JP2003500464A5 - - Google Patents
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- Publication number
- JP2003500464A5 JP2003500464A5 JP2000621320A JP2000621320A JP2003500464A5 JP 2003500464 A5 JP2003500464 A5 JP 2003500464A5 JP 2000621320 A JP2000621320 A JP 2000621320A JP 2000621320 A JP2000621320 A JP 2000621320A JP 2003500464 A5 JP2003500464 A5 JP 2003500464A5
- Authority
- JP
- Japan
- Prior art keywords
- alkenyl
- alkyl
- compound
- substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 99
- 229910052739 hydrogen Inorganic materials 0.000 description 79
- 239000001257 hydrogen Substances 0.000 description 79
- 125000000217 alkyl group Chemical group 0.000 description 64
- 125000003342 alkenyl group Chemical group 0.000 description 61
- 150000002431 hydrogen Chemical class 0.000 description 58
- 229910052736 halogen Inorganic materials 0.000 description 57
- 150000002367 halogens Chemical class 0.000 description 57
- 125000003118 aryl group Chemical group 0.000 description 40
- 125000005017 substituted alkenyl group Chemical group 0.000 description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 27
- 238000000034 method Methods 0.000 description 27
- 125000000547 substituted alkyl group Chemical group 0.000 description 27
- 125000002252 acyl group Chemical group 0.000 description 25
- 150000003334 secondary amides Chemical class 0.000 description 22
- 150000003511 tertiary amides Chemical class 0.000 description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 20
- 150000002148 esters Chemical class 0.000 description 20
- 239000002253 acid Substances 0.000 description 16
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 13
- 150000001266 acyl halides Chemical class 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 125000000304 alkynyl group Chemical group 0.000 description 10
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 9
- 230000002194 synthesizing effect Effects 0.000 description 9
- 150000004820 halides Chemical class 0.000 description 8
- 239000000651 prodrug Substances 0.000 description 6
- 229940002612 prodrug Drugs 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- -1 16A compound Chemical class 0.000 description 5
- 208000024172 Cardiovascular disease Diseases 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 5
- 206010033078 Otitis media Diseases 0.000 description 5
- 206010052779 Transplant rejections Diseases 0.000 description 5
- 206010045104 Tuberculous pleurisy Diseases 0.000 description 5
- 208000036142 Viral infection Diseases 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 201000005261 otitis interna Diseases 0.000 description 5
- 201000010098 pleural tuberculosis Diseases 0.000 description 5
- 208000008423 pleurisy Diseases 0.000 description 5
- 201000009890 sinusitis Diseases 0.000 description 5
- 230000009385 viral infection Effects 0.000 description 5
- 238000005698 Diels-Alder reaction Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 150000001993 dienes Chemical class 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 3
- KXKVLQRXCPHEJC-UHFFFAOYSA-N methyl acetate Chemical compound COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- TVHDZSRRHQKNEZ-UHFFFAOYSA-N (-) acanthoic acid Natural products OC(=O)C1(C)CCCC2(C)C3=CCC(C=C)(C)CC3CCC21 TVHDZSRRHQKNEZ-UHFFFAOYSA-N 0.000 description 1
- TVHDZSRRHQKNEZ-MGFONVBGSA-N (1r,4ar,7s,8as,10as)-7-ethenyl-1,4a,7-trimethyl-3,4,6,8,8a,9,10,10a-octahydro-2h-phenanthrene-1-carboxylic acid Chemical compound OC(=O)[C@]1(C)CCC[C@@]2(C)C3=CC[C@@](C=C)(C)C[C@@H]3CC[C@@H]21 TVHDZSRRHQKNEZ-MGFONVBGSA-N 0.000 description 1
- 0 C[C@@](*)(C(C(*)C(C1[C@@]2(*)C(*)C(*)C(*)[C@@]1*)N)C2=C(*)C1*)[C@]1C(*)=* Chemical compound C[C@@](*)(C(C(*)C(C1[C@@]2(*)C(*)C(*)C(*)[C@@]1*)N)C2=C(*)C1*)[C@]1C(*)=* 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13429599P | 1999-05-14 | 1999-05-14 | |
| US60/134,295 | 1999-05-14 | ||
| US18685300P | 2000-03-03 | 2000-03-03 | |
| US60/186,853 | 2000-03-03 | ||
| PCT/US2000/013202 WO2000073253A1 (en) | 1999-05-14 | 2000-05-12 | NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012137825A Division JP2012211162A (ja) | 1999-05-14 | 2012-06-19 | 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003500464A JP2003500464A (ja) | 2003-01-07 |
| JP2003500464A5 true JP2003500464A5 (https=) | 2007-07-05 |
| JP5059996B2 JP5059996B2 (ja) | 2012-10-31 |
Family
ID=26832188
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000621320A Expired - Lifetime JP5059996B2 (ja) | 1999-05-14 | 2000-05-12 | 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法 |
| JP2012137825A Withdrawn JP2012211162A (ja) | 1999-05-14 | 2012-06-19 | 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012137825A Withdrawn JP2012211162A (ja) | 1999-05-14 | 2012-06-19 | 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6365768B1 (https=) |
| EP (2) | EP1178952B1 (https=) |
| JP (2) | JP5059996B2 (https=) |
| KR (3) | KR100856353B1 (https=) |
| CN (1) | CN1361760A (https=) |
| AT (2) | ATE370928T1 (https=) |
| AU (2) | AU783372B2 (https=) |
| BR (1) | BR0011522A (https=) |
| CA (1) | CA2372962C (https=) |
| DE (2) | DE60043400D1 (https=) |
| DK (1) | DK1178952T5 (https=) |
| ES (2) | ES2337264T3 (https=) |
| IL (3) | IL146221A0 (https=) |
| MX (1) | MXPA01011613A (https=) |
| NZ (3) | NZ515675A (https=) |
| PT (2) | PT1178952E (https=) |
| WO (1) | WO2000073253A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100566422B1 (ko) * | 1998-01-26 | 2006-04-07 | 재단법인서울대학교산학협력재단 | 디테르펜 유도체 및 이를 포함하는 소염진통제 |
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US7119223B2 (en) | 1999-05-14 | 2006-10-10 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators |
| DE60043400D1 (de) | 1999-05-14 | 2010-01-07 | Nereus Pharmaceuticals Inc | Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren |
| US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| AU2002255963A1 (en) * | 2001-03-28 | 2002-10-15 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use |
| US20030087334A1 (en) * | 2001-04-02 | 2003-05-08 | Libraria, Inc. | Method of flexibly generating diverse reaction chemistries |
| US7176237B2 (en) | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| AU2003206179A1 (en) * | 2002-01-25 | 2003-09-02 | Korea Research Institute Of Bioscience And Biotechnology | An extract of acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug |
| US7517542B2 (en) * | 2004-03-03 | 2009-04-14 | Korea Research Institute Of Bioscience | Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease |
| EP2311795A3 (en) | 2005-07-21 | 2011-12-28 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators |
| EP2094651A1 (en) | 2006-11-17 | 2009-09-02 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| US8299046B2 (en) | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| EP1925301A1 (en) * | 2006-11-24 | 2008-05-28 | DSMIP Assets B.V. | Use of tricyclic diterpenes and their derivatives for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders |
| US7875853B2 (en) * | 2007-07-23 | 2011-01-25 | Honeywell International Inc. | Low-cost PIR scanning mechanism |
| BRPI0907423A2 (pt) | 2008-01-11 | 2020-10-27 | Reata Pharmaceuticals, Inc. | composto triterpenoide sintético para uso em um método de melhoria da função renal em um indivíduo, e uso do referido composto |
| JP5529851B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 |
| WO2009146218A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| KR101713140B1 (ko) | 2008-04-18 | 2017-03-08 | 리타 파마슈티컬스 잉크. | Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체 |
| US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| MX2010011439A (es) | 2008-04-18 | 2011-01-25 | Reata Pharmaceuticals Inc | Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17. |
| EP2309860B1 (en) | 2008-07-22 | 2014-01-08 | Trustees of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| US20110293653A1 (en) * | 2010-03-11 | 2011-12-01 | University Of Massachusetts | Antagonists of mir-155 for the treatment of inflammatory liver disease |
| DK2558105T3 (da) | 2010-04-12 | 2020-01-27 | Reata Pharmaceuticals Inc | Bardoxolonmethyl til behandling af fedme |
| JP5845274B2 (ja) * | 2010-10-27 | 2016-01-20 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | 生物学的特性を賦与されたジテルペノイド誘導体 |
| NZ703649A (en) | 2010-12-06 | 2016-08-26 | Penn State Res Found | Compositions and methods relating to proliferative diseases |
| CN103596929B (zh) | 2010-12-17 | 2016-10-19 | 里亚塔医药公司 | 作为抗氧化发炎调节剂的吡唑及嘧啶三环烯酮 |
| MX348862B (es) | 2011-03-11 | 2017-07-03 | Reata Pharmaceuticals Inc | Derivados c4-monometil triterpenoides y sus metodos de uso. |
| TWI623548B (zh) | 2012-04-27 | 2018-05-11 | 瑞塔醫藥有限責任公司 | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２-二氟基丙醯胺衍生物、多晶型及其使用方法 |
| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| WO2014040073A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| JP7074674B2 (ja) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
| CN110198718B (zh) | 2016-11-08 | 2023-01-10 | 里亚塔医药控股有限责任公司 | 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法 |
| CN106928095A (zh) * | 2017-03-14 | 2017-07-07 | 华东师范大学 | 氰基烯酮类三环二萜类似物及其制备方法和应用 |
| US10463631B2 (en) * | 2017-06-12 | 2019-11-05 | University Of South Carolina | Pimarane diterpenoids for use in wound healing and angiogenesis |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| EP3999522B1 (en) | 2019-07-19 | 2025-09-03 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5212708B2 (https=) | 1974-05-14 | 1977-04-08 | ||
| JPS522910B2 (https=) | 1974-05-17 | 1977-01-25 | ||
| GB1452053A (en) | 1974-08-28 | 1976-10-06 | Nippon Shinyaku Co Ltd | Abietamide derivatives and a method for the preparation thereof |
| US4874891A (en) | 1986-05-01 | 1989-10-17 | Washington University | Open "D" ring hormone analogs |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5192817A (en) | 1990-03-06 | 1993-03-09 | Otsuka Pharmaceutical Co., Ltd. | Phenanthrene derivatives |
| US5276182A (en) | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
| DE4039602A1 (de) | 1990-12-12 | 1992-06-17 | Bauer Kurt Heinz Prof Dr | Pharmazeutische formulierungen |
| KR100221695B1 (ko) | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
| US5653962A (en) | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| AU5612694A (en) | 1992-11-27 | 1994-06-22 | Napro Biotherapeutics, Inc. | Injectable composition |
| US5654286A (en) | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
| EP1475091A1 (en) | 1993-10-01 | 2004-11-10 | Roche Palo Alto LLC | Mycophenolate mofetil - high dose oral suspensions |
| KR0145941B1 (ko) * | 1994-06-13 | 1998-08-17 | 김은영 | 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물 |
| US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5653987A (en) | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| US5726181A (en) | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| US5667809A (en) | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
| FR2741262B1 (fr) | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
| KR100566422B1 (ko) * | 1998-01-26 | 2006-04-07 | 재단법인서울대학교산학협력재단 | 디테르펜 유도체 및 이를 포함하는 소염진통제 |
| US6051590A (en) | 1999-05-13 | 2000-04-18 | Merck & Co., Inc. | Immunosuppressant tricyclic compounds |
| DE60043400D1 (de) * | 1999-05-14 | 2010-01-07 | Nereus Pharmaceuticals Inc | Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren |
| AU2002255963A1 (en) | 2001-03-28 | 2002-10-15 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use |
-
2000
- 2000-05-12 DE DE60043400T patent/DE60043400D1/de not_active Expired - Lifetime
- 2000-05-12 AU AU50133/00A patent/AU783372B2/en not_active Ceased
- 2000-05-12 DK DK00932408T patent/DK1178952T5/da active
- 2000-05-12 CN CN00810323A patent/CN1361760A/zh active Pending
- 2000-05-12 MX MXPA01011613A patent/MXPA01011613A/es active IP Right Grant
- 2000-05-12 PT PT00932408T patent/PT1178952E/pt unknown
- 2000-05-12 IL IL14622100A patent/IL146221A0/xx active IP Right Grant
- 2000-05-12 DE DE60036101T patent/DE60036101T2/de not_active Expired - Lifetime
- 2000-05-12 US US09/570,202 patent/US6365768B1/en not_active Expired - Fee Related
- 2000-05-12 CA CA002372962A patent/CA2372962C/en not_active Expired - Fee Related
- 2000-05-12 KR KR1020017014545A patent/KR100856353B1/ko not_active Expired - Fee Related
- 2000-05-12 KR KR1020067025785A patent/KR100840925B1/ko not_active Expired - Fee Related
- 2000-05-12 BR BR0011522-3A patent/BR0011522A/pt not_active Application Discontinuation
- 2000-05-12 EP EP00932408A patent/EP1178952B1/en not_active Expired - Lifetime
- 2000-05-12 JP JP2000621320A patent/JP5059996B2/ja not_active Expired - Lifetime
- 2000-05-12 NZ NZ515675A patent/NZ515675A/en not_active IP Right Cessation
- 2000-05-12 WO PCT/US2000/013202 patent/WO2000073253A1/en not_active Ceased
- 2000-05-12 PT PT05076500T patent/PT1591437E/pt unknown
- 2000-05-12 AT AT00932408T patent/ATE370928T1/de active
- 2000-05-12 NZ NZ540001A patent/NZ540001A/en not_active IP Right Cessation
- 2000-05-12 KR KR1020067020613A patent/KR20060110013A/ko not_active Withdrawn
- 2000-05-12 ES ES05076500T patent/ES2337264T3/es not_active Expired - Lifetime
- 2000-05-12 AT AT05076500T patent/ATE449754T1/de active
- 2000-05-12 NZ NZ529505A patent/NZ529505A/en not_active IP Right Cessation
- 2000-05-12 ES ES00932408T patent/ES2295031T3/es not_active Expired - Lifetime
- 2000-05-12 EP EP05076500A patent/EP1591437B1/en not_active Expired - Lifetime
-
2001
- 2001-10-29 IL IL146221A patent/IL146221A/en not_active IP Right Cessation
-
2002
- 2002-02-04 US US10/068,333 patent/US6881857B2/en not_active Expired - Lifetime
-
2005
- 2005-04-19 US US11/108,941 patent/US7342125B2/en not_active Expired - Lifetime
-
2006
- 2006-01-19 AU AU2006200240A patent/AU2006200240B2/en not_active Ceased
-
2007
- 2007-03-28 IL IL182272A patent/IL182272A/en not_active IP Right Cessation
-
2012
- 2012-06-19 JP JP2012137825A patent/JP2012211162A/ja not_active Withdrawn
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