BR0011522A - Composto e método de sintetização para a fabricação do composto - Google Patents

Composto e método de sintetização para a fabricação do composto

Info

Publication number
BR0011522A
BR0011522A BR0011522-3A BR0011522A BR0011522A BR 0011522 A BR0011522 A BR 0011522A BR 0011522 A BR0011522 A BR 0011522A BR 0011522 A BR0011522 A BR 0011522A
Authority
BR
Brazil
Prior art keywords
compound
manufacture
synthesis method
produg
interleukin
Prior art date
Application number
BR0011522-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Michael Palladino
Emmanuel A Theodorakis
Original Assignee
Nereus Pharmaceuticals Inc
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc, Univ California filed Critical Nereus Pharmaceuticals Inc
Publication of BR0011522A publication Critical patent/BR0011522A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
BR0011522-3A 1999-05-14 2000-05-12 Composto e método de sintetização para a fabricação do composto BR0011522A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13429599P 1999-05-14 1999-05-14
US18685300P 2000-03-03 2000-03-03
PCT/US2000/013202 WO2000073253A1 (en) 1999-05-14 2000-05-12 NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS

Publications (1)

Publication Number Publication Date
BR0011522A true BR0011522A (pt) 2002-06-04

Family

ID=26832188

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011522-3A BR0011522A (pt) 1999-05-14 2000-05-12 Composto e método de sintetização para a fabricação do composto

Country Status (17)

Country Link
US (3) US6365768B1 (https=)
EP (2) EP1591437B1 (https=)
JP (2) JP5059996B2 (https=)
KR (3) KR100856353B1 (https=)
CN (1) CN1361760A (https=)
AT (2) ATE449754T1 (https=)
AU (2) AU783372B2 (https=)
BR (1) BR0011522A (https=)
CA (1) CA2372962C (https=)
DE (2) DE60036101T2 (https=)
DK (1) DK1178952T5 (https=)
ES (2) ES2337264T3 (https=)
IL (3) IL146221A0 (https=)
MX (1) MXPA01011613A (https=)
NZ (3) NZ515675A (https=)
PT (2) PT1178952E (https=)
WO (1) WO2000073253A1 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4615710B2 (ja) * 1998-01-26 2011-01-19 サエ ハン ファーム．シーオー．，エルティーディー． ジテルペン誘導体及びこれらを含む消炎鎮痛剤
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
JP5059996B2 (ja) * 1999-05-14 2012-10-31 ネレアス ファーマシューティカルズ インコーポレーテッド 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法
US7119223B2 (en) * 1999-05-14 2006-10-10 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
AU2002255963A1 (en) * 2001-03-28 2002-10-15 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use
US20030087334A1 (en) * 2001-04-02 2003-05-08 Libraria, Inc. Method of flexibly generating diverse reaction chemistries
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
WO2003061553A2 (en) * 2002-01-25 2003-07-31 Korea Research Institute Of Bioscience And Biotechnology An extract of acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug
JP4777970B2 (ja) * 2004-03-03 2011-09-21 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー 新規なアビエタンジテルペノイド系化合物、及び榧抽出物、またはそれから分離したアビエタンジテルペノイド系化合物またはテルペノイド系化合物を有効成分とする心臓循環系疾患の予防及び治療用組成物
EP2311795A3 (en) * 2005-07-21 2011-12-28 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP1925301A1 (en) * 2006-11-24 2008-05-28 DSMIP Assets B.V. Use of tricyclic diterpenes and their derivatives for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders
US7875853B2 (en) * 2007-07-23 2011-01-25 Honeywell International Inc. Low-cost PIR scanning mechanism
PL2252283T3 (pl) 2008-01-11 2019-09-30 Reata Pharmaceuticals, Inc. Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
WO2009129546A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
RS55631B1 (sr) 2008-04-18 2017-06-30 Reata Pharmaceuticals Inc Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
US20110293653A1 (en) * 2010-03-11 2011-12-01 University Of Massachusetts Antagonists of mir-155 for the treatment of inflammatory liver disease
MX357596B (es) 2010-04-12 2018-07-16 Reata Pharmaceuticals Inc Método para tratar obesidad utilizando moduladores de inflamación con antioxidantes.
NZ609769A (en) * 2010-10-27 2015-02-27 Sigma Tau Ind Farmaceuti Diterpenoid derivatives endowed of biological properties
WO2012078667A2 (en) * 2010-12-06 2012-06-14 The Penn State Research Foundation Compositions and methods relating to proliferative diseases
PL2651902T3 (pl) 2010-12-17 2018-04-30 Reata Pharmaceuticals, Inc. Pirazolilowe i pirymidynylowe tricykliczne enony jako modulatory zapalenia o działaniu przeciwutleniającym
SI2683731T1 (sl) 2011-03-11 2019-07-31 Reata Pharmaceuticals, Inc. C4-monometil triterpenoidni derivati in postopki njihove uporabe
JP6410710B2 (ja) 2012-04-27 2018-10-24 リアタ ファーマシューティカルズ インコーポレイテッド バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2013188818A1 (en) 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
WO2014040060A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
BR112018005861B1 (pt) 2015-09-23 2022-11-22 Reata Pharmaceuticals, Inc Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
KR102486434B1 (ko) 2016-11-08 2023-01-09 리아타 파마슈티컬즈 홀딩스, 엘엘씨 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법
CN106928095A (zh) * 2017-03-14 2017-07-07 华东师范大学 氰基烯酮类三环二萜类似物及其制备方法和应用
US10463631B2 (en) * 2017-06-12 2019-11-05 University Of South Carolina Pimarane diterpenoids for use in wound healing and angiogenesis
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
TWI861163B (zh) 2019-07-19 2024-11-11 美商瑞塔醫藥有限責任公司 C17經極性取代之雜芳合成三萜類化合物及其使用方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5212708B2 (https=) 1974-05-14 1977-04-08
JPS522910B2 (https=) 1974-05-17 1977-01-25
GB1452053A (en) 1974-08-28 1976-10-06 Nippon Shinyaku Co Ltd Abietamide derivatives and a method for the preparation thereof
US4874891A (en) 1986-05-01 1989-10-17 Washington University Open "D" ring hormone analogs
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5192817A (en) 1990-03-06 1993-03-09 Otsuka Pharmaceutical Co., Ltd. Phenanthrene derivatives
US5276182A (en) 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (de) 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
KR100221695B1 (ko) 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5683676A (en) 1991-12-12 1997-11-04 Glaxo Group Limited Canister containing aerosol formulations containing P134a and particulate medicaments
ES2224200T3 (es) 1992-11-27 2005-03-01 Mayne Pharma (Usa) Inc. Composicion inyectable estable de paclitaxel.
US5654286A (en) 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
CZ301771B6 (cs) 1993-10-01 2010-06-16 Syntex (U.S.A.) Llc. Farmaceutický prostredek ve forme suchého granulátu obsahující mofetil mykofenolát nebo kyselinu mykofenolovou a zpusob jeho prípravy
KR0145941B1 (ko) * 1994-06-13 1998-08-17 김은영 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물
US5707641A (en) 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
JP4615710B2 (ja) 1998-01-26 2011-01-19 サエ ハン ファーム．シーオー．，エルティーディー． ジテルペン誘導体及びこれらを含む消炎鎮痛剤
US6051590A (en) 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
JP5059996B2 (ja) * 1999-05-14 2012-10-31 ネレアス ファーマシューティカルズ インコーポレーテッド 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法
AU2002255963A1 (en) 2001-03-28 2002-10-15 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use

Also Published As

Publication number Publication date
IL182272A0 (en) 2007-07-24
EP1591437B1 (en) 2009-11-25
JP5059996B2 (ja) 2012-10-31
DK1178952T5 (da) 2008-03-17
IL146221A0 (en) 2002-07-25
EP1178952B1 (en) 2007-08-22
US20050209325A1 (en) 2005-09-22
ES2295031T3 (es) 2008-04-16
MXPA01011613A (es) 2003-10-14
ATE370928T1 (de) 2007-09-15
EP1178952A1 (en) 2002-02-13
ATE449754T1 (de) 2009-12-15
DE60043400D1 (de) 2010-01-07
ES2337264T3 (es) 2010-04-22
AU2006200240B2 (en) 2009-05-28
DE60036101D1 (de) 2007-10-04
EP1591437A3 (en) 2006-03-08
CN1361760A (zh) 2002-07-31
US6881857B2 (en) 2005-04-19
NZ540001A (en) 2007-06-29
NZ529505A (en) 2005-09-30
KR100840925B1 (ko) 2008-06-24
IL182272A (en) 2010-05-31
HK1084657A1 (en) 2006-08-04
US6365768B1 (en) 2002-04-02
KR100856353B1 (ko) 2008-09-04
EP1591437A2 (en) 2005-11-02
DK1178952T3 (da) 2008-01-28
CA2372962A1 (en) 2000-12-07
AU2006200240A1 (en) 2006-02-16
US20030040640A1 (en) 2003-02-27
NZ515675A (en) 2004-06-25
WO2000073253A1 (en) 2000-12-07
JP2012211162A (ja) 2012-11-01
AU5013300A (en) 2000-12-18
PT1178952E (pt) 2007-12-04
PT1591437E (pt) 2010-03-04
CA2372962C (en) 2008-04-08
AU783372B2 (en) 2005-10-20
KR20020028878A (ko) 2002-04-17
US7342125B2 (en) 2008-03-11
KR20060110013A (ko) 2006-10-23
DE60036101T2 (de) 2008-05-15
JP2003500464A (ja) 2003-01-07
IL146221A (en) 2007-07-04
KR20060135080A (ko) 2006-12-28

Similar Documents

Publication Publication Date Title
BR0011522A (pt) Composto e método de sintetização para a fabricação do composto
ATE360706T1 (de) Peptidakzeptor ligationsverfahren
PT1459751E (pt) (s,s)-reboxetina para tratar as enxaquecas
SE9900100D0 (sv) New compounds
AU2003244001A1 (en) Inorganic staple fiber accumulation for holding material, process for producing the same and holding material
BR0106878B1 (pt) "processo para produção de resina absorvente de água".
WO2003006570A3 (en) Novel mesogens and methods for their synthesis and use
FR2804681B1 (fr) Compose antidiabetique et procede pour sa production
BR9917475B1 (pt) processo para a manufatura de compostos, e, modificação do processo.
BR0208938B1 (pt) método de pré-tratamento para material de deposição não eletrolìtica.
AU2003233579A1 (en) Synthesis of inorganic structures using templation and catalysis by self assembled repeat protein polymers
AU1802100A (en) Floating pesticide compositions for paddy fields, method for the utilization thereof and process for producing the same
AU2002243235A1 (en) Novel nucleic acids, methods and transformed cells for the modulation of gibberellin production
AU2001260616A1 (en) Compounds generating amine by irradiation with light, photo-setting compositions and photoreactive adhesive compositions
BR0015861B1 (pt) método de produção de composição de poliamina.
ATE388953T1 (de) Pyrazolopyrimidine
AU2001277742A1 (en) Solid culture medium and method for preparing the same
PT1019347E (pt) Metodo para a sintese de taxanos
AU2003254862A1 (en) Molecule alignment polymer gel and molecule alignment polymer cast film having self-organizing amphiphilic compound as template and process for producing the same
IT1318716B1 (it) Impianto per la produzione di calore accumulabile.
AU2003272967A1 (en) Processes for producing optically active n-(2,3-epoxypropan-1-yl)phthalimide
EP1146517A4 (en) DISK DRIVE, MANUFACTURING METHOD THEREFOR, AND DISK DRIVE CONTROL UNIT
AU4692501A (en) Laminaribiose phosphorylase, process for producing the same and process for producing laminarioligosaccharide by using the enzyme
BG103087A (en) Method for the preparation of naphthiridons and intermediate compounds
IT1308677B1 (it) Procedimento per produrre 2,2,6,6-tetrametil-4-piperidone

Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: ATRAVES DA PETICAO NO 009397, DE 12/05/2003, O REQUERENTE SOLICITOU O EXAME DO PRESENTE PEDIDO E EFETUOU A RETRIBUICAO EQUIVALENTE A 81 REIVINDICACOES. NO ENTANTO, PELA PETICAO NO 013182, DE 07/07/2003 FOI APRESENTADO UM NOVO QUADRO REIVINDICATORIO CONSTANDO 97 REIVINDICACOES. DESSE MODO, A FIM DE DAR CONTINUIDADE AO EXAME DO PEDIDO O REQUERENTE DEVERA COMPLEMENTAR A RETRIBUICAO REFERENTE AS 16 REIVINDICACOES QUE EXCEDEM AS 81 APRESENTADAS

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements