JP2003518060A5 - - Google Patents
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- JP2003518060A5 JP2003518060A5 JP2001546641A JP2001546641A JP2003518060A5 JP 2003518060 A5 JP2003518060 A5 JP 2003518060A5 JP 2001546641 A JP2001546641 A JP 2001546641A JP 2001546641 A JP2001546641 A JP 2001546641A JP 2003518060 A5 JP2003518060 A5 JP 2003518060A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- carbon atoms
- acid derivative
- acyl
- hydroxamic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 imidazolylmethyl Chemical group 0.000 claims 51
- 239000002253 acid Substances 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- 125000004432 carbon atom Chemical group C* 0.000 claims 34
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 241000124008 Mammalia Species 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000002252 acyl group Chemical group 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 125000002883 imidazolyl group Chemical group 0.000 claims 8
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 8
- 125000004442 acylamino group Chemical group 0.000 claims 7
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 4
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 4
- 125000005605 benzo group Chemical group 0.000 claims 4
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 2
- SILNNFMWIMZVEQ-UHFFFAOYSA-N 1,3-dihydrobenzimidazol-2-one Chemical compound C1=CC=C2NC(O)=NC2=C1 SILNNFMWIMZVEQ-UHFFFAOYSA-N 0.000 claims 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 1
- ABCGRFHYOYXEJV-UHFFFAOYSA-N 4-methylisoindole-1,3-dione Chemical compound CC1=CC=CC2=C1C(=O)NC2=O ABCGRFHYOYXEJV-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241000102542 Kara Species 0.000 claims 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- KPGBXYROPKMUOQ-UHFFFAOYSA-N [[3-(1,3-dioxobenzo[e]isoindol-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoyl]amino] acetate Chemical compound C1=C(OC)C(OCC)=CC(C(CC(=O)NOC(C)=O)N2C(C3=C4C=CC=CC4=CC=C3C2=O)=O)=C1 KPGBXYROPKMUOQ-UHFFFAOYSA-N 0.000 claims 1
- GZFZOEHTHBPADL-UHFFFAOYSA-N [[3-(1,3-dioxoisoindol-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoyl]amino] pentanoate Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(CC(=O)NOC(=O)CCCC)C1=CC=C(OC)C(OCC)=C1 GZFZOEHTHBPADL-UHFFFAOYSA-N 0.000 claims 1
- RKUKMEJKLRORIR-UHFFFAOYSA-N [[3-(1,3-dioxoisoindol-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoyl]amino] propanoate Chemical compound C1=C(OC)C(OCC)=CC(C(CC(=O)NOC(=O)CC)N2C(C3=CC=CC=C3C2=O)=O)=C1 RKUKMEJKLRORIR-UHFFFAOYSA-N 0.000 claims 1
- VJTXUIHFOFREFB-UHFFFAOYSA-N [[3-(3-cyclopentyloxy-4-methoxyphenyl)-3-(5-methyl-1,3-dioxoisoindol-2-yl)propanoyl]amino] acetate Chemical compound COC1=CC=C(C(CC(=O)NOC(C)=O)N2C(C3=CC(C)=CC=C3C2=O)=O)C=C1OC1CCCC1 VJTXUIHFOFREFB-UHFFFAOYSA-N 0.000 claims 1
- UIGKRPMDNHMRCE-UHFFFAOYSA-N [[3-(3-ethoxy-4-methoxyphenyl)-3-(4-methyl-1,3-dioxoisoindol-2-yl)propanoyl]amino] acetate Chemical compound C1=C(OC)C(OCC)=CC(C(CC(=O)NOC(C)=O)N2C(C3=C(C)C=CC=C3C2=O)=O)=C1 UIGKRPMDNHMRCE-UHFFFAOYSA-N 0.000 claims 1
- TZYJLDLGDKPCJN-UHFFFAOYSA-N [[3-(4-acetamido-1,3-dioxoisoindol-2-yl)-3-(3-cyclopentyloxy-4-methoxyphenyl)propanoyl]-acetylamino] acetate Chemical compound COC1=CC=C(C(CC(=O)N(OC(C)=O)C(C)=O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)C=C1OC1CCCC1 TZYJLDLGDKPCJN-UHFFFAOYSA-N 0.000 claims 1
- MBEKEDVTWGAHSR-UHFFFAOYSA-N [[3-(4-acetamido-1,3-dioxoisoindol-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoyl]amino] acetate Chemical compound C1=C(OC)C(OCC)=CC(C(CC(=O)NOC(C)=O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)=C1 MBEKEDVTWGAHSR-UHFFFAOYSA-N 0.000 claims 1
- MTUSUIOBWDPHJZ-UHFFFAOYSA-N [[3-(5-acetamido-1,3-dioxoisoindol-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoyl]amino] acetate Chemical compound C1=C(OC)C(OCC)=CC(C(CC(=O)NOC(C)=O)N2C(C3=CC(NC(C)=O)=CC=C3C2=O)=O)=C1 MTUSUIOBWDPHJZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 208000002399 aphthous stomatitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 125000005293 bicycloalkoxy group Chemical group 0.000 claims 1
- 150000001602 bicycloalkyls Chemical group 0.000 claims 1
- 208000020670 canker sore Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-M nicotinate Chemical compound [O-]C(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-M 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/468,529 US6699899B1 (en) | 1999-12-21 | 1999-12-21 | Substituted acylhydroxamic acids and method of reducing TNFα levels |
| US09/468,529 | 1999-12-21 | ||
| PCT/US2000/034455 WO2001045702A1 (en) | 1999-12-21 | 2000-12-19 | SUBSTITUTED ACYLHYDROXAMIC ACIDS AND METHOD OF REDUCING TNFα LEVELS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003518060A JP2003518060A (ja) | 2003-06-03 |
| JP2003518060A5 true JP2003518060A5 (https=) | 2005-06-09 |
Family
ID=23860180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001546641A Pending JP2003518060A (ja) | 1999-12-21 | 2000-12-19 | 置換アシルヒドロキサム酸およびＴＮＦαレベルの減少方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6699899B1 (https=) |
| EP (1) | EP1246620A4 (https=) |
| JP (1) | JP2003518060A (https=) |
| KR (2) | KR100831339B1 (https=) |
| CN (1) | CN1413109A (https=) |
| AU (1) | AU782634B2 (https=) |
| CA (1) | CA2394604A1 (https=) |
| FI (1) | FI20021193L (https=) |
| HK (1) | HK1050625A1 (https=) |
| MX (1) | MXPA02005840A (https=) |
| NO (2) | NO323515B1 (https=) |
| NZ (1) | NZ519638A (https=) |
| TW (2) | TWI282788B (https=) |
| WO (1) | WO2001045702A1 (https=) |
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| US6699899B1 (en) * | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
| US8030343B2 (en) * | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
| EP2258363A1 (en) * | 2002-05-17 | 2010-12-08 | Celgene Corporation | Compositions for treatment of cancers |
| CN1713905A (zh) * | 2002-10-15 | 2005-12-28 | 细胞基因公司 | 用于治疗骨髓增生异常综合征的选择性细胞因子抑制药 |
| US20040087558A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
| US7776907B2 (en) | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
| MXPA05004777A (es) * | 2002-11-06 | 2005-07-22 | Celgene Corp | Metodos de uso y composiciones que comprenden farmacos inhibidores selectivos de citocina para el tratamiento y el manejo de padecimientos mieloproliferativos. |
| TW200501945A (en) | 2002-11-06 | 2005-01-16 | Celgene Corp | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
| NZ540546A (en) * | 2002-11-18 | 2008-03-28 | Celgene Corp | Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
| EP1581205A1 (en) * | 2002-11-18 | 2005-10-05 | Celgene Corporation | Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
| BR0317885A (pt) * | 2002-12-30 | 2005-12-06 | Celgene Corp | Composto, isÈmeros s e r enantiomericamente puros do mesmo, composição farmacêutica e métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa, de tratar ou prevenir mds, de tratar doença mieloproliferativa, angiogênese indesejada, câncer, uma doença, inflamação dos pulmões, depressão, distúrbio pulmonar obstrutivo crÈnico, doença inflamatória do intestino, dermatite atópica, psorìase, doença de crohn, artrite reumatóide, asma, eslcerose múltipla e doença cardìaca em um mamìfero e de tratar, prevenir ou controlar a sìndrome de dor regional complexa |
| US20040175382A1 (en) * | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
| DE602004032522D1 (de) * | 2003-03-12 | 2011-06-16 | Celgene Corp | Mit n-alkylhydroxamsäuren substituierte isoindolylverbindungen und deren pharmazeutische verwendung |
| JP4713465B2 (ja) | 2003-03-12 | 2011-06-29 | セルジーン コーポレイション | ７−アミド−イソインドリル化合物およびその薬学的使用 |
| CN100427465C (zh) * | 2003-03-12 | 2008-10-22 | 细胞基因公司 | N-烷基-异羟肟酸-异吲哚基化合物及其药物用途 |
| US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
| CN101010298A (zh) * | 2004-04-05 | 2007-08-01 | 默克Hdac研究有限责任公司 | 组蛋白脱乙酰酶抑制剂前药 |
| US20080213213A1 (en) * | 2004-04-14 | 2008-09-04 | Zeldis Jerome B | Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione |
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| US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| US20070190070A1 (en) * | 2004-09-03 | 2007-08-16 | Zeldis Jerome B | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
| WO2006050057A2 (en) * | 2004-10-28 | 2006-05-11 | Celgene Corporation | Methods and compositions using pde4 modulators for treatment and management of central nervous system injury |
| WO2007134169A2 (en) * | 2006-05-10 | 2007-11-22 | Nuada, Llc | Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof |
| KR20070092276A (ko) * | 2004-12-13 | 2007-09-12 | 셀진 코포레이션 | Ｐｄｅ４ 조절인자를 포함하는 조성물 및 이의 기도염의치료 또는 예방을 위한 용도 |
| US20080138295A1 (en) * | 2005-09-12 | 2008-06-12 | Celgene Coporation | Bechet's disease using cyclopropyl-N-carboxamide |
| KR100608487B1 (ko) * | 2006-05-08 | 2006-08-02 | (주)거산기계 | 웨어 임펙트 플레이트가 장착된 외벽 함몰형 로터 |
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| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| TWI519508B (zh) * | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| WO2009110947A2 (en) * | 2007-12-19 | 2009-09-11 | Alba Therapeutics Corporation | Compositions and methods for inhibiting cytokine production |
| BRPI0802255A2 (pt) * | 2008-06-17 | 2010-03-16 | Sespo Ind E Com Ltda | composição de uso tópico para controle de ectoparasitos em cães e gatos |
| CN101654427B (zh) * | 2008-08-19 | 2012-12-05 | 信谊药厂 | 抗凝化合物、组合物及其用途 |
| EP2395995A1 (en) * | 2009-02-10 | 2011-12-21 | Celgene Corporation | Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis |
| MX341050B (es) | 2010-04-07 | 2016-08-05 | Celgene Corp * | Metodos para tratar infeccion viral respiratoria. |
| EP2583098B1 (en) | 2010-06-15 | 2018-08-08 | Celgene Corporation | Biomarkers for the treatment of psoriasis |
| WO2015175956A1 (en) | 2014-05-16 | 2015-11-19 | Celgene Corporation | Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators |
| WO2017070291A1 (en) | 2015-10-21 | 2017-04-27 | Celgene Corporation | Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris) |
| CN105294533A (zh) * | 2015-12-02 | 2016-02-03 | 宋彤云 | 一种治疗骨病的药物组合物 |
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| PT871439E (pt) | 1996-01-02 | 2004-08-31 | Aventis Pharma Inc | Compostos do acido hidroxamico substituidos (arilo heteroarilo arilmetilo ou heteroarilmetilo) |
| NZ334148A (en) | 1996-08-12 | 2001-12-21 | Celgene Corp | 3-Substituted phenyl-ethyl or ethenyl derivatives terminated with a nitrile, alkane, carboxyl or carbamoyl group useful to reduce cytokine levels |
| HUP0003761A3 (en) * | 1997-07-31 | 2001-04-28 | Celgene Corp Warren | Substituted alkanohydroxamic acids and pharmaceutical compositions containing them |
| EP1030851B1 (en) * | 1997-11-12 | 2005-01-12 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| US6020358A (en) | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| US6699899B1 (en) * | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
| JP4713465B2 (ja) * | 2003-03-12 | 2011-06-29 | セルジーン コーポレイション | ７−アミド−イソインドリル化合物およびその薬学的使用 |
-
1999
- 1999-12-21 US US09/468,529 patent/US6699899B1/en not_active Expired - Fee Related
-
2000
- 2000-12-12 TW TW089125922A patent/TWI282788B/zh active
- 2000-12-12 TW TW095124062A patent/TWI295925B/zh not_active IP Right Cessation
- 2000-12-19 NZ NZ519638A patent/NZ519638A/en unknown
- 2000-12-19 CN CN00817538A patent/CN1413109A/zh active Pending
- 2000-12-19 EP EP00988151A patent/EP1246620A4/en not_active Withdrawn
- 2000-12-19 HK HK03101278.8A patent/HK1050625A1/zh unknown
- 2000-12-19 AU AU24389/01A patent/AU782634B2/en not_active Ceased
- 2000-12-19 CA CA002394604A patent/CA2394604A1/en not_active Abandoned
- 2000-12-19 KR KR1020027007915A patent/KR100831339B1/ko not_active Expired - Fee Related
- 2000-12-19 KR KR1020077015292A patent/KR20070086919A/ko not_active Ceased
- 2000-12-19 MX MXPA02005840A patent/MXPA02005840A/es active IP Right Grant
- 2000-12-19 JP JP2001546641A patent/JP2003518060A/ja active Pending
- 2000-12-19 WO PCT/US2000/034455 patent/WO2001045702A1/en not_active Ceased
-
2002
- 2002-06-18 NO NO20022936A patent/NO323515B1/no not_active IP Right Cessation
- 2002-06-19 FI FI20021193A patent/FI20021193L/fi not_active Application Discontinuation
-
2004
- 2004-02-25 US US10/786,822 patent/US7345062B2/en not_active Expired - Fee Related
-
2007
- 2007-03-21 NO NO20071498A patent/NO20071498L/no not_active Application Discontinuation
-
2008
- 2008-01-16 US US12/009,182 patent/US20080280967A1/en not_active Abandoned
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