|
US7601691B2
(en)
|
1999-05-17 |
2009-10-13 |
Conjuchem Biotechnologies Inc. |
Anti-obesity agents
|
|
US6887470B1
(en)
|
1999-09-10 |
2005-05-03 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
|
CA2363712C
(en)
|
1999-05-17 |
2011-05-10 |
Conjuchem Inc. |
Long lasting insulinotropic peptides
|
|
US20030054988A1
(en)
*
|
2000-11-02 |
2003-03-20 |
Weidong-Richard Ji |
Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
|
|
CN1491233A
(zh)
*
|
2001-02-02 |
2004-04-21 |
康久化学公司 |
长效生长激素释放因子衍生物
|
|
ATE396202T1
(de)
*
|
2001-02-16 |
2008-06-15 |
Conjuchem Biotechnologies Inc |
Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen
|
|
US7736654B2
(en)
|
2001-04-10 |
2010-06-15 |
Agensys, Inc. |
Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers
|
|
EP1381627B8
(en)
*
|
2001-04-18 |
2011-01-12 |
The Open University |
Polypeptides derived from amyloid precursor peptide (app) and their uses
|
|
US7491702B2
(en)
|
2001-04-18 |
2009-02-17 |
The Open University |
Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same
|
|
JP2004536062A
(ja)
*
|
2001-05-17 |
2004-12-02 |
セレメディックス,インク. |
反応性酸素種およびフリーラジカルの効力を中和するためのペプチド化合物
|
|
EP1395833B1
(en)
|
2001-05-31 |
2013-02-27 |
Adlyfe, Inc. |
Misfolded protein sensor method
|
|
US20050026165A1
(en)
*
|
2001-05-31 |
2005-02-03 |
Cindy Orser |
Detection of conformationally altered proteins and prions
|
|
US7741453B2
(en)
|
2001-05-31 |
2010-06-22 |
Conjuchem Biotechnologies, Inc. |
Long lasting fusion peptide inhibitors for HIV infection
|
|
RU2297238C2
(ru)
*
|
2001-10-18 |
2007-04-20 |
Златко АДЕМОВИЧ |
Аддитивные цитопротекторные эффекты двух биоактивных областей гормона про-опиомеланокортина
|
|
US6822073B2
(en)
*
|
2001-12-20 |
2004-11-23 |
Kimberly-Clark Worldwide, Inc. |
Modular peptide-based reagent
|
|
AU2003221096A1
(en)
*
|
2002-03-19 |
2003-09-29 |
Oncorex, Inc. |
Peptides, medicinal compositions containing the peptide and medicinal compositions for treating cancer
|
|
JP2004008027A
(ja)
*
|
2002-06-04 |
2004-01-15 |
Japan Science & Technology Corp |
cAMPの産生活性を有する新規ペプチド
|
|
WO2004011595A2
(fr)
*
|
2002-07-26 |
2004-02-05 |
Institut Pasteur |
Vecteurs destines au transfert de molecules d'interet dans des cellules cibles
|
|
AU2003246500A1
(en)
*
|
2002-07-31 |
2004-02-16 |
Conjuchem Biotechnologies Inc. |
Long lasting natriuretic peptide derivatives
|
|
CA2500248C
(en)
*
|
2002-09-24 |
2013-03-19 |
Frontier Biotechnologies Co., Ltd. |
Peptide derivative fusion inhibitors of hiv infection
|
|
US7378495B2
(en)
*
|
2002-10-21 |
2008-05-27 |
Pevion Biotech, Ltd. |
PTH-rP related peptide cancer therapeutics
|
|
WO2004039832A2
(en)
*
|
2002-10-31 |
2004-05-13 |
Albany Medical College |
Leptin-related peptides
|
|
JP5068428B2
(ja)
|
2002-11-07 |
2012-11-07 |
アメリカ合衆国 |
血管新生および抗血管新生療法のための標的
|
|
AU2003297583B2
(en)
*
|
2002-11-26 |
2010-01-14 |
Biocon, Ltd |
Modified naturetic compounds, conjugates, and uses thereof
|
|
US7648962B2
(en)
|
2002-11-26 |
2010-01-19 |
Biocon Limited |
Natriuretic compounds, conjugates, and uses thereof
|
|
US20060223767A1
(en)
*
|
2003-01-10 |
2006-10-05 |
Haruo Hanawa |
Vector for gene therapy and method of quantifying target protein in mammal or cultured cells with the administration of the vector for gene therapy
|
|
WO2004069270A1
(en)
*
|
2003-01-29 |
2004-08-19 |
Advanced Research And Technology Institute, Inc. |
Immunoregulating compounds and an associated method
|
|
DE10316583A1
(de)
*
|
2003-04-10 |
2004-10-28 |
B.R.A.H.M.S Aktiengesellschaft |
Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
|
|
EP1620734A1
(en)
*
|
2003-04-25 |
2006-02-01 |
Genova Ltd. |
Secreted polypeptide species reduced cardiovascular disorders
|
|
DE602004021603D1
(de)
*
|
2003-07-25 |
2009-07-30 |
Conjuchem Biotechnologies Inc |
Insulinderivative mit langanhaltender wirkung und verfahren zu deren herstellung
|
|
WO2005077094A2
(en)
*
|
2004-02-11 |
2005-08-25 |
Amylin Pharmaceuticals, Inc. |
Pancreatic polypeptide family motifs and polypeptides comprising the same
|
|
JPWO2005090399A1
(ja)
*
|
2004-03-24 |
2008-05-08 |
財団法人岐阜県研究開発財団 |
各種細胞の増殖・分化を認識する抗体、その抗体を用いた増殖・分化の評価方法
|
|
EP2518510A1
(en)
*
|
2004-04-20 |
2012-10-31 |
SphingoTec GmbH |
Use of precursors of tachykinins and/or their fragments in medical diagnostic
|
|
DE602005027461D1
(de)
|
2004-04-21 |
2011-05-26 |
Enobia Pharma Inc |
Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen
|
|
DK2100904T3
(da)
|
2004-04-23 |
2010-11-08 |
Conjuchem Biotechnologies Inc |
Fast fase til anvendelse i en fremgangsmåde til rensning af albuminkonjugater
|
|
ES2363156T3
(es)
*
|
2004-05-13 |
2011-07-22 |
B.R.A.H.M.S Gmbh |
Uso de precursores de encefalinas y/o sus fragmentos en diagnosis médica.
|
|
AU2012202855B2
(en)
*
|
2004-09-03 |
2015-02-26 |
Philipps-Universitat Marburg |
GLP-1 and exendin related invention
|
|
DE102004043153B4
(de)
*
|
2004-09-03 |
2013-11-21 |
Philipps-Universität Marburg |
Erfindung betreffend GLP-1 und Exendin
|
|
JP4849642B2
(ja)
|
2004-11-24 |
2012-01-11 |
ネオプロ ラブス, エルエルシー |
状態を処置するための方法および組成物
|
|
JP4720175B2
(ja)
*
|
2004-12-15 |
2011-07-13 |
富士ゼロックス株式会社 |
マレイミジル基含有材料およびその製造方法
|
|
DE102005003687A1
(de)
|
2005-01-26 |
2006-07-27 |
Sphingo Tec Gmbh |
Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
|
|
EP1853915B1
(en)
|
2005-02-15 |
2011-10-12 |
Adlyfe, Inc. |
Method for detecting misfolded proteins and prions
|
|
WO2006108686A2
(en)
*
|
2005-04-14 |
2006-10-19 |
Aic |
Bnp agonists
|
|
US7833979B2
(en)
|
2005-04-22 |
2010-11-16 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
WO2006121869A2
(en)
*
|
2005-05-05 |
2006-11-16 |
The Board Of Trustees Of The University Of Illinois |
Compositions and methods for treating mood and anxiety disorders
|
|
KR20080072639A
(ko)
*
|
2005-10-27 |
2008-08-06 |
주식회사 펩트론 |
생리활성 기질-혈액 단백질 복합체 및 이를 이용하는생리활성 기질의 안정화 방법
|
|
CA2647835A1
(en)
|
2006-03-28 |
2007-10-04 |
Neopro Labs, Llc |
Methods and compositions for treating conditions
|
|
US7982018B2
(en)
|
2006-10-16 |
2011-07-19 |
Conjuchem, Llc |
Modified corticotropin releasing factor peptides and uses thereof
|
|
WO2008052043A2
(en)
*
|
2006-10-24 |
2008-05-02 |
Cogenesys, Inc. |
Opioid receptor agonist fusion proteins
|
|
PE20081140A1
(es)
|
2006-10-25 |
2008-09-22 |
Amgen Inc |
Agentes terapeuticos a base de peptidos derivados de toxinas
|
|
AU2008232709C1
(en)
|
2007-03-28 |
2015-01-15 |
President And Fellows Of Harvard College |
Stitched polypeptides
|
|
JP2010527377A
(ja)
|
2007-05-17 |
2010-08-12 |
ネオプロ ラブス,エルエルシー |
ペプチドの結晶形および非結晶形
|
|
EP2162540A2
(en)
|
2007-05-22 |
2010-03-17 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
WO2009023125A1
(en)
*
|
2007-08-14 |
2009-02-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Neuronostatin and its uses
|
|
AU2008297411A1
(en)
*
|
2007-09-11 |
2009-03-19 |
Mondobiotech Laboratories Ag |
Use of a peptide as a therapeutic agent
|
|
EP2197469A2
(en)
*
|
2007-09-11 |
2010-06-23 |
Mondobiotech Laboratories AG |
Use of nf-kappab inhibitor sn50 and optionally angiotensin iii as therapeutic agents in the treatment of eg hbv infection
|
|
CA2698666A1
(en)
*
|
2007-09-11 |
2009-03-19 |
Mondobiotech Laboratories Ag |
Use of a peptide as a therapeutic agent
|
|
KR20100057642A
(ko)
*
|
2007-09-11 |
2010-05-31 |
몬도바이오테크 래보래토리즈 아게 |
치료제로서의 cnp-22 단독 또는 피살라에민과 배합된 이의 용도
|
|
MX2010008024A
(es)
*
|
2008-02-01 |
2010-12-21 |
Ascendis Pharma As |
Profarmaco que comprende un enlazador que se puede separar por si mismo.
|
|
ES2563553T3
(es)
|
2008-04-01 |
2016-03-15 |
Novo Nordisk A/S |
Conjugados de insulina-albúmina
|
|
WO2009142727A2
(en)
*
|
2008-05-19 |
2009-11-26 |
Vasogenix Pharmaceuticals, Inc. |
Sequence modified calcitonin gene related peptides (cgrp)
|
|
CA2751730A1
(en)
|
2009-02-25 |
2010-09-02 |
Merck Sharp & Dohme Corp. |
Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
|
|
MY161842A
(en)
*
|
2009-07-29 |
2017-05-15 |
Daiichi Sankyo Co Ltd |
Motilin-like peptide compound having transmucosal absorbability imparted thereto
|
|
PL2459171T3
(pl)
|
2009-07-31 |
2017-11-30 |
Sanofi-Aventis Deutschland Gmbh |
Kompozycja insuliny o długim działaniu
|
|
AU2010277559B2
(en)
|
2009-07-31 |
2016-08-11 |
Sanofi-Aventis Deutschland Gmbh |
Prodrugs comprising an insulin linker conjugate
|
|
US8815806B2
(en)
|
2009-10-28 |
2014-08-26 |
University Of Manitoba |
Yellow pea seed protein-derived peptides
|
|
BR112012020882A2
(pt)
|
2010-02-24 |
2015-11-03 |
Merck Sharp & Dohme |
métodos para produzir uma glicoproteína heteróloga e para produzir uma composição de glicoproteína, célula hospedeira, composição de glicoproteína, e, uso da pichia pastoris recombinante.
|
|
EP2552950A1
(en)
*
|
2010-03-26 |
2013-02-06 |
Novo Nordisk A/S |
Novel glucagon analogues
|
|
KR20170058446A
(ko)
|
2010-08-13 |
2017-05-26 |
에일러론 테라퓨틱스 인코포레이티드 |
펩티도미메틱 거대고리
|
|
EP2438930A1
(en)
|
2010-09-17 |
2012-04-11 |
Sanofi-Aventis Deutschland GmbH |
Prodrugs comprising an exendin linker conjugate
|
|
JP6055779B2
(ja)
|
2010-12-27 |
2016-12-27 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
ナトリウム利尿ペプチドを含む組成物およびその使用方法
|
|
RU2610175C2
(ru)
|
2011-09-23 |
2017-02-08 |
Ново Нордиск А/С |
Новые аналоги глюкагона
|
|
AR088392A1
(es)
|
2011-10-18 |
2014-05-28 |
Aileron Therapeutics Inc |
Macrociclos peptidomimeticos
|
|
HK1205454A1
(en)
|
2012-02-15 |
2015-12-18 |
Aileron Therapeutics, Inc. |
Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
|
|
CA2862038C
(en)
|
2012-02-15 |
2021-05-25 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles
|
|
JP2013179884A
(ja)
*
|
2012-03-01 |
2013-09-12 |
Mitsubishi Rayon Co Ltd |
メラニンカスケードに関与する成分を評価するための核酸マイクロアレイ及びメラニンカスケードに関与する成分の評価方法
|
|
CN108524919A
(zh)
|
2012-05-17 |
2018-09-14 |
延伸生物科学股份有限公司 |
用于改进的药物递送的载体
|
|
US10052366B2
(en)
|
2012-05-21 |
2018-08-21 |
Alexion Pharmaceuticsl, Inc. |
Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
|
|
BR112015009470A2
(pt)
|
2012-11-01 |
2019-12-17 |
Aileron Therapeutics Inc |
aminoácidos dissubstituídos e seus métodos de preparação e uso
|
|
SI2986313T1
(sl)
|
2013-04-18 |
2019-09-30 |
Novo Nordisk A/S |
Stabilni koagonisti GLP-1 / glukagonskega receptorja z dolgotrajnim učinkom za medicinsko uporabo
|
|
PT3016671T
(pt)
*
|
2013-07-04 |
2021-12-02 |
Univ Barcelona |
Péptidos ativamente transportados e resistentes à protease como transportes bbb e construtos de transporte de carga
|
|
US20150196651A1
(en)
*
|
2014-01-15 |
2015-07-16 |
USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, v.v.i. |
Lipidated peptides for lowering blood glucose
|
|
US10570184B2
(en)
|
2014-06-04 |
2020-02-25 |
Novo Nordisk A/S |
GLP-1/glucagon receptor co-agonists for medical use
|
|
US10822596B2
(en)
|
2014-07-11 |
2020-11-03 |
Alexion Pharmaceuticals, Inc. |
Compositions and methods for treating craniosynostosis
|
|
WO2016049359A1
(en)
|
2014-09-24 |
2016-03-31 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles and uses thereof
|
|
US9585934B2
(en)
|
2014-10-22 |
2017-03-07 |
Extend Biosciences, Inc. |
Therapeutic vitamin D conjugates
|
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
|
WO2016065052A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Insulin vitamin d conjugates
|
|
JP6787894B2
(ja)
|
2014-12-05 |
2020-11-18 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
組換えアルカリホスファターゼを用いた発作の処置
|
|
JP6868561B2
(ja)
|
2015-01-28 |
2021-05-12 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
アルカリホスファターゼ欠損を有する被験者を治療する方法
|
|
ES2740273T3
(es)
*
|
2015-02-22 |
2020-02-05 |
Omnix Medical Ltd |
Péptidos antimicrobianos
|
|
US10253067B2
(en)
|
2015-03-20 |
2019-04-09 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles and uses thereof
|
|
JP6993961B2
(ja)
|
2015-08-17 |
2022-01-14 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
アルカリホスファターゼの製造
|
|
EP3355904A4
(en)
|
2015-09-28 |
2019-06-12 |
Alexion Pharmaceuticals, Inc. |
IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA
|
|
WO2017074466A1
(en)
|
2015-10-30 |
2017-05-04 |
Alexion Pharmaceuticals, Inc. |
Methods for treating craniosynostosis in a patient
|
|
US11530243B2
(en)
*
|
2016-02-18 |
2022-12-20 |
Veiove Animal Health Inc. |
Non-cleavable substance P conjugates and methods of use thereof
|
|
WO2017155569A1
(en)
|
2016-03-08 |
2017-09-14 |
Alexion Pharmaceuticals, Inc. |
Methods for treating hypophosphatasia in children
|
|
KR20240160671A
(ko)
|
2016-04-01 |
2024-11-11 |
알렉시온 파마슈티칼스, 인코포레이티드 |
알칼리성 포스파타아제로 근육 약화의 치료
|
|
US10898549B2
(en)
|
2016-04-01 |
2021-01-26 |
Alexion Pharmaceuticals, Inc. |
Methods for treating hypophosphatasia in adolescents and adults
|
|
EP3464573B1
(en)
|
2016-06-06 |
2026-03-04 |
Alexion Pharmaceuticals, Inc. |
Metal impact on manufacturing of alkaline phosphatases
|
|
EP3500289B1
(en)
|
2016-08-18 |
2024-10-09 |
Alexion Pharmaceuticals, Inc. |
Asfotase alfa for use in treating tracheobronchomalacia
|
|
JP6965362B2
(ja)
|
2017-03-01 |
2021-11-10 |
チェンドゥ フイタイ バイオメディスン カンパニー リミテッドChengdu Huitai Biomedicine Co., Ltd. |
ポリペプチド、ポリペプチド断片及びその誘導体、並びに応用
|
|
KR20190129058A
(ko)
|
2017-03-31 |
2019-11-19 |
알렉시온 파마슈티칼스, 인코포레이티드 |
성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법
|
|
JP7376007B2
(ja)
*
|
2017-06-02 |
2023-11-08 |
株式会社Lsiメディエンス |
生体試料中からの標的タンパク質の抽出方法および標的タンパク質の分析方法
|
|
CN109503700A
(zh)
*
|
2017-09-14 |
2019-03-22 |
南京安吉生物科技有限公司 |
马来酰亚胺基团修饰的血管生成抑制剂hm-1及其应用
|
|
EP3717508A1
(en)
|
2017-12-01 |
2020-10-07 |
The University of Copenhagen |
Peptide hormone with one or more o-glycans
|
|
US11913039B2
(en)
|
2018-03-30 |
2024-02-27 |
Alexion Pharmaceuticals, Inc. |
Method for producing recombinant alkaline phosphatase
|
|
WO2019197313A1
(en)
|
2018-04-09 |
2019-10-17 |
Svar Life Science Ab |
Glucagon Assay
|
|
ES2972119T3
(es)
|
2018-08-10 |
2024-06-11 |
Alexion Pharma Inc |
Cicatrización ósea en implantes utilizando fosfatasa alcalina
|
|
WO2020142522A2
(en)
*
|
2018-12-31 |
2020-07-09 |
United Neuroscience |
Peptide immunogens targeting calcitonin gene-related peptide (cgrp) and formulations thereof for prevention and treatment of migraine
|
|
KR20220111693A
(ko)
|
2019-12-09 |
2022-08-09 |
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|
|
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(it)
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|
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|
|
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(en)
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|
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|
|
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(en)
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|
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|
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|
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|
|
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|
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|
|
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|
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|
|
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|
|
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|
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|
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|
|
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|
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|
|
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(en)
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|
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|