JP2002531498A5 - - Google Patents
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- Publication number
- JP2002531498A5 JP2002531498A5 JP2000586327A JP2000586327A JP2002531498A5 JP 2002531498 A5 JP2002531498 A5 JP 2002531498A5 JP 2000586327 A JP2000586327 A JP 2000586327A JP 2000586327 A JP2000586327 A JP 2000586327A JP 2002531498 A5 JP2002531498 A5 JP 2002531498A5
- Authority
- JP
- Japan
- Prior art keywords
- oxime
- methylisatin
- dichloroisatin
- pharmaceutically acceptable
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 1
- OIKFZVUNSNWSAD-UHFFFAOYSA-N 3-(hydroxyamino)-6,7-dimethylindol-2-one Chemical compound CC1=C(C)C=CC2=C(NO)C(=O)N=C21 OIKFZVUNSNWSAD-UHFFFAOYSA-N 0.000 description 1
- CVOUSAVHMDXCKG-UHFFFAOYSA-N 6,7-dichloro-3-(hydroxyamino)indol-2-one Chemical compound C1=CC(Cl)=C(Cl)C2=NC(=O)C(NO)=C21 CVOUSAVHMDXCKG-UHFFFAOYSA-N 0.000 description 1
- IGTXKVJLOUTKNB-UHFFFAOYSA-N 6,7-dichloro-3-hydroxyimino-1-methylindol-2-one Chemical compound C1=C(Cl)C(Cl)=C2N(C)C(=O)C(=NO)C2=C1 IGTXKVJLOUTKNB-UHFFFAOYSA-N 0.000 description 1
- HJFLMFUUYLJUPD-UHFFFAOYSA-N 6,7-difluoro-3-(hydroxyamino)indol-2-one Chemical compound C1=CC(F)=C(F)C2=C1C(=NO)C(=O)N2 HJFLMFUUYLJUPD-UHFFFAOYSA-N 0.000 description 1
- PNSCLWDBNGJLCG-UHFFFAOYSA-N 6-chloro-3-(hydroxyamino)-7-methylindol-2-one Chemical compound CC1=C(Cl)C=CC2=C(NO)C(=O)N=C12 PNSCLWDBNGJLCG-UHFFFAOYSA-N 0.000 description 1
- SHFGGAMLXGAYLG-UHFFFAOYSA-N 6-fluoro-3-(hydroxyamino)-7-methylindol-2-one Chemical compound C1=C(F)C(C)=C2NC(=O)C(=NO)C2=C1 SHFGGAMLXGAYLG-UHFFFAOYSA-N 0.000 description 1
- 206010048994 Bladder spasm Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801608 | 1998-12-04 | ||
| DK199801608 | 1998-12-04 | ||
| PCT/DK1999/000679 WO2000033834A1 (en) | 1998-12-04 | 1999-12-03 | Use of isatin derivatives as ion channel activating agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531498A JP2002531498A (ja) | 2002-09-24 |
| JP2002531498A5 true JP2002531498A5 (https=) | 2007-01-25 |
Family
ID=8106503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586327A Pending JP2002531498A (ja) | 1998-12-04 | 1999-12-03 | イオンチャネル活性剤としてのイサチン誘導体の使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20020016354A1 (https=) |
| EP (1) | EP1135123B1 (https=) |
| JP (1) | JP2002531498A (https=) |
| AT (1) | ATE285769T1 (https=) |
| AU (1) | AU1648600A (https=) |
| DE (1) | DE69922997T2 (https=) |
| WO (1) | WO2000033834A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1255734B1 (en) * | 2000-01-24 | 2006-06-21 | NeuroSearch A/S | Isatine derivatives with neurotrophic activity |
| AU2001265840A1 (en) * | 2000-06-26 | 2002-01-08 | Novo-Nordisk A/S | Use of potassium channel agonists for reducing fat food comsumption |
| EP1345618B1 (de) * | 2000-12-28 | 2005-03-23 | Switch Biotech Aktiengesellschaft | Chlorzoxazon zur behandlung von psoriasis |
| US20040077634A1 (en) * | 2001-02-15 | 2004-04-22 | Ulrik Lademann | Treatment of diseases characterized by excessive or insufficient cell death |
| US20020183395A1 (en) | 2001-04-04 | 2002-12-05 | Wyeth | Methods for treating hyperactive gastric motility |
| US7148007B2 (en) * | 2001-07-24 | 2006-12-12 | Kabushiki Kaisha Toshiba | Method for evaluating immunotoxicity of test substance |
| DE10250870A1 (de) * | 2002-10-31 | 2004-05-13 | Switch Biotech Ag | Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung |
| WO2004069213A2 (en) * | 2003-01-15 | 2004-08-19 | L'oreal | Cosmetic composition comprising a 2-alkylideneaminooxyacetamide |
| FR2849773B1 (fr) * | 2003-01-15 | 2006-07-14 | Oreal | Composition capillaire contenant un 2-alkylidene aminooxy-acetamide, son utilisation pour stimuler la pousse des cheveux et/ou freiner leur chute |
| JP4641942B2 (ja) | 2003-10-03 | 2011-03-02 | フェーイレン・ナムローゼ・フェンノートシャップ | ヒトおよび動物におけるｉｇｆ−１血清レベルの低下と関連した種々の疾患状態の治療用の治療用組成物の製造のための血清中ｉｇｆ−１レベルを増加できる化合物の使用 |
| DK1667678T3 (da) | 2003-10-03 | 2009-08-24 | Veijlen N V | Dyrefodersammensætning |
| WO2008034011A2 (en) | 2006-09-13 | 2008-03-20 | Mcw Research Foundation, Inc. | Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases |
| US8232310B2 (en) * | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| US20120190009A1 (en) * | 2010-12-14 | 2012-07-26 | Fatah Kashanchi | Viral Modulators and Processes Thereof |
| CN103380129B (zh) | 2010-12-20 | 2016-04-20 | 阿克图拉姆生命科学股份公司 | 2-甲酰胺-4-哌嗪基-苯并呋喃衍生物 |
| CA2869513C (en) | 2012-04-12 | 2020-07-07 | Georgetown University | Methods and compositions for treating ewings sarcoma family of tumors |
| CN105848654B (zh) * | 2013-10-24 | 2018-10-02 | 乔治城大学 | 用于治疗癌症的方法和组合物 |
| EP3131541A4 (en) * | 2014-04-14 | 2018-02-14 | Flex Pharma, Inc. | Ion channel activators and methods of use |
| WO2015160842A1 (en) * | 2014-04-14 | 2015-10-22 | Flex Pharma, Inc. | Methods and formulatiions of capsaicinoids and capsinoids |
| CN104130175A (zh) * | 2014-06-13 | 2014-11-05 | 天津科技大学 | 不同位置取代吲哚酮类衍生物及其应用 |
| EP3204376B1 (en) | 2014-10-09 | 2023-04-19 | Oncternal Therapeutics, Inc. | Indolinone compounds and uses thereof |
| EP3795563B1 (en) | 2016-03-31 | 2024-07-17 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| CA3029851A1 (en) | 2016-07-29 | 2018-02-01 | Oncternal Therapeutics, Inc. | Uses of indoline compounds such as tk216 for the treatment of cancer |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| WO2018136943A1 (en) | 2017-01-23 | 2018-07-26 | Flex Pharma, Inc. | Compositions and methods affecting exercise performance |
| CN108017570A (zh) * | 2017-12-21 | 2018-05-11 | 常州大学 | 一种靛红的生产方法 |
| CN108721297A (zh) * | 2018-05-15 | 2018-11-02 | 泰山医学院 | 一种减轻免疫抑制的抗肿瘤药物及其应用 |
| CN108403690A (zh) * | 2018-05-15 | 2018-08-17 | 泰山医学院 | 一种抑制黑色素瘤细胞增殖的药物及其应用 |
| CN113564623A (zh) * | 2021-06-17 | 2021-10-29 | 福建师范大学 | 电化学氧化n-取代吲哚衍生物制备靛红化合物的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR65270B (en) * | 1978-10-10 | 1980-07-31 | Fujisawa Pharmaceutical Co | Isatin derivatives and processes for the preparation thereof |
| US4322533A (en) * | 1980-03-17 | 1982-03-30 | Lesher George Y | 1H-Indole-2,3-dione derivatives |
| US4780477A (en) * | 1985-06-08 | 1988-10-25 | Kissei Pharmaceutical Co., Ltd. | Isatin compositions having anti-ulcer activities |
| GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
| IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
| US5192792A (en) * | 1990-12-07 | 1993-03-09 | Warner-Lambert Company | Isatine derivatives, and their method of use |
| US5312928A (en) * | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| US5514690A (en) * | 1992-11-17 | 1996-05-07 | E. R. Squibb & Sons, Inc. | Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline |
| TW281669B (https=) * | 1993-02-17 | 1996-07-21 | Chugai Pharmaceutical Co Ltd | |
| US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| EP1002535A1 (en) * | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | New use of glutamate antagonists for the treatment of cancer |
-
1999
- 1999-12-03 DE DE69922997T patent/DE69922997T2/de not_active Expired - Lifetime
- 1999-12-03 AU AU16486/00A patent/AU1648600A/en not_active Abandoned
- 1999-12-03 EP EP99959238A patent/EP1135123B1/en not_active Expired - Lifetime
- 1999-12-03 WO PCT/DK1999/000679 patent/WO2000033834A1/en not_active Ceased
- 1999-12-03 JP JP2000586327A patent/JP2002531498A/ja active Pending
- 1999-12-03 AT AT99959238T patent/ATE285769T1/de not_active IP Right Cessation
-
2001
- 2001-05-15 US US09/854,355 patent/US20020016354A1/en not_active Abandoned
-
2002
- 2002-10-16 US US10/270,536 patent/US6969729B2/en not_active Expired - Fee Related