JP2005505588A5 - - Google Patents

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Publication number
JP2005505588A5
JP2005505588A5 JP2003533853A JP2003533853A JP2005505588A5 JP 2005505588 A5 JP2005505588 A5 JP 2005505588A5 JP 2003533853 A JP2003533853 A JP 2003533853A JP 2003533853 A JP2003533853 A JP 2003533853A JP 2005505588 A5 JP2005505588 A5 JP 2005505588A5
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JP
Japan
Prior art keywords
compound
base
cancer
treating cancer
hydroxytetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003533853A
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English (en)
Japanese (ja)
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JP2005505588A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/031730 external-priority patent/WO2003030819A2/en
Publication of JP2005505588A publication Critical patent/JP2005505588A/ja
Publication of JP2005505588A5 publication Critical patent/JP2005505588A5/ja
Pending legal-status Critical Current

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JP2003533853A 2001-10-05 2002-10-04 テトラサイクリン誘導体、及びそれを使用する方法 Pending JP2005505588A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32750201P 2001-10-05 2001-10-05
PCT/US2002/031730 WO2003030819A2 (en) 2001-10-05 2002-10-04 Tetracycline derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2005505588A JP2005505588A (ja) 2005-02-24
JP2005505588A5 true JP2005505588A5 (https=) 2006-09-07

Family

ID=23276795

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003533853A Pending JP2005505588A (ja) 2001-10-05 2002-10-04 テトラサイクリン誘導体、及びそれを使用する方法

Country Status (10)

Country Link
US (4) US7214669B2 (https=)
EP (1) EP1439843A4 (https=)
JP (1) JP2005505588A (https=)
CN (2) CN1564690A (https=)
AU (1) AU2002341970B2 (https=)
CA (1) CA2462572C (https=)
MY (1) MY133403A (https=)
NO (1) NO20041272L (https=)
RU (1) RU2300380C2 (https=)
WO (1) WO2003030819A2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EA013835B1 (ru) * 2001-03-13 2010-08-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
RU2300380C2 (ru) * 2001-10-05 2007-06-10 Тетрадженекс Фармасьютикалс, Инк. Производные тетрациклина и способы их применения
US20050026833A1 (en) * 2001-11-08 2005-02-03 Rabbani Shafaat Ahmed PSP-94: use for treatment of hypercalcemia and bone metastasis
ES2551708T3 (es) * 2002-01-08 2015-11-23 Paratek Pharmaceuticals, Inc. Compuestos de 4-desdimetilamino tetraciclina
CA2503446C (en) 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
SI1753713T1 (sl) 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
CA2597212A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
WO2007117639A2 (en) * 2006-04-07 2007-10-18 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2431469A3 (en) * 2006-05-15 2012-05-30 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
EP2487160B1 (en) * 2006-10-11 2016-02-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
ES2469829T3 (es) * 2009-11-26 2014-06-20 Sandoz Ag Reacción de compuestos orgánicos con bajas cantidades de hidrógeno
WO2011109899A1 (en) * 2010-03-10 2011-09-15 University Health Network Use of tigecycline for treatment of cancer
CN102631356B (zh) * 2012-04-11 2014-03-12 广州市东来生物科技有限公司 4-去二甲氨基四环素衍生物在抗幽门螺旋杆菌方面的用途
EP2852383A4 (en) * 2012-05-21 2016-03-16 Dcb Usa Llc METHODS OF DRUG TEST USING THE ZEBRAFIC MODEL AND COMPOUNDS TESTED THEREIN
MA40836A (fr) * 2014-10-23 2017-08-29 Tetraphase Pharmaceuticals Inc Procédures de semi-synthèse
EP3612540A1 (en) 2017-04-20 2020-02-26 Rising Tide Foundation Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
CN110156624B (zh) * 2019-05-29 2022-03-08 河北冀衡药业股份有限公司 一种米诺环素及其衍生物的合成方法
AU2022215936A1 (en) * 2021-02-03 2023-08-24 Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet) Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1063598B (de) * 1957-02-14 1959-08-20 Hoechst Ag Verfahren zur Herstellung von wasserloeslichen Derivaten der Tetracycline
DE1088481B (de) * 1958-01-29 1960-09-08 American Cyanamid Co Verfahren zur Herstellung neuer Verbindungen der Tetracyclinreihe
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3104240A (en) * 1958-08-18 1963-09-17 Bristol Myers Co Mannich bases of tetracycline antibiotics
US3026284A (en) * 1959-05-13 1962-03-20 Westinghouse Electric Corp Process of treating a thermoplastic amine-aldehyde resin with a thermosetting additive and product obtained therefrom
US3029284A (en) * 1960-09-14 1962-04-10 Pfizer & Co C Nu-dealkylation of carboxamido-nu-alkyltetracycline and its analogs
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3509184A (en) * 1961-08-18 1970-04-28 Pfizer & Co C Anthracyclidine-acetic acid derivatives
US3502696A (en) * 1961-08-18 1970-03-24 Pfizer & Co C Antibacterial agents
US3829453A (en) * 1961-08-18 1974-08-13 Pfizer Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof
US3772363A (en) * 1961-08-18 1973-11-13 Pfizer 3,4,10-trioxo octahydroanthracene-2-aminoacetic acids and derivatives thereof
US3145228A (en) * 1962-09-06 1964-08-18 Pfizer & Co C 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof
US3265732A (en) * 1964-02-28 1966-08-09 American Cyanamid Co Novel 5alpha, 6-anhydrotetracyclines
US3609188A (en) * 1964-10-29 1971-09-28 American Cyanamid Co 4-dedimethylamino-4-substituted-amino-6-demethyltetracyclines
US3326761A (en) * 1964-11-16 1967-06-20 Pfizer & Co C 6-demethyl-6-deoxytetracycline, anti-tumor antibiotic
US3345370A (en) * 1965-03-16 1967-10-03 American Cyanamid Co 4-(n-mono-substituted) hydrazones of 4-dedimethylamino-4-oxo-tetracycline
US3388162A (en) * 1966-03-14 1968-06-11 American Cyanamid Co 7-and/or 9-nitro or amino tetracyclines
US3515731A (en) * 1966-06-17 1970-06-02 Pfizer & Co C Antibacterial agents
US3849493A (en) * 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3345410A (en) * 1966-12-01 1967-10-03 American Cyanamid Co Substituted 7- and/or 9-amino tetracyclines
US3502660A (en) * 1967-01-12 1970-03-24 Pfizer & Co C 2-((5'-(3' and/or 4'-substituted)isoxazoyl) methylidene)-3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes
FR1520600A (fr) * 1967-02-27 1968-04-12 Snecma Perfectionnements aux turbo-machines à flux axial, et en particulier aux compresseurs axiaux à deux rotors imbriqués contrarotatifs
US3824285A (en) * 1967-09-13 1974-07-16 Pfizer 4-oxo-4-dedimethylaminotetracycline-4,6-hemiketals
US3622627A (en) * 1967-09-13 1971-11-23 Pfizer 4-dedimethylaminatetracycline and 5a, 6-anhydro derivatives thereof
US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
USRE34656E (en) 1983-12-29 1994-07-05 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
US4925833A (en) * 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US4666897A (en) * 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US5122519A (en) * 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
US5045538A (en) * 1990-06-28 1991-09-03 The Research Foundation Of State University Of New York Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
US5776898A (en) * 1991-05-14 1998-07-07 Dana-Farber Cancer Institute Method for treating a tumor with a chemotherapeutic agent
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
DK0599397T3 (da) * 1992-11-17 1996-09-16 Univ New York State Res Found Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
EP0733369A1 (en) * 1995-03-23 1996-09-25 Stichting REGA V.Z.W. Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth
US6277061B1 (en) * 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
DE69932846T2 (de) * 1998-11-18 2007-03-15 Collagenex Pharmaceuticals, Inc. Neue 4-dedimethylaminotetracyclinderivate
EA200201046A1 (ru) * 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
RU2300380C2 (ru) * 2001-10-05 2007-06-10 Тетрадженекс Фармасьютикалс, Инк. Производные тетрациклина и способы их применения

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