DE19940238A1 - Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten - Google Patents
Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen SchichtenInfo
- Publication number
- DE19940238A1 DE19940238A1 DE19940238A DE19940238A DE19940238A1 DE 19940238 A1 DE19940238 A1 DE 19940238A1 DE 19940238 A DE19940238 A DE 19940238A DE 19940238 A DE19940238 A DE 19940238A DE 19940238 A1 DE19940238 A1 DE 19940238A1
- Authority
- DE
- Germany
- Prior art keywords
- layers
- therapeutic system
- polymer
- skin
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 32
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 14
- 239000004480 active ingredient Substances 0.000 title claims description 10
- 230000009477 glass transition Effects 0.000 claims abstract description 6
- 239000013543 active substance Substances 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000000699 topical effect Effects 0.000 claims description 2
- 230000037317 transdermal delivery Effects 0.000 claims description 2
- 239000010410 layer Substances 0.000 description 24
- 239000011159 matrix material Substances 0.000 description 16
- 239000000853 adhesive Substances 0.000 description 11
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 230000001070 adhesive effect Effects 0.000 description 8
- 238000004132 cross linking Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000011521 glass Substances 0.000 description 6
- 229920006267 polyester film Polymers 0.000 description 6
- -1 Polyethylene terephthalate Polymers 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 229920006125 amorphous polymer Polymers 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000720945 Hosta Species 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 230000006855 networking Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 238000009516 primary packaging Methods 0.000 description 2
- 239000011241 protective layer Substances 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- XBIUWALDKXACEA-UHFFFAOYSA-N 3-[bis(2,4-dioxopentan-3-yl)alumanyl]pentane-2,4-dione Chemical compound CC(=O)C(C(C)=O)[Al](C(C(C)=O)C(C)=O)C(C(C)=O)C(C)=O XBIUWALDKXACEA-UHFFFAOYSA-N 0.000 description 1
- 229920003139 Eudragit® L 100 Polymers 0.000 description 1
- 229920000877 Melamine resin Polymers 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000011102 Thera Species 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002998 adhesive polymer Substances 0.000 description 1
- 229920005601 base polymer Polymers 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 229960001652 norethindrone acetate Drugs 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000012070 reactive reagent Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000000930 thermomechanical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/02—Physical, chemical or physicochemical properties
- B32B7/027—Thermal properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/06—Interconnection of layers permitting easy separation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2250/00—Layers arrangement
- B32B2250/05—5 or more layers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2535/00—Medical equipment, e.g. bandage, prostheses or catheter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2556/00—Patches, e.g. medical patches, repair patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19940238A DE19940238A1 (de) | 1999-08-25 | 1999-08-25 | Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten |
| DE50015307T DE50015307D1 (de) | 1999-08-25 | 2000-08-14 | Ag auf die haut mit drei polymerhaltigen schichten |
| JP2001518037A JP2003507417A (ja) | 1999-08-25 | 2000-08-14 | 少なくとも二つのポリマー含有層を含む、皮膚に塗布するための活性物質含有治療システム |
| PCT/EP2000/007900 WO2001013899A2 (de) | 1999-08-25 | 2000-08-14 | Wirkstoffhaltiges therapeutisches system mit mindestens zwei polymerhaltigen schichten |
| EP00958444A EP1143939B1 (de) | 1999-08-25 | 2000-08-14 | Wirkstoffhaltiges therapeutisches system zum auftrag auf die haut mit drei polymerhaltigen schichten |
| AT00958444T ATE404182T1 (de) | 1999-08-25 | 2000-08-14 | Wirkstoffhaltiges therapeutisches system zum auftrag auf die haut mit drei polymerhaltigen schichten |
| AU69957/00A AU6995700A (en) | 1999-08-25 | 2000-08-14 | Therapeutic system containing an active substance for the application on the skin which contains at least two polymerous layers |
| KR1020017005127A KR100701212B1 (ko) | 1999-08-25 | 2000-08-14 | 활성성분함유 피부부착 치료 시스템 |
| US09/830,300 US7279178B1 (en) | 1999-08-25 | 2000-08-14 | Therapeutic system containing an active substance for the application on the skin which contains at least two polymerous layers |
| ES00958444T ES2312361T3 (es) | 1999-08-25 | 2000-08-14 | Sistema terapeutico que contiene principio activo para aplicar sobe la piel con tres capas que contienen polimero. |
| ARP000104414A AR025390A1 (es) | 1999-08-25 | 2000-08-25 | Sistema terapeutico que contiene un principio activo para su aplicacion sobre la piel, con un minimo de dos capas que contengan polimeros |
| US10/991,713 US7335378B2 (en) | 1999-08-25 | 2004-11-18 | Therapeutic system containing an active substance for the application on the skin which contains at least two polymerous layers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19940238A DE19940238A1 (de) | 1999-08-25 | 1999-08-25 | Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19940238A1 true DE19940238A1 (de) | 2001-03-01 |
Family
ID=7919502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19940238A Withdrawn DE19940238A1 (de) | 1999-08-25 | 1999-08-25 | Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten |
| DE50015307T Expired - Lifetime DE50015307D1 (de) | 1999-08-25 | 2000-08-14 | Ag auf die haut mit drei polymerhaltigen schichten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50015307T Expired - Lifetime DE50015307D1 (de) | 1999-08-25 | 2000-08-14 | Ag auf die haut mit drei polymerhaltigen schichten |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7279178B1 (https=) |
| EP (1) | EP1143939B1 (https=) |
| JP (1) | JP2003507417A (https=) |
| KR (1) | KR100701212B1 (https=) |
| AR (1) | AR025390A1 (https=) |
| AT (1) | ATE404182T1 (https=) |
| AU (1) | AU6995700A (https=) |
| DE (2) | DE19940238A1 (https=) |
| ES (1) | ES2312361T3 (https=) |
| WO (1) | WO2001013899A2 (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1256340A1 (en) * | 2001-05-08 | 2002-11-13 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of Parkinson's disease |
| EP1256339A1 (en) * | 2001-05-08 | 2002-11-13 | Schwarz Pharma Ag | Transdermal therapeutic system for Parkinson's disease inducing high plasma levels of rotigotine |
| EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
| US7309497B2 (en) | 2000-08-24 | 2007-12-18 | Schwarz Pharma Ag | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients |
| US20100166836A1 (en) * | 2006-01-12 | 2010-07-01 | Tobias Jung | Transdermal Therapeutic System for Volatile and/or Thermo-Labile Substances |
| US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| US8246980B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
| US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
| US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
| DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
| ATE295726T1 (de) * | 2002-12-02 | 2005-06-15 | Sanol Arznei Schwarz Gmbh | Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese |
| DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| US20050202073A1 (en) | 2004-03-09 | 2005-09-15 | Mylan Technologies, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
| US9205062B2 (en) | 2004-03-09 | 2015-12-08 | Mylan Pharmaceuticals, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
| WO2006082728A1 (ja) * | 2005-02-04 | 2006-08-10 | Hisamitsu Pharmaceutical Co., Inc. | 経皮吸収貼付剤 |
| JP5190358B2 (ja) * | 2006-02-28 | 2013-04-24 | 久光製薬株式会社 | 経皮吸収型製剤 |
| EP3067050A1 (en) | 2015-03-13 | 2016-09-14 | Acino AG | Transdermal therapeutic system with an overtape comprising two adhesive layers |
| EA202192644A1 (ru) * | 2019-03-28 | 2021-12-14 | Пк Мед | Многокомпонентный термопластичный продукт |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3200369A1 (de) * | 1981-01-08 | 1982-08-05 | Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka | Pharmazeutisches praeparat |
| DE3625767A1 (de) * | 1985-07-30 | 1987-02-12 | Tokyo Keiki Kk | Lichtdiffusionsvorrichtung mit rueckstrahler |
| US4661104A (en) * | 1983-12-28 | 1987-04-28 | Bayer Aktiengesellschaft | Active compound release systems |
| WO1996022084A2 (en) * | 1995-01-19 | 1996-07-25 | Cygnus, Inc. | Polymer adhesive formulation containing sorbent particles |
| DE19706824C1 (de) * | 1997-02-21 | 1998-03-26 | Lohmann Therapie Syst Lts | Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften |
| DE19804604A1 (de) * | 1998-02-06 | 1999-08-12 | Beiersdorf Ag | Vorrichtung zur Freigabe von Stoffen |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6059209B2 (ja) * | 1981-08-27 | 1985-12-24 | 日東電工株式会社 | 複合製剤 |
| GB2105990B (en) * | 1981-08-27 | 1985-06-19 | Nitto Electric Ind Co | Adhesive skin patches |
| JPS6059208B2 (ja) * | 1981-08-27 | 1985-12-24 | 日東電工株式会社 | 複合製剤 |
| JPS61502760A (ja) | 1984-07-24 | 1986-11-27 | キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド | 粘着性経皮投与層 |
| DE3525767A1 (de) | 1985-07-19 | 1987-01-22 | Boehringer Ingelheim Kg | Pharmazeutische zubereitung mit kontrollierter und verzoegerter wirkstofffreigabe und verfahren zu deren herstellung |
| US5023084A (en) * | 1986-12-29 | 1991-06-11 | Rutgers, The State University Of New Jersey | Transdermal estrogen/progestin dosage unit, system and process |
| JPH0818975B2 (ja) * | 1987-06-08 | 1996-02-28 | 日東電工株式会社 | 疾患治療用貼付剤 |
| JP2688062B2 (ja) * | 1988-06-20 | 1997-12-08 | 積水化学工業株式会社 | 医療用貼付部材 |
| JP2690112B2 (ja) * | 1988-09-14 | 1997-12-10 | 積水化学工業株式会社 | 医療用貼付剤 |
| DE4020144A1 (de) * | 1990-06-25 | 1992-01-09 | Lohmann Therapie Syst Lts | Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen |
| JPH04234317A (ja) * | 1990-12-28 | 1992-08-24 | Sekisui Chem Co Ltd | 貼付剤の製造方法 |
| US5580573A (en) * | 1991-02-01 | 1996-12-03 | E. R. Squibb And Sons, Inc. | Temperature activated controlled release |
| US5656297A (en) * | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| CA2200060A1 (en) * | 1994-09-16 | 1996-03-21 | Jesse C. Ercillo | Multi-layer pressure-sensitive adhesive construction |
| US6063838A (en) * | 1995-02-16 | 2000-05-16 | 3M Innovative Properties Company | Blended pressure-sensitive adhesives |
| ES2127711T1 (es) | 1996-12-10 | 1999-05-01 | Rotta Res Bv | Sistema de administracion transdermal de farmacos para el tratamiento de enfermedades del corazon. |
-
1999
- 1999-08-25 DE DE19940238A patent/DE19940238A1/de not_active Withdrawn
-
2000
- 2000-08-14 AT AT00958444T patent/ATE404182T1/de not_active IP Right Cessation
- 2000-08-14 JP JP2001518037A patent/JP2003507417A/ja active Pending
- 2000-08-14 EP EP00958444A patent/EP1143939B1/de not_active Expired - Lifetime
- 2000-08-14 KR KR1020017005127A patent/KR100701212B1/ko not_active Expired - Lifetime
- 2000-08-14 DE DE50015307T patent/DE50015307D1/de not_active Expired - Lifetime
- 2000-08-14 ES ES00958444T patent/ES2312361T3/es not_active Expired - Lifetime
- 2000-08-14 US US09/830,300 patent/US7279178B1/en not_active Expired - Lifetime
- 2000-08-14 WO PCT/EP2000/007900 patent/WO2001013899A2/de not_active Ceased
- 2000-08-14 AU AU69957/00A patent/AU6995700A/en not_active Abandoned
- 2000-08-25 AR ARP000104414A patent/AR025390A1/es unknown
-
2004
- 2004-11-18 US US10/991,713 patent/US7335378B2/en not_active Expired - Lifetime
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3200369A1 (de) * | 1981-01-08 | 1982-08-05 | Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka | Pharmazeutisches praeparat |
| US4661104A (en) * | 1983-12-28 | 1987-04-28 | Bayer Aktiengesellschaft | Active compound release systems |
| DE3625767A1 (de) * | 1985-07-30 | 1987-02-12 | Tokyo Keiki Kk | Lichtdiffusionsvorrichtung mit rueckstrahler |
| WO1996022084A2 (en) * | 1995-01-19 | 1996-07-25 | Cygnus, Inc. | Polymer adhesive formulation containing sorbent particles |
| DE19706824C1 (de) * | 1997-02-21 | 1998-03-26 | Lohmann Therapie Syst Lts | Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften |
| DE19804604A1 (de) * | 1998-02-06 | 1999-08-12 | Beiersdorf Ag | Vorrichtung zur Freigabe von Stoffen |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7309497B2 (en) | 2000-08-24 | 2007-12-18 | Schwarz Pharma Ag | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients |
| CN100457095C (zh) * | 2001-05-08 | 2009-02-04 | 施瓦茨制药有限公司 | 用于治疗帕金森氏病的改良经皮治疗系统 |
| EP1256339A1 (en) * | 2001-05-08 | 2002-11-13 | Schwarz Pharma Ag | Transdermal therapeutic system for Parkinson's disease inducing high plasma levels of rotigotine |
| EP1325742A1 (en) * | 2001-05-08 | 2003-07-09 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of Parkinson's disease |
| EP1344522A1 (en) * | 2001-05-08 | 2003-09-17 | Schwarz Pharma Ag | Transdermal therapeutic system for Parkinson's disease inducing high plasma levels of rotigotine |
| WO2002089777A1 (en) * | 2001-05-08 | 2002-11-14 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of parkinson's disese |
| EP1256340A1 (en) * | 2001-05-08 | 2002-11-13 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of Parkinson's disease |
| WO2002089778A3 (en) * | 2001-05-08 | 2004-08-19 | Sanol Arznei Schwarz Gmbh | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
| EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
| WO2004012730A1 (en) * | 2002-07-30 | 2004-02-12 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
| US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| US8246980B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
| US8617591B2 (en) | 2002-07-30 | 2013-12-31 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| US20100166836A1 (en) * | 2006-01-12 | 2010-07-01 | Tobias Jung | Transdermal Therapeutic System for Volatile and/or Thermo-Labile Substances |
| DE102006026060B4 (de) * | 2006-01-12 | 2013-01-31 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010080321A (ko) | 2001-08-22 |
| EP1143939B1 (de) | 2008-08-13 |
| WO2001013899A3 (de) | 2001-08-30 |
| JP2003507417A (ja) | 2003-02-25 |
| EP1143939A2 (de) | 2001-10-17 |
| US20050136101A1 (en) | 2005-06-23 |
| DE50015307D1 (de) | 2008-09-25 |
| AR025390A1 (es) | 2002-11-27 |
| ATE404182T1 (de) | 2008-08-15 |
| AU6995700A (en) | 2001-03-19 |
| KR100701212B1 (ko) | 2007-03-29 |
| ES2312361T3 (es) | 2009-03-01 |
| WO2001013899A2 (de) | 2001-03-01 |
| US7279178B1 (en) | 2007-10-09 |
| US7335378B2 (en) | 2008-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE19940238A1 (de) | Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten | |
| EP0617972B1 (de) | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)-acrylat-Mischung | |
| DE10060550C1 (de) | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten | |
| DE69813225T2 (de) | Blockcopolymere | |
| EP1191927B1 (de) | Mikroreservoirsystem auf basis von polysiloxanen und ambiphilen lösemitteln | |
| EP2111857A1 (de) | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon | |
| EP1372619B1 (de) | Verfahren zur herstellung eines hochflexiblen transdermalen therapeutischen systems mit nikotin als wirkstoff | |
| EP1855660B1 (de) | Faserfreies transdermales therapeutisches system und verfahren zu seiner herstellung | |
| WO1987006144A1 (fr) | Systeme therapeutique planiforme, son procede de fabrication et son utilisation | |
| DE19958554C2 (de) | Mikroreservoirsystem auf Basis von Polysiloxanen und ambiphilen Lösemitteln und ihre Herstellung | |
| WO1992022292A1 (de) | Nitroglycerin-pflaster und verfahren zu seiner herstellung | |
| EP1087759B1 (de) | Verfahren zur herstellung eines aus einzelnen schichten bestehenden laminats | |
| DE4429791C2 (de) | Medizinischer Haftkleber auf Basis von Polyacrylaten und dessen Verwendung | |
| DE19950066A1 (de) | Transdermales therapeutisches System mit einem Gehalt an Tulobuterol-hydrochlorid zur Verabreichung des Bronchodilatators Tulobuterol über die Haut | |
| DE3911699C2 (de) | Pharmazeutische Zubereitung mit einem perkutan absorbierbaren Arzneimittel | |
| EP3119444B1 (de) | Überpflaster mit verbesserter verträglichkeit und einer langen haftungsdauer und verfahren zu seiner herstellung | |
| DE10035891A1 (de) | Medizinischer Haftkleber mit einer zweiphasigen Klebermatrix aus Polyacrylaten und Polyaminsalzen | |
| DE19705138A1 (de) | Dehnbares transdermales therapeutisches System | |
| WO2018153413A1 (de) | Nicotin enthaltendes transparentes transdermales therapeutisches system | |
| DE69419973T2 (de) | Klebeband für medizinische Zwecke und Verfahren zu dessen Herstellung | |
| DE19811218A1 (de) | Silikonhaftkleber mit vermindertem Kalten Fluß | |
| DE4403709A1 (de) | Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid | |
| EP3400965A1 (de) | Ölige pflanzenextrakte enthaltende elemente und pflaster, die derartige wirkstoffhaltige elemente enthalten | |
| EP3651744B1 (de) | Fampridin-tts | |
| DE10304988A1 (de) | Transdermales Therapeutisches System mit verbessertem Hautklebeverhalten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8130 | Withdrawal |