JP2003500464A5 - - Google Patents

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Publication number
JP2003500464A5
JP2003500464A5 JP2000621320A JP2000621320A JP2003500464A5 JP 2003500464 A5 JP2003500464 A5 JP 2003500464A5 JP 2000621320 A JP2000621320 A JP 2000621320A JP 2000621320 A JP2000621320 A JP 2000621320A JP 2003500464 A5 JP2003500464 A5 JP 2003500464A5
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JP
Japan
Prior art keywords
alkenyl
alkyl
compound
substituted
hydrogen
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JP2000621320A
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English (en)
Japanese (ja)
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JP5059996B2 (ja
JP2003500464A (ja
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Priority claimed from PCT/US2000/013202 external-priority patent/WO2000073253A1/en
Publication of JP2003500464A publication Critical patent/JP2003500464A/ja
Publication of JP2003500464A5 publication Critical patent/JP2003500464A5/ja
Application granted granted Critical
Publication of JP5059996B2 publication Critical patent/JP5059996B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2000621320A 1999-05-14 2000-05-12 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法 Expired - Lifetime JP5059996B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13429599P 1999-05-14 1999-05-14
US60/134,295 1999-05-14
US18685300P 2000-03-03 2000-03-03
US60/186,853 2000-03-03
PCT/US2000/013202 WO2000073253A1 (en) 1999-05-14 2000-05-12 NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012137825A Division JP2012211162A (ja) 1999-05-14 2012-06-19 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法

Publications (3)

Publication Number Publication Date
JP2003500464A JP2003500464A (ja) 2003-01-07
JP2003500464A5 true JP2003500464A5 (enExample) 2007-07-05
JP5059996B2 JP5059996B2 (ja) 2012-10-31

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ID=26832188

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000621320A Expired - Lifetime JP5059996B2 (ja) 1999-05-14 2000-05-12 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法
JP2012137825A Withdrawn JP2012211162A (ja) 1999-05-14 2012-06-19 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012137825A Withdrawn JP2012211162A (ja) 1999-05-14 2012-06-19 新規インターロイキン−１および腫瘍壊死因子−αモジュレーター、前記モジュレーターの合成、ならびに前記モジュレーターの使用方法

Country Status (17)

Country Link
US (3) US6365768B1 (enExample)
EP (2) EP1591437B1 (enExample)
JP (2) JP5059996B2 (enExample)
KR (3) KR20060110013A (enExample)
CN (1) CN1361760A (enExample)
AT (2) ATE449754T1 (enExample)
AU (2) AU783372B2 (enExample)
BR (1) BR0011522A (enExample)
CA (1) CA2372962C (enExample)
DE (2) DE60043400D1 (enExample)
DK (1) DK1178952T5 (enExample)
ES (2) ES2337264T3 (enExample)
IL (3) IL146221A0 (enExample)
MX (1) MXPA01011613A (enExample)
NZ (3) NZ540001A (enExample)
PT (2) PT1591437E (enExample)
WO (1) WO2000073253A1 (enExample)

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US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP1925301A1 (en) * 2006-11-24 2008-05-28 DSMIP Assets B.V. Use of tricyclic diterpenes and their derivatives for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders
US7875853B2 (en) * 2007-07-23 2011-01-25 Honeywell International Inc. Low-cost PIR scanning mechanism
ME03529B (me) 2008-01-11 2020-04-20 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
EP2279197B1 (en) 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
CN102083442B (zh) 2008-04-18 2014-08-13 里亚塔医药公司 抗氧化剂炎症调节剂：在c-17具有氨基和其它修饰的齐墩果酸衍生物
SI2271658T1 (sl) 2008-04-18 2017-03-31 Reata Pharmaceuticals, Inc. Antioksidantni modulatorji vnetja: C-17 homologirani derivati oleanolne kisline
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
US20110293653A1 (en) * 2010-03-11 2011-12-01 University Of Massachusetts Antagonists of mir-155 for the treatment of inflammatory liver disease
EP2558105B1 (en) 2010-04-12 2019-11-20 Reata Pharmaceuticals, Inc. Bardoxolone methyl for the treatment of obesity
MY158661A (en) * 2010-10-27 2016-10-31 Sigma Tau Ind Farmaceutieche Riunite S P A Diterpenoid derivatives endowed of biological properties
EP2648706A4 (en) 2010-12-06 2014-07-23 Penn State Res Found COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES
CA2822071C (en) 2010-12-17 2019-07-16 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
HUE044081T2 (hu) 2011-03-11 2019-09-30 Reata Pharmaceuticals Inc C4 Monometil-triterpenoid-származékok, és módszerek azok alkalmazására
BR112014026640B1 (pt) 2012-04-27 2021-05-18 Reata Pharmaceuticals, Inc compostos derivados de 2,2-difluoropropionamida de metil bardoxolona, formas polimórficas, composição farmacêutica, e uso dos mesmos
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
RS59194B1 (sr) 2012-09-10 2019-10-31 Reata Pharmaceuticals Inc C17-alkandiilni i alkendiilni derivati oleanolne kiseline i metode za njihovu upotrebu
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
BR112018005861B1 (pt) 2015-09-23 2022-11-22 Reata Pharmaceuticals, Inc Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
CA3042123A1 (en) 2016-11-08 2018-05-17 Reata Pharmaceuticals, Inc. Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
CN106928095A (zh) * 2017-03-14 2017-07-07 华东师范大学 氰基烯酮类三环二萜类似物及其制备方法和应用
US10463631B2 (en) * 2017-06-12 2019-11-05 University Of South Carolina Pimarane diterpenoids for use in wound healing and angiogenesis
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
CN120248001A (zh) 2019-07-19 2025-07-04 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法

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WO2002079137A1 (en) 2001-03-28 2002-10-10 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use

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