDLNXRISA-N 1,2,3,4,5-pentafluoro-6-[(e)-3-(4-fluorophenyl)-3-[(e)-1-(4-fluorophenyl)-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]sulfonylprop-1-enyl]benzene Chemical compound C1=CC(F)=CC=C1C(S(=O)(=O)C(\C=C\C=1C(=C(F)C(F)=C(F)C=1F)F)C=1C=CC(F)=CC=1)\C=C\C1=C(F)C(F)=C(F)C(F)=C1F JYQVQRVNPTWWPZ-WGDLNXRISA-N 0.000 description 1
- ZBFGDONTPUMMDC-WGDLNXRISA-N 1,2,3,4,5-pentafluoro-6-[(e)-3-(4-iodophenyl)-3-[(e)-1-(4-iodophenyl)-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]sulfonylprop-1-enyl]benzene Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=C(F)C(F)=C(F)C=1F)F)C=1C=CC(I)=CC=1)C1=CC=C(I)C=C1 ZBFGDONTPUMMDC-WGDLNXRISA-N 0.000 description 1
- YFQFBQIGRJQFFS-BGPOSVGRSA-N 1,2,3-trifluoro-4-[(e)-3-(4-fluorophenyl)-3-[(e)-1-(4-fluorophenyl)-3-(2,3,4-trifluorophenyl)prop-2-enyl]sulfonylprop-1-enyl]benzene Chemical compound C1=CC(F)=CC=C1C(S(=O)(=O)C(\C=C\C=1C(=C(F)C(F)=CC=1)F)C=1C=CC(F)=CC=1)\C=C\C1=CC=C(F)C(F)=C1F YFQFBQIGRJQFFS-BGPOSVGRSA-N 0.000 description 1
- PZGCQHVZLVMFTO-FCXRPNKRSA-N 1-[(e)-3-(3,4-dichlorophenyl)-3-[(e)-1-(3,4-dichlorophenyl)-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]sulfonylprop-1-enyl]-2,3,4,5,6-pentafluorobenzene Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=C(F)C(F)=C(F)C=1F)F)C=1C=C(Cl)C(Cl)=CC=1)C1=CC=C(Cl)C(Cl)=C1 PZGCQHVZLVMFTO-FCXRPNKRSA-N 0.000 description 1
- YLDNMXSNYYBDFG-YDWXAUTNSA-N 1-[(e)-3-(4-bromophenyl)-1-[(e)-3-(4-bromophenyl)-1-(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]sulfonylprop-2-enyl]-2,3,4,5,6-pentafluorobenzene Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1C(S(=O)(=O)C(\C=C\C=1C=CC(Br)=CC=1)C=1C(=C(F)C(F)=C(F)C=1F)F)\C=C\C1=CC=C(Br)C=C1 YLDNMXSNYYBDFG-YDWXAUTNSA-N 0.000 description 1
- LBRHQENFVSXKJM-YDWXAUTNSA-N 1-[(e)-3-(4-chlorophenyl)-1-[(e)-3-(4-chlorophenyl)-1-(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]sulfonylprop-2-enyl]-2,3,4,5,6-pentafluorobenzene Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1C(S(=O)(=O)C(\C=C\C=1C=CC(Cl)=CC=1)C=1C(=C(F)C(F)=C(F)C=1F)F)\C=C\C1=CC=C(Cl)C=C1 LBRHQENFVSXKJM-YDWXAUTNSA-N 0.000 description 1
- ASWIUWIUYBQFRE-BGPOSVGRSA-N 1-[(e)-3-(4-chlorophenyl)-3-[(e)-1-(4-chlorophenyl)-3-(2,3,4-trifluorophenyl)prop-2-enyl]sulfonylprop-1-enyl]-2,3,4-trifluorobenzene Chemical compound FC1=C(F)C(F)=CC=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=C(F)C(F)=CC=1)F)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 ASWIUWIUYBQFRE-BGPOSVGRSA-N 0.000 description 1
- PBMCWLMEWFGPBX-ZPUQHVIOSA-N 1-[(e)-3-[(e)-1,3-bis(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]sulfonyl-3-(2,3,4,5,6-pentafluorophenyl)prop-1-enyl]-2,3,4,5,6-pentafluorobenzene Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=C(F)C(F)=C(F)C=1F)F)C=1C(=C(F)C(F)=C(F)C=1F)F)C1=C(F)C(F)=C(F)C(F)=C1F PBMCWLMEWFGPBX-ZPUQHVIOSA-N 0.000 description 1
- UYBARLRUHOODMT-JYFOCSDGSA-N 1-[(e)-3-[(e)-3-(4,5-dimethoxy-2-nitrophenyl)-1-(4-methoxyphenyl)prop-2-enyl]sulfonyl-3-(4-methoxyphenyl)prop-1-enyl]-4,5-dimethoxy-2-nitrobenzene Chemical compound C1=CC(OC)=CC=C1C(S(=O)(=O)C(\C=C\C=1C(=CC(OC)=C(OC)C=1)[N+]([O-])=O)C=1C=CC(OC)=CC=1)\C=C\C1=CC(OC)=C(OC)C=C1[N+]([O-])=O UYBARLRUHOODMT-JYFOCSDGSA-N 0.000 description 1
- IXKPKFXAOWLGBA-YTEMWHBBSA-N 2-[(e)-3-(4-bromophenyl)-3-[(e)-1-(4-bromophenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-enyl]sulfonylprop-1-enyl]-1,3,5-trimethoxybenzene Chemical compound COC1=CC(OC)=CC(OC)=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=CC(OC)=CC=1OC)OC)C=1C=CC(Br)=CC=1)C1=CC=C(Br)C=C1 IXKPKFXAOWLGBA-YTEMWHBBSA-N 0.000 description 1
- GMGWSYNUDNAELW-WXUKJITCSA-N 2-[(e)-3-(4-bromophenyl)-3-[(e)-1-(4-bromophenyl)-3-(4-fluoro-2,6-dimethoxyphenyl)prop-2-enyl]sulfonylprop-1-enyl]-5-fluoro-1,3-dimethoxybenzene Chemical compound COC1=CC(F)=CC(OC)=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=CC(F)=CC=1OC)OC)C=1C=CC(Br)=CC=1)C1=CC=C(Br)C=C1 GMGWSYNUDNAELW-WXUKJITCSA-N 0.000 description 1
- PNYMULXLZQBRJS-WXUKJITCSA-N 2-[(e)-3-(4-chlorophenyl)-3-[(e)-1-(4-chlorophenyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-enyl]sulfonylprop-1-enyl]-3,5-dimethoxyphenol Chemical compound COC1=CC(OC)=CC(O)=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=CC(OC)=CC=1O)OC)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 PNYMULXLZQBRJS-WXUKJITCSA-N 0.000 description 1
- VHWWYXCXNRDABI-WXUKJITCSA-N 2-[(e)-3-(4-chlorophenyl)-3-[(e)-1-(4-chlorophenyl)-3-(4-fluoro-2,6-dimethoxyphenyl)prop-2-enyl]sulfonylprop-1-enyl]-5-fluoro-1,3-dimethoxybenzene Chemical compound COC1=CC(F)=CC(OC)=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C(=CC(F)=CC=1OC)OC)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 VHWWYXCXNRDABI-WXUKJITCSA-N 0.000 description 1
- HOPUNXURSBBUQQ-YTEMWHBBSA-N 2-[(e)-3-[(e)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-enyl]sulfonyl-3-(4-methoxyphenyl)prop-1-enyl]-3,5-dimethoxyphenol Chemical compound C1=CC(OC)=CC=C1C(S(=O)(=O)C(\C=C\C=1C(=CC(OC)=CC=1O)OC)C=1C=CC(OC)=CC=1)\C=C\C1=C(O)C=C(OC)C=C1OC HOPUNXURSBBUQQ-YTEMWHBBSA-N 0.000 description 1
- LSQPHWBCMFQPAP-UHFFFAOYSA-N C1=CC(OC)=CC=C1C(S(=O)(=O)C(C=CC=1C(=CC(OC)=CC=1OC)OC)C=1C=CC(OC)=CC=1)C=CC1=C(OC)C=C(OC)C=C1OC Chemical compound C1=CC(OC)=CC=C1C(S(=O)(=O)C(C=CC=1C(=CC(OC)=CC=1OC)OC)C=1C=CC(OC)=CC=1)C=CC1=C(OC)C=C(OC)C=C1OC LSQPHWBCMFQPAP-UHFFFAOYSA-N 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000004404 Neurofibroma Diseases 0.000 description 1
- 208000005890 Neuroma Diseases 0.000 description 1
- 208000010191 Osteitis Deformans Diseases 0.000 description 1
- 208000027868 Paget disease Diseases 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 208000011379 keloid formation Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 208000027202 mammary Paget disease Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19784900P | 2000-04-14 | 2000-04-14 | |
| US60/197,849 | 2000-04-14 | ||
| US23470700P | 2000-09-22 | 2000-09-22 | |
| US60/234,707 | 2000-09-22 | ||
| US27164001P | 2001-02-27 | 2001-02-27 | |
| US60/271,640 | 2001-02-27 | ||
| PCT/US2001/012134 WO2001078712A1 (en) | 2000-04-14 | 2001-04-13 | Substituted styryl benzylsulfones for treating proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003530433A JP2003530433A (ja) | 2003-10-14 |
| JP2003530433A5 true JP2003530433A5 (https=) | 2008-05-29 |
| JP4677162B2 JP4677162B2 (ja) | 2011-04-27 |
Family
ID=27393791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001576013A Expired - Lifetime JP4677162B2 (ja) | 2000-04-14 | 2001-04-13 | 増殖性障害を治療するための置換スチリルベンジルスルホン |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6486210B2 (https=) |
| EP (2) | EP2359819A1 (https=) |
| JP (1) | JP4677162B2 (https=) |
| KR (1) | KR100768415B1 (https=) |
| AU (2) | AU2001251615C1 (https=) |
| CA (1) | CA2406212C (https=) |
| DK (1) | DK1305015T3 (https=) |
| ES (1) | ES2427088T3 (https=) |
| IL (2) | IL152190A0 (https=) |
| NZ (1) | NZ522551A (https=) |
| PT (1) | PT1305015E (https=) |
| SI (1) | SI1305015T1 (https=) |
| WO (1) | WO2001078712A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6762207B1 (en) * | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
| AU2001296677A1 (en) | 2000-10-05 | 2002-04-15 | Temple University - Of The Commonwealth System Of Higher Education | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| JP2004521126A (ja) * | 2001-02-27 | 2004-07-15 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | （ｚ）−スチリルベンジルスルホン及びそれらの医薬としての使用 |
| WO2002069892A2 (en) | 2001-02-28 | 2002-09-12 | Temple University Of The Commonwealth System Of Higher Education | METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES |
| EP1534284B1 (en) * | 2002-02-28 | 2011-07-27 | Temple University - Of The Commonwealth System of Higher Education | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| NZ535232A (en) * | 2002-02-28 | 2007-05-31 | Univ Temple | Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
| JP4182844B2 (ja) * | 2003-09-03 | 2008-11-19 | 株式会社島津製作所 | 質量分析装置 |
| WO2005046599A2 (en) * | 2003-11-14 | 2005-05-26 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
| NZ549962A (en) * | 2004-03-16 | 2010-04-30 | Univ Temple | Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders |
| US8058313B2 (en) | 2004-06-24 | 2011-11-15 | Temple University—Of the Commonwealth System of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| JP5156389B2 (ja) * | 2005-01-05 | 2013-03-06 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 薬剤耐性増殖性疾患の治療剤 |
| EP1896401B1 (en) * | 2005-02-25 | 2013-04-10 | Temple University - Of The Commonwealth System of Higher Education | Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis |
| WO2006104668A2 (en) * | 2005-03-11 | 2006-10-05 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| JP5278968B2 (ja) * | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| CA2663375A1 (en) * | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
| US8735620B2 (en) * | 2008-12-17 | 2014-05-27 | Epr Pharmaceuticals Pvt. Ltd | Processes for preparing (E)-styrylbenzylsulfone compounds and uses thereof for treating proliferative disorders |
| AU2013318206B2 (en) | 2012-09-20 | 2018-07-26 | Temple University - Of The Commonwealth System Of Higher Education | Substituted alkyl diaryl derivatives, methods of preparation and uses |
| WO2014089483A1 (en) | 2012-12-07 | 2014-06-12 | Onconova Therapeutics, Inc. | Methods and compositions for treatment of cancer |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| WO2024186641A1 (en) * | 2023-03-03 | 2024-09-12 | Onconova Therapeutics, Inc. | Methods and compositions for treating cancer |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2532612A (en) | 1945-08-29 | 1950-12-05 | Union Oil Co | Preparation of unsaturated thio-ethers |
| US3185743A (en) | 1960-08-24 | 1965-05-25 | Union Carbide Corp | Production of olefinic compounds from allyl sulfones |
| US3418101A (en) | 1965-12-15 | 1968-12-24 | Pennsalt Chemicals Corp | Process for plant desiccation |
| US3514386A (en) | 1967-12-11 | 1970-05-26 | Exxon Research Engineering Co | Stereoselective addition of thiols to acetylenic compounds |
| US3917714A (en) | 1972-09-06 | 1975-11-04 | American Cyanamid Co | Bis(alkylsulfonyl)vinylbenzenes |
| US4161407A (en) | 1977-10-06 | 1979-07-17 | Eastman Kodak Company | Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin |
| US4386221A (en) | 1981-10-28 | 1983-05-31 | Eastman Kodak Company | Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones |
| US4937388A (en) | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
| YU213587A (en) * | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
| FR2621038B1 (fr) * | 1987-09-28 | 1989-12-29 | Rhone Poulenc Sante | Derives d'alcadienes, leurs preparations, les medicaments les contenant et produits intermediaires |
| GB8902409D0 (en) * | 1989-02-03 | 1989-03-22 | Ici Plc | Aliphatic compounds |
| US5659087A (en) | 1995-06-07 | 1997-08-19 | Eli Lilly And Company | Diarylvinyl sulfoxides |
| JP3660395B2 (ja) * | 1995-06-22 | 2005-06-15 | 大鵬薬品工業株式会社 | フェニルスルホン誘導体及びその製造方法 |
| WO1997014678A1 (en) * | 1995-10-19 | 1997-04-24 | Ciba Specialty Chemicals Holding Inc. | Antioxidants containing phenol groups and aromatic amine groups |
| CN1163480C (zh) | 1997-10-03 | 2004-08-25 | 坦普尔大学 | 苯乙烯砜抗癌剂 |
| US6201154B1 (en) * | 1999-03-31 | 2001-03-13 | Temple University-Of The Commonwealth Of Higher Education | Z-styryl sulfone anticancer agents |
| JP4596651B2 (ja) * | 1999-04-02 | 2010-12-08 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | （ｅ）−スチリルスルホン抗癌剤 |
| JP2002541101A (ja) * | 1999-04-02 | 2002-12-03 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | スチリルスルホン抗癌剤 |
| WO2001026645A1 (en) * | 1999-10-12 | 2001-04-19 | Temple University-Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
-
2001
- 2001-04-12 US US09/833,287 patent/US6486210B2/en not_active Expired - Lifetime
- 2001-04-13 EP EP10178360A patent/EP2359819A1/en not_active Withdrawn
- 2001-04-13 WO PCT/US2001/012134 patent/WO2001078712A1/en not_active Ceased
- 2001-04-13 CA CA2406212A patent/CA2406212C/en not_active Expired - Lifetime
- 2001-04-13 PT PT1925014T patent/PT1305015E/pt unknown
- 2001-04-13 JP JP2001576013A patent/JP4677162B2/ja not_active Expired - Lifetime
- 2001-04-13 IL IL15219001A patent/IL152190A0/xx unknown
- 2001-04-13 SI SI200131022T patent/SI1305015T1/sl unknown
- 2001-04-13 KR KR1020027013708A patent/KR100768415B1/ko not_active Expired - Lifetime
- 2001-04-13 DK DK01925014.1T patent/DK1305015T3/da active
- 2001-04-13 ES ES01925014T patent/ES2427088T3/es not_active Expired - Lifetime
- 2001-04-13 AU AU2001251615A patent/AU2001251615C1/en not_active Expired
- 2001-04-13 NZ NZ522551A patent/NZ522551A/en not_active IP Right Cessation
- 2001-04-13 EP EP01925014.1A patent/EP1305015B1/en not_active Expired - Lifetime
- 2001-04-13 AU AU5161501A patent/AU5161501A/xx active Pending
-
2002
- 2002-07-29 US US10/207,429 patent/US6642410B2/en not_active Expired - Lifetime
- 2002-10-08 IL IL152190A patent/IL152190A/en active IP Right Grant