BR0012801A - Agonistas orl-1 receptores de nociceptina para uso no tratamento da tosse - Google Patents
Agonistas orl-1 receptores de nociceptina para uso no tratamento da tosseInfo
- Publication number
- BR0012801A BR0012801A BR0012801-5A BR0012801A BR0012801A BR 0012801 A BR0012801 A BR 0012801A BR 0012801 A BR0012801 A BR 0012801A BR 0012801 A BR0012801 A BR 0012801A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- orl
- cough
- treatment
- aryl
- Prior art date
Links
- 206010011224 Cough Diseases 0.000 title abstract 4
- 239000002762 nociceptin receptor agonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 239000000556 agonist Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 108010020615 nociceptin receptor Proteins 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- -1 substituted Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Patente de Invenção: "AGONISTAS ORL-1 RECEPTORES DE NOCICEPTINA PARA USO NO TRATAMENTO DA TOSSE". A presente invenção refere-se ao uso dos agonistas receptores ORL-1 para o tratamento da tosse, sozinho ou em combinação com um ou mais agentes para o tratamento de sintomas da tosse, alergia ou asma, em particular o uso de agonistas ORL-1 da fórmula (I) ou um seu sal ou solvato farmaceuticamente aceitável, onde: a linha pontilhada representa uma ligação dupla opcional; X^ 1^ é alquila, cicloalquila, arila, heteroarila ou heterocicloalquila opcionalmente substituída; X^ 2^ é -CHO, -CN, amino, alquila ou arila opcionalmente substituída; ou X^ 1^ é heterociclila benzo-fundida opcionalmente substituída e X^ 2^ é hidrogênio; ou X^ 1^ e X^ 2^ juntos formam um grupo heterociclila espiro opcionalmente benzofundido, R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são independentemente H e alquila ou (R^ 1^ e R^ 4^) ou (R^ 2^ e R^ 3^) ou (R^ 1^ e R^ 3^) ou (R^ 9^ e R^ 4^) juntos podem formar uma ponte alquileno de 1 a 3 átomos de carbono; Z é opcionalmente alquila, arila, heteroarila, cicloalquila ou heterocicloalquila substituída, ou -CO~ 2~(alquila ou amino substituído) ou CN; Z é H ou Z^ 1^; Z^ 3^ é H ou alquila; OU Z^ 1^, Z^ 2^ e Z^ 3^ juntos com o átomo de carbono ao qual eles estão ligados, formam anéis bicíclicos saturados ou insaturados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/359,771 US6262066B1 (en) | 1998-07-27 | 1999-07-26 | High affinity ligands for nociceptin receptor ORL-1 |
PCT/US2000/001853 WO2001007050A1 (en) | 1999-07-26 | 2000-01-26 | Nociceptin receptor orl-1 agonists for use in treating cough |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012801A true BR0012801A (pt) | 2002-05-07 |
Family
ID=23415204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012801-5A BR0012801A (pt) | 1999-07-26 | 2000-01-26 | Agonistas orl-1 receptores de nociceptina para uso no tratamento da tosse |
Country Status (13)
Country | Link |
---|---|
US (4) | US6262066B1 (pt) |
EP (1) | EP1200087A1 (pt) |
JP (1) | JP2003505420A (pt) |
CN (1) | CN1374865A (pt) |
AU (1) | AU2629800A (pt) |
BR (1) | BR0012801A (pt) |
CA (1) | CA2379398A1 (pt) |
HK (1) | HK1042236A1 (pt) |
HU (1) | HUP0203458A3 (pt) |
MX (1) | MXPA02001033A (pt) |
NO (1) | NO20020392L (pt) |
WO (1) | WO2001007050A1 (pt) |
ZA (1) | ZA200200275B (pt) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040067950A1 (en) * | 1998-07-27 | 2004-04-08 | Schering-Plough Corporation | High affinity ligands for nociceptin receptor ORL-1 |
US7485650B2 (en) * | 1998-07-27 | 2009-02-03 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
AU1816901A (en) * | 1999-12-06 | 2001-06-12 | Euro-Celtique S.A. | Benzimidazole compounds having nociceptin receptor affinity |
AU1948601A (en) * | 1999-12-06 | 2001-06-12 | Euro-Celtique S.A. | Triazospiro compounds having nociceptin receptor affinity |
DE20005049U1 (de) * | 2000-03-20 | 2000-05-18 | Dewert Antriebs Systemtech | Elektromotorische Antriebseinheit |
NZ570181A (en) * | 2001-04-10 | 2010-02-26 | Ortho Mcneil Janssen Pharm | 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
JP4280073B2 (ja) * | 2001-04-12 | 2009-06-17 | ファーマコペイア ドラッグ ディスカバリー, インコーポレイテッド | Mchアンタゴニストとして使用されるアリールピペリジンおよびビアリールピペリジン |
DK1975164T3 (da) | 2001-04-18 | 2010-05-25 | Euro Celtique Sa | Octahydrobenzimidazolon-forbindelser som analgetika |
ES2316559T3 (es) | 2001-04-18 | 2009-04-16 | Euro-Celtique S.A. | Compuestos espiroindeno y espiroindano. |
HUP0401109A3 (en) | 2001-04-18 | 2007-12-28 | Euro Celtique Sa | Nociceptin analogs, their use and pharmaceutical compositions containing them |
CA2444634C (en) | 2001-04-18 | 2011-06-07 | R. Richard Goehring | Spiropyrazole compounds |
KR100729242B1 (ko) | 2001-04-18 | 2007-06-15 | 유로-셀티크 소시에떼 아노뉨 | 노시셉틴 유사체 |
WO2002088089A1 (fr) * | 2001-04-19 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales |
WO2002100861A1 (en) * | 2001-06-13 | 2002-12-19 | Akzo Nobel N.V. | 1-(3-phenyloxypropyl)piperidine derivatives |
WO2003004034A1 (en) * | 2001-07-02 | 2003-01-16 | Omeros Corporation | Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump |
US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
FR2827281B1 (fr) * | 2001-07-16 | 2003-12-19 | Sanofi Synthelabo | Procede pour la preparation de la 4-methylamino-4-phenylpiperidine |
FR2827282B1 (fr) * | 2001-07-16 | 2004-08-13 | Sanofi Synthelabo | Procede pour la preparation de 4-amino-4-phenylpiperidines |
WO2003030828A2 (en) | 2001-10-09 | 2003-04-17 | Synvax, Inc. | Nociceptin-based analgesics |
AR037211A1 (es) * | 2001-11-07 | 2004-10-27 | Schering Corp | Derivados de heteroarilo como ligandos superiores para el receptor de nociceptina orl-1 |
TW200300757A (en) * | 2001-11-16 | 2003-06-16 | Schering Corp | Azetidinyl diamines useful as ligands of the nociceptin receptor orl-1 |
US20040033986A1 (en) | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
CN101404986B (zh) | 2002-05-17 | 2011-09-28 | 赛奎拉公司 | 用于诊断和治疗感染性疾病的组合物和制药方法 |
US6995168B2 (en) | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
CA2866848C (en) | 2002-07-30 | 2017-01-03 | Omeros Corporation | Ophthalmologic irrigation solutions and method |
WO2004020411A1 (en) * | 2002-08-29 | 2004-03-11 | Astrazeneca Ab | Naphthamide derivatives and their use |
KR20050043935A (ko) * | 2002-09-09 | 2005-05-11 | 얀센 파마슈티카 엔.브이. | Orl-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체 |
US7045527B2 (en) * | 2002-09-24 | 2006-05-16 | Amgen Inc. | Piperidine derivatives |
TWI299664B (en) | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
US7696225B2 (en) | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
PE20050250A1 (es) * | 2003-07-17 | 2005-04-08 | Glaxo Group Ltd | Antagonistas de los receptores muscarinicos de la acetilcolina |
AR045913A1 (es) * | 2003-07-17 | 2005-11-16 | Glaxo Group Ltd | Derivados olefinicos de 8-azabiciclo[3,2,1]octanos como antagonistas de receptores muscarinicos de acetilcolina |
US8067603B2 (en) * | 2003-09-25 | 2011-11-29 | Solvay Pharmaceuticals B.V. | Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors |
ATE494285T1 (de) * | 2003-10-14 | 2011-01-15 | Glaxo Group Ltd | Muscarinische acetylcholin-rezeptor-antagonisten |
AP2006003575A0 (en) * | 2003-10-17 | 2006-04-30 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists. |
US20070078120A1 (en) * | 2003-10-21 | 2007-04-05 | Hitoshi Ban | Novel piperidine derivative |
TW200524577A (en) * | 2003-11-04 | 2005-08-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
AR046756A1 (es) * | 2003-12-12 | 2005-12-21 | Solvay Pharm Gmbh | Derivados de hidronopol como agonistas de receptores orl-1 humanos. |
US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
US20090253908A1 (en) * | 2004-03-11 | 2009-10-08 | Glaxo Group Limited | Novel m3 muscarinic acetylchoine receptor antagonists |
EP1725564A4 (en) | 2004-03-17 | 2007-09-12 | Glaxo Group Ltd | ANTAGONISTS OF THE M3 MUSCARIN ACETYL CHOLIN RECEPTOR |
US8007827B2 (en) * | 2004-04-02 | 2011-08-30 | Impax Laboratories, Inc. | Pharmaceutical dosage forms having immediate release and/or controlled release properties |
AR050902A1 (es) | 2004-04-27 | 2006-12-06 | Glaxo Group Ltd | Compuesto de quinuclidina, composicion farmaceutica que lo comprende y su usopara preparar dicha composicion |
EP1747219A4 (en) * | 2004-05-13 | 2010-05-26 | Glaxo Group Ltd | Antagonists of muscarinic acetylcholine receptor |
US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
US7459556B2 (en) * | 2004-09-15 | 2008-12-02 | Schering-Plough Ltd. | Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
AU2006252781A1 (en) * | 2005-06-02 | 2006-12-07 | Janssen Pharmaceutica, N.V. | Novel 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators |
WO2007011810A1 (en) | 2005-07-18 | 2007-01-25 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
EP1937230A4 (en) * | 2005-08-02 | 2009-08-26 | Glaxo Group Ltd | M3-MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS |
WO2007016639A2 (en) * | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
WO2007022351A2 (en) * | 2005-08-18 | 2007-02-22 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
WO2007028638A1 (en) | 2005-09-09 | 2007-03-15 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
KR101289995B1 (ko) | 2005-09-27 | 2013-07-26 | 시오노기 앤드 컴파니, 리미티드 | Pgd2 수용체 길항제 활성을 갖는 설폰아마이드 유도체 |
PE20071159A1 (es) * | 2005-10-31 | 2007-11-30 | Schering Corp | Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina |
JP2009525269A (ja) * | 2006-01-30 | 2009-07-09 | ユーロ−セルティーク エス.エイ. | カルシウムチャネルブロッカーとしての環状尿素化合物 |
EP1847542A1 (en) * | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
JP2009541342A (ja) * | 2006-06-20 | 2009-11-26 | ワイス | Kv1.5カリウムチャネル阻害剤 |
AU2007293416A1 (en) * | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
AU2007325355A1 (en) * | 2006-11-28 | 2008-06-05 | Janssen Pharmaceutica N.V. | Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl) -1,3,8-triaza-spiro[4.5]decan-4-one |
ES2353448T3 (es) * | 2007-01-16 | 2011-03-02 | Purdue Pharma L.P. | Piperidinas heterocíclico-sustituidas como ligandos de orl-1. |
AU2008219980B2 (en) * | 2007-03-01 | 2012-01-12 | Mitsubishi Tanabe Pharma Corporation | Benzimidazole compound and pharmaceutical use thereof |
WO2008124209A1 (en) * | 2007-04-09 | 2008-10-16 | Janssen Pharmaceutica, N.V. | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
TWI448289B (zh) | 2007-08-31 | 2014-08-11 | Purdue Pharma Lp | 經取代之喹啉型哌啶化合物及其用途 |
CN101861321B (zh) | 2007-10-11 | 2013-02-06 | 阿斯利康(瑞典)有限公司 | 作为蛋白激酶b抑制剂的吡咯并[2,3-d]嘧啶衍生物 |
UA99540C2 (ru) | 2008-07-21 | 2012-08-27 | Пердью Фарма Л.П. | Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение |
PE20110777A1 (es) * | 2008-11-23 | 2011-10-29 | Pfizer | Nuevas lactamas como inhibidores de beta secretasa |
ITNA20090026A1 (it) * | 2009-05-14 | 2010-11-15 | Agostino Bruno D | Agonisti del recettore nop e loro usi terapeutici |
SG177752A1 (en) * | 2009-07-27 | 2012-03-29 | Trigemina Inc | Methods for treatment of pain |
WO2011099980A1 (en) | 2010-02-12 | 2011-08-18 | The Johns Hopkins University | Use of the lactosylceramide synthase isoform b1, 4galt-v as a biomarker for cancer |
US9402847B2 (en) | 2011-04-01 | 2016-08-02 | Astrazeneca Ab | Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide |
CA2856646C (en) | 2011-11-30 | 2020-01-14 | Astrazeneca Ab | Combination treatment of cancer |
EP2797912B1 (en) | 2011-12-01 | 2016-05-25 | Purdue Pharma L.P. | Azetidine-substituted quinoxaline-type piperidine compounds and uses thereof |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
WO2013164954A1 (ja) * | 2012-05-01 | 2013-11-07 | 住友化学株式会社 | ピペリジン化合物及びその有害生物防除用途 |
AU2013201465B2 (en) | 2012-10-24 | 2016-03-03 | Rayner Surgical (Ireland) Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
WO2014102592A2 (en) * | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
CA2896871A1 (en) | 2012-12-31 | 2014-07-03 | Kerry L. Spear | Heterocyclic compounds and methods of use thereof |
TWI809304B (zh) | 2014-12-01 | 2023-07-21 | 奥默羅斯公司 | 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液 |
PT3242676T (pt) | 2015-01-07 | 2023-12-06 | TONIX Pharmaceuticals Holding Corp | Formulações de ocitocina que contém magnésio e métodos de uso |
WO2017161017A1 (en) * | 2016-03-15 | 2017-09-21 | The Scripps Research Institute | Signaling-biased mu opioid receptor agonists |
GB201706162D0 (en) * | 2017-04-19 | 2017-05-31 | Nat Univ Singapore | Compounds |
CN115611856A (zh) | 2021-07-14 | 2023-01-17 | 宜昌人福药业有限责任公司 | 一种哌啶衍生物及其药物组合物、制备方法和用途 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE633914A (pt) * | 1962-06-22 | |||
GB1052302A (pt) | 1963-04-22 | |||
US3318900A (en) | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
US3311264A (en) | 1964-12-14 | 1967-03-28 | Arthur W Cayer | Measuring and dispensing device |
US4526896A (en) * | 1978-12-26 | 1985-07-02 | Riker Laboratories, Inc. | Tetrazol-5-yl 2-nitro-3-phenylbenzofurans and antimicrobial use thereof |
US4521537A (en) | 1982-08-20 | 1985-06-04 | Hoechst-Roussel Pharmaceuticals Incorporated | Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents |
DK139684A (da) | 1983-04-11 | 1984-10-12 | Janssen Pharmaceutica Nv | N-aryl-alpha-amino-carboxamider |
CA1261835A (en) | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
FR2579596B1 (fr) | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
JPS61225167A (ja) | 1985-03-28 | 1986-10-06 | Yoshitomi Pharmaceut Ind Ltd | ベンゾ〔g〕キノリン誘導体 |
GB8607294D0 (en) | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
ATE165088T1 (de) | 1990-10-12 | 1998-05-15 | Merck Frosst Canada Inc | Ungesättigte hydroxyalkylchinolinsäuren als leukotrien-antagonisten |
GB9100505D0 (en) | 1991-01-10 | 1991-02-20 | Shell Int Research | Piperidine derivatives |
JP2600644B2 (ja) | 1991-08-16 | 1997-04-16 | 藤沢薬品工業株式会社 | チアゾリルベンゾフラン誘導体 |
US5583000A (en) | 1991-09-03 | 1996-12-10 | The Regents Of The University Of California | Protease-binding compounds and methods of use |
GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
US5352707A (en) | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
US5270324A (en) | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
US5436255A (en) | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
US5472964A (en) | 1992-12-22 | 1995-12-05 | Merck Frosst Canada, Inc. | Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists |
AU691829B2 (en) * | 1993-07-16 | 1998-05-28 | Merck & Co., Inc. | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists |
US5495052A (en) * | 1994-09-29 | 1996-02-27 | Arco Chemical Technology, L.P. | Process for producing enantiomerically enriched guaifenesin |
EP0709375B1 (en) | 1994-10-25 | 2005-05-18 | AstraZeneca AB | Therapeutic heterocycles |
IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
DE19519245C2 (de) | 1995-04-14 | 2003-04-30 | Boehringer Ingelheim Kg | Neue Arylglycinamidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
EP0742208A1 (en) | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamide derivatives |
FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
US5654316A (en) | 1995-06-06 | 1997-08-05 | Schering Corporation | Piperidine derivatives as neurokinin antagonists |
CZ248798A3 (cs) | 1996-02-08 | 1999-01-13 | Merck And Co., Inc. | Farmaceutický prostředek |
CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
AU7916798A (en) | 1997-05-22 | 1998-12-11 | Boots Company Plc, The | Pharmaceutical compositions of flurbiprofen and burn-masking agent for treating sore throat |
SI0921125T1 (en) | 1997-12-05 | 2002-04-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro(4,5)decan-4-on derivatives |
AU1679099A (en) | 1998-01-19 | 1999-08-02 | Pfizer Inc. | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists |
US6277991B1 (en) * | 1998-05-18 | 2001-08-21 | Novo Nordisk A/S | 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
EP0997464B1 (en) * | 1998-10-23 | 2005-02-16 | Pfizer Inc. | 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists |
AR037211A1 (es) * | 2001-11-07 | 2004-10-27 | Schering Corp | Derivados de heteroarilo como ligandos superiores para el receptor de nociceptina orl-1 |
-
1999
- 1999-07-26 US US09/359,771 patent/US6262066B1/en not_active Expired - Lifetime
-
2000
- 2000-01-26 JP JP2001511934A patent/JP2003505420A/ja active Pending
- 2000-01-26 EP EP00904560A patent/EP1200087A1/en not_active Withdrawn
- 2000-01-26 WO PCT/US2000/001853 patent/WO2001007050A1/en not_active Application Discontinuation
- 2000-01-26 CA CA002379398A patent/CA2379398A1/en not_active Abandoned
- 2000-01-26 CN CN00813077A patent/CN1374865A/zh active Pending
- 2000-01-26 HU HU0203458A patent/HUP0203458A3/hu unknown
- 2000-01-26 MX MXPA02001033A patent/MXPA02001033A/es unknown
- 2000-01-26 BR BR0012801-5A patent/BR0012801A/pt not_active IP Right Cessation
- 2000-01-26 AU AU26298/00A patent/AU2629800A/en not_active Abandoned
-
2001
- 2001-01-25 US US09/769,824 patent/US6455527B2/en not_active Expired - Lifetime
-
2002
- 2002-01-11 ZA ZA200200275A patent/ZA200200275B/xx unknown
- 2002-01-25 NO NO20020392A patent/NO20020392L/no not_active Application Discontinuation
- 2002-05-08 HK HK02103499.8A patent/HK1042236A1/zh unknown
- 2002-05-23 US US10/155,277 patent/US6716846B2/en not_active Expired - Fee Related
-
2004
- 2004-01-21 US US10/761,977 patent/US7094784B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO20020392L (no) | 2002-03-25 |
US20030073690A1 (en) | 2003-04-17 |
CN1374865A (zh) | 2002-10-16 |
US20040152707A1 (en) | 2004-08-05 |
NO20020392D0 (no) | 2002-01-25 |
HUP0203458A2 (hu) | 2003-02-28 |
US6455527B2 (en) | 2002-09-24 |
US6716846B2 (en) | 2004-04-06 |
EP1200087A1 (en) | 2002-05-02 |
US20010011092A1 (en) | 2001-08-02 |
WO2001007050A1 (en) | 2001-02-01 |
CA2379398A1 (en) | 2001-02-01 |
AU2629800A (en) | 2001-02-13 |
HK1042236A1 (zh) | 2002-08-09 |
MXPA02001033A (es) | 2002-08-20 |
JP2003505420A (ja) | 2003-02-12 |
ZA200200275B (en) | 2003-06-25 |
HUP0203458A3 (en) | 2004-01-28 |
US7094784B2 (en) | 2006-08-22 |
US6262066B1 (en) | 2001-07-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0012801A (pt) | Agonistas orl-1 receptores de nociceptina para uso no tratamento da tosse | |
AR019478A1 (es) | Ligandos derivados de piperidina de alta afinidad para el receptor de nociceptina orl-1, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos. | |
NO20050164L (no) | Nye quinuklidin-amid-derivater | |
DE60004564D1 (de) | Neue piperidin und piperazin-derivate als p2x7-rezeptor antagonisten | |
DE60041973D1 (de) | Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivität | |
BR0011097A (pt) | Derivados de 5-fenil-piridina | |
EA200300713A1 (ru) | Производные бензимидазола и пиридилимидазола в качестве лигандов рецепторов гамма-аминомасляной кислоты | |
BRPI0314308B8 (pt) | antagonistas de opióide, seus usos, e composição farmacêutica | |
BR0315815A (pt) | Agentes para prevenir ou tratar neuropatia, para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor, neuroprotetor e farmacêutico, composto, métodos para prevenir ou tratar neuropatia e para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor para proteger um nervo em um mamìfero e para produzir um composto e uso de um composto | |
BR0015193A (pt) | Composto, composição farmacêutica, uso de um composto, e, método para tratamento de uma condição associada com trasmissão reduzida de nicotina, para tratamento ou profilaxia de distúrbios psicóticos ou distúrbios de deterioração intelectual e para tratamento ou profilaxia de doenças ou condições humanas | |
MA26904A1 (fr) | Aminoalkyl 1-lactames substituees et leur utilisation en tant qu'antagonistes du recepteur muscarinique. | |
KR900003203A (ko) | 뉴로펩타이드 y 길항제 및 이의 제조방법 | |
BR0116365A (pt) | Uso de um composto, composto, derivado de 3-indolina, composição farmacêutica, e, método de tratamento de sintomas positivos ou negativos | |
MA26906A1 (fr) | Aminoalkyl 1-lactames substituees et leur utilisation en tant qu'antagonistes du recepteur muscarinique | |
ATE247652T1 (de) | 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden | |
BR0016953A (pt) | Derivados de 4-fenil-1-piperazinila, -piperidinila e tetraidropiridila substituìdo por halogênio, composto, composição farmacêutica, uso e método de tratamento | |
ATE313539T1 (de) | Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten | |
BR0311315A (pt) | Sulfonas aromáticas e sua utilização médica | |
EA200500882A1 (ru) | N-арилсульфонил-3-аминоалкоксииндолы | |
KR950701332A (ko) | 세로토닌 5HT₂길항제로서의 4-이미도메틸-1-[2'페닐-2'옥소에틸-]피페리딘, 이의 제조방법 및 치료에서의 용도(4-Imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5HT₂-antagonists, their preparation and use in therapy) | |
DE60208694D1 (de) | Piperidinylmorpholinylderivate als modulatoren der aktivität des chemokinrezeptors | |
NO931342L (no) | Benzimidazoler, medisinske preparater inneholdende disse,og fremgangsmaate for deres fremstilling | |
BR0207730A (pt) | Derivados de ácido alcoxicarbonila-mino-heteroaril carboxìlico, como antagonistas de ip | |
BR0112130A (pt) | Composições farmacêuticas e métodos para uso | |
CO5540342A2 (es) | Compuestos derivados de tetraisoquinolina que son agentes hipoglicemiantes e hipolipidemicos, y composiciones farmaceuticas que los contienen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |