JP2003505420A - 咳を処置するのに使用するノシセプチンレセプタｏｒｌ−１ - Google Patents

咳を処置するのに使用するノシセプチンレセプタｏｒｌ−１

Info

Publication number
JP2003505420A
JP2003505420A JP2001511934A JP2001511934A JP2003505420A JP 2003505420 A JP2003505420 A JP 2003505420A JP 2001511934 A JP2001511934 A JP 2001511934A JP 2001511934 A JP2001511934 A JP 2001511934A JP 2003505420 A JP2003505420 A JP 2003505420A
Authority
JP
Japan
Prior art keywords
alkyl
aryl
hydrogen
phenyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001511934A
Other languages
English (en)
Japanese (ja)
Inventor
ディーン チュールシアン，
ジニー ディー． ホ，
リサ エス． シルバーマン，
ジュリアス ジェイ． マテイシ，
ロビー エル． マックラウド，
ジョン エイ． ヘイ，
リチャード ダブリュー． チャプマン，
アナ バーコビチ，
フランシス エム． カス，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2003505420A publication Critical patent/JP2003505420A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
JP2001511934A 1999-07-26 2000-01-26 咳を処置するのに使用するノシセプチンレセプタｏｒｌ−１ Pending JP2003505420A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/359,771 US6262066B1 (en) 1998-07-27 1999-07-26 High affinity ligands for nociceptin receptor ORL-1
US09/359,771 1999-07-26
PCT/US2000/001853 WO2001007050A1 (en) 1999-07-26 2000-01-26 Nociceptin receptor orl-1 agonists for use in treating cough

Publications (1)

Publication Number Publication Date
JP2003505420A true JP2003505420A (ja) 2003-02-12

Family

ID=23415204

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001511934A Pending JP2003505420A (ja) 1999-07-26 2000-01-26 咳を処置するのに使用するノシセプチンレセプタｏｒｌ−１

Country Status (13)

Country Link
US (4) US6262066B1 (US06262066-20010717-C00461.png)
EP (1) EP1200087A1 (US06262066-20010717-C00461.png)
JP (1) JP2003505420A (US06262066-20010717-C00461.png)
CN (1) CN1374865A (US06262066-20010717-C00461.png)
AU (1) AU2629800A (US06262066-20010717-C00461.png)
BR (1) BR0012801A (US06262066-20010717-C00461.png)
CA (1) CA2379398A1 (US06262066-20010717-C00461.png)
HK (1) HK1042236A1 (US06262066-20010717-C00461.png)
HU (1) HUP0203458A3 (US06262066-20010717-C00461.png)
MX (1) MXPA02001033A (US06262066-20010717-C00461.png)
NO (1) NO20020392L (US06262066-20010717-C00461.png)
WO (1) WO2001007050A1 (US06262066-20010717-C00461.png)
ZA (1) ZA200200275B (US06262066-20010717-C00461.png)

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WO2005037269A1 (ja) * 2003-10-21 2005-04-28 Dainippon Sumitomo Pharma Co., Ltd. 新規ピペリジン誘導体
JP2009513655A (ja) * 2005-10-27 2009-04-02 シェーリング コーポレイション ノシセプチンレセプターｏｒｌ−１のリガンドとしての８−［ビス−（２−クロロ−フェニル）−メチル］−３−フェニル−８−アザ−ビシクロ［３．２．１］オクタン−３−カルボン酸アミド
JP2010516687A (ja) * 2007-01-16 2010-05-20 パーデュー、ファーマ、リミテッド、パートナーシップ 複素環置換ピペリジン化合物とその使用
JP2010523687A (ja) * 2007-04-09 2010-07-15 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
JP5313865B2 (ja) * 2007-03-01 2013-10-09 田辺三菱製薬株式会社 ベンゾイミダゾール化合物およびその医薬用途
JP2016508142A (ja) * 2012-12-31 2016-03-17 サノビオン・ファーマシューティカルズ・インコーポレイテッドＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 複素環式化合物及びその使用方法
JP2020517745A (ja) * 2017-04-19 2020-06-18 ナショナル ユニヴァーシティ オブ シンガポール Ｂｃｌ−２関連死プロモーター（ｂａｄ）のリン酸化の小分子阻害剤

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JP2020517745A (ja) * 2017-04-19 2020-06-18 ナショナル ユニヴァーシティ オブ シンガポール Ｂｃｌ−２関連死プロモーター（ｂａｄ）のリン酸化の小分子阻害剤
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US6262066B1 (en) 2001-07-17
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