JP2003507417A - 少なくとも二つのポリマー含有層を含む、皮膚に塗布するための活性物質含有治療システム - Google Patents

少なくとも二つのポリマー含有層を含む、皮膚に塗布するための活性物質含有治療システム

Info

Publication number
JP2003507417A
JP2003507417A JP2001518037A JP2001518037A JP2003507417A JP 2003507417 A JP2003507417 A JP 2003507417A JP 2001518037 A JP2001518037 A JP 2001518037A JP 2001518037 A JP2001518037 A JP 2001518037A JP 2003507417 A JP2003507417 A JP 2003507417A
Authority
JP
Japan
Prior art keywords
polymer
active substance
layers
skin
therapeutic system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001518037A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003507417A5 (https=
Inventor
ベアトルド、アッヒム
Original Assignee
エルティエス ローマン テラピー−ズュステーメ アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エルティエス ローマン テラピー−ズュステーメ アーゲー filed Critical エルティエス ローマン テラピー−ズュステーメ アーゲー
Publication of JP2003507417A publication Critical patent/JP2003507417A/ja
Publication of JP2003507417A5 publication Critical patent/JP2003507417A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/02—Physical, chemical or physicochemical properties
    • B32B7/027—Thermal properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/06—Interconnection of layers permitting easy separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/05—5 or more layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2535/00—Medical equipment, e.g. bandage, prostheses or catheter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2556/00—Patches, e.g. medical patches, repair patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2001518037A 1999-08-25 2000-08-14 少なくとも二つのポリマー含有層を含む、皮膚に塗布するための活性物質含有治療システム Pending JP2003507417A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19940238.8 1999-08-25
DE19940238A DE19940238A1 (de) 1999-08-25 1999-08-25 Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten
PCT/EP2000/007900 WO2001013899A2 (de) 1999-08-25 2000-08-14 Wirkstoffhaltiges therapeutisches system mit mindestens zwei polymerhaltigen schichten

Publications (2)

Publication Number Publication Date
JP2003507417A true JP2003507417A (ja) 2003-02-25
JP2003507417A5 JP2003507417A5 (https=) 2011-10-20

Family

ID=7919502

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001518037A Pending JP2003507417A (ja) 1999-08-25 2000-08-14 少なくとも二つのポリマー含有層を含む、皮膚に塗布するための活性物質含有治療システム

Country Status (10)

Country Link
US (2) US7279178B1 (https=)
EP (1) EP1143939B1 (https=)
JP (1) JP2003507417A (https=)
KR (1) KR100701212B1 (https=)
AR (1) AR025390A1 (https=)
AT (1) ATE404182T1 (https=)
AU (1) AU6995700A (https=)
DE (2) DE19940238A1 (https=)
ES (1) ES2312361T3 (https=)
WO (1) WO2001013899A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5084496B2 (ja) * 2005-02-04 2012-11-28 久光製薬株式会社 経皮吸収貼付剤
US8524273B2 (en) 2006-02-28 2013-09-03 Hisamitsu Pharmaceutical Co., Inc. Transdermal absorption preparation
JP2022526952A (ja) * 2019-03-28 2022-05-27 ピーケイ・メッド 多成分熱可塑性製品

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
PT1256339E (pt) * 2001-05-08 2004-02-27 Lohmann Therapie Syst Lts Sistema terapeutico transdermico para doenca de parkinson que induz niveis plasmaticos altos de rotigotina
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
EP1256340B1 (en) * 2001-05-08 2003-08-13 Schwarz Pharma Ag Improved transdermal therapeutic system for the treatment of Parkinson's disease
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246980B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
EP1386605A1 (en) * 2002-07-30 2004-02-04 Schwarz Pharma Ag Improved transdermal delivery system for the administration of rotigotine
ATE295726T1 (de) * 2002-12-02 2005-06-15 Sanol Arznei Schwarz Gmbh Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese
DE10261696A1 (de) 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
US20050202073A1 (en) 2004-03-09 2005-09-15 Mylan Technologies, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
US9205062B2 (en) 2004-03-09 2015-12-08 Mylan Pharmaceuticals, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
DE102006026060B4 (de) * 2006-01-12 2013-01-31 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme
EP3067050A1 (en) 2015-03-13 2016-09-14 Acino AG Transdermal therapeutic system with an overtape comprising two adhesive layers

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835112A (ja) * 1981-08-27 1983-03-01 Nitto Electric Ind Co Ltd 複合製剤
JPS5835113A (ja) * 1981-08-27 1983-03-01 Nitto Electric Ind Co Ltd 複合製剤
JPH024376A (ja) * 1988-06-20 1990-01-09 Sekisui Chem Co Ltd 医療用貼付部材
JPH0278614A (ja) * 1988-09-14 1990-03-19 Sekisui Chem Co Ltd 医療用貼付剤
JPH04230212A (ja) * 1990-06-25 1992-08-19 Lts Lohmann Therapie Syst Gmbh & Co Kg 高い含有量の活性物質、または活性物質および補助剤を有するプラスター
JPH04234317A (ja) * 1990-12-28 1992-08-24 Sekisui Chem Co Ltd 貼付剤の製造方法
JPH0818975B2 (ja) * 1987-06-08 1996-02-28 日東電工株式会社 疾患治療用貼付剤
JPH10504017A (ja) * 1994-05-03 1998-04-14 アルカームズ コントロールド セラピューティックス，インコーポレイテッド 生体適合性ポリマーからの薬物放出調節方法
WO1998036740A2 (de) * 1997-02-21 1998-08-27 Lts Lohmann Therapie-Systeme Gmbh Transdermales oder topisches pflastersystem mit polyacrylatmatrix mit verbesserten physikalischen eigenschaften

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JPS57116011A (en) * 1981-01-08 1982-07-19 Nitto Electric Ind Co Ltd Pharmaceutical preparation
GB2105990B (en) * 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
DE3347277A1 (de) * 1983-12-28 1985-07-11 Bayer Ag, 5090 Leverkusen Wirkstoffabgabesysteme
JPS61502760A (ja) 1984-07-24 1986-11-27 キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド 粘着性経皮投与層
DE3525767A1 (de) 1985-07-19 1987-01-22 Boehringer Ingelheim Kg Pharmazeutische zubereitung mit kontrollierter und verzoegerter wirkstofffreigabe und verfahren zu deren herstellung
JPS6229003A (ja) * 1985-07-30 1987-02-07 株式会社トキメック 背面反射式光拡散装置
US5023084A (en) * 1986-12-29 1991-06-11 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US5580573A (en) * 1991-02-01 1996-12-03 E. R. Squibb And Sons, Inc. Temperature activated controlled release
CA2200060A1 (en) * 1994-09-16 1996-03-21 Jesse C. Ercillo Multi-layer pressure-sensitive adhesive construction
WO1996022084A2 (en) * 1995-01-19 1996-07-25 Cygnus, Inc. Polymer adhesive formulation containing sorbent particles
US6063838A (en) * 1995-02-16 2000-05-16 3M Innovative Properties Company Blended pressure-sensitive adhesives
ES2127711T1 (es) 1996-12-10 1999-05-01 Rotta Res Bv Sistema de administracion transdermal de farmacos para el tratamiento de enfermedades del corazon.
DE19804604A1 (de) * 1998-02-06 1999-08-12 Beiersdorf Ag Vorrichtung zur Freigabe von Stoffen

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835112A (ja) * 1981-08-27 1983-03-01 Nitto Electric Ind Co Ltd 複合製剤
JPS5835113A (ja) * 1981-08-27 1983-03-01 Nitto Electric Ind Co Ltd 複合製剤
JPH0818975B2 (ja) * 1987-06-08 1996-02-28 日東電工株式会社 疾患治療用貼付剤
JPH024376A (ja) * 1988-06-20 1990-01-09 Sekisui Chem Co Ltd 医療用貼付部材
JPH0278614A (ja) * 1988-09-14 1990-03-19 Sekisui Chem Co Ltd 医療用貼付剤
JPH04230212A (ja) * 1990-06-25 1992-08-19 Lts Lohmann Therapie Syst Gmbh & Co Kg 高い含有量の活性物質、または活性物質および補助剤を有するプラスター
JPH04234317A (ja) * 1990-12-28 1992-08-24 Sekisui Chem Co Ltd 貼付剤の製造方法
JPH10504017A (ja) * 1994-05-03 1998-04-14 アルカームズ コントロールド セラピューティックス，インコーポレイテッド 生体適合性ポリマーからの薬物放出調節方法
WO1998036740A2 (de) * 1997-02-21 1998-08-27 Lts Lohmann Therapie-Systeme Gmbh Transdermales oder topisches pflastersystem mit polyacrylatmatrix mit verbesserten physikalischen eigenschaften

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
化学大辞典２ 縮刷版, vol. １９６３年８月２５日, JPN6007005599, pages 523 - 524, ISSN: 0000919487 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5084496B2 (ja) * 2005-02-04 2012-11-28 久光製薬株式会社 経皮吸収貼付剤
US8524273B2 (en) 2006-02-28 2013-09-03 Hisamitsu Pharmaceutical Co., Inc. Transdermal absorption preparation
JP2022526952A (ja) * 2019-03-28 2022-05-27 ピーケイ・メッド 多成分熱可塑性製品

Also Published As

Publication number Publication date
KR20010080321A (ko) 2001-08-22
EP1143939B1 (de) 2008-08-13
WO2001013899A3 (de) 2001-08-30
DE19940238A1 (de) 2001-03-01
EP1143939A2 (de) 2001-10-17
US20050136101A1 (en) 2005-06-23
DE50015307D1 (de) 2008-09-25
AR025390A1 (es) 2002-11-27
ATE404182T1 (de) 2008-08-15
AU6995700A (en) 2001-03-19
KR100701212B1 (ko) 2007-03-29
ES2312361T3 (es) 2009-03-01
WO2001013899A2 (de) 2001-03-01
US7279178B1 (en) 2007-10-09
US7335378B2 (en) 2008-02-26

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