BR0207730A - Derivados de ácido alcoxicarbonila-mino-heteroaril carboxìlico, como antagonistas de ip - Google Patents
Derivados de ácido alcoxicarbonila-mino-heteroaril carboxìlico, como antagonistas de ipInfo
- Publication number
- BR0207730A BR0207730A BR0207730-2A BR0207730A BR0207730A BR 0207730 A BR0207730 A BR 0207730A BR 0207730 A BR0207730 A BR 0207730A BR 0207730 A BR0207730 A BR 0207730A
- Authority
- BR
- Brazil
- Prior art keywords
- antagonists
- carboxylic acid
- acid derivatives
- minoheteroaryl
- alkoxycarbonyl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108091006335 Prostaglandin I receptors Proteins 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE áCIDO ALCOXICARBONILA-MI-NO-HETEROARIL CARBOXìLICO, COMO ANTAGONISTAS DE IP". A presente invenção refere-se a compostos que são antagonistas do receptor IP e que são representados pela fórmula geral (1) onde G^ 2^ é um grupo heteroarila contendo um ou dois átomos de nitrogênio, sendo substituído por um grupo de ácido carboxílico e G~ 1~ é como definido no relatório descritivo; ou isómeros individuais, misturas de isómeros racêmicas ou não-racêmicas ou sais ou solvatos farmaceuticamente aceitáveis dos mesmos. A invenção refere-se ainda a composições farmacêuticas contendo tais compostos, ao seu uso como agentes terapêuticos e a métodos para preparação dos mesmos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27284901P | 2001-03-02 | 2001-03-02 | |
| PCT/EP2002/001942 WO2002070514A1 (en) | 2001-03-02 | 2002-02-25 | Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0207730A true BR0207730A (pt) | 2004-03-23 |
Family
ID=23041569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0207730-2A BR0207730A (pt) | 2001-03-02 | 2002-02-25 | Derivados de ácido alcoxicarbonila-mino-heteroaril carboxìlico, como antagonistas de ip |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6569860B2 (pt) |
| EP (1) | EP1368345B1 (pt) |
| JP (1) | JP2004526721A (pt) |
| KR (1) | KR100589990B1 (pt) |
| CN (1) | CN1280289C (pt) |
| AR (1) | AR033429A1 (pt) |
| AT (1) | ATE321041T1 (pt) |
| BR (1) | BR0207730A (pt) |
| CA (1) | CA2438813C (pt) |
| DE (1) | DE60210058T2 (pt) |
| ES (1) | ES2260425T3 (pt) |
| MX (1) | MXPA03007864A (pt) |
| WO (1) | WO2002070514A1 (pt) |
| ZA (1) | ZA200306283B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040054008A1 (en) | 2002-09-13 | 2004-03-18 | Tohru Araki | Medicament for treatment of nocturia |
| US20060171945A1 (en) * | 2003-02-14 | 2006-08-03 | Critchley Hilary Octavia D | Ip receptor antagonists for the treatment of pathological uterine conditions |
| US7262313B2 (en) * | 2005-10-20 | 2007-08-28 | Lg Chem, Ltd. | Organic silane compound |
| KR100822142B1 (ko) * | 2005-10-20 | 2008-04-14 | 주식회사 엘지화학 | 신규한 유기 실란 화합물 |
| AR069650A1 (es) * | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| WO2014143591A1 (en) | 2013-03-12 | 2014-09-18 | Allergan, Inc. | Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors |
| US9321745B2 (en) * | 2013-03-12 | 2016-04-26 | Allergan, Inc. | Inhibition of neovascularization by inhibition of prostanoid IP receptors |
| SI3762368T1 (sl) | 2018-03-08 | 2022-06-30 | Incyte Corporation | Aminopirazin diolne spojine kot zaviralci PI3K-y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| EP4119138A1 (en) * | 2021-07-12 | 2023-01-18 | Universität Hamburg | Dhodh inhibitors and their use as antiviral agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908842A (en) | 1995-12-08 | 1999-06-01 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
| US6184242B1 (en) | 1997-09-04 | 2001-02-06 | Syntex Usa (Llc) | 2-(substituted-phenyl)amino-imidazoline derivatives |
| WO1999026925A1 (fr) * | 1997-11-26 | 1999-06-03 | Yoshitomi Pharmaceutical Industries, Ltd. | Inhibiteurs de tryptase comprenant des composants d'amide heterocycliques |
| NZ510719A (en) * | 1998-10-06 | 2003-02-28 | Dainippon Pharmaceutical Co | 2,3-disubstituted pyridine derivatives exhibiting phosphodiesterase IV inhibitory activity |
| US6335459B1 (en) * | 1998-12-23 | 2002-01-01 | Syntex (U.S.A.) Llc | Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators |
| ES2249270T3 (es) * | 1999-08-12 | 2006-04-01 | Pharmacia Italia S.P.A. | Derivados de 3(5)-aminopirazol, procedimiento para su preparacion y su uso como agentes antitumorales. |
| WO2001068591A1 (en) | 2000-03-16 | 2001-09-20 | F. Hoffmann-La Roche Ag | Carboxylic acid derivatives as ip antagonists |
-
2002
- 2002-02-25 MX MXPA03007864A patent/MXPA03007864A/es active IP Right Grant
- 2002-02-25 KR KR1020037011464A patent/KR100589990B1/ko not_active IP Right Cessation
- 2002-02-25 JP JP2002569834A patent/JP2004526721A/ja not_active Ceased
- 2002-02-25 WO PCT/EP2002/001942 patent/WO2002070514A1/en active IP Right Grant
- 2002-02-25 BR BR0207730-2A patent/BR0207730A/pt not_active IP Right Cessation
- 2002-02-25 AT AT02722126T patent/ATE321041T1/de not_active IP Right Cessation
- 2002-02-25 ES ES02722126T patent/ES2260425T3/es not_active Expired - Lifetime
- 2002-02-25 CN CNB028058690A patent/CN1280289C/zh not_active Expired - Fee Related
- 2002-02-25 EP EP02722126A patent/EP1368345B1/en not_active Expired - Lifetime
- 2002-02-25 CA CA002438813A patent/CA2438813C/en not_active Expired - Fee Related
- 2002-02-25 DE DE60210058T patent/DE60210058T2/de not_active Expired - Fee Related
- 2002-02-28 AR ARP020100715A patent/AR033429A1/es unknown
- 2002-03-01 US US10/086,615 patent/US6569860B2/en not_active Expired - Fee Related
-
2003
- 2003-08-13 ZA ZA200306283A patent/ZA200306283B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20020169171A1 (en) | 2002-11-14 |
| ES2260425T3 (es) | 2006-11-01 |
| EP1368345B1 (en) | 2006-03-22 |
| DE60210058T2 (de) | 2006-11-09 |
| CA2438813C (en) | 2008-07-29 |
| DE60210058D1 (de) | 2006-05-11 |
| AR033429A1 (es) | 2003-12-17 |
| MXPA03007864A (es) | 2003-12-04 |
| WO2002070514A1 (en) | 2002-09-12 |
| CA2438813A1 (en) | 2002-09-12 |
| EP1368345A1 (en) | 2003-12-10 |
| CN1280289C (zh) | 2006-10-18 |
| ZA200306283B (en) | 2004-11-15 |
| US6569860B2 (en) | 2003-05-27 |
| JP2004526721A (ja) | 2004-09-02 |
| KR100589990B1 (ko) | 2006-06-15 |
| ATE321041T1 (de) | 2006-04-15 |
| KR20030078962A (ko) | 2003-10-08 |
| CN1494544A (zh) | 2004-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |