ES2257298T3 - Proteccion de peptidos terapeuticos endogenos contra la actividad de la peptidasa a traves de la conjugacion con componentes sanguineos. - Google Patents
Proteccion de peptidos terapeuticos endogenos contra la actividad de la peptidasa a traves de la conjugacion con componentes sanguineos.Info
- Publication number
- ES2257298T3 ES2257298T3 ES00936023T ES00936023T ES2257298T3 ES 2257298 T3 ES2257298 T3 ES 2257298T3 ES 00936023 T ES00936023 T ES 00936023T ES 00936023 T ES00936023 T ES 00936023T ES 2257298 T3 ES2257298 T3 ES 2257298T3
- Authority
- ES
- Spain
- Prior art keywords
- fmoc
- peptide
- therapeutic
- amino acid
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/575—Hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/575—Hormones
- C07K14/605—Glucagons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13440699P | 1999-05-17 | 1999-05-17 | |
| US134406P | 1999-05-17 | ||
| US15340699P | 1999-09-10 | 1999-09-10 | |
| US153406P | 1999-09-10 | ||
| US15978399P | 1999-10-15 | 1999-10-15 | |
| US159783P | 1999-10-15 |
Publications (1)
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| ES2257298T3 true ES2257298T3 (es) | 2006-08-01 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| ES00936023T Expired - Lifetime ES2257298T3 (es) | 1999-05-17 | 2000-05-17 | Proteccion de peptidos terapeuticos endogenos contra la actividad de la peptidasa a traves de la conjugacion con componentes sanguineos. |
Country Status (11)
| Country | Link |
|---|---|
| EP (5) | EP1591453A1 (https=) |
| JP (6) | JP4217004B2 (https=) |
| AT (1) | ATE318835T1 (https=) |
| AU (1) | AU765753B2 (https=) |
| CA (4) | CA2499211A1 (https=) |
| DE (1) | DE60026300T2 (https=) |
| DK (1) | DK1105409T3 (https=) |
| ES (1) | ES2257298T3 (https=) |
| PT (1) | PT1105409E (https=) |
| SI (1) | SI1105409T1 (https=) |
| WO (1) | WO2000069900A2 (https=) |
Families Citing this family (124)
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| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| CA2363712C (en) | 1999-05-17 | 2011-05-10 | Conjuchem Inc. | Long lasting insulinotropic peptides |
| US20030054988A1 (en) * | 2000-11-02 | 2003-03-20 | Weidong-Richard Ji | Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors |
| CN1491233A (zh) * | 2001-02-02 | 2004-04-21 | 康久化学公司 | 长效生长激素释放因子衍生物 |
| ATE396202T1 (de) * | 2001-02-16 | 2008-06-15 | Conjuchem Biotechnologies Inc | Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| EP1381627B8 (en) * | 2001-04-18 | 2011-01-12 | The Open University | Polypeptides derived from amyloid precursor peptide (app) and their uses |
| US7491702B2 (en) | 2001-04-18 | 2009-02-17 | The Open University | Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same |
| JP2004536062A (ja) * | 2001-05-17 | 2004-12-02 | セレメディックス，インク． | 反応性酸素種およびフリーラジカルの効力を中和するためのペプチド化合物 |
| EP1395833B1 (en) | 2001-05-31 | 2013-02-27 | Adlyfe, Inc. | Misfolded protein sensor method |
| US20050026165A1 (en) * | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
| US7741453B2 (en) | 2001-05-31 | 2010-06-22 | Conjuchem Biotechnologies, Inc. | Long lasting fusion peptide inhibitors for HIV infection |
| RU2297238C2 (ru) * | 2001-10-18 | 2007-04-20 | Златко АДЕМОВИЧ | Аддитивные цитопротекторные эффекты двух биоактивных областей гормона про-опиомеланокортина |
| US6822073B2 (en) * | 2001-12-20 | 2004-11-23 | Kimberly-Clark Worldwide, Inc. | Modular peptide-based reagent |
| AU2003221096A1 (en) * | 2002-03-19 | 2003-09-29 | Oncorex, Inc. | Peptides, medicinal compositions containing the peptide and medicinal compositions for treating cancer |
| JP2004008027A (ja) * | 2002-06-04 | 2004-01-15 | Japan Science & Technology Corp | ｃＡＭＰの産生活性を有する新規ペプチド |
| WO2004011595A2 (fr) * | 2002-07-26 | 2004-02-05 | Institut Pasteur | Vecteurs destines au transfert de molecules d'interet dans des cellules cibles |
| AU2003246500A1 (en) * | 2002-07-31 | 2004-02-16 | Conjuchem Biotechnologies Inc. | Long lasting natriuretic peptide derivatives |
| CA2500248C (en) * | 2002-09-24 | 2013-03-19 | Frontier Biotechnologies Co., Ltd. | Peptide derivative fusion inhibitors of hiv infection |
| US7378495B2 (en) * | 2002-10-21 | 2008-05-27 | Pevion Biotech, Ltd. | PTH-rP related peptide cancer therapeutics |
| WO2004039832A2 (en) * | 2002-10-31 | 2004-05-13 | Albany Medical College | Leptin-related peptides |
| JP5068428B2 (ja) | 2002-11-07 | 2012-11-07 | アメリカ合衆国 | 血管新生および抗血管新生療法のための標的 |
| AU2003297583B2 (en) * | 2002-11-26 | 2010-01-14 | Biocon, Ltd | Modified naturetic compounds, conjugates, and uses thereof |
| US7648962B2 (en) | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| US20060223767A1 (en) * | 2003-01-10 | 2006-10-05 | Haruo Hanawa | Vector for gene therapy and method of quantifying target protein in mammal or cultured cells with the administration of the vector for gene therapy |
| WO2004069270A1 (en) * | 2003-01-29 | 2004-08-19 | Advanced Research And Technology Institute, Inc. | Immunoregulating compounds and an associated method |
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| EP1620734A1 (en) * | 2003-04-25 | 2006-02-01 | Genova Ltd. | Secreted polypeptide species reduced cardiovascular disorders |
| DE602004021603D1 (de) * | 2003-07-25 | 2009-07-30 | Conjuchem Biotechnologies Inc | Insulinderivative mit langanhaltender wirkung und verfahren zu deren herstellung |
| WO2005077094A2 (en) * | 2004-02-11 | 2005-08-25 | Amylin Pharmaceuticals, Inc. | Pancreatic polypeptide family motifs and polypeptides comprising the same |
| JPWO2005090399A1 (ja) * | 2004-03-24 | 2008-05-08 | 財団法人岐阜県研究開発財団 | 各種細胞の増殖・分化を認識する抗体、その抗体を用いた増殖・分化の評価方法 |
| EP2518510A1 (en) * | 2004-04-20 | 2012-10-31 | SphingoTec GmbH | Use of precursors of tachykinins and/or their fragments in medical diagnostic |
| DE602005027461D1 (de) | 2004-04-21 | 2011-05-26 | Enobia Pharma Inc | Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen |
| DK2100904T3 (da) | 2004-04-23 | 2010-11-08 | Conjuchem Biotechnologies Inc | Fast fase til anvendelse i en fremgangsmåde til rensning af albuminkonjugater |
| ES2363156T3 (es) * | 2004-05-13 | 2011-07-22 | B.R.A.H.M.S Gmbh | Uso de precursores de encefalinas y/o sus fragmentos en diagnosis médica. |
| AU2012202855B2 (en) * | 2004-09-03 | 2015-02-26 | Philipps-Universitat Marburg | GLP-1 and exendin related invention |
| DE102004043153B4 (de) * | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
| JP4849642B2 (ja) | 2004-11-24 | 2012-01-11 | ネオプロ ラブス， エルエルシー | 状態を処置するための方法および組成物 |
| JP4720175B2 (ja) * | 2004-12-15 | 2011-07-13 | 富士ゼロックス株式会社 | マレイミジル基含有材料およびその製造方法 |
| DE102005003687A1 (de) | 2005-01-26 | 2006-07-27 | Sphingo Tec Gmbh | Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation |
| EP1853915B1 (en) | 2005-02-15 | 2011-10-12 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
| WO2006108686A2 (en) * | 2005-04-14 | 2006-10-19 | Aic | Bnp agonists |
| US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
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-
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- 2000-05-17 PT PT00936023T patent/PT1105409E/pt unknown
- 2000-05-17 CA CA002499211A patent/CA2499211A1/en not_active Abandoned
- 2000-05-17 DE DE60026300T patent/DE60026300T2/de not_active Expired - Lifetime
- 2000-05-17 ES ES00936023T patent/ES2257298T3/es not_active Expired - Lifetime
- 2000-05-17 SI SI200030836T patent/SI1105409T1/sl unknown
- 2000-05-17 EP EP05105384A patent/EP1591453A1/en not_active Withdrawn
- 2000-05-17 AT AT00936023T patent/ATE318835T1/de active
- 2000-05-17 EP EP05105387A patent/EP1598365A1/en not_active Withdrawn
- 2000-05-17 EP EP00936023A patent/EP1105409B1/en not_active Expired - Lifetime
- 2000-05-17 JP JP2000618316A patent/JP4217004B2/ja not_active Expired - Fee Related
- 2000-05-17 EP EP08158878A patent/EP2100901A1/en not_active Withdrawn
- 2000-05-17 EP EP05108328A patent/EP1623994A3/en not_active Withdrawn
- 2000-05-17 WO PCT/US2000/013576 patent/WO2000069900A2/en not_active Ceased
- 2000-05-17 DK DK00936023T patent/DK1105409T3/da active
- 2000-05-17 CA CA002373680A patent/CA2373680C/en not_active Expired - Fee Related
- 2000-05-17 CA CA002623458A patent/CA2623458A1/en not_active Abandoned
- 2000-05-17 CA CA002505617A patent/CA2505617A1/en not_active Abandoned
- 2000-05-17 AU AU51393/00A patent/AU765753B2/en not_active Ceased
-
2005
- 2005-04-12 JP JP2005115175A patent/JP4219339B2/ja not_active Expired - Fee Related
- 2005-05-12 JP JP2005140407A patent/JP4221392B2/ja not_active Expired - Fee Related
-
2008
- 2008-01-17 JP JP2008008555A patent/JP2008150384A/ja not_active Withdrawn
- 2008-09-25 JP JP2008246982A patent/JP2009079048A/ja not_active Withdrawn
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2010
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| JP2003508350A (ja) | 2003-03-04 |
| JP2010168384A (ja) | 2010-08-05 |
| JP2009079048A (ja) | 2009-04-16 |
| WO2000069900A3 (en) | 2001-02-15 |
| WO2000069900A2 (en) | 2000-11-23 |
| EP1105409B1 (en) | 2006-03-01 |
| EP1623994A2 (en) | 2006-02-08 |
| EP1598365A1 (en) | 2005-11-23 |
| EP1591453A1 (en) | 2005-11-02 |
| CA2373680A1 (en) | 2000-11-23 |
| DK1105409T3 (da) | 2006-07-03 |
| JP2005239736A (ja) | 2005-09-08 |
| DE60026300D1 (de) | 2006-04-27 |
| EP1623994A3 (en) | 2008-07-16 |
| JP4219339B2 (ja) | 2009-02-04 |
| AU5139300A (en) | 2000-12-05 |
| SI1105409T1 (sl) | 2006-06-30 |
| AU765753B2 (en) | 2003-09-25 |
| ATE318835T1 (de) | 2006-03-15 |
| CA2373680C (en) | 2008-07-29 |
| EP1105409A2 (en) | 2001-06-13 |
| DE60026300T2 (de) | 2006-11-16 |
| CA2499211A1 (en) | 2000-11-23 |
| JP2008150384A (ja) | 2008-07-03 |
| JP2005263807A (ja) | 2005-09-29 |
| EP2100901A1 (en) | 2009-09-16 |
| PT1105409E (pt) | 2006-07-31 |
| CA2505617A1 (en) | 2000-11-23 |
| CA2623458A1 (en) | 2000-11-23 |
| JP4217004B2 (ja) | 2009-01-28 |
| JP4221392B2 (ja) | 2009-02-12 |
| WO2000069900A9 (en) | 2002-07-04 |
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