JP2003503309A5 - - Google Patents
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- Publication number
- JP2003503309A5 JP2003503309A5 JP2000600553A JP2000600553A JP2003503309A5 JP 2003503309 A5 JP2003503309 A5 JP 2003503309A5 JP 2000600553 A JP2000600553 A JP 2000600553A JP 2000600553 A JP2000600553 A JP 2000600553A JP 2003503309 A5 JP2003503309 A5 JP 2003503309A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antisense oligonucleotide
- seq
- trpm
- antisense
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 15
- 108091034117 Oligonucleotide Proteins 0.000 description 11
- 239000000074 antisense oligonucleotide Substances 0.000 description 11
- 238000012230 antisense oligonucleotides Methods 0.000 description 11
- 102000003780 Clusterin Human genes 0.000 description 8
- 108090000197 Clusterin Proteins 0.000 description 8
- 230000000692 anti-sense effect Effects 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 229940046166 oligodeoxynucleotide Drugs 0.000 description 5
- 210000004881 tumor cell Anatomy 0.000 description 4
- 239000003098 androgen Substances 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 208000023958 prostate neoplasm Diseases 0.000 description 3
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 description 1
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 description 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000003473 lipid group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12172699P | 1999-02-26 | 1999-02-26 | |
| US60/121,726 | 1999-02-26 | ||
| PCT/US2000/004875 WO2000049937A2 (en) | 1999-02-26 | 2000-02-25 | Trpm-2 antisense therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003503309A JP2003503309A (ja) | 2003-01-28 |
| JP2003503309A5 true JP2003503309A5 (https=) | 2007-03-22 |
| JP4785252B2 JP4785252B2 (ja) | 2011-10-05 |
Family
ID=22398429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600553A Expired - Fee Related JP4785252B2 (ja) | 1999-02-26 | 2000-02-25 | Trpm−2アンチセンス療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US7534773B1 (https=) |
| EP (1) | EP1163254B1 (https=) |
| JP (1) | JP4785252B2 (https=) |
| KR (2) | KR100768109B1 (https=) |
| AT (1) | ATE385237T1 (https=) |
| AU (1) | AU767133B2 (https=) |
| CA (2) | CA2850318A1 (https=) |
| DE (1) | DE60037938T2 (https=) |
| DK (1) | DK1163254T3 (https=) |
| ES (1) | ES2300257T3 (https=) |
| HU (1) | HU227190B1 (https=) |
| IL (2) | IL144975A0 (https=) |
| NO (1) | NO330799B1 (https=) |
| NZ (1) | NZ513757A (https=) |
| WO (1) | WO2000049937A2 (https=) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6383808B1 (en) * | 2000-09-11 | 2002-05-07 | Isis Pharmaceuticals, Inc. | Antisense inhibition of clusterin expression |
| US6900187B2 (en) * | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
| JP4785252B2 (ja) | 1999-02-26 | 2011-10-05 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | Trpm−2アンチセンス療法 |
| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| WO2003062421A1 (en) | 2002-01-17 | 2003-07-31 | The University Of British Columbia | Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| SI1530636T1 (sl) * | 2002-08-21 | 2010-12-31 | Stry Liaison Ofiice The University Of British Columbia Umiversity Indu | Zdravljenje melanoma z zniĹľanjem nivojev klusterina |
| KR101238701B1 (ko) | 2002-08-21 | 2013-03-05 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 |
| AU2003298921A1 (en) * | 2002-12-04 | 2004-06-23 | Algos Therapeutics, Inc. | Methods and materials for modulating trpm2 |
| US20040224914A1 (en) * | 2003-04-18 | 2004-11-11 | The University Of British Columbia | Method for treatment of angiogenic disorders |
| US20040220131A1 (en) * | 2003-04-18 | 2004-11-04 | The University Of British Columbia | Method for treatment of cancerous angiogenic disorders |
| US7399853B2 (en) | 2003-04-28 | 2008-07-15 | Isis Pharmaceuticals | Modulation of glucagon receptor expression |
| US7480382B2 (en) * | 2003-09-30 | 2009-01-20 | Microsoft Corporation | Image file container |
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| US8710020B2 (en) * | 2004-04-02 | 2014-04-29 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| US7919472B2 (en) | 2004-09-17 | 2011-04-05 | Isis Pharmaceuticals, Inc. | Enhanced antisense oligonucleotides |
| CA2584646C (en) * | 2004-11-23 | 2015-11-03 | The University Of British Columbia | Treatment of cancer with a combination of an agent that perturbs the egf signaling pathway and an oligonucleotide that reduces clusterin levels |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| JP5713377B2 (ja) | 2005-12-28 | 2015-05-07 | ザ スクリプス リサーチ インスティテュート | 薬物標的としての天然アンチセンスおよび非コードrna転写物 |
| ES2310434B1 (es) | 2006-01-19 | 2009-11-12 | Consejo Superior Investig. Cientificas | Un pmto de identificacion de un proceso de fibrosis renal, pmto de identificacion de compuestos inhibidores, uso de los compuestos inhibidores de la expresion del gen del factor de transcripcion snail en la elaboracion de composiciones farmaceuticas, dichas composiciones..... |
| US8785409B2 (en) | 2007-01-30 | 2014-07-22 | Geron Corporation | Compounds having anti-adhesive effects on cancer cells |
| ES2310469B1 (es) | 2007-03-08 | 2009-11-16 | Consejo Superior Investig. Cientificas | Uso compuestos inhibidores actividad snail1 en elaboracion composiciones farmaceuticas utiles para tratamiento de condrodisplasias, procedimiento identificacion compuestos inhibidores, dichas composiciones farmaceuticas, procedimiento diagnostico condrodisplasias y aplicaciones. |
| US20080234946A1 (en) * | 2007-03-22 | 2008-09-25 | University Of South Florida | Predictive radiosensitivity network model |
| US20090076734A1 (en) | 2007-03-22 | 2009-03-19 | Torres-Roca Javier F | Gene Signature for the Prediction of Radiation Therapy Response |
| JP2010539890A (ja) * | 2007-09-14 | 2010-12-24 | ユニヴァーシティ オブ サウス フロリダ | 放射線治療の応答を予測するための遺伝子シグネチャー |
| ES2345091B1 (es) | 2007-12-05 | 2011-07-18 | Consejo Superior De Investigaciones Científicas (Csic) | Peptidos y anticuerpos utiles para la elaboracion de medicamentos para el tratamiento o prevencion de enfermedades humanas neurodegenerativas. medicamentos asi obtenidos y sus aplicaciones. |
| WO2009126160A1 (en) * | 2008-04-10 | 2009-10-15 | University Of Florida Research Foundation | Compositions and methods for the treatment of prostate carcinoma |
| WO2010035231A1 (en) * | 2008-09-29 | 2010-04-01 | Universität Regensburg | Sense and antisense transcripts of trpm2 and uses thereof |
| CN102239260B (zh) * | 2008-10-03 | 2017-04-12 | 库尔纳公司 | 通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病 |
| US20100204335A1 (en) * | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
| ES2600781T3 (es) | 2008-12-04 | 2017-02-10 | Curna, Inc. | Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf |
| ES2629630T3 (es) | 2008-12-04 | 2017-08-11 | Curna, Inc. | Tratamiento de enfermedades relacionadas con eritropoyetina (EPO) mediante inhibición del transcrito antisentido natural a EPO |
| US20110294870A1 (en) | 2008-12-04 | 2011-12-01 | Opko Curna, Llc | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
| CN102341116A (zh) | 2009-01-08 | 2012-02-01 | 阿勒根公司 | 用于促进甲生长的组合物 |
| ES2762610T3 (es) | 2009-02-12 | 2020-05-25 | Curna Inc | Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF |
| CN102482677B (zh) | 2009-03-16 | 2017-10-17 | 库尔纳公司 | 通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病 |
| WO2010107740A2 (en) | 2009-03-17 | 2010-09-23 | Curna, Inc. | Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1 |
| CN103223177B (zh) | 2009-05-06 | 2016-08-10 | 库尔纳公司 | 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病 |
| ES2609655T3 (es) | 2009-05-06 | 2017-04-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP |
| JP5931720B2 (ja) | 2009-05-08 | 2016-06-08 | クルナ・インコーポレーテッド | Dmdファミリーに対する天然アンチセンス転写物の抑制によるジストロフィンファミリー関連疾患の治療 |
| DK2432881T3 (en) | 2009-05-18 | 2018-02-26 | Curna Inc | TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR |
| CA2762987A1 (en) | 2009-05-22 | 2010-11-25 | Joseph Collard | Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3 |
| KR101704988B1 (ko) | 2009-05-28 | 2017-02-08 | 큐알엔에이, 인크. | 항바이러스 유전자에 대한 천연 안티센스 전사체의 억제에 의한 항바이러스 유전자 관련된 질환의 치료 |
| WO2010148050A2 (en) | 2009-06-16 | 2010-12-23 | Curna, Inc. | Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene |
| US8951981B2 (en) | 2009-06-16 | 2015-02-10 | Curna, Inc. | Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1 |
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| EP2446037B1 (en) | 2009-06-26 | 2016-04-20 | CuRNA, Inc. | Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene |
| CN102712925B (zh) | 2009-07-24 | 2017-10-27 | 库尔纳公司 | 通过抑制sirtuin(sirt)的天然反义转录物来治疗sirtuin(sirt)相关性疾病 |
| CN102762731B (zh) | 2009-08-05 | 2018-06-22 | 库尔纳公司 | 通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病 |
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| CA2771172C (en) | 2009-08-25 | 2021-11-30 | Opko Curna, Llc | Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap |
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| EA034462B1 (ru) | 2009-11-24 | 2020-02-11 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
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