MXPA01011613A - Nuevos moduladores de interleucina-1 y factor-alfa de necrosis tumoral, sistesis de dichos moduladores y metodos de utilizar dichos moduladores. - Google Patents
Nuevos moduladores de interleucina-1 y factor-alfa de necrosis tumoral, sistesis de dichos moduladores y metodos de utilizar dichos moduladores.Info
- Publication number
- MXPA01011613A MXPA01011613A MXPA01011613A MXPA01011613A MXPA01011613A MX PA01011613 A MXPA01011613 A MX PA01011613A MX PA01011613 A MXPA01011613 A MX PA01011613A MX PA01011613 A MXPA01011613 A MX PA01011613A MX PA01011613 A MXPA01011613 A MX PA01011613A
- Authority
- MX
- Mexico
- Prior art keywords
- modulators
- necrosis factor
- tumor necrosis
- syntheses
- methods
- Prior art date
Links
- 102000000589 Interleukin-1 Human genes 0.000 title abstract 2
- 108010082786 Interleukin-1alpha Proteins 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 206010054094 Tumour necrosis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
- C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/35—Unsaturated compounds having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13429599P | 1999-05-14 | 1999-05-14 | |
| US18685300P | 2000-03-03 | 2000-03-03 | |
| PCT/US2000/013202 WO2000073253A1 (en) | 1999-05-14 | 2000-05-12 | NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01011613A true MXPA01011613A (es) | 2003-10-14 |
Family
ID=26832188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01011613A MXPA01011613A (es) | 1999-05-14 | 2000-05-12 | Nuevos moduladores de interleucina-1 y factor-alfa de necrosis tumoral, sistesis de dichos moduladores y metodos de utilizar dichos moduladores. |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6365768B1 (https=) |
| EP (2) | EP1178952B1 (https=) |
| JP (2) | JP5059996B2 (https=) |
| KR (3) | KR100856353B1 (https=) |
| CN (1) | CN1361760A (https=) |
| AT (2) | ATE370928T1 (https=) |
| AU (2) | AU783372B2 (https=) |
| BR (1) | BR0011522A (https=) |
| CA (1) | CA2372962C (https=) |
| DE (2) | DE60043400D1 (https=) |
| DK (1) | DK1178952T5 (https=) |
| ES (2) | ES2337264T3 (https=) |
| IL (3) | IL146221A0 (https=) |
| MX (1) | MXPA01011613A (https=) |
| NZ (3) | NZ515675A (https=) |
| PT (2) | PT1178952E (https=) |
| WO (1) | WO2000073253A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100566422B1 (ko) * | 1998-01-26 | 2006-04-07 | 재단법인서울대학교산학협력재단 | 디테르펜 유도체 및 이를 포함하는 소염진통제 |
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US7119223B2 (en) | 1999-05-14 | 2006-10-10 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators |
| DE60043400D1 (de) | 1999-05-14 | 2010-01-07 | Nereus Pharmaceuticals Inc | Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren |
| US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| AU2002255963A1 (en) * | 2001-03-28 | 2002-10-15 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use |
| US20030087334A1 (en) * | 2001-04-02 | 2003-05-08 | Libraria, Inc. | Method of flexibly generating diverse reaction chemistries |
| US7176237B2 (en) | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| AU2003206179A1 (en) * | 2002-01-25 | 2003-09-02 | Korea Research Institute Of Bioscience And Biotechnology | An extract of acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug |
| US7517542B2 (en) * | 2004-03-03 | 2009-04-14 | Korea Research Institute Of Bioscience | Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease |
| EP2311795A3 (en) | 2005-07-21 | 2011-12-28 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators |
| EP2094651A1 (en) | 2006-11-17 | 2009-09-02 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| US8299046B2 (en) | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| EP1925301A1 (en) * | 2006-11-24 | 2008-05-28 | DSMIP Assets B.V. | Use of tricyclic diterpenes and their derivatives for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders |
| US7875853B2 (en) * | 2007-07-23 | 2011-01-25 | Honeywell International Inc. | Low-cost PIR scanning mechanism |
| BRPI0907423A2 (pt) | 2008-01-11 | 2020-10-27 | Reata Pharmaceuticals, Inc. | composto triterpenoide sintético para uso em um método de melhoria da função renal em um indivíduo, e uso do referido composto |
| JP5529851B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 |
| WO2009146218A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| KR101713140B1 (ko) | 2008-04-18 | 2017-03-08 | 리타 파마슈티컬스 잉크. | Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체 |
| US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| MX2010011439A (es) | 2008-04-18 | 2011-01-25 | Reata Pharmaceuticals Inc | Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17. |
| EP2309860B1 (en) | 2008-07-22 | 2014-01-08 | Trustees of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| US20110293653A1 (en) * | 2010-03-11 | 2011-12-01 | University Of Massachusetts | Antagonists of mir-155 for the treatment of inflammatory liver disease |
| DK2558105T3 (da) | 2010-04-12 | 2020-01-27 | Reata Pharmaceuticals Inc | Bardoxolonmethyl til behandling af fedme |
| JP5845274B2 (ja) * | 2010-10-27 | 2016-01-20 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | 生物学的特性を賦与されたジテルペノイド誘導体 |
| NZ703649A (en) | 2010-12-06 | 2016-08-26 | Penn State Res Found | Compositions and methods relating to proliferative diseases |
| CN103596929B (zh) | 2010-12-17 | 2016-10-19 | 里亚塔医药公司 | 作为抗氧化发炎调节剂的吡唑及嘧啶三环烯酮 |
| MX348862B (es) | 2011-03-11 | 2017-07-03 | Reata Pharmaceuticals Inc | Derivados c4-monometil triterpenoides y sus metodos de uso. |
| TWI623548B (zh) | 2012-04-27 | 2018-05-11 | 瑞塔醫藥有限責任公司 | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２-二氟基丙醯胺衍生物、多晶型及其使用方法 |
| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| WO2014040073A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| JP7074674B2 (ja) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
| CN110198718B (zh) | 2016-11-08 | 2023-01-10 | 里亚塔医药控股有限责任公司 | 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法 |
| CN106928095A (zh) * | 2017-03-14 | 2017-07-07 | 华东师范大学 | 氰基烯酮类三环二萜类似物及其制备方法和应用 |
| US10463631B2 (en) * | 2017-06-12 | 2019-11-05 | University Of South Carolina | Pimarane diterpenoids for use in wound healing and angiogenesis |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| EP3999522B1 (en) | 2019-07-19 | 2025-09-03 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5212708B2 (https=) | 1974-05-14 | 1977-04-08 | ||
| JPS522910B2 (https=) | 1974-05-17 | 1977-01-25 | ||
| GB1452053A (en) | 1974-08-28 | 1976-10-06 | Nippon Shinyaku Co Ltd | Abietamide derivatives and a method for the preparation thereof |
| US4874891A (en) | 1986-05-01 | 1989-10-17 | Washington University | Open "D" ring hormone analogs |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5192817A (en) | 1990-03-06 | 1993-03-09 | Otsuka Pharmaceutical Co., Ltd. | Phenanthrene derivatives |
| US5276182A (en) | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
| DE4039602A1 (de) | 1990-12-12 | 1992-06-17 | Bauer Kurt Heinz Prof Dr | Pharmazeutische formulierungen |
| KR100221695B1 (ko) | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
| US5653962A (en) | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| AU5612694A (en) | 1992-11-27 | 1994-06-22 | Napro Biotherapeutics, Inc. | Injectable composition |
| US5654286A (en) | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
| EP1475091A1 (en) | 1993-10-01 | 2004-11-10 | Roche Palo Alto LLC | Mycophenolate mofetil - high dose oral suspensions |
| KR0145941B1 (ko) * | 1994-06-13 | 1998-08-17 | 김은영 | 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물 |
| US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5653987A (en) | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| US5726181A (en) | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| US5667809A (en) | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
| FR2741262B1 (fr) | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
| KR100566422B1 (ko) * | 1998-01-26 | 2006-04-07 | 재단법인서울대학교산학협력재단 | 디테르펜 유도체 및 이를 포함하는 소염진통제 |
| US6051590A (en) | 1999-05-13 | 2000-04-18 | Merck & Co., Inc. | Immunosuppressant tricyclic compounds |
| DE60043400D1 (de) * | 1999-05-14 | 2010-01-07 | Nereus Pharmaceuticals Inc | Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren |
| AU2002255963A1 (en) | 2001-03-28 | 2002-10-15 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use |
-
2000
- 2000-05-12 DE DE60043400T patent/DE60043400D1/de not_active Expired - Lifetime
- 2000-05-12 AU AU50133/00A patent/AU783372B2/en not_active Ceased
- 2000-05-12 DK DK00932408T patent/DK1178952T5/da active
- 2000-05-12 CN CN00810323A patent/CN1361760A/zh active Pending
- 2000-05-12 MX MXPA01011613A patent/MXPA01011613A/es active IP Right Grant
- 2000-05-12 PT PT00932408T patent/PT1178952E/pt unknown
- 2000-05-12 IL IL14622100A patent/IL146221A0/xx active IP Right Grant
- 2000-05-12 DE DE60036101T patent/DE60036101T2/de not_active Expired - Lifetime
- 2000-05-12 US US09/570,202 patent/US6365768B1/en not_active Expired - Fee Related
- 2000-05-12 CA CA002372962A patent/CA2372962C/en not_active Expired - Fee Related
- 2000-05-12 KR KR1020017014545A patent/KR100856353B1/ko not_active Expired - Fee Related
- 2000-05-12 KR KR1020067025785A patent/KR100840925B1/ko not_active Expired - Fee Related
- 2000-05-12 BR BR0011522-3A patent/BR0011522A/pt not_active Application Discontinuation
- 2000-05-12 EP EP00932408A patent/EP1178952B1/en not_active Expired - Lifetime
- 2000-05-12 JP JP2000621320A patent/JP5059996B2/ja not_active Expired - Lifetime
- 2000-05-12 NZ NZ515675A patent/NZ515675A/en not_active IP Right Cessation
- 2000-05-12 WO PCT/US2000/013202 patent/WO2000073253A1/en not_active Ceased
- 2000-05-12 PT PT05076500T patent/PT1591437E/pt unknown
- 2000-05-12 AT AT00932408T patent/ATE370928T1/de active
- 2000-05-12 NZ NZ540001A patent/NZ540001A/en not_active IP Right Cessation
- 2000-05-12 KR KR1020067020613A patent/KR20060110013A/ko not_active Withdrawn
- 2000-05-12 ES ES05076500T patent/ES2337264T3/es not_active Expired - Lifetime
- 2000-05-12 AT AT05076500T patent/ATE449754T1/de active
- 2000-05-12 NZ NZ529505A patent/NZ529505A/en not_active IP Right Cessation
- 2000-05-12 ES ES00932408T patent/ES2295031T3/es not_active Expired - Lifetime
- 2000-05-12 EP EP05076500A patent/EP1591437B1/en not_active Expired - Lifetime
-
2001
- 2001-10-29 IL IL146221A patent/IL146221A/en not_active IP Right Cessation
-
2002
- 2002-02-04 US US10/068,333 patent/US6881857B2/en not_active Expired - Lifetime
-
2005
- 2005-04-19 US US11/108,941 patent/US7342125B2/en not_active Expired - Lifetime
-
2006
- 2006-01-19 AU AU2006200240A patent/AU2006200240B2/en not_active Ceased
-
2007
- 2007-03-28 IL IL182272A patent/IL182272A/en not_active IP Right Cessation
-
2012
- 2012-06-19 JP JP2012137825A patent/JP2012211162A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA01011613A (es) | Nuevos moduladores de interleucina-1 y factor-alfa de necrosis tumoral, sistesis de dichos moduladores y metodos de utilizar dichos moduladores. | |
| IL147037A0 (en) | Peptide acceptor ligation methods | |
| EP1591462A3 (en) | Temperature-responsive polymer compound and process for producing the same | |
| MXPA03006934A (es) | Metodo para controlar organismos daninos en el cultivo de plantas utiles. | |
| WO2003008475A3 (en) | Light-emitting organic oligomer compositions | |
| AU7936500A (en) | Windturbine driven by trafic | |
| AU1802100A (en) | Floating pesticide compositions for paddy fields, method for the utilization thereof and process for producing the same | |
| PL348765A1 (en) | Tack free surface cures of polymers by organic peroxides in the presence of air | |
| WO2001042250A3 (en) | Process for production of diphenyl-dialkoxysilane, phenylalkyl-dialkoxysilane, octaphenylcyclotetrasiloxane and sym-tetraalkyltetraphenyl-cyclotetrasiloxane | |
| IT1318624B1 (it) | Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi. | |
| AU2003241785A1 (en) | Intravenous composition, process for producing the same and preparation thereof | |
| AU4122901A (en) | Novel 7,8-dihydro-xanthenone-8-carboxylic acid derivative and novel microbe producing the same | |
| AU2001260616A1 (en) | Compounds generating amine by irradiation with light, photo-setting compositions and photoreactive adhesive compositions | |
| AU2001252591A1 (en) | Novel promoters and gene expression method by using the promoters | |
| AU2001277742A1 (en) | Solid culture medium and method for preparing the same | |
| AU4710800A (en) | Methods of software driven flow sorting for reiterative synthesis cycles | |
| EP1158006A4 (en) | POLYMER, PROCESS FOR PREPARING THE POLYMER, AND CURABLE COMPOSITION CONTAINING THE POLYMER | |
| AU2002221164A1 (en) | (r)-hydroxycarboxylic acid producing recombinant microorganism and process for preparing (r)-hydroxycarboxylic acid using the same | |
| CA2143348A1 (en) | The methylation of organic compounds | |
| CA2416769A1 (en) | Process for preparing discodermolide and analogues thereof | |
| AU2002224102A1 (en) | Promoter for the culture of autrotrophic bacterium at high density | |
| WO2004031176A3 (de) | Delta1-pyrroline als schädlingsbekämpfungsmittel | |
| BG103087A (en) | Method for the preparation of naphthiridons and intermediate compounds | |
| ZA200110246B (en) | Novel interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators. | |
| AU2001262240A1 (en) | Process for the production of 2,2,6-trimethylcyclohexane-1,4-dione |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |